Vietnam: Quang Ninh Prov.: Disclosure of avian influenza in Tien Phong commune (Hung Yen)

07/04/2010

7-4 morning, provincial People's Committee Decision No. 923/QD-UBND avian announced in Tien Phong commune, Yen Hung district.
-snip-

It is known, from 29-3, in four villages some households, Tien Phong commune has the phenomenon of mass bird deaths.

The sample for this bird were positive for the H5N1 virus.

Immediately after the test results, the functional bodies of Hung Yen has conducted a number of measures to put services, not to prevent a widespread epidemic.

Up to 6-4 days, Hung Yen has culled 1,602 poultry diseases, including 1552 and 302 ducks lay eggs; set up checkpoints at the local level for social Pioneer 72 liters of chemicals is spray disinfection; 10,000 doses of bird flu vaccines.

Currently, forces are conducting functional testing on the flu situation in the whole district and conduct disinfection spray the entire area is translated, the work of surveillance, inspection of all neighboring communes. If the findings will proceed promptly destroyed.

Earlier, in February and early March, flu occurred in the hamlet of Mai Hoa and Dong Mai Commune Nam Hoa with the number 670 infected children.

Vietnam: Avian Flu & Foot & Mouth Still Raging in some Provinces/Cities

Interested in prevention and disease for cattle, poultry

April 8, 2010

ND - From the Lunar New Year so far, avian flu, foot and mouth disease in cattle again raging in some provinces and cities, causing thousands of poultry, cattle disease.

Immediately after detecting the disease, the local initiative in carrying out anti-epidemic measures. However, because of complicated disease and the subjectivity of people have created favorable conditions for disease spread and development.

According to experts, the causes of recurrent disease on livestock and poultry vaccination is due process and implementation measures for prevention of people at the grassroots level and bad.

The most worried is the status of transportation, slaughtering and trading of poultry products is widespread, very difficult to control; the quarantine of animals is limited, so it can not detect cattle are incubation.

In addition, although people's awareness in the prevention and diseases have been raised, but not less farmers also subjective, not implemented the measures for prevention seriously.

In some localities, diagnostic capacity of veterinary staff is weak. Households when the disease is not detected immediately with vets that arbitrarily treated with traditional measures, causing difficulties in detecting and stamping service enclosure.

-snip-

H1N1 Outbreaks in US, Abroad Carefully Monitored

H1N1 Outbreaks in US, Abroad Carefully Monitored

by Anthony L. Kimery

Tuesday, 06 April 2010

'We are not seeing any significant evidence of a resurgent ‘third wave’ As the deadly H1N1 flu is making a comeback in places around the world, including in the southwest United States – Georgia in particular, which has been hit particularly hard – authorities are wondering whether these new outbreaks of the influenza virus represent a worrisome “third wave,” a new mutation, or whether something else is in play that’s responsible. Alabama and North Carolina also have reported outbreaks, Centers for Disease Control and Prevention (CDC) officials reported in their latest update on the spread of the virus. CDC warned Georgians to get vaccinated for the H1N1 flu. Georgia has one of the lowest rates of vaccination among its population, which some experts believe is likely contributing to the increase in new infections there. Local activity has also been reported in Arkansas, Louisiana, Mississippi, Tennessee, Virginia, Hawaii, New Mexico and Puerto Rico. Across the world in Malaysia, new A H1N1 clusters have been detected throughout the country, putting the country’s Health Ministry on high alert. Between March 21 and 27, 83 people in Selangor, Malacca and Terengganu were confirmed infected with the virus. Health Director General Tan Sri Dr Ismail Merican said the sudden clusters indicate the H1N1 virus is still active, but stressed that the government is on top of the new outbreaks. The World Health Organization (WHO) reported that the H1N1 pandemic influenza remains the most prominent influenza virus circulating around the world and that the virus remains active in parts of the tropical zones of Asia, the Americas, and Africa. Elsewhere, "an increasing trend in pandemic influenza activity for at least one week during March," according to the WHO, occurred in Guatemala, Nicaragua, El Salvador, Panama, Brazil, Peru, and Bolivia all reported. “At present, we are not seeing any significant evidence of a resurgent ‘third wave’ in the US,” the “notable exception [being] the recent sharp increase in cases in Georgia,” HSToday.us was told be a senior government public health preparedness official. “CDC was concerned enough to hold a conference call last week, where we learned that the state had this absolute lowest vaccination rate in the country last year. Thus it was left with a vulnerable population at a time when the virus was still in circulation. The official said “the average vaccination rate for the whole country stands at ~ 23 percent.” In Connecticut, in comparison, the rate is one of the highest in the country, at 43 percent. “Other New England states also fared well in this regard, a result of their intense regional cooperative planning,” the official noted. “Regarding H5N1, there have been sporadic reports of minor changes in viral structure, but none that have thus far led to increased transmissibility,” the official added, saying that “virulence remains the same with a consistent 60 percent mortality rate in the human population. The most recent cases are still coming from Egypt and Viet Nam. Overall, WHO’s case count now stands at 492 documented cases, with 291 associated deaths.” Authorities continue to be concerned that as pandemic H1N1 comingles with the highly fatal H5N1 bird flu there could be a genetic “reassortment” of the two viruses, potentially resulting in a deadly new flu virus. Writing in his latest bulletin, Michael Osterholm, director of the Center for Infectious Disease Research & Policy (CIDRAP) and director of the National Institutes of Health-supported Center of Excellence for Influenza Research and Surveillance within CIDRAP, said “recent novel H1N1 influenza developments in the southeastern region of the United States merit … attention. They're prime examples of why we must vigilantly expect the unexpected. Osterholm pointed out “an unusual level of hospitalizations linked to lab-confirmed novel H1N1 influenza in the state of Georgia prompted CDC to call a short-notice press briefing and describe the uptick as a ‘worrisome trend.’” “Most of the hospitalized patients are adults who have chronic medical conditions and did not get the H1N1 vaccine,” Osterholm wrote, adding “Georgia had one of the lowest rates of H1N1 vaccination last fall, and people with chronic medical conditions are among the groups considered at high risk of developing complications if they're infected by the novel H1N1 pandemic virus. “I don't know the last time in April we've seen an increasing number of hospitalizations for influenza,” Osterholm stated, adding, “of note, the number in Georgia is similar to the number of hospitalizations seen at the height of the second pandemic wave last October. In short, the trend is unexpected. Does it portend a third wave of the pandemic? We just don't know … But I sure wouldn't rule out the possibility.” “For now, what we do know is that what's happening in Georgia is unusual for this time of the year and that people who are getting sick enough to need hospital care did not get vaccinated and are among the groups considered to be at high risk of developing complications,” Osterholm wrote. Meanwhile, researchers have reported in a new a study published in Science Translational Medicine that the H1N1 swine influenza virus shares an important surface protein with the virus responsible for the 1918 flu.

Swine flu scare was unnecessarily exaggerated: WHO

STAFF WRITER 17:30 HRS IST New Delhi, Apr 6 (PTI) A top official of the World Health Organization today admitted that the global swine flu scare was unnecessarily exaggerated, an allegation the international body faced when the killer disease claimed thousands of lives in several countries including India.

"Yes, yes," said Dr Samlee Pilanbangchang, regional director, South-East Asia, WHO, when asked whether the swine flu scare was unnecessarily exaggerated.

He was addressing an function here on the eve of World Health Day.

When the WHO official made the candid admission his colleagues in the organisation intervened and he did not speak further on the matter.

WHO was criticised last year for its handling of the swine flu pandemic and was accused of exaggerating the danger of the virus under pressure from different countries and drug manufacturers.

Malaysia: H1N1 Mother/Daugher Confirmed - Update

[This sounds to me like the Mother had recently contracted H1N1, probably from her daughter, but it did not disperse enough to cause her death.]

54 yo (Mother)
Adm: 3/30
Notes: Diabetic
DOD: 3/31

From the Ministry of Health Website:
Excerpt:

The first case was a 54-year-old woman who is a diabetic (diabetes mellitus). He was admitted on March 30 with symptoms of Inclusion and further treated with Tamiflu. Laboratory tests confirmed he was positive for H1N1. However, he also experienced problems, uncontrolled diabetes, the complications caused "severe metabolic acidosis" due to total kidney failure, other bacterial infections (sepsis) and diabetes was not controlled. X-ray of the lungs did not show any signs of pneumonia to be associated with H1N1. So his death was directly caused by complications of diabetes.

hat-tip RoRo

Malaysia: National Svc. Training Prg. @ Gua Musang - 40 quarantined in Hospital

Berita Harian
Selasa, 06/04/2010 Tuesday, 06/04/2010

40 trainees in Gua Musang quarantined

KOTA BHARU: A total of 40 trainees of the National Service Training Program (NS) at Camp Ethnobotany, Gua Musang, quarantined since yesterday afternoon after experiencing symptoms of disease detection, such as influenza (Inclusion).

All students involved are now placed under strict surveillance Gua Musang Hospital and other health workers involved in the camp is not allowed to interact and mingled with 310 other trainers at the camp said.

Director General of the National Service Training Department (JLKN), Datuk Abdul Hadi Awang Minor, said up to yesterday, the health status of 40 students involved, including 11 women had no concern for treatment, including medication to prevent flu that they suffer from prolonged.

"We still have not received confirmation of whether the student is infected 40 Influenza A (H1N1) or not because so far the medical officer conducting the examination to only inform the group that appears to be the inclusion of symptoms that concern," he said when contacted yesterday.

"However, to ensure their health guaranteed, 40 trainees are not allowed to participate in any activities and training with other trainers, but quarantined in two blocks of each food they are normally well enough drugs," he said when contacted yesterday.

Abdul Hadi said, JLKN also have direct management of the camp is to increase the level of cleanliness around, in addition to ensuring that canteen operators maintain personal hygiene and cooking food properly to avoid the problem persists.

"I have ordered 79 NS camps around the country ready to face a variety of possibilities including the second wave of H1N1 is reported to be affected due to the Ministry of Health warned," he said.

He said parents who are now quarantined students do not need to worry because their health condition is not worrisome, other will follow the usual practice after a medical officer.

Meanwhile, Kelantan Health Department Deputy Director, Dr Wan Mansor Hamzah, said his party is carrying out vaccination against 5.091 injections health officials around the country, as well as 2.270 other officers of various agencies working in the front line, and 1.370 of the public, especially among high risk groups affected infection.

Alor Setar: Test sample inclusion disease, which is taken from students and staff of the three schools in Langkawi last week has been confirmed in laboratory Sungai Buloh Hospital, Selangor as H1N1 infection.

Until yesterday another school of the Chinese National Type Schools (SJKC) Chung Hwa in Langkawi closed for five days from the day it closed four schools in the country, while two of the National Secondary School (SMK) Mahsuri and the Mara Junior Science College (MRSM ) is in the attention of the State of NSW Department of Health following the spread of diseases such as influenza (Inclusion).

. Langkawi District Health Officer, Dr Mansor Ismail, said that at about 8.30 am yesterday the Special Task Force (CDC) Langkawi District Health Office to bring more than 40 students SJKC Chung Hwa to Madiun Health Clinic to receive treatment early after infection Inclusion.

hat-tip kiwibird

Malaysia: Fourth school in Langkawi closes over flu-like illness

Previous reported here . Update on the 3 schools last week:

Alor Setar: Test sample inclusion disease, which is taken from students and staff of the three schools in Langkawi last week has been confirmed in laboratory Sungai Buloh Hospital, Selangor as H1N1 infection. Link

By EMBUN MAJID
embun@thestar.com.my

ALOR SETAR: A fourth school in Langkawi has closed after its pupils were found to be suffering from influenza-like illness.

The Kedah Education Department closed SJKC Chung Hwa after 40 pupils were found with the illness.

Department director Shahidan Abdul Rahman said the school would be closed for five days beginning today.

“This is the fourth cluster of influenza-like illness in Langkawi and the Health Department is closely monitoring all schools on the island.

“Last week, SMK Langkawi Pulau Tuba, SK Bagan Nyiur Selat and SMK Teknik Langkawi were ordered closed between five and six days,” he added.

Shahidan said SMK Langkawi Pulau Tuba was re-opened on Sunday, SK Bagan Nyiur Selat was re-opened yesterday while SMK Teknik Langkawi would be opened today.

It is learnt that the state Health Department is also closely monitoring SMK Mahsuri and Maktab Rendah Sains Mara after more than 20 students from both schools were treated for flu yesterday.

Meanwhile, Kedah Health Committee chairman Dr Ismail Salleh said 200 students from SMK Langkawi Pulau Tuba, SMK Teknik Langkawi and SK Bagan Nyiur Selat were confirmed positive for the A(H1N1) virus.

“All of them were given anti-viral drugs and then quarantined at home.

The state had earlier recorded a total of 14 A(H1N1) cases with no deaths recorded.

“The state Health Department will closely monitor all schools, higher learning institutions and colleges,” he added yesterday.

hat-tip Pathfinder

Malaysia: Quarantine Family of Mother/Daugher Confirmed Deaths

From previous post:

He added that Mustaza’s family and his youngest daughter Fatimah, 17, were put under house quarantine for a week since Friday and that the authorities were monitoring their condition daily.

Berita Harian
Isnin, 05/04/2010 Monday, 05/04/2010

Two-child family of fatal H1N1 quarantined
Oleh Amir Mamat By Amir Mamat

JASIN: Family of two who died after birth confirmed infected with the epidemic of Influenza A (H1N1) on Tuesday, while quarantined in their homes in Batu 14 Jalan Jasin, Merlimau near here, to avoid spreading the disease.

Chairman of the Committee of Women, Family and Health states, Datuk Norpipah Abdol, Jasin said the Health Department is directed to monitor the cleanliness of the home involved while ensuring that residents are not independent of external activities. He said his house was also ordered residents to wear face masks at all times when outside the home than they need to keep the house clean of any contamination. "They should not leave home independently until certified safe by the State Health Department.

"I hope that the family comply with all instructions from the relevant parties," he said when contacted here yesterday.

The newspaper reported yesterday, Maimunah Dimah, 54, died on Wednesday last before, followed her second child, Sumarni Md Nor, 30, last Friday due to H1N1 infection.

More sad family involved when Sumarni not find time to see a small child she brought a new, four days ago that had to be placed in the Intensive Care Unit (ICU) Melaka Hospital unconscious shortly after undergoing surgery to remove her baby.

hat-tip kiwibird

Malaysia: H1N1 Mother & Daugher Confirmed; Died

Previously reported here and here ... [We still do not have an onset date....]

Monday April 5, 2010
Wife’s last wish to hubby — look after family and mum


MALACCA: Be strong and don’t worry, these were the last words Mustaza Sarmat, 29, said to his wife Surmani Mah Nor as he held her hands before she underwent a Caesarean operation to save their child at the Malacca Hospital last Wednesday.

“I was by her side. I told her to be strong. I even promised her that both of us would raise our family together,” a tearful Mustaza said as he related his last moments with his wife who slipped into a coma during the operation and died two days later on April 2.

“She told me to look after our family and her mother,” he added. Surmani, 29, and her mother, Maimunah Dimah, 54, who died on March 31, had both contracted the A(HINI) virus.

He said that Surmani, who had a mild fever and slight cough, had sought treatment at a private clinic near their home in Jalan Jasin, Merlimau.


He added a routine pre-natal check up at the Malacca Hospital on March 29 revealed the baby’s heart was beating rapidly, prompting doctors to perform a Caesarean to save the girl.
The 2.95kg baby is free from the A(HINI) virus and is in an incubator at the hospital.

“We have yet to name her,” said Mustaza, a contract worker with Indah Water Consortium in Muar.

Meanwhile, Maimunah’s husband and Surmani’s father, Mah Nor Mah Nasir, 65, was still in shock over the family’s double loss but accepted it as fate.

He said the family had not told Surmani’s three-year-old daughter Nuraira Batrisyia of her mother’s death.

He added that Mustaza’s family and his youngest daughter Fatimah, 17, were put under house quarantine for a week since Friday and that the authorities were monitoring their condition daily.

hat-tip kiwibird

More bird flu cases arising in Vietnam

Tuesday ,Apr 06,2010, Posted at: 15:02(GMT+7)

Another person suffering from a severe case of avian influenza is being treated at the National Tropical Diseases Hospital in Hanoi, the hospital announced on April 5. Vets will spray chemicals to disinfect the areas where have had infected bird flu patients A 22-year-old male from the northern province of Bac Kan, the sixth bird flu case since the beginning of the year, is in serious condition and requires the use of a breathing machine, said the hospital’s director Nong Quoc Chi. The patient was transferred to the hospital from the province’s General Hospital on April 3 with symptoms including a cough and high fever. Tests conducted by the National Epidemiology Institute on April 4 showed he was positive for the bird flu virus (A/H5N1). An investigation has revealed there were dead waterfowl in the man’s neighborhood. Four other residents from the man’s commune also showing bird flu symptoms have been quarantined and are also under treatment at the National Tropical Diseases Hospital. Bird flu has claimed two lives in Vietnam so far this year.

Vietnam: Outbreak of encephalitis, meningitis in children

06/04/2010,
Excerpt:

In the emergency room less than 30m ² of the science-NERVES Infection Children's Hospital 1, more than 15 children will be breathing machine and fall into the encephalitis, meningitis. Dr. Truong Huu Khanh, Dean, said in two weeks encephalitis, meningitis abnormal increase in number of hospital admissions. If the past 3-4 days I shall only about 40 yesterday (5-4) already are 58 grandchildren.

"Since the New Year so far Dan Geng cases continued to increase. This is unusual, because the previous year every month only a few scattered cases. But now it is up to tens of cases, "said Dr. Khanh.

Meanwhile, Dr. Tran Van Ngoc, Head of Children's A City Hospital for Tropical Diseases, said that recent weeks of children with meningitis, encephalitis also increased significantly. Dr. Ngoc warning meningitis are due to seasonal weather changes, prolonged hot ... Information from the Department of Children's Hospital Infection 2 City yesterday said more than 10 children being treated with meningitis, encephalitis increase over the previous week.

http://translate.googleusercontent.com/translate_c?hl=en&ie=UTF-8&sl=vi&tl=en&u=http://www.sggp.org.vn/ytesuckhoe/2010/4/222694/&prev=_t&rurl=translate.google.com&twu=1&usg=ALkJrhghSZYmmYHjRxUTE7nSMZlQVWDqpA

Commonground's Map Vietnam H5N1 & H1N1 Outbreaks

Vietnam 2010 [click on map]

Red: H5N1 Human Confirmed
Blue: H5N1 Poultry Confirmed in assoc. with Human Confirmed
Yellow: H5N1 Confirmed Poultry Outbreaks
Purple: H1N1 Confirmed Humans
Green: Misc. ex: H5N1 Suspected Cases, Respiratory; hospital overloads...

Vietnam: H5N1 Human Confirmed Case+4 others in Hospital w/symptoms (2 articles)

Young men critical because bird flu
Thứ hai, 5/4/2010, 18:20 GMT+

The dead poultry slaughter contagious bird flu. Photo: Hoang Ha.

Patients 22 years old, hamlet Nà Tào, commune Như Cố, Bac Kan province newly identified positive for H5N1. He is in critical condition, have ventilation.

Mr. Nong Quoc Chi, Director of Health Department of Bac Kan province, said on 2 / 4, patients in the provincial hospital with signs of fever and cough. A day later, he was transferred to hospital treatment in the central tropical diseases, to breathing machines.

To date 4 / 4, Institute of Hygiene and Epidemiology result of male patients tested positive for H5N1. According to epidemiological investigation, in which patients live poultry have died phenomenon.

Chi also said, in the commune seemed to have four more people with symptoms of high fever and cough, are isolated, tracking. But the health of all four men are stable.

Recently, in Soc Son, Hanoi, a pregnant women infected with H5N1 has killed nearly three times over 20 days in hospital.

Many experts are worried that H5N1 viruses are getting stronger motivation, especially the ability to combine with influenza H1N1 virus, spread rapidly.

In 2010, Vietnam has also recorded cases of death due to this virus is the first female patients, aged 38, in An Thai Trung commune, Cai Be district, Tien Giang Province. In the last year, including five cases of H5N1 have died.
hat-tip Treyfish

A bird flu case detected in Bac Kan province
: 6:52 PM, 04/05/2010
The Director of the Bac Kan provincial Health Department, Nong Quoc Chi, confirmed an A/H5N1-infected case on April 5.
The patient, Trung Van Hoa, 22, from Na Tao hamlet, Nhu Co commune, Cho Moi district, is currently in critical condition. He is being treated at the Central Hospital for Tropical Diseases.
The patient got sick on March 30 with symptoms of high fever and cough. He was admitted to Bac Kan provincial hospital, and then sent to the Central Hospital for Tropical Diseases on April 3 where he tested positive for the lethal strain of A/H5N1 virus.
At present, four other people in Nhu Co commune show similar symptoms of high fever and cough. They are under quarantine and being treated at Bac Kan provincial hospital.
http://english.vovnews.vn/Home/A-bird-flu-case-detected-in-Bac-Kan-province/20104/114331.vov
hat-tip Treyfish

Egypt: Case #109 Died - Fayoum

[This is from Egypt State Information Service]
Sunday, April 4, 2010
Ministry of Health announced in a statement in 3 / 4 / 2010, for a new human virus (H 5 to 1) causes AIDS "bird flu", bringing the total casualties since the disease appeared in Egypt in 2006 and so far 109 cases.

وأوضحت وزارة الصحة أن المصابة سيدة تبلغ من العمر 18 عاما من "إطسا" بمحافظة الفيوم -صعيد مصر- وحالتها حرجة,حيث دخلت مستشفى حميات الفيوم يوم 31 مارس الماضي وهى تعانى من ارتفاع شديد فى درجة الحرارة وصعوبة فى التنفس وضيق فى الصدر. The ministry of health, to the infected woman at the age of 18 years of "Atsa" Fayoum Governorate - Upper Egypt - and in critical condition, where he entered the hospital admitted Fayoum on March 31, suffering from high fever and difficulty in breathing and tightness in the chest.

وذكر البيان أنه تم إعطاء المصابة عقار "تاميفلو" على الفور إلا أن حالتها حرجة وتم تحويلها إلى مستشفى صدر الجيزة. The statement said it was given infected drug "Tamiflu" immediately but in critical condition was transferred to a hospital in Giza.

Egypt: Listing of H1N1 Confirmed/Suspected/Death & H5N1 Poultry Outbreaks

Swine Flu

[Death #273 and #274 - the location is not known]

Confirmed Death

9 mos

From: Asafra

DOD: 4/3

Suspected Cases

4/3: 20 yo

From: Kafr el-Dawwar

MOH Report Confirmed

4/3: 274

Admitted: 16

Total Cases: 16,183

Confirmed Cases

4/2:

22(F) – Sidi Bach district

37 - Kabary district– West

32 – Amiriya district (6 mos preg.)

9 mos – Asafra area district park – DOD: 4/3

5 yo – Sidi Bishr – Park

6 yo - (Frankincense?)

27 yo – Samouha East District (8 mos preg.)

Avian Flu Poultry

3/3

350 Birds executed

48 issued sale of live birds

17 breeding nests removed

10 stores closed

4/1:
Execution of 924 birds, East & West Alexandria.... to remove 122 of breeding birds nest and re-closure of 28 shops selling live birds.

3/19
East & West of the City...arrest 47 in Alexandria, issue of sale of live birds have been culled 550 birds alive and in the framework of the efforts of security officers,...remove 20 of the breeding birds nest and re-closure of 23 shops for the sale of birds...And seized a truck carrying 270 live birds before they are sold in markets east of the city

Malaysia: Johor Bahru: 40 H1N1 Confirmed Cases

April 4, 2010
By FARIK ZOLKEPLI


JOHOR BARU: A total of 40 patients in Johor have been confirmed positive for A (H1N1) virus this year.

State Health department director Dr Mohd Khairi Yaakub said that all the cases, which were recorded in the first three months this year, were transmitted locally and no deaths were reported.

“All the infected patients have been quarantined.

“These patients are being treated at the respective hospitals in the state,” he said adding that, the state recorded a total of 704 positive cases were recorded last year.

Dr Mohd Khairi, who was speaking to newsmen after attending the launch of the Malaysia Clinic in Taman Megah Ria here, said the department was continually conducting checks at various checkpoints in the state to prevent the virus from spreading.

He also reminded the people to take precautionary measures such as going for medical check-up when experiencing coughing or flu and wearing masks.

“The people must not be complacent by thinking that the virus is not around anymore.

“They must always be on their guard to prevent infection or spread of the virus,” he said.

Meanwhile, he also announced that the state had already recorded 691 dengue cases this year, resulting in three deaths.

“Two of the patients died in Segamat while another in Kota Tinggi.

“It is a serious matter and thus, the people must play their part in curbing the spread of dengue,” he said.

He added that the people must ensure the cleanliness of their homes or premises to prevent the breeding of mosquitoes.

MALAYSIA: two schools closed due to pandemic

Previously reported here:

04/03/2010
Langkawi island district authorities, the state of Kedah, Malaysia has decided to temporarily close two schools to ...

Langkawi island district authorities, the state of Kedah, Malaysia has decided to temporarily close two schools to prevent contagious diseases when there are nearly 200 school children here suffer from symptoms of cough and high fever.

As representatives of the local health agency, has 112 students from a cold, cough and fever, the island of Pulau Tuba schools have closed six days, longer school Pulau Dayang Bunting Island Elementary School has closed for more than 50 students suffer from these symptoms.

In addition, a technology center in Langkawi also in a state of being closely monitored and shut down because of suspected influenza infection students exceed safe levels.

Langkawi authorities then formed a specialized team to monitor the situation and not to prevent the disease spreading. "We have sent samples to the Sungai Buloh Hospital tested, but so far no results so provisional that is not yet determined what flu strains," a member state of Kedah for the Department of Health know.

At many other schools in Langkawi, students and teachers went to school with medical masks.

Egypt: H5N1 Human Case #109 - Died

2010-04-04 PM

She died Saturday, April 3rd - Amani welcome on the rain - 20 years - mother of a child one year old and a half from the village of Minya Hait Atsa Fayoum as a result of being infected with avian influenza.

Have been booked Ms. after the suspected condition Wednesday afternoon at the hospital admitted Fayoum, but poor care and lack of network gas, which crashes on a respirator for work, and the lack of intensive care at the hospital increased the deterioration in her condition, was transferred Friday evening to a hospital in the urban province Giza, but woman has died there .

The cause of bird flu is dealing directly with domestic birds.
The breeding domestic birds with a high priority in the villages of Fayoum, especially after the rise in prices of meat and poultry in the last period.

Egypt Confirmed Human H5N1 Cases For 2010

This listed will be located under Egypt Fact Box in the right sidebar.

Confirmed Human Cases For 2010

Age, Location, Onset Date and # confirmed by Min. of Health

20 yo, [Beni Suef] January 6,- Given Tamiflu for 10 days- #91- Died

1.5 yo [Dakahliya], January 7, #92

3 yo [Asyut] January 19, #93

45 yo [Ash Sharqiyah] January 12, #94

40 yo [Daqahliya] January 31, #95 (WHO Update #28)

29 yo [Menoufiya], January 27, #96 - WHO update #28 - Died

37 yo (Helwan] January 31, #97 - Died 2/9

32 yo [Menoufiya] February 6, #98

29 yo [Menoufiya], February 6, #99 - Died

10 yo [Daqahliyah] February 10; #100

30 yo [Ash Shaykh] February 10; #101

13 yo [Ash Shaykh] February 10; #102

1 yo [Qalyubia Gov.] February 22; #103

53 yo [Qalyubia Gov.] February 27; #104 - Died

20 yo [Qalyubia/Qaloubiyah Gov.] Adm: 3/5; #105 - Died

1.5 [Ash Shaykh Gov.] Adm: 3/2; #106

4 yo [Beni Suef Gov.] Adm: 3/18; #107 - Died

30 yo [Damietta Gov.] Onset: 3/24; #108

18 yo [Fayoum Gov.] Adm: 3/31; #109 - Died

20 yo [Qalyubia/Qaloubiyah Gov.] Adm: 7/21; #110 - Died

2 yo [Cairo Gov.] Adm: 8/4; #111

Egypt: H5N1 Human Case #109 - Fayoum Gov.

Ministry of Health: a new human case of bird flu, a woman from Fayoum

The Ministry of Health for a new human virus (H 5 to 1) causes AIDS "bird flu", bringing the total casualties since the disease appeared in Egypt in 2006 and so far 109 cases.

وأوضحت وزارة الصحة - فى بيان صحفى اليوم "السبت" -أن المصابة سيدة تبلغ من العمر 18 عاما من "إطسا" بمحافظة الفيوم -صعيد مصر- وحالتها حرجة،حيث دخلت مستشفى حميات الفيوم يوم 31 مارس الماضى،وهى تعانى من إرتفاع شديد فى درجة الحرارة وصعوبة فى التنفس وضيق فى الصدر.

The ministry of health - in a press release today, "Saturday" - that the infected woman at the age of 18 years of "Atsa" Fayoum Governorate - Upper Egypt - and in critical condition, where he entered the hospital admitted Fayoum on March 31, suffering from a very high degree of heat and difficulty in breathing and tightness in the chest.

وذكر البيان أنه تم اعطاء المصابة عقار "تاميفلو" على الفور، إلا ان حالتها حرجة وتم تحويلها إلى مستشفى صدر الجيزة.

The statement said it was given infected drug "Tamiflu" immediately, but the critical condition was transferred to a hospital in Giza.

Campaigns to larger markets and shops selling live birds and frozen meat refrigerators in Cairo

3/4/2010
In the fight against avian influenza, said Dr. Ezzat Ramadan, Director of Directorate of Veterinary Medicine in the seizure of the car number 865 AD. E.'s Driving b / Sheriff Abdel-Mohsen loaded ..

The number of 1455 live chickens weigh about 2852 kilograms and does not have any licenses for the transfer of live birds, was immediately confiscated the car and go to the abattoir the United Company for Poultry Production walks and supply the amount of forfeiture to the state treasury, as the Directorate ambush zone of peace at the position X, which enables set of 4 cars loaded with live birds, the number of 2650 birds were confiscated four cars and edit the records of the facts.

This comes following the instructions of Dr. Abdel Azim Wazir, Cairo Governor need to tighten control on markets, shops and ambushes on the entrances and exits of Cairo to prevent the circulation of live birds, which is prohibited by law No. 70 of 2009 sold live for citizens around without causing any injuries from bird flu, as well as directives of the Governor of Cairo to set the meat, fish unfit for human consumption in order to preserve the health of citizens, the Directorate of Veterinary Medicine campaigns enlarged to increase its grip on the market and prevent any attempts to manipulate and endanger public health campaigns have resulted in seizures of live birds and frozen meat and fish corrupt.

In the context of control over markets and shops selling, offering meat and fish, and in preparation for the Spring Festival, has been seized 1853 kilograms fish herring and Fissek and salinity unfit for human consumption, and adjust the plant is not authorized City of Peace fills, and meat processing without a license and control of veterinary terms is set to 1300 kilogram of sausage and meatballs and frozen meat and non-anonymous blogger on the data to the production and shelf life, and is set to 140 kg of smoked fish in an invalid state of the central market and consumption market random Nile city of peace.

Also managed the Directorate to set the Shader unauthorized Square Isbeko city of peace in a bid for goat meat, of great age weighing 350 kg and the state unfit for human consumption, and the execution of the meat in a healthy way, as well as to adjust the 75 kg of meat outside the massacres place of Butcher Quarter Tenth City Nasr, corrupt, and with jaundice and yellow, and adjust the car number P-963. and. p ambush umbrellas carry 225 kg liver imported unfit for human consumption, and adjust the 350 kilogram liver Moqattam invalid.

Were raided Store Street Revolution were seized large quantities of meat, fish, shrimp and Alcalmari and artifacts fish weighing 4667 kg unfit for human consumption, were also seized 12 kilograms of cheese, different factory were burned quantities of rotten meat and fish Holocaust slaughter automation gardens.

During the traffic on the massacres to make sure there are no violations of it, transmitted d. Ezzat Ramadan, the doctor in charge of the abattoir Bibo 2 to investigate the lack of presence and to supervise the slaughter of animals Palmdzr and also decided to withdraw the licenses of movement of birds from slaughter for three days because he is developing products in the bags of white does not have any data for the slaughterhouse or product.

The execution of 350 birds alive in the campaign against avian influenza in Alexandria

Saturday, April 3, 2010

Investigation of Supply officers managed to Alexandria, to set the 48 issue of the sale of live birds and the execution of 350 birds alive, and in the framework of the efforts of security officers of the Directorate of Alexandria in the fight against bird flu.

During the campaign, which included east and west of the city, and was attended by officers of the Investigation of Supply and criminal investigators, and bodies and the environment and facilities in coordination with the Directorate of Veterinary Medicine and Department of Agriculture, remove 17 of the nest of breeding birds and re-closure of 10 stores selling live birds by their owners seals were broken and open, as awareness citizens the seriousness of the disease. And continue the Security Directorate of Alexandria efforts to combat the disease.

Egypt: 4 cases of swine flu in Alexandria

There is also a lot of H5N1 in poultry in Alexandria recently.

3/19
East & West of the City...arrest 47 in Alexandria, issue of sale of live birds have been culled 550 birds alive and in the framework of the efforts of security officers,...remove 20 of the breeding birds nest and re-closure of 23 shops for the sale of birds...And seized a truck carrying 270 live birds before they are sold in markets east of the city

4/1:
Execution of 924 birds, East & West Alexandria.... to remove 122 of breeding birds nest and re-closure of 28 shops selling live birds.

Saturday, April 3rd, 2010 - 15:48

Dubai Chamber of follow-up to the swine flu, Alexandria governorate, the emergence of 4 new cases of the disease, which is of a girl (22 years) from the region of Sidi Bach district park and Confectioner (37 years) from the Kabary district of the West, and a woman (32 years) Amriya district and are months pregnant and the sixth child 9 months Asafra area district park. All cases have been transferred to the fever hospital in Alexandria.

US Capital, New York and Wisconsin Add 15 Recent Samples to the Cross-Linked Background

2010-03-26
Silent HA and NA Polymorphisms Correlated with Fatal 225G Cases in the Ukraine and Russia

• HA:syn413K encoded from A1281G, AAa->AAg
• NA:syn407V encoded from T1221C, GTt->GTc

PF11 Sequences Demonstrating Cross Segment Linkage

• Iraq8529E3 with HA 131L, 160L, 194I, 298V and syn419L (Kentucky19 and 225G Utah42)
• Iraq8529M1 with HA 131L, 160L, 298V and syn419L (Kentucky19 and 225G Utah42)
• Iraq8531 with HA 130E, 131L, 298V and syn419L (Kentucky19 and 225G Utah42)
• Australia Victoria2129 with potential H5N2 inclusions and NA 454S
• Australia Victoria2130 with NA 454S
• Ukraine Kyiv377 with mixture of 225D, 225G, 225N, 225S, 225T and 225A
• Ukraine Lviv673
• Ukraine Lviv682
• Ukraine Cherkasy332
• Ukraine Cherkasy333
• Ukraine Cherkasy346
• Ukraine Chernihiv855L with mixture of wt 225D / 225G and additional 1918 Markers (syn238E & 324I), Fatal outcome
• Ukraine Chernihiv856 with mixture of wt 225D / 225G , Fatal outcome
• Ukraine Chernihiv857 with mixture of wt 225D / 225G and additional 1918 Markers (186P, syn238E, 324I & G796A), Fatal outcome
• Ukraine Chernihiv858, Fatal outcome
• Ukraine Dnipropetrovsk260
• Ukraine Dnipropetrovsk267
• Ukraine Dnipropetrovsk268
• Ukraine Dnipropetrovsk272
• Ukraine Dnipropetrovsk273 with mixture of wt 225D and 225G
• Ukraine Dnipropetrovsk274
• Ukraine Dnipropetrovsk1124
• Ukraine Dnipropetrovsk1171
• Ukraine LvivN2 with 225G
• Ukraine LvivN6 with 225G
• Ukraine TernopilN10 with 225G
• Ukraine TernopilN11 with 225G
• Ukraine Volin226 with 225G
• MoldovaG120
• MoldovaG140
• MoldovaG181
• MoldovaG182
• MoldovaG191
• HA and NA Norway2924 with mixture of wt 225D and 225G
• HA and NA Norway3364-2
• HA and NA Denmark AarhusINS82 with syn177L and 324I
• HA and NA Denmark CopenhagenINS95 with 69K, syn157K and 176I
• HA and NA Denmark CopenhagenINS98
• HA and NA Poland WarsawINS100 with 324I and 377K
• HA and NA Greece AthensINS85 with syn57C, syn233Y, 324I and 377K
• HA and NA CatNS7362 TamiFlu Resistant
• HA and NA CatS1096
• HA and NA CatS1162
• HA and NA CatS1179
• HA and NA CatS1181
• HA and NA CatS1267
• HA and NA CatS1268
• HA and NA CatS1402
• HA and NA CatS1501
• HA and NA CatS1687
• HA and NA CatS1748
• HA and NA CatS1751
• HA and NA CatS1761
• HA and NA CatS1827
• HA and NA CatS1935
• HA and NA CatS2120 with multiple swine markers
• HA and NA CatS2151 with swine markers and 165N (TamiFlu Resistant CatNS7632 and Russian 225G Salekhard01)
• HA and NA Guangdong02
• HA and NA Guangdong05
• HA and NA SingaporeON1156
• HA and NA India BloreNIV236 with 226R, syn372Q, 454N and 550T
• HA and NA Sweden Stockholm31
• Sweden Malmoe1 from 2010 with 190Y, 324I and 377K
• Sweden Gothenburg2 with 146G, 324I (1918) and markers found extensively in Moldova and Russia
• HA and NA Russia4 with syn238E and 324I (1918)
• HA and NA Russia12 with 324I (1918)
• HA and NA Russia14
• HA and NA Russia19 with 324I (1918)
• HA and NA Russia74
• HA and NA Russia149
• HA and NA Russia165
• HA and NA Russia171 with 165N
• HA and NA Russia178
• HA and NA Russia180 with 165N, syn239P and 264G
• HA and NA Russia190
• HA and NA Russia191
• HA and NA Kurgan01 with HA 214E (MoldovaG168, G176, G188) and NA mixture at 407 (Fatal 225G Abakan02)
• HA and NA Omsk02
• HA and NA Tver2969 with 225G, Fatal outcome
• HA and NA Salekhard01 with 165N and 225G, presumptive Fatal outcome
• HA and NA Orenburg2974 with 225N, potential Fatal outcome
• HA and NA Perm01 with 131P, 225G and 324I, presumptive Fatal outcome
• HA and NA District of ColumbiaINS43 with 22I, syn157K and 176I *
• HA and NA NY3702
• HA and NA NY3715
• HA and NA NY3828
• HA and NA NY4398 *
• HA and NA NY4977 with 189T *
• HA and NA NY5086 with 22I, syn157K, 176I and 264T *
• HA and NA NY5186 *
• HA and NA NY5227 with 189T *
• HA and NA NY5931 with 22I, syn157K, 176I and 262K *
• United States NewYork96
• HA and NA RhodeIsland08
• HA and NA Texas42102708
• HA and NA Texas45072128
• HA and NA Texas45122886
• HA and NA Wisconsin629_D00544 with 22I, syn157K and 176I *
• HA and NA Wisconsin629_D00853 with 22I, syn157K, 176I, 188I, 231K and 277N *
• HA and NA Wisconsin629_D01915 with 22I, syn157K, 176I, 188I, 231K and 277N *
• HA and NA Wisconsin629_D01987 with 189T and 324I *
• HA and NA Wisconsin629_D02060 with 22I, syn157K and 176I *
• HA and NA Wisconsin629_D02337 with 22I, syn157K, 176I, 188I, 231K, 277N and 285S *
• HA and NA Wisconsin629_S1252 with 189T and 324I *
• United States Kentucky19 from an 18 year old subject with HA 298V
• United States Indiana20 from a 10M subject with 5 Avian H5N1 markers
• US Private Sequence TamiFlu Resistant
• United States NorthCarolina37 from a 24F subject with HA 298V
• United States NorthCarolina44 from a 50M subject with 6 Avian H5N1 markers
• United States NorthCarolina46_C2 from a 39F subject with HA 298V
• United States NorthCarolina46_C2C1 from a 39F subject with HA 298V
• HA and NA swine/NC/34752 with 298V
• HA and NA swine/OR4060 Emergent Non-PF11 Lineage of H1N1 2009-12-31 *

113 sequences have encircled the globe as of 2010-03-24 * with high fidelity carrying a cross-segment paired set of background markers matching and contributing to fatal cases in the Ukraine and Russia. 225G appears in 14 on this background; 225N once and 225E precisely zero. The first occasion of 226R entered the list this week retrospectively due to sequence release delay with a June 2009 case from India.

The 15 newest entries represent a diverse geography within the United States of ΣPF11 infections, including 1 entry for Washington D.C., the nation's capital, 6 from New York and 7 from Wisconsin. The final entry is an H1N1 swine from Oregon that documents an emergent non-PF11 lineage building onto this cross segment linkage.

The available data, though sparse, requires the simple evaluation that this pandemic reservoir is not approaching stasis. The background continues to widen within the existing clades adding polymorphisms from H5N1 and 1918 strains demonstrating that ΣPF11 is far from reaching Omega status. Movement onto this cross-linked background has accelerated recently, now encompassing 2% of all available pandemic sequences.

Areas covered include Texas (3), the Northeastern United States (11), Wisconsin (7), Oregon, Washington D.C., Kentucky, Indiana, North Carolina (5), China (2), Singapore, India, Australia (2), the Ukraine (23), Moldova (5), Russia (18), Iraq (3), Denmark(3), Norway (2), Sweden (3), Poland, Greece and extensive penetration in Spain (17 sequences).

Receptor Binding Site (RBS) changes at 225 are associated with fatality, 225G and 225N at a rate higher than 225E.

If LvivN6 is officially confirmed as a vaccine escape event, these cross-segment pairs may be surveilled as potential future effectors of vaccine efficacy failure.

Zoonotic H9N2 Avian Influenza Further Destabilises Pandemic Genetics

2010-03-31
Is the Pandemic Influenza Reservoir Stable?

If you enjoy counting, even measuring by observation, please continue reading.

But you must realize that the iota, the jot and even the title, will be considered of value in this forthcoming exercise. Some in the science community appear to find the process of discovery by observation just too tedious. If you are of that mindset, please direct your attention to any of the many “Science for Hire” venues where illogical, but comforting, summations are drawn from cleverly manipulated data streams. Science sells today. But we sometimes speculate that science is becoming just another sell-out, an industry pursuing profit over knowledge?

On the other hand, if careful examination, even hard work, is part of your daily lab book, you'll find evidence in this discussion to introspect.

Leading public health officials continue even today to indicate that the pandemic virus is unchanged. Keep that statement in mind as you read this analysis of heavy change activity in the pandemic reservoir, watching closely for the recent branching into genetic areas matching H9N2.

Also keep in mind that even single changes have demonstrated substantial importance.

Ongoing worldwide studies duplicated by independent, geographically dispersed laboratories, including the labs of those noted public health officials, indicate that a single polymorphism may produce a significant outcome within a Pandemic Influenza reservoir. Numerous accounts of important revisions are on record across a vast geography. 225G has produced a Vaccine Escape event in LvivN6, an elevated Case Fatality Rate and a substantial number of severe outcomes. Individual changes between 157 and 159 have also demonstrated “low reactor” status and registered as Vaccine Escape events. 230I entered the H5N1 Gharbiyah cluster in Egypt and the resultant Case Fatality Rate was 80% for that strain, a substantial increase from the accepted H5N1 CFR.

Three separate single genetic changes are well characterised in leading to various forms of Anti-Viral resistance. TamiFlu Resistance has now dispersed widely in a pattern following the rapid spread of resistance in seasonal influenza via the same Single Nucleotide Polymorphism coding for 275Y on the Neuraminidase. Emergent and attractant H1N1 strains (Triple Reassortments again) co-circulating alongside the pandemic reservoir also carry 275Y. H5N1 inclusions increase in the pandemic reservoir with a continuous flow. The PB2 627K is confirmed as leading to increased replication speed in humans and has recently been documented in a second pandemic sequence. As we have maintained from the beginning of this pandemic, TamiFlu Resistance and 627K are foregone conclusions according to our calculations.

Our team noted an increase in Avian inclusions and recently predicted HA 230I for ΣPF11. The polymorphism was documented last week in Wisconsin (US) on a background that does not deter transmission. The geographic area has a notable increase in cross-linked activity. The individual sample, A/Wisconsin/629-D00337, is primed for spread with 2 additional HA markers, 275A (TX, NM, CA and Sweden) and 377K (aggressively emerging). The NA carries 220K, a marker found on one cross-linked sequence from the Ukraine and across a wide US geographic pattern from December 2009 to the most recent 2010 sequences (North Carolina, New Hampshire, Wisconsin and Nebraska). We consider the Wisconsin0337 sample to be an excellent candidate as a universal donor of sorts due to limited polymorphisms and the fact that each revision is currently an emergent change.

H9N2, a "bird flu" serotype, has been recently evaluated for human pandemic potential. By all appearances, the present H9N2 reservoir is not becoming a pandemic virus, but is very much influencing the genetic acquisition cycle of the currently circulating PF11 pandemic virus. Which is worse, another species-jumping serotype entering the fray or a combinational virus with genetics from multiple pandemic potential reservoirs appending onto the current partially-adapted virus? In either case, the Hydra Effect appears to be operating in full force.

Given this information, obvious questions begin to form. If one genetic change may potentiate variant clinical outcomes, drug resistance or Vaccine Escape, what is the potential for multiple changes producing a variant outcome? And if a single genetic change and/or multiple changes are capable of producing large changes in behaviour, should we, in turn, have a very high and accurate level of surveillance on this reservoir? And what should we do with that important information? Should our public health officials speak from a platform of candor and accuracy when carrying out the responsibilities of their trusted positions?

Let’s investigate now if the viral reservoir is, in fact, unchanged?

More than 80% of the Hemagglutinin positions between 188 and 244, including antigenic areas of the RBD, are on record as polymorphic. Many positions rate multiple changes. Tracking these revisions against various baselines has informed our studies over the past year. One particular range of those variations is documented in the trailing data. For the sake of brevity, only one section of the HA gene segment is discussed. The list is certainly not comprehensive.

The positional summary may perhaps be instructive for those who hold the belief that the pandemic reservoir is stable. The report may provide reversing guidance for those who make public statements to the effect that pandemic H1N1 is not changing. Repetition of their “All Clear” social messaging cannot reverse the weight of the actual data. Repetition of an untruth does not create a fact, but that ongoing strategy of repetition is apparently very effective in managing the perception and manipulating the belief of the unsuspecting public.

The viral reservoir backing this present pandemic is far from stable and is actively acquiring new genetics. Current data does not indicate an immediate direction toward stability.

As is the nature with an IDRREAV, the positions reported here will not necessarily be the most important amino acid positions in the future. The reservoir will evade immunity and escape vaccine by heavily self-revising in the near future at key locations between 131 and 182 (emphasis at 155 to 177). Variation will occur with lower penetration at the head of the HA and from 272 downstream approximately 55 positions. Potential is very high that 22I will achieve density in one or more sub-clades. Expect 100N to spread and penetrate initially on sub-clades without the 22I appearances. South American polymorphisms from their fatal mid-pandemic strains of 2009 will recycle into the United States and other Northern Hemisphere nations with substantial thrust in the coming 90 days. Acceleration of the Avian based cross-linking will continue in the Western world.

Bear in mind also that a solid portion of the changes documented in this current list will become fixed even as additional donations are accumulated. The zoonotic movement from birds into human PF11 sequences is earnestly progressing in the most recent 45 days of available data. Several polymorphisms, HA and NA, from the Georgia hospitalization resurgence may have originated in Avian Influenza samples. Expect continued acquisition from Avian H5N1 and H1N1, and also watch the acceleration from one particularly new Avian donor serotype. H9N2 demonstrated a human jump in late 2008 and has very recently become fully engaged in ΣPF11 genetics with a well-defined etching on the newest cross-linked sequences. The reservoir flux will also be influenced by Swine H1N2 and H1N1 (emphasis on 3 particular emergent strains).

Is the Pandemic Influenza Reservoir Stable?

You decide . . .

188N SC16, SC31, NY3502, MA15, CatS1187, Milan433, Japan, S5
188I Growing in US on cross-linked background (4), BZSP53823
189V Sydney2503
189T Growing on US cross-linkage (4), H5N1 2009, H9N2 2008
189A synonymous (GCc), Georgia01_2010, swOR4060
190D synonymous (GAt) Milan326, 1918
190Y SwedenMalmoe1_2010_01_01
191R Chengdu18 (129P)
192Q synonymous (CAg) RomaISS50, Nebraska01_2010
193S synonymous (AGc) SC18, US 2010 (3), Milan294, Japan, H9N2
193G AR08
193N Washington72, H9N2
194I NC38E3, VA27, SC18, Bangladesh3009, StPete59, StPete99
194L synonymous (CTa) Japan4081
196Q synonymous (CAa) Wisc (3), Malaysia (2), Milan326
197T Malaysia4039
198V Malaysia5283, Malaysia9117
199N Milan80, Milan83
199D synonymous (GAc) swine Illinois, H5, H9N2
200T FL31, Asia (13), MilanUSHR1, H5, H9N2
200S NC57, SC46
201H Wisc1140, Darwin2140
202A MXinDRE797 2010 TmX, IA14, KY25, HK34360
202V synonymous (GTc) YAMAGATA778, YAMAGATA803, swIllinois
204V synonymous (GTa) PA31, SHIZUOKA1573, 1918, S7
205G synonymous (GGa) Texas76C2, S5, H9N2 (GCa)
206A CatS1161
206T Extensive
207S synonymous (TCg) California01_2010
208K US, UK, HK, MX, Italy (2), Australia (12), Asia (3), swOR4060
208S Australia43, Australia45, ChukkarH6N1
208G NY6292
208T Norway3440
210S synonymous (AGt) Bogota0466N, Malaysia9131, H9N2 (Aat)
210N Texas76C2
211K synonymous MXinDRE50617 (225G)
211R swOR4060_2009_12_31, 1918
212R swOR4060_2009_12_31, 1918
212E Vlad01 (225G), Argentina8574_41, IN21, Malaysia4039
212N MA15
212T Anadyr177_F (225G), CA07X179, CA07X181
213L TX15
213F synonymous StPete99 (225E)
214E Kurgan01, Moldova (3), swOR4060_2009_12_31
214N ENG92960012, SHIZUOKA1514
214Q Wisc0936 (237L)
214K synonymous (AAa) CatS1937, NM13, ENG620, China22811
215P synonymous (CCa) SC33, Eng616, GuangdongyunchengSWL51
215P synonymous (CCt) NY_WC37RG, MO02
216E synonymous (GAg) Moldova (4), Belarus, Bosnia (3, 225G), Indiana, H9N2 (GTg), tn
218A synonymous (GCg) Belarus, H9N2 (GGg)
218E Texas77 (159S, syn173G, 275A, 377K, 454I)
218T Hiroshima201 (225G)
218V GuangdongyunchengSWL51, Malaysia (2 mix wt) (GtA)
218V swIll02930, 2931, 2932, 2937 (2009-12-29, 30) (GTc)
219I synonymous Ancona451_F, Lyon2490
219T Wisc0134 (225E), RomaISS223, swOR4060_2009_12_31
220R synonymous (AGg) Mexico476, Malaysia9451
223V synonymous (GTa) Utah59
223M CA33
224K SC18_VxX
224M NY5186
225N BZ_SP53838, Ukraine mix wt, Victoria2125, Malaysia8860 et al
225E Extensive on multiple backgrounds
225G LvivN6_VxX with syn413K, UkDnip273 (GgT mix wt), H9N2
225G RomaISS1897 & 1941, EgyptVacsera138 (300S) ex225E (Gga)
225E+226R Russia (3), GermanyBY74, swMX4
226R Trabzon01 (Turkey), et al
227A swOR4060_2009_12_31, 1918
227V RomaISS50
227G Utah20 with wt mix
229R synonymous (AGg) swMX04 (225G, 226R)
230I Wisc0337_2009_12_15, H5 Gharbiyah 80% CFR, H9N2
231D Ankara05, OSAKA2143, H9N2 2008
231N CalifVRDL36
231K Wisc0853, Wisc1915, Wisc2337
232Y synonymous (TAc) Florida30, PuertoRico51, H9N2, H5, S9, S7, M7, Sask
233Y synonymous (TAt) AthensINS85, Hiroshima645, H9N2 2008
233H NC Duke (5, wt, 225G, 225N), AZ17 & Australia6
235A CatNS7632, CalifVRDL55
236V Eng93120020, ENG645, H9N2
237I Cal_SDINS69, England (2), Russia (4), Asia (2)
237L Wisc0936 (214Q), 1918, H5, tn
237V synonymous (GTg) Pennsylvania31, H9N2 (TTg), M7 (CTg)
238D Kaliningrad01 (225E+226R), tn
238K Wisc2485 (225E), Spain (2), China, swOR4060, H5, H9N2 2008
238E synonymous. Extensive and recently growing
239P synonymous (CCt) ENG621, swOR4060_2009_12_31
239P synonymous (CCa) Ancona508PG, Russia180, Australia60
240G synonymous (GGg) DC_INS24, H9N2, S9, S7, M7, Sask
241D synonymous (GAt) CatS1943, tn
241G NH17, ENG93040048
241E China22811
242K synonymous (AAg) swOR4060_2009_12_31
244I ThaiCU_H9
244T synonymous (ACt) CatS1935, CatS2120

The truth is in the sequences.

via email from NS1 -


Our analyses are intended to provide the most straightforward explanation possible . . . but as you must realise, the backing science of Influenza is far from robust. Simplicity is simply not attainable. Though the community produces thousands of point studies with valuable content data, a lack of cohesive framework results in frequent knowledge gaps. We are working to bridge those gaps, but today’s tools and the scarcity of data unfortunately limit the scope.

H5N1 and H9N2 are the two Influenza A serotypes considered most capable of reaching human pandemic status. Each is on record as zoonotic. H5N1 has been an active, but limited, contributor to ΣPF11. Throughout the current human pandemic, H9N2 has provided consistent influence as well. In the most recent sequences, a new trend is emerging as H9N2 accelerates to become a dominant contributor, especially on the cross-linked backgrounds.

If you’re able to review the idea of Influenza Flux at GeneWurx.com, you’ll begin to understand why an emergent contributor (H9N2) to a presently adapting viral reservoir is important. Every new combination presents the human immune system with a potentially separate challenge. An advancing Avian Influenza donor reservoir introduces new genetic material that is quite valuable to the virus, but quite dangerous to humans. Until the pandemic viral reservoir reaches a level of stability, an Omega state, the clinical outcomes may be highly variant with symptoms and outcomes that are beyond the normal parameters of seasonal influenza.

In a word, the pandemic virus is “confused”.

That’s what a pandemic is: a virus that doesn’t belong in humans, but really wants to belong. And, as you’ve seen, a pandemic reservoir is willing to do some work to become capable. This reservoir will continue to produce “confused” symptoms and “confused” outcomes until some reasonable stasis is achieved with the human host.

Yes, advancing H9N2 influence will be more of a problem. An accelerating donor pool from an Avian Influenza serotype is more likely than not to prolong the adjustment period.