#Coronavirus: France: 2nd Confirmed Case....Roomate of 1st Case!

 May 12, 2013
Translation (editing is mine)

A second French case of infection with the new coronavirus (NCoV) was confirmed during the night from Saturday to Sunday by the Ministry of Social Affairs and Health. The reviews from someone who shared the room with a contaminated hospital Valenciennes patient were positive. Concerning the person of the immediate environment of the patient, isolated Saturday at his home, the results provided by the Pasteur Institute, on the contrary, proved negative. "The Institute of Health continues epidemiological investigation to identify people who have been in contact with this new case of infection with the new coronavirus," said the ministry statement.

http://www.ouest-france.fr/ofdernmin_-Coronavirus.-Un-deuxieme-cas-d-infection-confirme_6346-2191556-fils-tous_filDMA.Htm

Saudi Arabia: Student suspected bird flu #Coronavirus threaten her colleagues .. And a new patient Dhahran

12/05/2013
Hofuf where seen director and monitor the school on a report stating «to prevent the mixing of suspected« where they will be booked at the King Fahd Hospital after taking the tests, and the girl who taught in the fourth grade to end all tests and assessments of the parameters in the school without informing students and teachers as suspected hide this subject for administrators at the school,

And wandered suspected in school and have peace on her colleagues and wander with them in the break before going to the hospital to take the tests and ensure safety of the virus, and showed a Almnsupac to school we did not know suspected them except by her mother after the completion of the evaluation and that there is a report prevents the completion of her studies and mixing days the next three until the completion of analyzes and to maintain her colleagues, is noteworthy that this virus is transmitted by direct contact and contamination of the hands and spray respiratory is a viral disease of acute respiratory and must reserve them Palmakm and gags that were not present with the girl as evaluated parameters,; did not find a young family (p), which make sure his Corona virus and the Ministry of Health announced his injury with patients, but to pray for her son, who became a pitiful state, suffering from this virus and was transferred to a hospital in Dhahran. «Today» met with the father of the young man, who refused to disclose the name of his son and said that we were shocked by the news of injured son and confirmation of the Ministry of Health wound infection after undergoing the necessary tests and make sure that after the deterioration of his health and the appearance of these symptoms. 
and transmission of infection to his son, said: My son is suffering from kidney failure and reviewing the hospital for the washing process permanently With the advent of the cases and discovered showing that my son, who were with the virus do not know until this moment how to go to him and said: I hope the Ministry of Health working seriously on the face of this serious matter we have become live great concern the case of our son, especially after that was transferred to the intensive care unit and confirm doctors that his condition is very difficult and can not be allowed to visit him at the moment and said all we have is to pray for our son, and those who were with the virus recovery. 
On the other hand, Dr. Keiji Vakuda Assistant Director-General of the World Health Organization for Security Health on the importance of collecting information Corona virus belonging to know the causes and eliminate it, in addition to providing anti-virus team precautionary Ahsa health information and epidemiological investigation works to reduce its spread in the region and the exchange of experiences and advice in an extended meeting with them came in a meeting which was held at the Directorate of Health Affairs Ahsa and chaired by Dr. Ziad Mamish and Undersecretary of the Ministry of Health for public health in the presence of d. Connie Bryce consultant infectious diseases from the University of Denver, and Professor Trish Burrell consultant infectious diseases of Johns Hopkins University, and Professor Paul Tambaya consultant infectious diseases from the University of Singapore, Professor Allison Mack Qier Hospital Mount سياني Toronto Canada, and Dr. Jawad quarantined director contagious diseases WHO Cairo, Director of Health Affairs Ahsa Mohsen Al-Melhem and official spokesman for the Ministry of Health Khaled Marghalani. 
, Dar es in meeting many of the topics that belong virus Corona and follow-up developments and most treatments that have been used and look at the health situation in the governorate and the total cases that have been inspected and that has been impounded and the number of people living with HIV in Al-Ahsa, and the state of Investigation epidemic in the province and the measures that have been taken by the health Ahsa and enhancements and support which has been submitted by the ministry, explained the official spokesman for the Ministry of Health, Dr. Khalid Marghalani that the delegation of experts will be in the process of gathering information Ahsa and visit the injured in a number of hospitals in Al-Ahsa and the delegation met with members of the Scientific Committee for Infectious Diseases at the Ministry of Health, which includes a selection of consultants and specialists from military hospitals and specialized university and government health sectors Marghalani added that there will be a detailed report to the key recommendations which will come out by the delegation to eliminate the virus.

http://www.alyaum.com/News/art/81794.html 

#Coronavirus: 8th Death in our Cluster of 15 Saudi Arabia

Corona Saudi reap the victim 'eighth' ..And an international delegation in Al-Ahsa
 Sunday, May 12, 2013

I joined the Saudi woman victims of the virus «Corona» as Gebha death after a month of Mlazemtha bed in a hospital in the province of Al-Ahsa (eastern Saudi Arabia), while the visiting delegation from the World Health Organization hospitals Ahsa, which recorded the death of 8 people, in addition to 13 wounded announced injury officially . It is feared that the real number of people affected is even greater. (more)

With imposed Saudi Ministry of Health cordon of secrecy on the tour international delegation, which includes consultants and specialists from universities and international organizations and bodies, expected to be held Saudi Health Minister Dr. Abdullah Al-Rabiah a press conference today (Sunday) revealing an update on the disease, who announced his appearance officially about 10 days ago.

Al «life» that the Saudi minister will announce an update to the list of injured and dead. The number of people on the white family in Al-Ahsa private hospitals and the public. While still a number of suspected cases awaiting the arrival of the results of laboratory analyzes of Riyadh and Jeddah, which takes a long time. And died Ms. Latifa Mohamed (69 years) life at dawn Wednesday, dragged bird flu Pfyrus, 'Corona'. Al «life» that the deceased was lying in the intensive care unit at a private hospital in Al-Ahsa, about a month ago, even the same health deteriorated, and she died. And one of the sons of the deceased told «life» that his mother received treatment in a number of government and private hospitals, and was in relatively good health but the health suddenly deteriorated unchanged. And lose the delegation of the World Health Organization health facilities in the province of Eastern yesterday, also met with health practitioners Anti-Virus supervisors 'Corona' in 'Ahsa health', and exchange their experiences and advice.

http://tinyurl.com/dxhajdn

#Coronavirus Saudi Arabia: 25 Recent Deaths in Elementary School Students and 5 Currently With Sym's

[Here is another article, that explains the situation better (regarding the post directly before this one, at this blog.]

Five primary school students and Twenty-fifth Ahsa Asibo-virus "Corona"

Mohammed Sheikh - today - Mfg: I learned that the General Directorate of Health Affairs in Al-Ahsa province conducts epidemiological fact for elementary school students and 25 who died recently of her students girl sacrificed Abraham, to see whether the Corona virus and the presence or not.



Sources familiar with the operations of Investigation epidemiological came after reporting one of the parameters of the school for the emergence of symptoms at 5 students at the school to infection with influenza, which are symptoms that appear in all people infected with Corona, and continues to hardware health Find students to sign a disclosure they did not disclose the sources of all ages of students or the school year studying it. noted the sources that the actions of Investigation epidemic that is to work on an ongoing basis is a precautionary measure to make sure that non-registration of new cases, indicating that the symptoms that the students may be flu normal unrelated to HIV Corona, but the directorate dealing with all cases seriously, especially if symptoms of influenza appeared Mkhaltin of cases have been recorded in advance.



The sources indicated that the statistical community has become fears of flu symptoms, where it is believed both showing symptoms of influenza that infected Coruna.




http://tinyurl.com/bprjqa9

#Coronavirus Saudi Arabia: After reporting a 25 Primary School parameters for girls

I would take this translation to mean that after surveillance of 25 schools, that 5 are suspected cases of Coronavirus.

May 11, 2013
Translation & Excerpt:

Translation:
According to informed sources, the that Ahsa health services are looking for 5 students they showed symptoms of "Corona", after reporting a 25 Primary School parameters for girls for the emergence of the disease on them.

http://tinyurl.com/cbtl8yd

Experts from the "World Health" visiting Al-Ahsa to follow the virus, #Coronavirus

May 11, 2013
Translation:

 Riyadh: visited a team of consultants and officials of the World Health Organization, who came to Saudi Arabia at the invitation provided to them by the Ministry of Health, Al Ahsa morning, in a series of efforts of the Ministry in order to exchange experiences to identify the disease virus, "Corona."

The official spokesman of the ministry, Dr. Khalid Marghalani that global team included both Dr. Assistant Director-General of the World Health Organization health security Geneva Keiji Vakuda, Dr. Jawad quarantined director of communicable diseases at WHO in Cairo, in addition to the WHO representative in Saudi Arabia, Dr Mustafa طيان.

The group held several meetings with stakeholders in the health sector governorate of Al-Ahsa, as well as with staff supervisors to deal with the infected cases to combat the virus, as well as some members of the international team consultant in charge of the ministry to complete protocols therapy and to identify the infected cases, including Professor Allison Mack Qier from hospital Mount سياني, Toronto, Canada.

The discussion touched on the efforts made in the investigation of the epidemic, and to identify the policies and procedures in the treatment and prevention of the disease, also known as the team briefly on the health status and history of the disease in each case.

The team visited one of the sites which recorded some cases, and briefed on the procedures followed in dealing with patients in outpatient clinics and intensive care rooms. The team will complete its meetings tonight to complete the collection of the necessary information for fact-situation.

It is important to note that there are other international experts will in the coming days to visit the province of Al-Ahsa; also to stand on the situation on the ground in order to supplement the efforts being made in dealing with the new virus.

 

http://tinyurl.com/cdlb3v4 

WHO Update on #Coronavirus 2 Latest Confirmed Cases 48 & 58 yo - May 9, 2013

9 May 2013 - The Ministry of Health in Saudi Arabia has informed WHO of an additional two laboratory confirmed cases of infection with the novel coronavirus (nCoV).
The first patient is a 48-year-old man with multiple coexisting medical conditions who became ill on 29 April 2013. He is in stable condition. The second patient is a 58-year-old man with existing medical condition who became ill on 6 April 2013. He fully recovered and was discharged from the hospital on 3 May 2013.
The two patients are from the same cluster reported since the beginning of May 2013, which is linked to an outbreak in a health care facility. The government is conducting ongoing investigation into this outbreak. Since the beginning of May 2013, a total of 15 patients have been reported from this outbreak, of which seven have died. Of the 15 patients, 12 are men and three women. The age range of the patients are from 24 to 94 years old.
From September 2012 to date, WHO has been informed of a global total of 33 laboratory confirmed cases of human infection with nCoV, including 18 deaths.
Based on the current situation and available information, WHO encourages all Member States (MS) to continue their surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns. Health care providers are advised to be vigilant among recent travelers returning from areas affected by the virus who develop severe SARI. Specimens from patients’ lower respiratory tracts should be obtained for diagnosis where possible.
All MS are reminded to promptly assess and notify WHO of any new case of infection with nCoV, along with information about potential exposures that may have resulted in infection and a description of the clinical course.
WHO does not advise special screening at points of entry with regard to this event nor does it currently recommend the application of any travel or trade restrictions.
WHO continues to closely monitor the situation. 

http://www.who.int/csr/don/2013_05_09_ncov/en/index.html 

#H7N9 kills 1 in Shanghai

SHANGHAI, May 11 (Xinhua) -- The H7N9 bird flu killed one person in Shanghai Friday, local health authorities said Saturday, bringing the nationwide death toll to 33.

An 83-year-old woman surnamed Jiang died Friday evening in a local hospital one month after her infection was confirmed, the Shanghai Municipal Health and Family Planning Commission announced.

As of 5 p.m. Saturday, Shanghai has confirmed 33 H7N9 cases. Four of them are being treated in the hospital, 15 have recovered and 14 others died.

Since China confirmed the first human infections with the bird flu virus in late March, the country has so far reported 130 confirmed H7N9 cases, including 33 deaths.
 

http://news.xinhuanet.com/english/health/2013-05/11/c_132375363.htm

China steps up #H7N9 flu monitoring

BEIJING, May 10 (Xinhua) -- China's local health organs have been instructed to step up flu monitoring as part of the country's efforts to fight H7N9 flu, according to a government document issued Friday.
The instruction features an upgraded plan for H7N9 flu prevention and control, which was issued by the National Health and Family Planning Commission, to replace a previous version issued in early April.
In counties where any human infections with H7N9 have been confirmed, a two-week-long period of closer monitoring over local flu cases should be in place soon after the bird flu case confirmation, the new document said.
Within the two weeks, any patients with flu or a severe, acute respiratory infection in such counties should give samples and enquiries should be made of them on any possible exposure to H7N9, it said.
Those regions where no H7N9 cases have been reported are also urged to increase the number of samples taken from flu cases.
Furthermore, the document said any hospital or clinic receiving a patient who demonstrates flu-like symptoms should inquire about possible exposure to birds or live poultry markets, especially those involved in live poultry raising, slaughter, trade and transport.
The new document also differs from the old version in saying that any clustering of H7N9 human infections, if confirmed, should be reported to health authorities within two hours.
Since China confirmed the first human infections with the bird flu virus in late March, the country has so far reported 130 confirmed H7N9 cases, including 32 deaths.
 

http://news.xinhuanet.com/english/china/2013-05/11/c_124695098.htm 

M'sian govt urged to stop chicken imports from China #H7N9

May 10, 2013
By News Desk in Putrajaya
 

Malaysia's livestock industry players have joined calls to the government to stop an incoming batch of chicken consignments from China.

Leong Hup Holdings Bhd executive director Tan Sri Francis Lau urged local authorities to impose a ban on poultry imports from China to prevent a pandemic of the H7N9 virus here.

As at May 1, 26 deaths due to the virus have been reported in China while confirmed cases of infection have risen to 127 since the outbreak of the disease.

"When I was in Shanghai two weeks ago, the Chinese restaurants there had removed chicken and duck from their menu.

"I hope our authorities will not wait until someone dies of the disease in Malaysia before they take action to prevent the virus from spreading here," Lau told The Star yesterday.

Federation of Livestock Farmers Association secretary-general Jeffrey Ng, however, said the body would not go so far as to call for a blanket ban on Chinese poultry imports, but stressed that the authority should prioritise public health.

"As an association, (calling for a ban) is a very sensitive issue and we do not wish to comment on that.

"All we can say is that we are producing 120 per cent of the poultry market demand locally and we support calls to prioritise consumer health."

Ng was referring to the Muslim Consumers Association of Malaysia's appeal to the government to stop an incoming batch of 98 containers containing frozen, deboned chicken from China.

Its secretary-general Dr Ma'amor Osman had said that the shipment, which had not been scanned for the H7N9 virus, should not be allowed into the country.

An earlier statement by Veterinary Services Department director-general Abdul Aziz Jamaluddin had said each shipment would be tested for the virus first.

http://ph.news.yahoo.com/msian-govt-urged-stop-chicken-imports-china-041003395.html 

H.R. 307: Pandemic and All-Hazards Preparedness Reauthorization Act of 2013

As mentioned in the JAMA article below, here is the bill that was signed by the President on March 13, 2013

Full Title:
To reauthorize certain programs under the Public Health Service Act and the Federal Food, Drug, and Cosmetic Act with respect to public health security and all-hazards preparedness and response, and for other purposes.


http://www.govtrack.us/congress/bills/113/hr307#overview

Major Challenges in Providing an Effective and Timely Pandemic Vaccine for Influenza A(H7N9)

From The Journal of the American Medical Association, JAMA Network

Michael T. Osterholm, PhD, MPH; Katie S. Ballering, PhD; Nicholas S. Kelley, PhD 

JAMA. 2013;():1-2. doi:10.1001/jama.2013.6589.

Published online May 9, 2013

The emergence of avian influenza A(H7N9) virus in humans has public health authorities around the world on high alert for the potential development of a human influenza pandemic.¹ As of May 8, 2013, authorities had identified 131 confirmed cases and 32 deaths among residents of 8 provinces and 2 municipalities in China.²

Three primary scenarios exist for how this A(H7N9) virus outbreak will unfold. First, the virus could disappear in the animal reservoir, ending new human cases. Second, the virus could persist in the animal reservoir, resulting in sporadic human infections. Third, the virus could, through mutation or reassortment, become readily transmissible between humans, resulting in a global pandemic.

The arsenal of public health tools to reduce morbidity and mortality from an influenza pandemic is limited. Options include vaccines, antiviral drugs, and interventions such as respiratory protection and social distancing. According to the World Health Organization (WHO), “Influenza vaccination is the most important intervention in reducing the impact of influenza, and a key component of the WHO response and preparedness efforts for influenza of pandemic potential, including avian influenza A(H5N1), A(H9N2) and A(H7N9).”³ However, seasonal and pandemic influenza vaccines have significant limitations,⁴ including limited vaccine effectiveness, the inability to identify reliable correlates of protection, and the need to distribute large quantities of vaccine early in the pandemic course.

ESTIMATED EFFECTIVENESS OF A(H7N9) VACCINES

  Data for seasonal influenza vaccines and the 2009 A(H1N1)pdm09 vaccines provide a basis for estimatingpotential effectiveness of A(H7N9) vaccines. Inactivated seasonal influenza vaccines have a pooled efficacy estimate of 59%, primarily for younger adults.4 A paucity of evidence exists for demonstrating protection in adults aged 65 years or older, particularly with influenza A vaccines. The pooled efficacy of live-attenuated influenza vaccines (LAIVs) is 83% in children aged 6 months to 7 years, but currently available data do not support effectiveness in the population aged 8 years or older.4 The median effectiveness reported in 6 studies of adjuvanted A(H1N1)pdm09 pandemic vaccines was 72% (range, 60%-93%).4 In a study of unadjuvanted A(H1N1)pdm09 vaccine conducted in the United States, effectiveness was 56% (95% CI, 23%-75%).4 For these studies, most participants were younger than 50 years, with approximately half younger than 18 years. There is no reason to believe that a yet-to-be-developed pandemic A(H7N9) vaccine will perform any better than existing seasonal vaccines or the A(H1N1)pdm09 vaccines, particularly with regard to vaccine efficacy in persons older than 65 years. To date, the median age of H7N9 cases is 60 years. If a pandemic occurs and this epidemiologic pattern persists, a pandemic A(H7N9) vaccine, even if it includes an adjuvant, will likely have limited to modest effects on the overall morbidity and mortality from the novel strain.

DETERMINING AND MEASURING CORRELATES OF PROTECTION FOR A(H7N9) VACCINES

In the United States, vaccine dose for inactivated pandemic vaccines is determined by the amount of hemagglutinin head antigen needed to achieve a hemagglutination inhibition (HI) titer of 1:40 in at least 70% of children and adults younger than 65 years or, alternatively, the amount of antigen needed to demonstrate that 40% of recipients have a 4-fold or greater increase in HI.⁵ Even though HI titers have been used for decades as a correlate of protection for influenza vaccines, the US Food and Drug Administration (FDA) noted that “prospectively designed studies to evaluate the effectiveness of influenza vaccines have not identified a specific HI antibody titer associated with protection against culture-confirmed influenza illness.”⁵ LAIVs do not have a recognized correlate of protection, which will create challenges for interpreting immunogenicity of candidate H7N9 vaccines.

The limited data available suggest that for an H7N9 vaccine to provide protection, it will likely require significantly more antigen than seasonal vaccines, will likely require an adjuvant, or both. Two phase 1 clinical studies of an inactivated H7 vaccine have been conducted to date.^6- 7 In one study using an unadjuvanted H7N7 vaccine, only 8 of 22 recipients receiving 2 doses of 90-μg vaccines had at least a 4-fold HI increase; none achieved a 1:40 titer.⁶ In another study of an H7N1 vaccine with adjuvant, none of 13 recipients receiving 2 doses of a 24-μg adjuvanted vaccine had a 1:40 titer.⁷ A single phase 1 study of an H7N3 LAIV demonstrated safety and most participants had a measurable immune response, although a recognized correlate of protection for LAIV has not been identified.⁸ Previous studies with H5N1 vaccines required 2 90-μg doses for 50% of adults to develop 1:40 HI titers; however, an adjuvanted vaccine using 3.8 μg showed improved results.

TIMELY AVAILABILITY OF A(H7N9) VACCINES

For A(H7N9) vaccines to be beneficial during an emerging pandemic, vaccines must be made available quickly. Factors determining availability include time to develop and distribute vaccine and global manufacturing capacity. Both factors will be influenced by the minimum immunogenic antigen dosage.

Efforts are under way to develop seed strains for A(H7N9) vaccines, manufacture clinical study vaccine lots, and conduct phase 1 clinical studies. The US Department of Health and Human Services anticipates that these efforts will be completed within 5 months. However, actual vaccine manufacturing likely will not occur until an A(H7N9) pandemic is considered imminent. Since it typically takes 17 to 22 weeks from preparation of the seed strain until vaccine can be shipped, the best-case scenario is a timeframe of 4 months from placement of vaccine orders to availability of production lots for distribution. Recent federal investments in potency testing may reduce this time. Depending on when vaccines are ordered, the manufacturers' ability to convert from seasonal vaccine to pandemic vaccine production, and how quickly the pandemic spreads, it is possible that vaccines will arrive in limited quantities but after the critical point when they will significantly affect morbidity and mortality, as occurred in 1957, 1968, and 2009.⁴

The 2009 A(H1N1)pdm09 illustrates the potential challenges of vaccine availability during an A(H7N9) pandemic. In late April 2009, public health officials determined that the A(H1N1)pdm09 pandemic was under way. Within weeks, the first vaccine seed strains were made available to manufacturers. At the same time, government agencies in a number of countries placed large orders for pandemic vaccine. Phase 1 clinical studies and the early manufacturing of bulk vaccine antigen occurred in parallel. Despite these efforts, most pandemic vaccine was not available in the United States until late October, almost 2 months after the second wave peaked.⁴ This same situation occurred in 1957 and 1968; vaccine was too little, too late.

Current annual global capacity for manufacturing hemagglutinin-head influenza vaccine is approximately 4.54 billion monovalent 15-μg doses.⁹ The antigen concentration for an H7N9 vaccine is currently unknown, but if 90 μg is required, global annual manufacturing capacity will be approximately 757 million doses of monovalent influenza vaccines. This is less than 15% of the global need and much of it will not be available until 6 or more months after manufacturing begins. Adjuvants may augment vaccine capacity, but development of an adequate global vaccine supply will remain an unprecedented challenge.

REGULATORY APPROVAL PROCESS FOR A(H7N9) VACCINE

A(H7N9) pandemic vaccine, if needed in the near future, will require a different regulatory process compared with the 2009 pandemic vaccine. Because A(H7N9) influenza virus is a novel human virus strain and limited data are available for H7 strains, manufacturers will not be able to apply to the FDA for license approval of an A(H7N9) vaccine under the provisions of a “strain change” request. Rather, the FDA will likely need to review data from the planned clinical studies and determine whether to issue Emergency Use Authorizations for A(H7N9) vaccines; this would be the first such authorization for vaccines.¹⁰

TOWARD THE FUTURE

Another influenza pandemic is inevitable. Even with recent additional vaccine manufacturing capacity and improvements in potency testing, the global public health community remains woefully underprepared for an effective vaccine response to a pandemic. To be successful in meeting the challenge of a severe pandemic, the influenza vaccine enterprise must move forward with the development of novel antigen influenza vaccines that protect most individuals from multiple strains of influenza.

AUTHOR INFORMATION

Corresponding Author: Michael T. Osterholm, PhD, MPH, Center for Infectious Disease Research and Policy, University of Minnesota, 420 Delaware St, SE MMC263, Minneapolis, MN 55455 (mto@umn.edu).

Published Online: May 9, 2013. doi:10.1001/jama.2013.6589

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Funding/Support: This work has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract HHSN266200700007C.

Role of the Sponsor: The National Institute of Allergy and Infectious Diseases had no role in the preparation, review, or approval of the manuscript or in the decision to submit the manuscript for publication.

Disclaimer: The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.

REFERENCES

1

 Emergence of Avian Influenza A(H7N9) Virus Causing Severe Human Illness—China, February-April 2013. MMWR. http://www.cdc.gov/mmwr/pdf/wk/mm62e0501.pdf. Accessed May 8, 2013

2

Schnirring L. Another death in China raises H7N9 fatalities to 32. CIDRAP NEWS. May 8, 2013. http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/may0813china.html. Accessed May 9, 2013

3

World Health Organization.  Vaccine response to the avian influenza A(H7N9) outbreak. May 2013. http://www.who.int/influenza/vaccines/virus/CandidateVaccineVirusesH7N9_02May13.pdf. Accessed May 9, 2013

4

Osterholm MT, Kelley NS, Manske JM,  et al.  The compelling need for game-changing influenza vaccines: an analysis of the influenza vaccine enterprise and recommendations for the future. CIDRAP. Oct 2012. http://www.cidrap.umn.edu/cidrap/center/mission/articles/ccivi-landing.html. Accessed May 8, 2013

5

US Food and Drug Administration.  Guidance for industry: clinical data needed to support licensure of pandemic influenza vaccines. May 2007. http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/ucm074786.htm. Accessed May 8, 2013

6

Couch RB, Patel SM, Wade-Bowers CL, Niño D. A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine.  PLoS One. 2012;7(12):e49704
PubMed   |  Link to Article

7

Cox RJ, Madhun AS, Hauge S,  et al.  A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine.  Vaccine. 2009;27(13):1889-1897
PubMed   |  Link to Article

8

Talaat KR, Karron RA, Callahan KA,  et al.  A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a phase I trial in healthy adults.  Vaccine. 2009;27(28):3744-3753
PubMed   |  Link to Article

9

Partridge J, Kieny MP. Global production capacity of seasonal influenza vaccine in 2011.  Vaccine. 2013;31(5):728-731
PubMed   |  Link to Article

10

 Pandemic and All-Hazards Preparedness Reauthorization Act, Pub L No. 113-5, §564 (b)(1)(C). http://www.govtrack.us/congress/bills/113/hr307 

 

 

 

 

 

http://jama.jamanetwork.com/article.aspx?articleid=1686871 

 

 

 

 

 

D. Ziad Mamish, meet with the delegation of the World Health Organization and experts from universities to exchange experiences about the Corona virus

Ministry of Health Saudi Arabia Website:

Complement the efforts undertaken by the Ministry of Health to address the virus Corona, and within the procedures coordinating routine carried out by the ministry with the health authorities and international experts in the field of viruses and infectious diseases in such cases, to exchange experiences, and to benefit from their experience and guided Bmriyatem, has reached Riyadh elite group of consultants and specialists from universities and international organizations and bodies, and the World Health Organization.

I have met with the delegation of the World Health Organization and experts from universities Thursday morning Undersecretary of Public Health Dr.. Ziad Mamish, in the presence of a number of officials of the Public Health Agency and health awareness, and during the meeting, see the strategies, policies and procedures carried out by the ministry to deal with this virus, and review The precautionary its efforts and the work of fact-epidemic and to reduce the spread of the disease; where the delegation expressed satisfaction with the organization of these efforts and confidence in what has been done by the ministry.

The delegation will tomorrow, Saturday morning visit to the province of Al-Ahsa, and visit health facilities to maintain, and meet with health practitioners involved in the work of supervisors control the virus in the health-Ahsa, and the exchange of experiences and advice them.

This, the delegation includes both: d. Connie Bryce consultant infectious diseases from the University of Denver, and Professor Trish Burrell consultant of infectious diseases at Johns Hopkins University, and Professor Paul Tambaya consultant infectious diseases from the University of Singapore, Professor Allison Mack Qier Hospital Mount سياني Toronto Canada, and Dr. Keiji Vakuda the Assistant Director General of the World Health Organization (WHO) for health security in Geneva, and Dr. Jawad quarantined director of communicable diseases World Health Organization (WHO) in Cairo.

It is important to note that the delegation of experts and a delegation of representatives of the World Health Organization will meet - later - the members of the Scientific Committee for Infectious Diseases at the Ministry of Health, which includes a selection of consultants and specialists from military hospitals and specialized university and government health sectors.

http://www.moh.gov.sa/Ministry/MediaCenter/News/Pages/News-2013-05-10-001.aspx 

#Coronavirus: three suspected cases are negative in France

 11-05-2013

FALSE ALARM. Virological investigation is ongoing in the entourage of the first and only time infected with the new coronavirus that has killed 18 people in the world since September French.

 

Last minute: "A fifth case contact was identified in the entourage of the sick patient Samples were made ​​that we know the results later in the day." Said Marisol Touraine during a press conference at the Lille University Hospital. According to Professor Benoit Guery who heads the infectious diseases service hotel, it is a "relatively young" man, whose symptoms are "somewhat disturbing" and also did not require hospitalization.

Relief for three people, further examination for another

While the Minister of Health, Marisol Touraine was expected Saturday at the University Hospital of Lille, where was transferred the 65 year old man suffering from new coronavirussimilar to SARS, health authorities announced the first results of the epidemiological investigation among those that could contaminate the past few weeks are reassuring.

A doctor, a nurse and a patient he touched the Hospital Douai and Valenciennes who develop symptoms of the disease were detected are not met. Rest at least one suspect to clarify case, that of a patient who has roommates proven carrier nCoV virus that "further investigations are necessary."

In a "serious but stable" condition

"One hundred and twenty individuals identified [in the entourage of 'Patient Zero'], three, and a fourth in the 10th of May had symptoms that led to virological sampling and placing them under observation in isolation in service of infectious diseases "recalls the statement released at night. "For three people, negative results are to be confirmed by the national reference center of the Pasteur Institute in Paris," the ministry.

The man who contracted the virus can cause serious respiratory problems during a stay in the Persian Gulf, it is still in solitary confinement serving resuscitation University Hospital of Lille, the only area that may bring assistance respiratory extracorporeal required the state still considered "serious but stable" by the Regional Health Agency (ARS) Nord / Pas de Calais. This was not the case in particular in Douai hospital where the patient was supported April 29, lack of space to that of Valenciennes where he presented the 23. There, he was followed for a chronic illness and was hospitalized during his last visit to digestive disorders.

Thirty-three cases of infections reported to WHO

Besides the toll in place to inform the population, a dedicated telephone line must be established at Valenciennes hospital to answer questions from the staff of the institution, provided, does not yield to panic. "The teams are perfectly serene" has at least said Dr. Jean-Luc Chagnon practicing in this hospital.

For the record, between September 2012 and so far, the World Health Organization has identified 33 cases of infection in Saudi Arabia, Jordan, Germany and the United Kingdom. Eighteen were fatal, including eleven in Saudi Arabia. There is great concern, however it should be noted that this new coronavirus whose mode of transmission is still unknown is "genetically quite different" from that of the Severe Acute Respiratory Syndrome (SARS), which killed more than 800 people a decade ago .

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#Coronavirus: three suspects in the North France

Translation
5/10/2013
After a doctor and a patient, a nurse who has been in contact with a 65 year old man infected with a new virus causing severe respiratory problems, also has symptoms raising fears of contamination, said Friday the agency of the regional Health Nord-Pas-de-Calais (ARS).

"We have a third suspect this morning, with a nurse in Douai," announced Dr. Sandrine Segovia Kueny, Deputy Director General of the LRA, on France Bleu Nord.

The patient, who is the first confirmed case in France of acute respiratory infection linked to the new coronavirus, SARS close, had stayed at the hospital Douai (North) April 29 to the night of Wednesday to Thursday, when he was transferred at the University Hospital of Lille.

Thursday evening, the LRA issued a press release announcing that two people have been in contact with this man, who had spent a week in Dubai from April 9 to 17, had symptoms requiring tests.

"Currently we're investigating on three case contacts," said Ms. Segovia Kueny "are not confirmed cases so far." "We have isolated, number, people who had been contact with the patient, both health professionals and patients, and we have an incubation period of ten days," she said.

Symptoms are "breathing and feverish," she said, "we have a very broad definition of cases to sample and isolate all persons who may have been in contact with this person," she explained.

The results of the tests on suspected cases should be known on Friday in the afternoon, said the LRA told AFP. Regional Health Agency of Nord-Pas-de-Calais announced Wednesday the first confirmed case in France of the new coronavirus infection, a 65 year old man, whose identity was not disclosed.

The man was presented April 23 at the Hospital of Valenciennes (North), where he was followed for a chronic disease. He had digestive problems and was placed in intensive care.

This service is complete, it was then transferred April 29 to hospital Douai (Nord) where respiratory problems had been reported.

His health has necessitated the establishment of cardiopulmonary support to take over its respiratory functions. He must therefore be transferred to the University Hospital of Lille, the only institution in the region practicing this type of medical care. The patient is placed in an isolation room, intensive care unit in a "serious but stable condition," according to the ARS.

A man in his fifties who had shared his room at Valenciennes from 27 to 29 April in turn presented disorders requiring specialized consulting infectious disease, sampling and monitoring in the hospital in a private room, according ARS.

A doctor from the hospital 35 years of Valenciennes, which had been in contact with the patient with the new coronavirus, also had symptoms requiring hospitalization in Tourcoing (North) to practice specimens, according to the same source.

The French first confirmed case of infection with the new coronavirus occurs ten years after the pandemic of SARS (Severe Acute Respiratory Syndrome), part of China, which had killed more than 800 people and caused concern in the world. Cases of infection have been detected in Saudi Arabia, Jordan, the United Kingdom and Germany.

A total of 33 confirmed cases in the world of this novel coronavirus, have been reported to WHO since September 2012 and 18 people died, including 11 in Saudi Arabia.

http://www.liberation.fr/societe/2013/05/10/coronavirus-un-troisieme-cas-suspect-dans-le-nord_901944