Wednesday, February 25, 2009

Two of Klaten 'suspect' Bird Flu

Wednesday, 25 February 2009 16:20 WIB

Author: Djoko Sardjono
KLATEN - MI: Two of Klaten regency, Central Java, was stated suspect bird flu and is now treated in RSUP dr Soeradji Tirtonegoro, Klaten.

Victims of the virus avian influenza (AI), the Roslik Rev. Adiarta, 5, and Vishnu Chandra, 1. They are a bunch of the Village, District Kemalang, Klaten.

Roslik treated in RSUP dr Soeradji Tirtonegoro since Tuesday (24 / 2) with symptoms of high fever accompanied by shortness of breath. Meanwhile, Vishnu is referred to the hospital, and Wednesday (25 / 2), with the same symptoms.

Second suspect bird flu victims who still have family relationships that are now treated in isolation rooms with strict vigilance.

Deputy Director RSUP dr Soeradji Tirtonegoro Bambang Purwoatmojo journalist said to the doctors at this time still mengobservasi patient suspected of contracting the bird flu virus.

Meanwhile, hundreds of fowl in five districts, namely Kemalang, Tulong, Polanharjo, Bayat, and Juwiring, died in sporadic terakkhir in two weekends. Including dozens of chickens in the house of the second suspect is bird flu. (JS/OL-01)

Indo: Bird Flu virus mutation has not occurred

Wednesday, 25 February 2009 17:30 WIB

YOGYAKARTA - MI: Chairman of the Executive Committee of the National Bird Flu Control and Preparedness for pandemic influenza, said Bayu Krisnamurti, mutation virus bird flu (avian influenza) has not occurred in Indonesia.

"Hopefully will not happen, has happened is that the virus found in birds such as the outside cats, dogs and pigs in different regions, and that is already there since two years ago," he said on the sidelines simulated bird flu response in Yogyakarta on Wednesday, (25 / 2).

The telling, the incident was not the bird flu virus mutation because it is not from poultry, but other animals. He said that, the number of cases of bird flu in Indonesia from year to year decrease. However the community must remain vigilant against the bird flu virus infection. Based on data since 2005 to 2009 total of 145 people bird flu, 119 of them died.

According to Bayu, for the period January-February 2009 there were four cases of bird flu are all dead. "Previously, in the same period in 2007 there were ten cases, seven of them died in 2008 and of 12 cases, ten of them died," he said.

He said that, the source of most of the live poultry market, which is about 80 percent, because the environment is not so easy to clean the virus spread. "To prevent it in the live poultry market is relatively difficult," he said.

He added, although there have the pressing of a bird flu virus, for example, one day a week in the market and given a clean disinfektan. "There are other ways such as no sales ungas life. But this difficult because of the people," he said.

Say, for the medium term it may be done. "For example, the existing regulation (regulation) problems, and will be applied starting in 2010," he said.

Bayu explained, to prepare for the resources that can merspon happen if a bird flu pandemic, the work with UNICEF to simulate the response bird flu virus that involve various institutions. "They are expected to immediately respond and respond quickly and do not panic if a pandemic outbreak," he said.

In addition, the simulation also antarnegara people to be able to handle the cross-country. [?]

Meanwhile, the UNICEF Representative Central Java - Yogyakarta (Central Java, DIY), I Made Sutama, said UNICEF concerned with the case of bird flu based on the data because the victim was a woman and children that number reaches 60 percent. "This problem is related to the health condition of mother and child who is one of the focus areas of the UNICEF," he said. (Ant/OL-06)

Yogyakarta has two bird flu suspects early 2009

[I believe this article may be referring to this posted below....]

Tuesday, February 17, 2009
Resident alarmed the Spreading of Bird Flu Yogyakarta
On February 18 2009
the Resident alarmed the Spreading of Bird Flu Yogyakarta
- since several days ago the plague of bird flu threatened Yogyakarta. That was just recently recorded by hundreds of chickens in Bantul and Sleman died. That was acknowledged positive was attacked resulting from the Avian virus influenza (bird flu). -snip-
Stated by Suspect It was further that he explained, the owner of the positive chicken bird flu could be with several of his relatives treated in RS Dr Sardjito because of experiencing signs like the fever, flu, and pain. They had also been stated suspect bird flu. However after being held by the laboratory test in RS Dr Sardjito or to Jakarta finally was stated by the negative and was permitted to come home.


02/25/09 19:13

Yogyakarta (ANTARA News) - The Yogyakarta authorities have warned the people to be on alert, as two bird flu suspects were found in Yogyakarta early 2009.

Bird flu cases were first detected in Yogyakarta in 2005, Tri Harjun Ismaji, the secretary of the Yogyakarta special autonomous province, said here on Tuesday in a speech read out by Bondan Agus Suryanto.

In 2005, Yogyakarta had six bird flu suspects, four suspects in 2006, 24 in 2007, and three suspects last year, he said.

Bird flu or avian influenza (AI) was very dangerous as there were 129 cases of AI infections including 113 fatalities, or 81.3 percent, he said.
(*)

Laos bird flu confirmed in Phongsaly province

VIENTIANE, Feb 25 (VNA) – Laos’ Phongsaly province has become the first locality in the country this year where bird flu was detected when an avian influenza outbreak was confirmed by Food and Agriculture Organisation (FAO) last week.

According to the source from FAO Lao office, two red zones of 1 km radius around a place in Muang Koua District where the fetal disease was detected, have been declared.

Lao News Agency (KPL) said one red zone is located directly in the district capital city and the centre of the other is located approximately three kilometres away on the road to Oudomxay.

A joint Department of Livestock and Fisheries (DLF) and Food and Agriculture Organization (FAO) team has been on field mission since Feb. 14 to directly advise the local authorities on adequate control measures and enabled good coordination.

The villagers of the bird flu stricken area were informed of the necessary actions to control the disease, including movement control, culling and disinfection, and ban on poultry selling.

At present, the ongoing surveillance is being conducted not only in Phongsaly but also in the other neighboring provinces in order to ensure the rapid detection of new avian flu cases in the poultry population. (VNA)

Bird flu appears in Czech Republic

25 February 2009

Hodonin, South Moravia, Feb 24 (CTK) - Czech vets on Tuesday discovered a virus of bird flu when checking the breeding of waterfowl in the Rybarstvi Hodonin fishing company, local vet authority head Jaroslav Salava told CTK.

It was discovered in nine out of the 60 randomly checked geese near the Pisecensky pond. However, it is not the risky type H5N1, but the much less dangerous H7 stem, Salava said.

Nevertheless, vets will still order the putting down of all the roughly 3000 geese and 350 ducks, Salava said.

An area with the 1-km radius was created around the focus of the epidemic, Salava said, adding that special veterinary measures for the disinfection of the farms and movement of people and poultryž would be in effect there.

Salava said the staff and locals were not exposed to any serious danger in the area.

"The found H7 stem is among the low pathogenic stems of bird flu with a minimum risk. The transfer of the infection to humans can be discounted," Renata Vaverkova from the regional sanitation authority told CTK.

The low pathogenic stem of bird flu was recently discovered also in Germany, France, Belgium and Italy.

There are about 90 ponds with the acreage of 520 hectares in the Hodonin region.

Malaysia Can Source Bird Flu Vaccine From Iran

KUALA LUMPUR, Feb 25 (Bernama) -- Malaysia will be able to control the bird flu and foot-and-mouth disease soon with vaccines imported from Iran.

The vaccines, offered to Malaysia by Iranian-backed outfit PNPI Group Sdn Bhd, had been tested extensively in Iran and proven to be effective in preventing the diseases.

The company's general manager, Vahid Tahmasebi, said the company would be bringing in a few thousand doses of the vaccines soon for a trial run.

"If we find the market suitable we will even set up our own vaccine manufacturing plant here," he told Bernama on the sidelines of the Business Leaders Meeting in conjunction with the D8 Ministers Meeting on Food Security, here today.

The PNPI Group is the franchise holder of various vaccines from Iran's biggest research institute -- Razi Vaccine & Serum Research Institute.

The Razi institute, with more than eight decades of experience in research and production of biologicals, has established an outstanding international reputation with the production of over 3.5 billion doses of different products including medical and veterinary vaccines.

Tahmasebi said PNPI Group Sdn Bhd, which was set up recently, had imported 28 other types of vaccines for use in the agricultural sector here.

He also said that the vaccines imported by his company would be much cheaper than those from Europe or the United States.

Iranian Deputy Agriculture Minister Dr. J. Khalghani said Iran produced some of the best agricultural vaccines, which were of very high international standard.

Khalghani said Iran was willing to work closely with Malaysia to develop and improve on the various types of vaccines under the D8 initiative.

The countries that make up the D-8 are Malaysia, Indonesia, Bangladesh, Pakistan, Iran, Turkey, Egypt and Nigeria.

-- BERNAMA

Indo: Bali: Denpasar holds rite to ward off bird flu, rabies

Wed, 02/25/2009 3:17 PM | Bali

The recent bird flu outbreak and ongoing war against rabies have raised public anxiety in Bali, forcing the Denpasar municipal administration to hold Tuesday the Pamahayu Jagad rite at Serangan Beach to ward off the diseases.

Administration spokesman Made Erwin Suryadarma said the ritual was similar to the Nangluk Merana held a month ago at Sanur Beach.

Tuesday's ceremony was led by Balinese Hindu priest Ida Peranda Kaleran Sanur and attended by municipal officials and religious leaders from other faiths such as Buddhism, Catholicism, Islam and Protestantism. Denpasar Mayor IB Rai Darmawijaya Mantra performed the mulang pakelem or floating of banten (offerings) out to sea.

"We are using banten madya *medium offerings* in the ritual, consisting of two chickens and a swan, as well as other offerings," Erwin said.

Dewa Made Ngurah, head of the Denpasar Animal Husbandry and Maritime Affairs Agency, said the agency was concerned with the fact that Denpasar was still offi-cially under threat from both bird flu and rabies.

"Nobody wants this to happen. We have done all we can, but there are still outbreaks," he said.

"That's why we are seeking guidance and protection from Sang Hyang Widhi Wasa *Almighty God*."

He added his office was still combing Denpasar to vaccinate pet dogs and cull stray dogs, with some residents actively seeking out help from his office.

"The agency is also active in trying to prevent bird flu by spraying disinfectant in markets, homes and vehicles carrying chickens," he said.

"We even distribute free disinfectant."

In addition to invoking supernatural help, Ngurah said his agency was also conducting further registrations of chicken owners and vendors residing in Denpasar. The agency recorded some 200 vendors selling fowl, including broiler chickens, in markets as well as from their homes.

"But there are many seasonal vendors, especially ahead of Balinese Hindu holidays. These vendors sell chickens as offerings," he said.

Bird flu appears in Czech Republic

25 February 2009

Hodonin, South Moravia, Feb 24 (CTK) - Czech vets on Tuesday discovered a virus of bird flu when checking the breeding of waterfowl in the Rybarstvi Hodonin fishing company, local vet authority head Jaroslav Salava told CTK.

It was discovered in nine out of the 60 randomly checked geese near the Pisecensky pond. However, it is not the risky type H5N1, but the much less dangerous H7 stem, Salava said.

Nevertheless, vets will still order the putting down of all the roughly 3000 geese and 350 ducks, Salava said.

An area with the 1-km radius was created around the focus of the epidemic, Salava said, adding that special veterinary measures for the disinfection of the farms and movement of people and poultryž would be in effect there.

Salava said the staff and locals were not exposed to any serious danger in the area.

"The found H7 stem is among the low pathogenic stems of bird flu with a minimum risk. The transfer of the infection to humans can be discounted," Renata Vaverkova from the regional sanitation authority told CTK.

The low pathogenic stem of bird flu was recently discovered also in Germany, France, Belgium and Italy.

There are about 90 ponds with the acreage of 520 hectares in the Hodonin region.

NEPAL: Bird flu returns

KATHMANDU, 24 February 2009 (IRIN) - Bird flu has reappeared in Jhapa District, nearly 500km south-east of the capital, Kathmandu, despite government efforts to control the deadly virus.

The Himalayan nation confirmed its first case of the H5NI virus on 16 January.

Barely a week earlier the government reported that the risk had been contained after culling more than 28,000 chickens and other birds in the area.

But on 20 February, the Central Veterinary Laboratory in Kathmandu and the World Organisation for Animal Health (OIE) Reference Laboratory, Weybridge, in London confirmed the H5NI strain in six chicken samples collected from a poultry farm in Sharamati Village Development Committee (VDC) in the district. The samples had been sent to the labs after 150 chickens died.

“Our rapid response team [RRT] has been working actively to control the virus,” said senior government official Hari Dahal, a spokesman for the Ministry of Agriculture and Cooperatives (MOAC), which is leading control efforts.

According to the agriculture minister, the rapid response teams have culled more than 1,000 chickens, ducks, pigeons and eggs in the areas around Sharamati.

Places including Pathnapada, Biringkhola, Tangandubba and Mechetole, near the Indian border in the south, have been declared emergency areas.

The government hopes to complete the culling process soon given that there are not many poultry farms with more than 9,000 chickens.

Growing concerns

However, even government officials expressed concern that as a landlocked country, Nepal remained at risk given its geographical proximity to China and India, which have a history of bird flu epidemics.

A week ago, a team of experts from the UN Crisis Management Centre-Animal Health (CMC-AH) warned of significant risks after visiting affected areas in the eastern region in the first week of February.

They stressed the urgent need for more laboratory equipment and upgrades for effective diagnosis. In addition, there was a crucial need for active surveillance.

Officials told IRIN the government was already planning a three-month-long surveillance campaign in the affected areas. It has also banned the transportation of poultry products countrywide.

The MOAC has issued strict instructions to officials to quarantine border areas, with particular attention to the Nepal-India border, which stretches about 1,800km in the south.

Meanwhile, the west of the country has also been put on high alert, according to officials.

"There is no case of bird flu virus but we have been taking extra precautions to avoid any risks,” said Muni Lal Chaudhary, chief of the western region’s Regional Livestock Quarantine Office.

He explained that active testing of poultry had started on farms in Banke, Bardiya and Dang districts and others, more than 500km west of the capital.

At the same time, government teams have been mobilised to alert local communities about the potential dangers.

According to the World Health Organization (WHO), since 2003 there have been 408 confirmed human cases of avian influenza worldwide, of whom 254 died.

WHO remains concerned that the H5N1 virus might mutate or combine with a highly contagious seasonal influenza virus to spark a pandemic that could kill millions of people.

WHO warns of lengthy wait for bird flu vaccine

15 hours ago

GENEVA (AFP) — The production capacity of bird flu vaccines has tripled since 2007 but it could still take up to four years to meet global demand if a pandemic were to occur, a WHO-backed study said on Tuesday.

Even in the best case scenario, 18 months would be required for sufficient doses of medication to be produced to cover the worldwide population, the study said.

Marie-Paule Kieny, who heads the World Health Organization's initiative for vaccine research, expressed concern that production facilities might cut back because supply had more than met demand for regular, seasonal vaccines.

"We still don't have enough production capability to cover the whole world in the early months of the pandemic... and what is worrying especially is that the capacity to make seasonal vaccines ... is now much larger than the demand for these vaccines."

Kieny noted that global demand at the moment for regular flu vaccines stands at 500 million doses per year, but capacity is running at 800 million doses a year and climbing up to 1.7 billion doses in 2014.

"We are now building a surplus capacity. What will the manufacturers do with it? Either they maintain it... or they close some of them down," she said.

Stephen Gardner from pharmaceutical giant GlaxoSmithKline warned: "You cannot create vaccine capacity and then mothball this capacity until a pandemic outbreak."

He pointed out the need to use surplus capacity to produce stockpiles of H5N1 bird flu vaccines, as well as to encourage more seasonal vaccination.

In Europe, for instance, only 20 percent of the population gets seasonal vaccination, Gardner said.

Some 408 people have been infected by the bird flu since 2003, with 255 of them dying, most of them in Asia, according to official figures.

The H5N1 virus typically spreads from birds to humans via direct contact, but experts fear that it could mutate into a form easily transmissible between humans, with the potential to kill millions in a pandemic.

The study was conducted by the WHO, consulting group Oliver Wyman and industry group the International Federation of Pharmaceutical Manufacturers and Associations.

Recombinomics: Hospitalized Indonesian Paramedics Raise Pandemic Concerns


Commentary

Hospitalized Indonesian Paramedics Raise Pandemic Concerns
Recombinomics Commentary 22:37
February 24, 2009

A doctor (anesthesiologist) and 4 paramedics of Dr Sutomo hospital Surabaya were quarantined due to bird flu-like symptoms on early February.

This is right after one Surabaya bird flu victim (St/18) was treated in that hospital. Further test revealed that the doctor and one of paramedic tested negative bird flu infection.

Up to last Sunday (22/2), three other paramedics are still in critical condition.

The above comments, from the Bird Flu Information Corner website raise additional concerns of unreported human to human H5N1 transmissions in Indonesia. The above health care workers are associated with the same facility where an H5N1 confirmed patient died in late January (see updated map). Although this is not an official case, hospital personal indicate H5N1 was confirmed, even though the patient did not have a history of contact with poultry.

If the patient and health care workers are H5N1 infected, they would represent one of the largest H5N1 clusters in Indonesia reported to date. Health care workers are rarely infected with H5H1 because they are aware of hazards H5N1 infected patients prevent. Moreover, they are quickly treated, so they rarely progress to a critical state. The report of three health workers in critical condition is alarming.

More information on the status of these patients and test results would be useful.

Media Links

Tuesday, February 24, 2009

Indo: Team Novartis Research Discover How Quick Test Bird Flu Vaccines

25/2/2009 3:15 WIB

The team of the scientist in the Swiss medicine factory, Novartis, said found the method was faster to test the bird flu vaccine H5N1 to humankind. Said, this apparently could speed up preparations for the mass immunisation if the global pandemic happening. The method that now often eats time a year or more to measure the immunity response someone. On the other hand, said the team of the researcher, this new technique can predict after one dose whether a vaccine gave the protection.

More news from Quang Ninh

Tue, 24/02/2009 - 23:13 "GMT +7


Published HPAI in Dam Ha district, and disorders of the respiratory tract and in pigs in Yen Hung district

. On 23-2, the provincial People's Committee issued Decision 443 and 444 announced HPAI in district Dam Ha Syndrome and respiratory disorders and in pigs in Yen Hung district.

. Accordingly, the Chairman of the local People's Committee and the heads of relevant departments implement emergency measures to prevent outbreaks include: ringed outbreak, not to transport animals, animal products and the outside the outbreak, treatment, handling animals out with the guidance of the expert; sanitation targets in chuồng camp and the surrounding areas, implementation of the care and feeding to improve the health resistance of animals. Expense of support for prevention and be deducted from the budget for the district's layout in the budget estimate in 2009.

Previous situation Syndrome and respiratory disorders in swine reproductive risk Bùng and spread of, 24-2 yesterday, Mr. Le Dinh Tram, Director of the Department of Agriculture and Rural Development, Deputy Chief of the direction to prevent disease and livestock, poultry and other provincial agencies went to check, guide the prevention of disease in the district in Hung Yen.

. According to the report of the district, and has occurred in the province under 5 villages in 3 Minh City, Hai Yen, Hoa Nam with a total of 327 pigs infected. The district has destroyed the 116 and continue for the number of pigs destroyed infection remaining.

After checking in the village, directly guiding the organization destroyed, the Steering Committee has requested the local veterinary facilities to implement the emergency measures and fold dập area. For a number of pigs infected in the village and has conducted immediately destroyed; seriously implement the instruction of agencies in the fold region and dập; establishment of the core in the area are available on ; propaganda campaign when people detect sick pigs should be immediately veterinary officers or local authorities are not in prison to the treatment. Prepare the conditions to organize khử same targets in the district.

PV

Quang Ninh has bird flu, blue eared disease in pigs, and foot and mouth disease in cattle. This is a serious outbreak area..

Foot and-mouth disease hits 9 provinces

18:55' 24/02/2009 (GMT+7)

VietNamNet Bridge - The provinces of Nghe An and Quang Ngai are the latest to join the list of provinces infected with foot-and-mouth disease, according to the Animal Health Department, under the Ministry of Agriculture and Rural Development on February 23.

In central Quang Ngai province, on February 19-22, the disease was detected in 19 cows from 8 households in the 2 communes of Son Dung and Son Tan, in Son Tay district.

The Quang Ngai provincial Animal Health Department has worked with the authorities in Son Tay district to cull 10 cows infected with the disease in Son Dung commune, and another 9 cows in Son Tan commune.

In central Nghe An province, between February 8-18, 50 cows in the districts of Con Cuong and Quy Chau also tested positive for foot-and-mouth disease.

Currently, in the country, 9 provinces have been dealing with outbreaks of foot-and-mouth disease for less than 3 weeks, including Kon Tum, Hoa Binh, Quang Binh, Bac Kan, Quang Ninh, Quang Nam, Phu Tho, Nghe An and Quang Ngai.

Bird flu outbreaks have also been confirmed in 10 provinces within 21 days, such as Ca Mau, Soc Trang, Nghe An, Hau Giang, Quang Ninh, Quang Tri, Bac Ninh, Bac Lieu, Khanh Hoa and Ninh Binh.

Most seriously, the two provinces of Quang Ninh and Quang Nam have also had to deal with the recent outbreaks of blue ear pig disease.

Thai border guards testing for malaria

Friday, 20 February 2009

LOCAL traders making day-trips into Thailand are coming under increased scrutiny, with a particular increase in medical checks - including blood tests - being applied by Thai officials, according to border guards.

Kim Sothy, an immigration official posted at the Cham Yeam international border crossing in Koh Kong province, told the Post that the new tests showed that Thai officials were "looking down on Cambodians".

He said that there had been no advance warnings of the new tests, which had put off local traders from doing business in Thai markets across the border.

"Three people were forced to do blood tests, and 30 minutes later Thai physicians come to apologise to us," he said, adding that the physicians had been told to give at least three days' advance warning to make it easier to inform local people.

Koh Kong Governor Yuth Puthong said the blood tests were unexpected, but that Thai authorities were screening border commuters for infectious diseases.

"There's no problem because the Thai physicians are testing blood to find malaria. But our people didn't know, so it made them afraid," he said. "If they tell us in advance, we will cooperate and work with them."

Suon Sovannarith of Legal Support for Children and Women, an NGO working with migrant workers in Thailand, said the new measures sounded unusual but had not heard confirmations of a new crackdown on infectious diseases.

Many children hospitalized because of the type of measles

24/02/2009 20h54 (GMT +7)

Not only are children not vaccinated with measles, but children vaccinated stage 1 has been infected.

12 provinces appear fever patients in the form of measles
> Open campaign vaccine measles vaccines for primary HS
Agree and complication of measles

T.U, 4 patients had fever and the type of measles must be sharing a bed. Many children have to be complication pneumonia.

BS Phi Nga, Deputy Director General Pediatrics - BV Pon Green, said there are 15 children with fever and measles are the type of treatment is. Average per day from this disease of the 500-600 exam, in which 30 to 40% have fever, measles type rash.

. Points special note is that many children have been vaccinated since the age of 9 months but were measles. Age children had measles lasts from 1 to 14 years old. This shows that the quality of measles vaccines was not as expected.

The doctor warns that parents should detect the symptoms of fever, rash type measles, avoid children being serious complication to the lungs. They are symptoms such as fever, inflammation, respiratory long road, where you scattered from ear to cause surface ... it should be brought to the examination early.

When a child has had measles, the child hygiene clean with warm water, dental care, eating soft food, with nutrients and should not be too forbearance.

Currently, prevention measures are the best vaccine vaccines.

Vietnam: Report: The Health 02 Months in 2009

Date 23/02/2009
(from 21/01/2009 to 20/02/2009)
To: Office of Government
I. SITUATION The HEALTH MONTH 02 2009
A. The preventive health
1. Disease situation in thangnhu follows:
1st pneumonia due to viruses (Flu A H5N1): 0 2 recorded the field of the infected in Quang Ninh and Ninh Binh. Total infected / dead in a 2 / 0 in 0 2 city. Total infected from 12/2003 to now 109 cases in 36 provinces / cities, including 53 fatal cases.
-snip-
2. Activities for Health:
Immediately after information about the northern area appears more cases of the fever Soi form (including Hanoi), Ministry of Health has directed the Department of Health in the North province, about the birth and Central integration of up to 05 mission to inspect and guide implementation of preventive local, not to play on Bùng.
Ministry of Health has official numbers 365/BYT-DPMT sent on 20/01/2009 Ministry of Agriculture and Rural Development proposed guiding local drastically flu influenza. Ministry of Health also directed the Department of Health 63 provinces / cities directly under the central government and the students about epidemiology / Pasteur strengthening measures flu A (H5N1) in people, and organize đoàn check, steering against flu A (H5N1) in Quang Ninh and Ninh Binh province is detected 02 cases of infection with influenza A (H5N1).
Ministry of Health has directed all units assigned to direct staff on 24/24 hours daily in the Chinese New Year festival Ky Suu 2009; g iam closely in the form of fever and measles, influenza A (H5N1), fever in blood and other diseases, the report and advised of measures against the disease in time to play and Bùng.
-snip-

8. The International Cooperation Ministry of Health are actively expanding collaboration with other countries on health, has worked with mission specialists Oxford University (England) on measures to prevent fever in the blood; The participants the scientific Vietnamese-French; Next he Naceaur Boucherit, Ambassador Algieri cooperation on science and technology bilateral health among Vietnamese-Algieri. Ministry of Health also meet the Ambassador, Counselor, according to health of many countries have cooperation in the field of health, the development of countries, international organizations and a number of the non-government overseas. Ministry of Health are preparing the conference on Trade and Health (Trade and Health) with the participation of experts, some countries (Switzerland, Philipine, Thailand ...), from the WHO and of the ministries, research institutes concerned.
-snip-
II. Activities of Leadership and Ministry of Health
During June, the leaders of the Ministry of Health has directed the health service in the Chinese New Year festival, disease prevention and winter-spring, and measles, influenza A H5N1. Was directed to provide timely information to the media's handling and timely status poor quality milk. Excess of the authorized officials of the Government party, Mr. Secretary of the Party Committee, Minister of Health report of the Politburo of the project of renewing the financial and operational health sector and the Ministry of through politics. Directing the activities implemented to prepare for the meeting of Mr. Nong Duc Manh, General Secretary of the Executive Board of the Central Party Committee staff health facilities excellent typical mountainous, areas difficult On Anniversary of doctors in Vietnam 27/02/2009. Ministry of Health guiding the expanding international cooperation. Actively guide the health in the province.
-snip-
These results are in operation by the Ministry of Health from 21/01/2009 to 20/02/2009. Ministry of Health would send the Government Office for general report and the Prime Minister. /.

Avian influenza Outbreak in Phongsaly: Control and surveillance measures ongoing

(KPL) An avian influenza outbreak was confirmed last week in Muang Koua District, Phongsaly Province. This is the first province this year where the disease is detected and where previously avian influenza was not found.
According to the source from FAO Lao office, two red zones, meaning the 1 km zones around a place where avian influenza was detected, have been declared. One red zone is located directly in the district capital city and the center of the other is located approximately three kilometers away on the road to Oudomxay. A joint Department of Livestock and Fisheries (DLF) and Food and Agriculture Organization (FAO) team has been on field mission since February 14th to directly advise the local authorities on adequate control measures and enabled good coordination.
Dr. Bounlom Douangngeun, Director of the National Animal Health Center (NAHC), who is on site within the FAO mission, explained “Intense active surveillance is still ongoing in the villages of the 5km yellow zone surrounding the two red zones to ensure that the disease is not spreading further. The number of samples per village flock being taken is such that it will detect, with 95% confidence, a positive bird at 5% of prevalence. Movement control check posts have been set up and the market in Muang Koua has been closed for poultry and poultry products. Mainly chicken eggs and poultry meat originating from China was confiscated. Outbreak investigation has determined onset of the disease at the end of January, which was simultaneous with the Chinese New Year and Tet festivals. The outbreaks are located at only 1.5 hours road from Vietnam, though origin of poultry products usually available on the market is estimated to be 80% from China passing through Oudomxay province, and only 20% directly from Vietnam. Exact origin of the disease could however so far not be determined. Mortality of infected birds was found to be extremely rapid.”
The villagers from the red zone were informed about the necessary actions, which had to be put in place to control the disease and this included movement control, culling and disinfection, and ban on poultry selling. The main culling operation was finalized yesterday with more than 2500 poultry culled, but a few small scavenging chicken which could not be caught still remain and will be culled within the next days. Compensation is expected to be provided shortly to the poultry farmers at sixty percent of the market value.

Dr. Ricarda Mondry, Chief Technical Adviser for the FAO Avian Influenza Programme pointed out that “Rapid laboratory testing of suspect samples and immediate declaration of avian influenza outbreaks is essential to avoid further spread to other provinces. Furthermore farmers should be well informed on the exact amount and procedures of compensation paid for culled poultry, so that they collaborate with the authorities during the control operations. This will also encourage reporting of suspect poultry mortalities in other villages. Finally it is crucial that adequate funds for implementation of control measures on district level are available immediately.”
The DLF and the Avian Influenza Programme managed by the FAO have been working intensively with all the provinces since 2006 to strengthen the veterinary services in preventing and controlling avian influenza, financed by the governments of Germany, Japan, and the United States.
Dr. Ricarda Mondry mentioned that “the outbreak investigation training for provincial and district livestock staff conducted by FAO and NAHC in Phongsaly seems to have built sufficient local capacity to determine the extent of the outbreak and adjust the culling zone accordingly. Livestock staff from Phongsaly province had also attended the simulation exercise supported by FAO in Oudomxay in June 2008. FAO had furthermore trained 80 VVW in Muang Koua District beginning of 2008, who were responsible for reporting poultry mortality occurring in their village. Since August 2007, FAO has provided continuous support to 10 provinces to follow up any disease reported, be it through the provincial and district livestock offices or through the 166 hotline. The livestock staff have rapidly conducted adequate disease investigation measures and sent in the samples to the AI laboratory.”“The first report of poultry mortality in the district, later confirmed to be avian influenza, was given by a Village Veterinary Worker (VVW) trained by DLF staff with support through FAO in April 2008. This clearly indicates the impact the joint AI programme has on early detection of the disease and that continuous support to train VVW would be beneficial” adds Dr. Mondry.
During an outbreak, coordination among staff at different levels and among involved sectors is an essential factor to contain rapidly the disease. FAO in collaboration with the NAHC of the DLF took the lead in the animal disease investigation and control measures. Information on the diagnosis was shared with the office of the World Health Organization (WHO) and National Center for Laboratory and Epidemiology (NCLE) to ensure rapid response action from the human health side.
“Efficient coordination and implementation of emergency measures by the staff from different sectors from the central, provincial to district level as well as the international partners involved in the rapid detection and control of avian influenza outbreaks is very important, in order to avoid further
spread of the disease which would take a high toll on the livelihood of poor farmers’’, said Dr. Bounkhouang Khambounheuang, Director General of the Department of Livestock and Fisheries.
At present, the ongoing surveillance is being conducted not only in Phongsaly but also in the other neighboring provinces as well in order to ensure the rapid detection of new HPAI cases in the poultry population.

Indo: Two Village Bird Flu Positive

[And, here is a story dated the 20th, on those other two villages they are monitoring, mentioned in Treyfishs' post on "AR". Stories of chickens dying in Indo are a "dime a dozen". We don't post them here. But, this is an example of a typical poultry story, come to find out, there is a suspected bf case, they "they feel is bf", has been in "intensive" for "several days" now - and he tests negative (possibly from the Tamiflu)]

Two Village Bird Flu Positive
20 FEBRUARY 2009 25 VIEWS NO COMMENT
94 Chicken Dead
REMBANG - Posko Bird Flu Control District Rembang again found two positive cases of bird flu (Avian influenza) in the Village Sumurpule, Kragan District and Village Weton, District of Rembang.

In the Village Sumurpule, 21 chickens belonging to six of RT 12 RW 1 died suddenly. Meanwhile in the village Weton, bird flu caused the death of 73 chickens belonging to citizens RT 3 and RT 1 RW 1 RW 2.

Head of Animal Health as well as Section Coordinator Posko Bird Flu Idham Rahmadi emphasize, to stop the spread of bird flu, the spraying was conducted in two villages.

In addition, the government also has requested the residents to chicken stall. Villagers''positive infected bird flu has also been forbidden to sell chicken to the sunday times three to the front. With this effort, we expect the spread of bird flu virus can also be stopped,''he said.

He emphasized, the findings in the case of bird flu in a number of sporadic village shows off the virus is still frighten people.

The findings''two new cases of this, we hope that residents and the village to be more proactive in preventing the spread further to other areas,''he said.

Start Week
Meanwhile Jasmani, Weton Village resident, said, the death of poultry occurred since early this weekend.

He said, without a known cause, chicken in the village just suddenly found dead.

''At home I have an 30-chickens that suddenly died unexpectedly without a known cause. Then, the dead chicken growing up to Wednesday,''he said.

He did not claim to swallow losses less Rp 400,000 more because ayamnya sudden death.

Chicken''is like a savings account for the villagers. Now our family only have three chickens,''he said.

He said, the death of chickens in the village has gradually subside after Pemkab the spraying program disinfektan regularly once every two days around the house and chicken pen.

Because the death of chickens is declining, people deny the existence of the destruction of poultry. ''We do not want more big losers because they had to destroy the remaining chicken,''explicitly. (H19-69)
Source: Suara Merdeka Muria

Indo: Pemkab Rembang Siaga face Bird Flu

[No where in this article dated yesterday, does it mention a suspect (AR). I did not have AR in my notes.



23 FEBRUARY 2009 9
REMBANG - Pemerintah Kabupaten (Pemkab) Rembang now standby for possible re-emergence of bird flu (Avian influenza) in the local area, following a finding that the disease in village poultry Sumurpule (Kragan) and Village Weton (Rembang), some time ago.

Sekda H Hamzah Fatoni SH MKn said, Pemkab device through a working area (SKPD) related to increased frequency of spraying disinfectant at the point that a number of suspected vulnerable bird flu cases arise.
This is done to anticipate the spread bird flu virus. Spraying is also done on a vehicle transporter cattle from outside the area in a number of the entrance area Rembang.

"We also send out letters that are important to all the offices / offices / agencies / institutions vertical, camat, and UPT puskesman whole head," he said.

There are some important things in the letter, of which, invites the community to improve the culture of clean and healthy life, to optimize the working team of bird flu, and to report immediately to know if there are birds that die suddenly. Hamzah Fatoni revealed, Pemkab also form the cadre anticipation bird flu in each district.

Besides able to do spraying, cadres binaan Agriculture can also provide counseling to the community. Recognized, at this time Pemkab still having trouble controlling the health of cattle dove (dove) peliharaan community. The birds are kept in the wild.

That is, birds removed for their own meals. While awareness of the dove in the villages is still low in the health of poultry peliharaannya.

potential
"The dove is one of the birds the most potential to be the spread of AI virus. But most people who have dove merawatnya reluctant, "he said.

Disinggung about the condition of the two villages (Sumurpule and Weton) stated positive bird flu, Hamzah said, at least, there are three things in the support suburnya virus bird flu. According to the officials, the system of disposal of waste water does not drain or road, causing stagnant water.

Then the garbage disposal does not qualify, people close to the house, smell, and straggle. In addition, many livestock excrement.
Things that need to diwaspadai, of bird flu in poultry can occur quickly with the number of deaths is high enough.

Bird flu virus can also spread from poultry to humans, but people need not panic at the case of bird flu in the village Sumurpule and Weton. "What is important, we increase vigilance to avoid disease," he said. (jl-71)
Source: Suara Merdeka Muria

AR Negatif Flu Burung

Rembang - the Kesehatan Service of the Regency (ET AL) Rembang ascertained AR (4), villagers Plawangan, Kecamatan Kragan that received the intensive maintenance for several days in Puskemas Kragan and the Daerah Public Hospital (RSUD) R Soetrasno Rembang Doctor the negative terjangkit the bird flu virus.
ET AL suggested, this assurance after spreading out the laboratory test against AR. Kepala DKK Sutejo yesterday admitted, AR initially indeed was expected terjangkit bird flu. His article, the child experienced flu was accompanied by the sign of the high fever. Although not yet having the spread, his side continued to monitor three villages, that is Plawangan and Sumurpule in the Kragan Subdistrict and Weton in the Kota Subdistrict that was affected by the bird flu virus. ”Masa the incubation of the bird flu virus 21 days. Therefore, three villages still in the tight supervision to anticipate the spread of the virus to manusia,” he explained.

UN warns Vietnam to be "vigilant" on bird flu

Posted: 24 February 2009 2203 hrs

HANOI : UN agencies called on Tuesday for Vietnam to be vigilant in fighting bird flu after three new human cases were discovered this year, including one woman who died.

The World Health Organisation (WHO) and the UN's Food and Agriculture Organisation (FAO) said Vietnam, which has seen more bird flu deaths than any country except Indonesia, had to monitor the situation closely.

"While avian influenza poses a threat to humans and poultry throughout the year, experience in Vietnam has shown that the threat is highest at this time of year," Jean Marc Olive, a Vietnam-based WHO official, said in a joint statement.

"There is a real possibility that the virus will mutate and become easily transmissible between humans. If this occurs we could see the start of a new influenza pandemic."
-snip-

"The avian influenza virus is also not currently able to spread easily between humans, but influenza viruses are known for their ability to change quickly and can become more adapted to humans with dire consequences," the statement said.
-snip-
- AFP/vm

Tangerang: Kayla Nabila

3 Patients Died in Hospital DBD Fatmawati

TUESDAY, FEBRUARY 24 2009 | 22:59 WIB
JAKARTA, TUESDAY - As many as three patients dengue dengue fever (DBD) died at Fatmawati Hospital, South Jakarta, in February 2009 during the month.

"Already there are three people who died because of DBD in February," said the Head of PR RS Fatmawati, Atom Kadam, when it was contacted in Jakarta on Tuesday.

Three people are Fahriza Muhammad (11 years), Kayla nabila (2 years 9 months), and Zulfa Agisna (6 years). Kayla Fahriza and died on 17 February, while Zulfa against last breath on 16 February.

The three, said the Atom, it has been in a condition that is quite severe at the time was brought to hospital by the family.

Address the victims DBD is Fahriza in Depok, West Java, Kayla in Serpong, Tangerang, and Zulfa in Kalibata, South Jakarta.

Based on data from the RS Fatmawati, the number of DBD from adults in general, amounted to two to three times more than the number of people aged children.

However, the patient's children more vulnerable to disease DBD to the level of the condition worsened. Meanwhile, data from the Health Office Pemprov DKI Jakarta said that the number of DBD from January to last weekend in February 2009 reached more than 3,000 people.

Of these, there have been eight patients who died due to various DBD in the capital region.

WHO Update: Avian influenza – situation in Viet Nam - update 3

24 February 2009 -- The Ministry of Health in Viet Nam has announced the death of a previously confirmed case of H5N1 infection. The 23 year old female from Dam Ha District, Quang Ninh Province died on 21 February.
Of the 109 cases confirmed to date in Viet Nam, 53 have been fatal.

hat-tip Laidback Al

Embassy of Japan in Vietnam

February 23, 2009
Embassy of Japan in Vietnam

1. Situation in Vietnam
(1) 23, reported here on Sunday, Vietnam Ministry of Health is highly pathogenic bird flu in the northern province KUANNIN (H5N1 type) announced that the death was confirmed.

(2) February 3 patients living in the ministry was in the hospital 23-year-old woman from the province, 9 to H5N1 have been confirmed positive for the virus with 21 Yoshinori died.

(3) cases of human deaths from bird flu in the first year, the total death cases to 53 cases (cases 109 cases).

(4) According to the Ministry of Agriculture and Rural Development here, the bird flu outbreak among poultry in Vietnam in the last three weeks has been over the next 10 saving.
(Northern) KUANNIN province, Bac Ninh province, Ninh-binh province
(Middle) GEAN Ministry, Ministry of Quang-tri
(Southern) province Ca Mau, Chang Suk Ministry, the Ministry HAUZAN, BAKURIEU Ministry, the Ministry KAINHOA

Two. General infection prevention measures
(1) live birds (especially chickens, ducks, poultry and duck) to avoid contact.
(2) of raw meat and poultry, eating raw eggs. When adequate heating and cooking, and cleaning and cooking the eggs thoroughly.
(3) washing hands and gargling enforcement.
(4) wear a mask if necessary.
(5) lead a regular life and health.
(6) If you suspect the flu symptoms, see a doctor as soon as possible.
(7) Consult with the doctor, the influenza vaccine inoculation.
Three. References
(1) where the bird flu information
For information about avian influenza is available from the following sites in addition to the hotel website. Also occur if a pandemic of avian flu
If you are issued a Foreign Ministry travel information ( "be careful", "consider whether to travel (considering the possibility of evacuation)," "against travel (hortative shelter)," etc.) please note.
○ Home Safety Foreign Affairs http://www.mofa.go.jp/anzen/
○ MHLW about bird flu
http://www.mhlw.go.jp/bunya/kenkou/kekkaku-kansenshou02/index.html
○ Information Center, National Institute of Infectious Diseases Infectious Diseases
http://idsc.nih.go.jp/disease/avian_influenza/index.j.html
○ The Ministry of Agriculture Avian Influenza Information http://www.maff.go.jp/tori/index.html
○ World Health Organization (WHO) http://www.who.int/csr/disease/avian_influenza/en/
   (2) designated hospital for bird flu Vietnam Ministry of Health (※ The foreign designation)
Northern
National Institute of Clinical Research in Tropical Medicine ※
Address: 78 Giai Phong Str., Hanoi
Phone: 04-576-4319
Bach Mai Hospital
Address: 78 Giai Phong Str., Hanoi
Phone: 04-869-3731
National Institute of Pediatric
Address: 18/879 De La Thanh Str., Hanoi
Phone: 04-834-3700
Central
Hue Central Hospital ※
Address: 16 Le Loi Str., Hue
Phone: 054-822325
Southern
Tropical Disease Hospital ※
Address: 190 Ben Ham Tu Str., Phuong 1, No5 District, Ho Chi Minh
Tel :08-923-8704
Children Hospital No.1
Address: 341 Su Van Hanh Str., No10 District, Ho chi Minh
Phone: 08-927-1119
Children Hospital No.2
Address: 14 Ly Tu Trong Str., No1 District, Ho chi Minh
Phone: 08-829-8385
Cho Ray Hospital
Address: 201B, Nguyen Chi Thanh Str., Phuong 12, No5 Dist, Ho Chi Minh
Phone: 08-855-4137


   (3) with the preparation of an emergency

Bird flu epidemic is not limited to, the preparation of the items you carry around in preparation for the following emergencies occur.

Lee. Passport

The validity of what was less than a year, please update as soon as possible.

Russia. Cash

10 here for the whole family about the amount needed to live,

Ha. Emergency food and drinking water

Amount for the whole family can live about 10 days

2. Drug and mask (N95)

Medicine, thermometers, soap for disinfection, hygiene, cotton, and bandages. In addition, N95 mask can be purchased at drug stores back in my hospital near Hanoi.

Ho. Radio

An emergency, when mail was lost as the phone network, broadcast from the hotel FM (frequency 88.8Mhz) provides the information you need at.
(AFP)

A doctor and 4 paramedics of Dr Sutomo hospital Surabaya are quarantined [revised]

Additional information from Bird Flu Information Corner:
February 24, 2009
"Revision: Dr Soetomo health workers reported sick on early February 2009, where bird flu suspect patients were hospitalized in the same hospital at the end of January.

Ilness onset of each health worker is vary.

They had developed bird flu-like symptoms.

Two of them have been tested negative bird flu infection".
hat-tip Dutchy

Monday, February 23, 2009

A doctor and 4 paramedics of Dr Sutomo hospital Surabaya are quarantined

[As a refresher:
Sutini (21) Adm: 1/23. Died: 1/24. confirmed positive. From: Darmo Permai. Sumberwuluh, Kec. Candipuro Nomor 17 Surabaya. Worked there. Hospital: RSUD Soetomo Surabaya. Recon: RS Rahayu on 1/22. Onset: 1/16, admitted to a private maternity service.]


February 24, 2009

This is related with the flash news from AI lab unair, posted 4th of February. A doctor (anesthesiologist) and 4 paramedics of Dr Sutomo hospital Surabaya were quarantined due to bird flu-like symptoms on early February. This is right after one Surabaya bird flu victim (St/18) was treated in that hospital. Further test revealed that the doctor and one of paramedic tested negative bird flu infection. Up to last Sunday (22/2), three other paramedics are still in critical condition.

ProMED: AVIAN INFLUENZA, HUMAN (39): INDONESIA, SUSPECTED

Date: Sun 22 Feb 2009
Source: Okezone News [in Indonesian, trans. by a submitter who wishes
to remain anonymous; summ. & edited]



Two suspected human cases of avian influenza in Tangerang, one fatal
--------------------------------------------------------------------
A child (aged 2 years 9 months) residing in the Serpong Subdistrict
of Tangerang City South [Banten province] is suspected to have died
as a result of avian influenza virus infection.

Another Tangerang resident (a 15-year-old boy) is suspected also to
have contracted avian influenza virus infection and is currently
being treated in hospital.

The child's father stated that his son developed a high fever on 14
Feb 2009 and he immediately took the child to the local community
health centre and contacted his doctor. After 3 days the clinic
transferred the child to hospital on suspicion that he was suffering
from avian influenza virus infection. However despite intensive care
the condition of the child continued to deteriorate and he died on 17
Feb 2009. In a statement to correspondents the father admitted he did
not know the precise cause of his son's death, and so far he had been
given no information by the hospital. The child has now been buried
in TPU Kramat Tajug.

An [agricultural service official] stated that he has received
information from Litbangkes (Laboratory Dep of Health) that the child
had tested positive for avian H5N1 influenza virus infection. [This
official] had been responsible for collecting samples from poultry in
the area, but had not yet received results of the tests.

--
Communicated by:
ProMED-mail


[The outcome of laboratory tests is awaited.

The location of the city of Tangerang (close to the capital Jakarta)
on the island of Java in the Indonesian archipelago can be found by
accessing the HealthMap/ProMED-mail interactive map of Indonesia at
. -
Mod.CP]
-

Recombinomics: WHO Hoarding of H5N1 Sequences Raise Pandemic Concerns


Commentary

WHO Hoarding of H5N1 Sequences Raise Pandemic Concerns
Recombinomics Commentary 01:55
February 23, 2009

Of the most recent isolates from China, A/Guangxi/1/2009 belongs to clade 2.3.2, the first human isolate from this clade. A/Hunan/2/2009, belonging to clade 2.3.4, shows genetic divergence from other viruses of this clade. Both viruses should be considered as potential vaccine strains pending further characterization.

The above comments are from the latest version of the WHO publication on H5N1 vaccine targets, “Antigenic and genetic characteristics of H5N1 viruses and candidate H5N1 vaccine viruses developed for potential use as human vaccines”, which was released earlier this month.

Although the comments, in conjunction with the HA phylogenetic tree at the end of the document, provide insight into the rapid evolution and divergence of H5N1 clades and sub-clades, the report is more notable for the data withheld than the data released.

In recent months, the increasing lack of transparency in reports on H5N1 outbreaks has reached an alarming level. China created concern when 8 confirmed cases of H5N1 were reported in January, this year. The concerns were increased because China has not reported associated outbreaks in poultry. Prior to the spike in human cases, China reported two outbreaks of asymptomatic clade 7 H5N1 in poultry in Jiangsu in December, raising concerns that the human cases were also clade 7.

The WHO report is glaringly silent of six of the eight cases. As noted above, the two disclosed cases involve the Funjian strain (clade 2.3). One is linked to a more divergent clade 2.3.4. Previously, almost all human cases in China were clade 2.3.4. The other case is a different Fujian sub-clade, 2.3.2, which led to the first human isolate. However, this sub-clade has been isolated from wild birds in Hong Kong for the past three seasons, and was also isolated in Japan and southern Russia in the spring of 2008. South Korea has also isolated clade 2.3.2 from poultry, but has not released any sequence data. Moreover, a soldier / culler involved in the spring Korean outbreak developed bird flu symptoms and was PCR H5 confirmed. However, South Korea did not file a WHO report because they could not isolate the clade 2.3.2 virus. They argued that the soldier wasn’t clade 2.3.2 positive because the sub-clade had not previously been reported in human cases. The current WHO report shows that the sub-clade can fatally infect humans, which increases concerns because the virus is widespread in wild birds migrating along the East Asian flyway.


However, of greater concern is the WHO silence on the other 6 confirmed human cases in China. The virus isolated from the first case, A/Beijing/1/2009 was said to not have any human flu gene segments, indicating all eight gene segments had been sequenced in early January. Moreover, the sequences were characterized as having small differences with prior isolates from China. The likelihood that the sequence was clade 7 was increased when officials in Hong Kong indicated that the dead birds there were infected Fujian strains. Calde 2.3.2 was in the wild birds, while clade 2.3.4 was in the poultry washing ashore, signaling additional unreported outbreaks in China. However, the officials also said that the human cases in China were due to a strain from the north, strongly suggesting that the human infections were clade 7.

In the WHO report above, clade 7 was discussed because more outbreaks were reported in Vietnam, and the newer clade 7 isolates in Vietnam were distinct from earlier clade 7 isolates, although all isolates were from 2008. Moreover, the isolates in Vietnam were distinct from the previosuly reported clade 7 isolates in China, raising concerns that this clade was rapidly evolving and causing widespread human infections in China.

However, WHO failed to comment on the other isolates from China, and these isolates, including A/Beijing/1/2009 were also not in the phylogenetic tree. The tree had an unprecedented number of recent isolates of interest that were lacking public disclosure of the underlying sequence. This lack of transparency has created concerns because it is well known that H5N1 transmission can be dramatically affected by a very small number of changes in the receptor binding domain, such as those seen in public clade 7 sequences.

In addition to withholding the sequences of the six isolates from China that are not on the tree, WHO regional labs are withholding an unprecedented number of sequences.


Prior to being designated a WHO regional lab, NAMRU-3 would promptly release human H5N1 sequences. However, this season there have been no sequences released, even though two 2009 isolates, A/Egypt/0001-NAMRU-3/2009 and A/Egypt/0585-NAMRU-3/2009 are listed on the WHO tree. These isolates are related to the vaccine resistant sequences reported last season, and raise concerns that there are additional receptor binding domain changes in the human isolates.

Similarly, NAMRU-3 has not released the sequence, A/Pakistan.540-NAMRU-3/2008 from the outbreak in Pakistan at the end of 2007. This outbreak involved one of the most extended human to human transmission chains reported to date for H5N1, yet the sequence of the only recovered isolate has been withheld. It is in the phylogenetic tree and is the first reported human case linked to the Uvs Lake strain the Qinghai sub-clade, 2.2.3, and was said to not have receptor binding domain changes, which would also be a first for a clade 2.2 extended human to human transmission chain. Moreover, the second reported human Uvs Lake isolate, A/Bangladesh/ 2070095/2008, has also been withheld.

In addition to the withholding of human isolates from China, Egypt, Pakistan, and Bangladesh, the novel clade 2.2.3 isolate from western Africa, A/chicken/Togo/CHEK2/2008 is also in the tree, but withheld.

In addition to the withholding of the human and bird clade 2.2 isolates, WHO has also withheld the various clade 7 isolates from Vietnam, A/chicken/Vietnam/NCVD-016/2008, A/chicken/Vietnam/NCVD-093/2008, and clade 7 vaccine target, A/chicken/Vietnam/NCVD-03/2008.

This withholding of important sequences, including those selected or recommended as vaccine targets is without precedent. Even Indonesia, which has a glaring lack of transparency in reporting H5N1 cases, has placed four recent human isolates, A/Indonesia/7379/2008, A/Indonesia/7272/2008, A/Indonesia/7261/2008, and A/Indonesia/8228/2008 on deposit at GISAID.

Thus, the increased hoarding of H5N1 sequences by WHO raises pandemic concerns and these scandalous actions are increasingly harder to justify.

Media Links

Recombinomics: H5N1 Cluster in Tangerang Indonesian Neighborhood Grows



Commentary

H5N1 Cluster in Tangerang Indonesian Neighborhood Grows
Recombinomics Commentary 01:55
February 23, 2009

Two people Sepatan, Kabupaten Tangerang, Banten, West Java, is now treated at the Hospital General Regional Tangerang because presumed bird flu. The two presumed victims of avian influenza that is MS, 15 years old, and a five MH, 2 years old.

"The pain that they experience similar to bird flu, we conclude they are presumed," said the Head of Public Health Tangerang District Hani Haryanto told Tempo, Monday (23 / 2).

MS and MH began treatment in the isolation room bird flu Regional General Hospital Tangerang since three days ago. According to Hani, suspected bird flu because they suffer a high fever with hot Geruduk after the Village, Village Mekar Jaya, Sepatan, where they have dozens of live poultry that died earlier.

However, Hani said, not yet known whether the two people that previous contact with poultry or not. "But in the neighborhood where they live poultry that have died," he said.

The above translations describes a second suspect H5N1 in the same neighborhood as the earlier suspect case in Sepatan (see updated map). The two patients are about 10 miles from the confirmed fatal case, and follow reports of additional confirmed or suspect cases in or around Jakarta.

Although many of the patients have not been declared official cases, the clustering of these cases in Jakarta or neighboring locals, including Bogor raises concerns.

Indonesia has imposed a media blackout, and reports confirmed cases on a delayed basis. The delay is reflected in WHO updates, and continues to violate International Health Regulations. The latest confirmed cases from Indonesia were also from the Jakarta area. The January 22 WHO update described a Tangerang housekeeper (29F) who developed symptoms December 11 and died December 16. The second confirmed case (5F) was in the Jakarta suburb of Bekaski who developed symptoms December 23 and died January 22.. These reporting delays, as well as these more recent cases in Bogor and Tangerang continue to raise concerns about Indonesian reporting and WHO enforcement of these reporting delays.

The most recent cases are linked to confirmed or suspect clusters, which also increase concerns.

Timely reporting of these lab confirmed cases would be useful.

Media Links

Surabaya Avian Influenza Human Case

[Hat-tip Dutchy: From Surabaya Lab Blog, Dr Nidoms team.
More on the confirmed case in Surabaya.]

February 4, 2009

On January 24, 2009 there was a new human case of Avian Influenza infection. The victim, S, 21 years, was a housemaid. She was living in Darmo Permai.

On January 31, 2009 we went to the house of S and investigated the factor of infection. After we arrived there, many questions occured in our mind. How can she get infected? in what way? why there were many questions in our mind because we saw that the living are were clean and hygiene. No pets, no bird and no chicken in her house.

According to her friend who lived there too, she had not contact with chicken before she got sick and she have had fever 3 days before finally the family took her to Soetomo Hospital.

After we investigated deeply, we found the fact that everyday she went to wet market, which was about 1 km from her house. And in the wet market, we found 2 chicken seller who pooled chicken from many area in East Java. Until now we are still tracking the origin of the chicken and do the surveillance in that wet market.

And on February 2, 2009 we went to Muji Rahayu hospital. It was the first hospital which S came to the medical doctor and hospitalized before she finally was brought to Soetomo Hospital. In this hospital there were 32 health worker who involved directly to treat the victim.

Until now, the investigation is still going on.

FLASH NEWS : we got information that 5 staff of Soetomo Hospital are quarantine because suspected bird flu. One of the suspect is medical doctor.

Sunday, February 22, 2009

H5N1 Confirmed Case Concerns in Tangerang Indonesia


Recombinomics Commentary 01:55
February 23, 2009

two residents of the Regency and the Tangerang City South are contaminated with the virus H5N1 or Bird Flu. They were Kaila Nabila (2.9) the resident of the Village of Cilenggang Rt 02/04 the District Cilenggang the Subdistrict Serpong the Tangerang City South and Maya Suparni (15) villagers Mekar Jaya the Subdistrict Sepatan the Tangerang Regency.

information from Litbangkes, Kaila Nabila positive affected H5N1.

The above translation describes two cases with bird flu symptoms. One (2.9M) has died and has been lab confirmed, while the other is a hospitalized suspect case. The two cases are about 10 miles apart (see satellite map).

The number of confirmed cases and clusters in Tangerang has been high. The clusters included the first confirmed cases in Indonesia, in 2005. A recently released phylogenetic tree has four isolates from human cases in 2008. These sequences have been placed on deposit at GISAID and continue to evolve away from the clade 2.1 pandemic target sequence, which was from the first confirmed case.
The continued reports of H5N1 confirmed cases or clusters in Tangerang remains a cause for concern.

Clusters in Indonesia last year led to a news blackout and a significant delay on reporting of cases. Moreover, many milder cases in Indonesia are treated with Tamiflu and not tested. This protocol contributes to the high case fatality rate, which has been close to 80% since 2005 and suggests a high level of unreported milder cases.

The recent fixing of Tamiflu resistance, H274Y in H1N1 seasonal flu has increased concerns that co-infections involving season flu with H274Y and H5N1 in hosts being treated with Tamiflu will selected Tamiflu resistant H5N1.

The latest confirmed and suspect cases in Tangerang continue to increase those concerns.

Media Links

Lab-made Proteins Neutralize Multiple Strains Of Seasonal And Pandemic Flu

ScienceDaily (Feb. 23, 2009) — Scientists have identified a small family of lab-made proteins that neutralize a broad range of influenza A viruses, including the H5N1 avian virus, the 1918 pandemic influenza virus and seasonal H1N1 flu viruses. These human monoclonal antibodies, identical infection-fighting proteins derived from the same cell lineage, also were found to protect mice from illness caused by H5N1 and other influenza A viruses.

Because large quantities of monoclonal antibodies can be made relatively quickly, after more testing, these influenza-specific monoclonal antibodies potentially could be used in combination with antiviral drugs to prevent or treat the flu during an influenza outbreak or pandemic.

A report describing the research, supported by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health as well as the Centers for Disease Control and Prevention, appears online in Nature Structural & Molecular Biology. Wayne Marasco, M.D., Ph.D., associate professor of medicine at the Dana-Farber Cancer Institute and Harvard Medical School in Boston led the research team, which included collaborators from the Burnham Institute for Medical Research in La Jolla, Calif., and the CDC in Atlanta.

"This is an elegant research finding that holds considerable promise for further development into a medical tool to treat and prevent seasonal as well as pandemic influenza," notes NIAID Director Anthony S. Fauci, M.D. "In the event of an influenza pandemic, human monoclonal antibodies could be an important adjunct to antiviral drugs to contain the outbreak until a vaccine becomes available."

Using standard methods of production, initial doses of a new influenza vaccine to fight pandemic influenza would be expected to take four to six months to produce.

Key to their research, Dr. Marasco and his colleagues discovered and described the atomic structure of an obscure but genetically stable region of the influenza virus to which their monoclonal antibodies bind. The hidden part of the influenza virus is in the neck below the peanut-shaped head of the hemagglutinin (HA) protein. HA and neuraminidase are the two main surface proteins on the influenza virus.

The scientists also identified a new mechanism of antibody action against influenza: Once the antibody binds, the virus cannot change its shape, a step required before it can fuse with and enter the cell it is attempting to infect.

Dr. Marasco, Jianhua Sui, M.D., Ph.D., and other Dana-Farber colleagues began their study with avian flu viruses. They scanned tens of billions of monoclonal antibodies produced in bacterial viruses, or bacteriophages, and found 10 antibodies active against the four major strains of H5N1 avian influenza viruses. Encouraged by these findings, they collaborated with Ruben O. Donis, Ph.D., of the CDC Influenza Division, and found that three of these monoclonal antibodies had broader neutralization capabilities when tested in cell cultures and in mice against representative strains of other known influenza A viruses.

Influenza A viruses can include any one of the 16 known subtypes of HA proteins, which fall into two groups, Group 1 and Group 2. Their monoclonal antibodies neutralized all testable viruses containing the 10 Group 1 HAs--which include the seasonal H1 viruses, the H1 virus that caused the 1918 pandemic and the highly pathogenic avian H5 subtypes--but none of the viruses containing the six Group 2 HAs.

Simultaneously, Dr. Marasco's group teamed up with Robert C. Liddington, Ph.D., professor and chair of the Infectious and Inflammatory Disease Center at Burnham, to determine the atomic structure of one of their monoclonal antibodies bound to the H5N1 HA. Their detailed picture shows one arm of the antibody inserted into a genetically stable pocket in the neck of the HA protein, an interaction that blocks the shape change required for membrane fusion and virus entry into the cell.

When they surveyed more than 6,000 available HA genetic sequences of the 16 HA subtypes, they found the pockets to be very similar within each Group but to be significantly different between the two Groups. The genetically stable pockets, they note, may be a result of evolutionary constraints that enable virus-cell fusion. This could also explain why they did not detect so-called escape mutants, viruses that elude the monoclonal antibodies through genetic mutation.

"One of the most remarkable findings of our work is that we identified a highly conserved region in the neck of the influenza hemagglutinin protein to which humans rarely make antibodies," says Dr. Marasco. "We believe this is because the head of the hemagglutinin protein acts as a decoy by constantly undergoing mutation and thereby attracting the immune system to produce antibodies against it rather than against the pocket in the neck of the protein."

Their findings could also assist vaccine developers. Current influenza vaccines target the constantly mutating head of the HA protein and do not readily generate antibodies against the conserved region in the neck.

"An important goal is to redirect the immune response of vaccines to this invariable region of the hemagglutinin to try to obtain durable lifelong immunity," Dr. Marasco states.

The monoclonal antibodies identified in their paper are very well-characterized, Dr. Marasco notes, and he is optimistic about their further clinical development. "These are fully human monoclonal antibodies that are ready for advanced preclinical testing," he says. He currently is arranging to use NIAID research resources to take the next steps: first, testing the antibodies in ferrets, the gold standard animal model for influenza, and then developing a clinical grade version of one antibody that could enter human clinical trials as soon as 18 months from when the development program begins. Should the antibodies prove safe and effective in humans, it could take several years to develop a licensed product.

Despite the availability of influenza drugs and vaccines, seasonal influenza still kills more than 250,000 people worldwide each year. During seasonal flu outbreaks, monoclonal antibodies could be used to treat individuals with impaired immunity due to pre-existing medical conditions or advanced age. In the event of an influenza pandemic, these individuals plus others at risk--for example, first responders and medical personnel and exposed family members and coworkers--could also benefit from this type of therapy.

The Demand For Center for Animal Health in Payakumbuh

[google translation]
Payakumbuh | Sunday, 22/02/2009 16:58 WIB
Payakumbuh, (ANTARA) - Center for Animal Health (Puskeswan) Payakumbuh City, starting Dilirik pet owners, where every day there were 15 pet owners came to Puskeswan for treatment and consultation.

It was said by the Head of Department of Agriculture Payakumbuh Ir. Gazali Majid, Sunday (22 / 2).

"Attendance at Puskeswan Payakumbuh, truly felt of the citizens. They are very terbantu, caring for the animal health peliharaannya correctly, "said Gazali.

According Gazali, many city residents have pets such as dogs, cats and birds that are millions of rupiah. But, during this treatment done in a traditional and nutritious food is given dimandikan with fragrant soap every day.

Besides the pet, Puskeswan Payakumbuh also care for the livestock population is big enough. Currently Payakumbuh recorded in 7840 cut cows, 1,742 buffaloes, 6,435 goats and 1,435 horses.

"Puskeswan also provide community services in order to avoid cattle from dangerous diseases such as rabies, ngorok, bird flu and other infectious diseases," he said.

Puskeswan development, funded by three sources of the budget, State Budget, Provincial Budgets and Budgets Sumbar Payakumbuh. Building value Rp210.743.000. Meanwhile, Pemko own in the year 2008, to allocate funds Rp375.499.750, for health maintenance and disease prevention (cpw2/RAR)

Map of Payakumbuh, West Sumatra:
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A Child was in Tangerang expected by Bird Flu

A Child was in Tangerang expected by Bird Flu
on February 23 2009 6:04 WIB Metrotvnews.com,
Tangerang: One Of of the resident's children Gruduk, Mekar Jaya, of Sepatan, Tangerang, Banten, it was suspected suffered bird flu. Already a week more, Muhamad Heru, 2 years, experienced the high fever, the cough, and breathless. Heru is currently treated intensive in the Public Hospital of Daerah Tangerang. Beforehand, the couple's sweetheart Rusdi and Siti Istina, this could receive medical treatment in the Sepatan Community Health Centre. But his condition also did not improve. According to casualties's neighbour, lately around the Heru house often was found by the chicken that died suddenly. Although being not yet proven, the worried resident, the virus H5NI in fact spread in their village. (ICH)

Two Tangerang residents Terjangkit Bird Flu, one died

22 February, 2009 by redaksiMetro
CILENGGANG- Kaila Nabila (2.9) the resident Kp cilenggang RT 02/04, the Serpong Subdistrict, the Tangerang City South was suspected of dying resulting from terjangkit the bird flu virus. Apart from Kaila, the Tangerang resident other that is Maya Suparni (15) the resident blossomed Jaya, Sepatan was expected also terjangkit the bird flu virus and currently still in the process of the maintenance in bird flu space of RSU Tangerang. Ade Sulaiman, casualties's father claimed in the date to be 14 Febuari then his child experienced the high fever. And at that time also he at once carried the child both of them this to the community health centre and the clinic of the child's specialist close to his house. The "clinic at that time told so that in referred to RS Fatmawati because of having the affected assumption DBD,"ujar him when being met in his house." And in this RS Fatmawati his child received the maintenance for three days. However because the condition for his child continued to descend finally his life was not helped again. Ironically again, Ade admitted to not knowing definitely what became the cause of the death of his child. "Until this I had not received the news from RS Fatmawati what caused my child to die." And I only received the news from the village staff that Litbangkes said my child terjangkit the flu virus burung,"sesal him. Ade also admitted to submitting on his child's trip and currently the child him has been buried in TPU Kramat Tajug. Despite this he hoped that the Kesehatan Service side of the Tangerang Regency to the front more was open to casualties's family. The death of the resident Cilenggang that was expected terjangkit the bird flu virus was justified by the Training of the Team of the Cepat Movement of Bird Flu and Livestock Breeding of the agricultural service of Kabupaten Tangerang, Zaifiwar. According to him, he has received information from Litbangkes that Kaila Nabila positive affected H5N1. And his side has carried out the taking of the sample of the poultry that in this area. "It will not yet have results, later if having me kabarkan,"ucap him." In the meantime the Tangerang resident other that was expected terjangkit the bird flu virus was Maya Suparni (15) the resident blossomed Jaya, Kecamatan Sepatan. And up to now casualties still in treated in RSU Tangerang. Unfortunately the side of RSU Tangerang and casualties's family reluctantly gave information,

Rapid response team off to affected area

By Lila Baral
JHAPA, Feb 22 - In its bid to control the outbreak of bird flu in other parts of Jhapa district from Sharanamati VDC, the government mobilised a rapid response team in the affecteda area on Saturday.

Laboratory tests conducted on dead chickens of a poultry firm belonging to Sajibul Rahaman in Sharanamati have proved that 149 chickens from the firm died of bird flu a week ago. This is the second outbreak of bird flu in Jhapa and the country.

Following the confirmation, the government, on Sunday, declared emergency in the area within a perimeter of three kilometres from Rahman's poultry farm. The 50-member team will start culling chickens in the designated area from Sunday. Coordinator of the team Dr. Suvash Siwakoti said, “We'll start culling chickens and other birds in the designated area from Sunday morning.”

The team said it would cull over 9,000 chickens and other birds in the area in course of a week. The government had culled around 24,000 birds following the confirmation of a bird flu outbreak in Kakadbhitta in the second week of January.

The government has also set up a bird flu control section at the border police post of Taghandubba to curb import of chickens and poultry products from India.

On Saturday, the 50-member team held discussions with local people and apprised them of safety precautions that need to be taken.

Posted on: 2009-02-22 03:26:30