Thursday, April 9, 2009

Egypt must intensify efforts to combat avian flu, say experts


By Tamim Elyan
First Published: April 9, 2009
AP Photo/Nasser Nouri
Egyptian Health workers collect live ducks, confiscated from farms, for culling at the town of Qalyoub in the Qalyiubiya governorate north of Cairo, Egypt in this file picture.


AFP PHOTO/CRIS BOURONCLE
An Egyptian boy offers a live duck for sale in an street market of the populous district of Imbaba in Cairo in this file picture.

CAIRO: As the number of reported bird flu cases continues to rise in Egypt, attention is directed towards the government’s efforts in controlling and eradicating the disease.

H5N1 first hit Egypt in February 2006. So far, 63 people have contracted the virus, 23 of which died and 35 were treated. Three patients are still undergoing treatment.

On Wednesday, another case was reported of a two-year-old from a village in Giza.

This week, the Ministry of Health announced that 6,337 cases were isolated for suspicion of carrying the virus. From Cairo alone 843 cases were tested but were all found negative.

The highest infected cases were found in Menufiya with seven people carrying the disease. Six cases were reported in Fayoum and Qena each; while Menya, Qaliubiya and Gharbeya reported five cases each.

Three cases were reported in each of Cairo, Aswan, Kafr El-Sheikh and Daqahleya, two cases in each of Assiut, Sohag, Beni Suef, Damietta, and Sharqeya, while Alexandria, Suez and Beheira only reported one case each.

Young victims

The disease has spread among children between the ages of one and two over the past month.

An 18-month-old child was reported to contract the H5N1 virus on March 10.

Also early March, two two-year-old boys from Alexandria and Fayoum were reported to be infected.

Young children, old people and health workers are most likely to contract the virus, and WHO called for an investigation of this phenomenon.

“The rapid growth rate of bird flu infections in children is worrying,” John Jabbour, senior epidemiologist with WHO, told the UN news agency IRIN.

Jabbour speculated that the reason for the increased number of cases in this age group was that families were no longer as alert as they were after the last awareness campaign.

“This is a problem that will not go away in poultry; hence people who deal with birds cannot afford to relax. Those who come in contact with birds must make caution part of their daily routine,” he said.

“When children are infected then the message hasn’t arrived yet. There must be better funding, support and subsidization policies for farmers,” Diaa Salman, a virology expert who has been working on avian flu in Egypt since 2006, said.

“The Ministry of Health has implemented a comprehensive awareness plan that comprised more than 13,000 rural advisors moving from house to house, in addition to mass media campaigns,” Abdel Rahman Shahin, spokesperson of the Ministry of Health told the press.

“We also succeeded in saving the lives of children infected with the virus,” he said, adding that no fatalities were reported for children under 10 years old.

However, experts think that there is still a long way to go.

Getting the science right

Salman believes there is still room for improvement.

“Although it hasn’t reached the epidemic stage yet, Egypt is now second to Indonesia among the most affected countries by avian flu virus,” he told Daily News Egypt.

“The number of human and poultry infections show that some policies are ineffective; we need to reevaluate and assess the current capacities from laboratories and personnel operating at these laboratories, and update them as well as reviewing expenditure in this field,” he explained.

Salman also called for reassessing the types of vaccinations used, their sources and quality. He also called for cooperation between the Ministries of Health, Environmental Affairs and Agriculture in monitoring immigrant birds and the developments of the virus in Egypt.

According to Salman, monitoring the disease requires highly equipped laboratories with isolation and identification devices that can spot the microbes in live and dead infected bodies as well as high safety standards.

“They aren’t available at most places,” he said.

Nasr El-Din Al-Tantawy, a former epidemiologist at the World Health Organization (WHO), said that the Egyptian government’s efforts are not sufficient especially since the virus is now enzootic in the poultry sector.

“In Egypt, we deal with special kind of cultural and economic habits related to poultry farming especially in rural areas which demands intensifying awareness campaigns among farmers,” he previously told Al-Masry Al-Youm independent daily.

“The level of biological safety and vaccinations is excellent in major farms but it declines in small and new farms which enables the virus to become enzootic there,” he explained.

However, Hala Esmat, technical officer at the WHO, says that Egypt is on the right track concerning developing its laboratories.

“Most of the laboratories in Egypt are highly equipped; the latest was the WHO’s laboratory which has been promoted last week as the national laboratory for examinations,” Esmat told Daily News Egypt.

She added that the WHO is working closely with the Ministry of Health to follow up on various issues.

While the chances of infections remain relatively low, experts fear H5N1 could mutate into a form that can easily be passed from one person to another, leading to a pandemic which could kill millions.

“Most farmers in rural areas don’t apply safety standards like having backyards for raising poultry or separation between immigrating birds and the farm birds. The ministry doesn’t visit these places regularly for inspection nor do the local authorities help farms get rid of dead birds safely or compensate them for dead animals,” Salman said.

“Alternative policies must be implemented as well as heavy awareness campaigns especially as economic circumstances force farmers to depend on poultry rather than meat,” he added.


HAND, FOOT AND MOUTH DISEASE - CHINA (07): (HENAN, SHANDONG)

Archive Number 20090408.1357
Published Date 08-APR-2009
Subject PRO/EDR> Hand, foot & mouth disease - China (07): (HE, SD)

************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 7 Apr 2009
Source: Reuters News [edited]
<http://www.reuters.com/article/healthNews/idUSTRE5362MP20090407>


33 children in 2 crowded rural provinces of China have died in an
outbreak of hand, foot and mouth disease that could claim more
victims as it spreads in summer heat, state media reported on Tuesday
[7 Apr 2009].

The disease, a common childhood illness, is rarely fatal but can
cause fever, mouth sores and blisters. Severe forms of [the illness]
can be deadly if not properly treated.

18 children have died from the disease in central Henan province and
at least 15 in eastern Shandong province this year [2009], the
official Xinhua news agency reported.

Henan, a rural province crowded with poor farmers, is the center of
China's latest outbreak of the disease, which killed 40 children
nationwide last year [2008], spreading alarm among parents. The
deaths in Henan were among nearly 20 000 cases of the disease
confirmed in the province, including 5965 in hospital, as of Monday [6
Apr 2009], the Xinhua News Agency stated.

A provincial official warned that worse may come. "As the weather
warms, cases of hand, foot and mouth disease in Henan may rise
further," a vice governor of Henan, Song Xuantao, told Xinhua. "The
situation facing prevention and treatment is very grim."

In late March 2009, Minquan County in Henan said one child had died of
the disease. Minquan has now confirmed that 8 children have died from
the disease, the Xinhua report said. They were among the 18 dead
reported by Henan.

The report from Shandong said 11 500 children had been diagnosed with
the disease and 7100 had already recovered. Earlier this year [2009],
a 17-month-old boy died of the disease in eastern Anhui province.

[Byline: Chris Buckley]

--
Communicated by:
HealthMap Alerts via
ProMED-mail <promed@promedmail.org>

[The hand, foot & mouth disease epidemic in China continues to
escalate, from 19 deaths reported on 1 Apr 2009 to the 33 deaths
reported on 7 Apr 2009. The epidemic remains centered on the provinces
of Henan and Shandong, in contrast to the preceding year [2008], when
Anhui was the most affected province. It seems likely that the final
death toll, currently at 33, may exceed the 40 deaths recorded in
2008, since the epidemic is predicted to peak in mid-summer.

AVIAN INFLUENZA (LPAI), POULTRY - USA (02): (KENTUCKY), H7N9

Archive Number 20090408.1361
Published Date 08-APR-2009
Subject PRO/AH/EDR> Avian influenza (LPAI), poultry - USA (02): (KY), H7N9


************************************************************
A ProMED-mail post

ProMED-mail is a program of the
International Society for Infectious Diseases


Date: 9 Apr 2009
Source: OIE WAHID [edited]



Low pathogenic avian influenza (poultry), United States of America
------------------------------------------------------------------
Information received on 6 Apr 2009 from Dr John Clifford, Deputy
Administrator, Animal and Plant Health Inspection Service, United
States Department of Agriculture, Washington, United States of America

Summary
Report type Immediate notification
Start date 31 Mar 2009
Date of 1st confirmation of the event 31 Mar 2009
Report date 6 Apr 2009
Date submitted to OIE 6 Apr 2009
Reason for notification Recurrence of a listed disease
Date of previous occurrence October 2008
Manifestation of disease Sub-clinical infection
Causal agent Low pathogenic avian influenza virus Serotype H7N9
Nature of diagnosis Laboratory (advanced)
This event pertains to a defined zone within the country

New outbreaks

Outbreak 1 - Grayson County, Grayson County, Kentucky
Date of start of the outbreak 31 Mar 2009
Outbreak status Continuing (or date resolved not provided)
Epidemiological unit Farm

Affected animals: Species Birds
Susceptible 20 000
Cases -
Deaths - 0
Destroyed 20 000
Slaughtered 0

Affected population A commercial poultry broiler-breeder operation
consisting of 2 poultry broiler-breeder houses with 20 000 birds that
were 49 weeks old.

Summary of outbreaks
Total outbreaks: 1
Outbreak statistics:
Species Birds
Apparent morbidity rate **
Apparent mortality rate 0.00 percent
Apparent case fatality rate **
Proportion susceptible animals lost* 100.00 percent

* Removed from the susceptible population through death, destruction
and/or slaughter
** Not calculated because of missing information

Epidemiology
Source of the outbreak(s) or origin of infection *Unknown or inconclusive

Epidemiological comments
31 Mar 2009: a National Poultry Improvement Plan (NPIP) laboratory
reported seropositive results for avian influenza. The birds were
being tested as part of the NPIP Avian Influenza.

Clean Program (H5 and H7) for breeding facilities. No clinical signs,
other than a modest drop in egg production, were reported. There was
no increase in mortality.

1 Apr 2009: Enhanced surveillance at the broiler-breeding operation
was implemented, and additional laboratory samples were taken.

There were no clinical indications of disease at the time of
diagnostic testing.

2 Apr 2009: The National Veterinary Services Laboratory (NVSL)
confirmed H7 RRT-PCR and hemagglutinin subtype as H7 positive.

Laboratory testing is continuing, but to date, no virus has been isolated.

Kentucky State animal health officials, in coordination with USDA
APHIS Veterinary Services, implemented the LPAI response plan in
accordance with the Kentucky Initial State Response and Containment
Plan for H5 and H7 LPAI.

Implementation included:
An enhanced surveillance zone of 10 km (6.2 miles) was implemented as
outlined in the plan. There are 4 farms, all breeder facilities and
all owned by the same company, within the 10-km radius of the
positive premises. Laboratory samples were collected and submitted
from all 4 farms. Surveillance of backyard poultry flocks is being
conduced within a 3-km (2-mile) radius of the premises.

4 Apr 2009: NVSL reported that sera tested by hemagglutination
inhibition test and neuraminidase inhibition test were seropositive
for H7N9

4 Apr 2009: As a precautionary measure, all birds in the 2 houses
were depopulated.

5 Apr 2009: All laboratory samples collected from the enhanced
surveillance on the 4 breeding facilities yielded negative laboratory
results for avian influenza.

Note by the OIE Animal Health Information Department: H5 and H7 avian
influenza in its low pathogenic form in poultry is a notifiable
disease as per Chapter 10.4. on avian influenza of the Terrestrial
Animal Health Code (2008).

Control measures:

Measures applied:
* Stamping out
* Quarantine
* Zoning
* Vaccination prohibited
* No treatment of affected animals

Measures to be applied:
* Disinfection of infected premises/establishment(s)

Diagnostic test results

Laboratory name and type National Poultry Improvement Plan (NPIP)
laboratory (Local laboratory)
Tests and results:
Species - Test - Test date - Result
Birds - agar-gel immunodiffusion (AGID) - 31 Mar 2009 - Positive

Laboratory name and type National Veterinary Services Laboratory
(NVSL) (National laboratory)
Tests and results:
Species - Test - Test date - Result
Birds - agar-gel immunodiffusion (AGID) - 5 Apr 2009 - Negative
Birds - enzyme-linked immunosorbent assay (ELISA) - 5 Apr 2009 - Negative
Birds - hemagglutination inhibition test (HIT) - 4 Apr 2009 - Positive
Birds - neuraminidase inhibition assay - 4 Apr 2009 - Positive
Birds - real-time reverse transcriptase/polymerase chain reaction
(RRT-PCR) - 2 Apr 2009 - Positive
Birds - real-time reverse transcriptase/polymerase chain reaction
(RRT-PCR) - 4 Apr 2009 - Positive

Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.

Calif: State reporting widespread flu outbreak

04/08/2009

California continues to report widespread cases of the flu, possibly because of a late start to an otherwise mild season, health experts said.

State health officials said that while influenza often peaks in January and February, it is not unusual to see influenza in April and May.

Health experts use the term "widespread" when flu cases are being seen in half the state.

Still, the vaccine appeared to match well with flu strains found in California, though three children died statewide this year. Residents in other states haven't been so lucky.

"It was a slower start, but we also have been very successful in vaccinating people, and the vaccine is a better match," said Gil Chavez, epidemiologist for the state's public health department.

Chavez cautioned that even a few cases can still spread if residents don't remember to wash their hands and cover their mouths when they cough.

"The most important thing with influenza is to never predict," said Alicia Fry, medical epidemiologist with the federal Centers for Disease Control and Prevention.

"It's a flu year that is still puttering along."

This season's vaccine matched three of four strains, but experts also noticed that in some cases, flu germs were resistant to the most common antiviral treatment, Tamiflu.

Last year, the CDC released new recommendations for children from 6 months to 18 years, especially those attending school, to receive the flu shot.


Advertisement

About 5 percent to 20 percent of the population gets the flu in any given year. More than 200,000 people are hospitalized from complications and about 36,000 people die, according to health experts.

Bird Flu Reoccurring

Kamis, 9 April 2009

Heard by me the news in the media indeed him had the case of bird flu in Bali. My hope to the related side so that more tightened the guarding in Balinese entrances, so as not until the smuggling of the poultry from outside the area that will endanger the Balinese condition happened.

Hundreds Birds Residents Jombang Died Suddenly

[video of residents dealing with the dead birds]
06/04/2009 06:15

Flu Burung
Hundreds of of the Resident's Jombang chickens died Mendadak Hundreds of chickens in Jombang died suddenly in two last weeks. The official still researched and did not yet confirm whether the chicken died that was attacked by the bird flu virus.

Pandemic Influenza: Challenges and Questions

Dr. Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy (CIDRAP) will be speaking in Bloomington, Minnesota on May 7, 2009 at a joint meeting of the American Filtration and Separations Society (AFS) and the Center for Filtration Research (CFR).

Minneapolis, MN (PRWEB) April 8, 2009 -- Dr. Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy (CIDRAP) will be speaking in Bloomington, Minnesota on May 7, 2009 at a joint meeting of the American Filtration and Separations Society (AFS) and the Center for Filtration Research (CFR).

"Like earthquakes, hurricanes, and tsunamis, influenza pandemics are recurring natural disasters.*"

In the March/April 2007 issue of Foreign Affairs, Dr. Osterholm sounded the alarm once again on how unprepared governments and industry are to deal with a major pandemic. A relatively mild pandemic, such as what occurred in 1968, would kill 1.4 million people and cost about $330 billion in lost economic output. If the pandemic would be as bad as 1918-19, 142 million people would die and the world's GDP would lose $4.4 trillion.

"Besides getting sick, what else could go wrong?"

Along with the obvious health issues that a pandemic creates, Dr. Osterholm will also address how a pandemic could present serious disruptions in everyday services. In a November, 2008 report published by the CIDRAP, "Pandemic Influenza, Electricity, and the Coal Supply Chain",
Dr. Osterholm demonstrates how a pandemic could disrupt coal supplied to electrical power plants and cause shortages of electricity.

"Just in time Economy"

To reduce costs, the US and world economies have developed "just in time" supply chains. In other words, many critical products like drugs, safety items and food are delivered as needed. Any disruption in the supply chain would result in shortages of critical products. Or if the pandemic produces an increased demand for certain products, they will not be quickly available.

What can be done?

Dr. Osterholm will present the questions that both the public and private sectors need to be addressing. Does your community have any type of preparedness plan? Does your company have a plan? Do you have a plan?

To register for the conference and hear Dr. Osterholm's presentation go to the web page listed below.

http://www.afssociety.org/spring2009/

To learn more about the American Filtration and Separations Society go to:

http://www.afssociety.org

To learn more about the Center for Filtration Research go to:

http://www.me.umn.edu/research/faculty/pui.shtml

To learn more about the Center for Infectious Disease Research and Policy go to:

http://www.cidrap.umn.edu/

*Foreign Affairs, Vol. 86 No. 2, March/April 2007

Contact Information:
Suzanne Sower
American Filtration and Separations Society
7608 Emerson Ave S.
Richfield, MN 55423
Phone: 612-861-1277
Fax: 612-861-7959

hat-tip Shiloh

348 * ‬ case of suspicion, and 12 * ‬ positive bird flu infection in * ‬ 3 * ‬ months

The government failed to finance the activity of the control committees

Achieve the best Emad *: ‬ failed siege of the Government's efforts in bird flu in all the governorates of Egypt after the hotbeds of the disease has spread among birds and humans in contact with the rising rate of infections and suspects at the provincial level is frightening and more than double the figures recorded in the same period a year Last *. ‬ reports of the Ministries of Health and Agriculture, which was discussed at the High Commission of avian influenza confirmed the failure of the current plan for dealing with disease and recognized that some sources of veterinary vaccination programs and the investigation and sampling and analysis suffer from a serious financial deficit,

* ‬ An official source said the current plan failed in the siege disease and is supposed to adopt a new plan to tackle the spread of the disease after the patient in spots all over Egypt *. ‬ issued Amin Abaza, Minister of Agriculture decided to travel * ‬ Dr made me director of the Institute of Animal Health Research, Dr. Mohamed Hassan Khalifa, Director General National Laboratory for the control of poultry production to United States to participate in the Seventh Conference of the bird flu virus and become acquainted with the new plans to cope with the disease, which failed efforts to curb the spread of the disease, * ‬ as Minister of Agriculture has issued a decision to travel

* ‬ Dr. Najla pilgrims and Dr. Mahmoud Znati of the National Laboratory for the task of combating the disease in other States the United States to attend training courses on new ways to diagnose and cope with bird flu *. ‬ Dr. Hamed Samaha chief of veterinary services confirmed that things are under control and that the men were cooperating with the body of the Ministry of Health in dealing with the immediate spots are detected and added that the Authority was in need of funding more cars to cope with sick spots, he said the current plan is in the way of control but there are serious and other variables are shown and we address them and promised to send all data on the disease *. ‬

For his part, admitted Dr. Amr Qandil, director of infectious diseases in the Ministry of Health that this year registered the highest incidence of The suspect said that the reports of the ministry recorded * »‬ 348 *« ‬ case of suspicion of the disease during the month of March only *. ‬ recorded positive cases of the disease since the beginning of this year and as of yesterday I * »‬ 12 *« ‬ positive cases compared with * »‬ 7 *« ‬ cases in the same period last year, "said Dr Amr said to deal with suspected cases are immediate * ‬ are also the dangers of the veterinary services to deal with the sick spots, which show the suspect cases of the disease on humans *

‬ He added that the Ministry of Health implemented a plan to train medical teams in hospitals to define the nature of the disease and symptoms that appear on the suspects, * ‬ confirmed that the ministry has allocated Line No. * »‬ 105 *« ‬ around the clock to receive complaints of citizens and foster media campaigns and visits daily to make the pioneers of rural citizens in the establishment and expansion of the factor analysis of human samples for the rapid handling *. ‬ On the other hand, Dr. Fattuh Darwish Director of the Department of Preventive Medicine Veterinary Services Corporation that the development of the disease requires the development of methods and techniques of confrontation and acknowledged that the parties concerned to confront the disease has not been able to eliminate it and said he has not yet been besieged outposts sick in Egypt and the hot new show, but not in the form of epidemiological *. ‬ Dervis stressed that the Ministry of Health and the Veterinary Services exchange In the case of communications data to tell us in the injured human or suspicion * ‬ immediately begin the work of immunization program and to explore and collect samples from birds from the nearby and caught the suspect, if confirmed, analysis of the positive cases are executed and buried the bird through the health and vice versa if we are in the form of veterinary services, we found spots * ‬ injury poultry disease * ‬ inform the Ministry of Health and the names and addresses of places to start is to take other precautions, and the withdrawal of samples from contacts of birds *

* ‬ Commenting on the travel of a group of specialists in the veterinary services to the United States to identify new ways to confront the disease, an official source Authority refused to be named, said expanding the current epidemiological situation and that it is necessary to become acquainted with the experience and expertise of developed countries in the face of disease, * ‬ The source confirmed that the bird flu disease, talk and deal with it is subject to various criteria, and therefore face the question of the need to identify new ways commensurate with the variables inherent in the development of a focused disease specialists sent to the United States to search for modern methods to curb sick spots, which began increasing significantly, *

‬ The source added that over the periods of low temperature and delayed the onset of summer has led to the continued emergence of hotbeds of disease and helped in the proliferation of cases and suspected *

Obtained ‬ * »‬ delegation *« ‬ records of suspected cases sent by the Ministry of Health to the veterinary services in the days * ‬ 2 * ‬ and 3 * ‬ and 4 * ‬ April include * ‬ 3 * ‬ lists, each containing one * ‬ 9 * ‬ injury cases of suspected bird flu from all the provinces *.

On ‬ * ‬ 2 * ‬ April recorded statements of suspicion in a noble Mohamed Ismail * »‬ 21 * ‬ years *« ‬ Almnecat the village Aqrab Hosseinieh Center Hospital East has been admitted depositing Zagazig, * ‬ and Princess Razeq Abulhasan * »‬ 20 Year * ‬ * «‬ al-Alfi, the status of the province of Qena, we inaugurated the conversion was admitted to hospital in Qena, * ‬ Hassan and Hossam Hassan *» ‬ 5 * ‬ years * «‬ Shady queens of the division of his hospital fevers were the Upper Egyptian Mohamed Medhat Abduljawad *» ‬ Year 17 * ‬ * «‬ Bazkp of the status of enemy and queens have been admitted into a hospital this morning and the enemy Mohamed Abdulaziz *» ‬ 39 * ‬ years * «‬ from the village of Kom * ‬ 2 * ‬ Rashid Center for Lake County Hospital was deposited Damanhour fevers and Samiha Mohamed Treasure * »‬ 50 * ‬ years *« ‬ Gemayzeh of the village of West County Center Alsentp entered the hospital admitted Tanta, informed Ali Shaaban * »‬ 36 * ‬ years *« ‬ Khurshid of the park and entered the hospital in Alexandria, Alexandria, fevers Rowan Ahmed Ibrahim * »‬ 7 years * ‬ * «‬ of people before me, Sir, and entered Alexandria, Alexandria, fevers and allow Mohamed Mahmoud *» ‬ 35 * ‬ years * «‬ Dronka of Assiut and entered the hospital with fevers Assiut *. ‬ registered on the lists of suspected * ‬ 3 * ‬ * ‬ isolate April 9 * ‬ diets of hospitals for suspected bird flu patients have been isolated Aida Ali Ahmed Isa * »‬ 55 * ‬ years *« ‬ Almenderp of Alexandria, Alexandria, was deposited Bhmyat Walid Mohamed Said * »‬ 6 * ‬ years *« ‬ of Sir humans and entered Alexandria Alexandria fevers and Omaima Fathi mind * »‬ 41 * ‬ years *« ‬ Kos from entering the province of Qena, was admitted hospital Qena and Ahmed Ali Yacoub * »‬ two *« ‬ of Kos and deposited QENA fevers, Zeinab Mohamed Ahawadi * »‬ 40 Year * ‬ * «‬ entered from Qena, Qena and fevers Naima Hassan Jaber *» ‬ 11 * ‬ years * «‬ Badir from a bad Albderman Moas entered Menya Menya, fevers Sana Secretary Secretary *» ‬ 39 * ‬ years * «‬ Salhia of eastern region was Hospital East deposit fevers and Mr. Muhammad grew * »‬ 13 * ‬ years *« ‬ Vaqos of the East and entered the eastern and fevers Saad Mohammed Atta * »‬ 14 * ‬ years *« ‬ Belkas of Dakahliya and deposited a Hospital Mansoura *. ‬ * testified on ‬ 4 * ‬ suspicion of wounding, April * ‬ 9 * ‬ persons were recorded fever isolation hospital lists of suspected infection of Muhammad Ali * »‬ 57 * ‬ years *« ‬ by * ‬ Izbat Osman West Shubra al-Khaimah Balqlliopip Demerdash and entered the hospital and Mr. Hiam Ahmed * »‬ 28 * ‬ years *« ‬ Srsena the status of the village met Monday Fayyoum entered fevers Fayyoum Riham Mohammed Ahmed * »‬ 10 * ‬ years *« ‬ met Monday of the deposit was admitted Fayyoum Inamul Mohammad Abu Yusuf * »‬ 27 * ‬ years * «‬ Kafr Masood Btnta West entered Tanta fevers and survival Abdulnabi Razeq *» ‬ 41 * ‬ years * «‬ Mansheya of the new West Mahala area and entered the fevers Maysp Hamid Makhluf *» ‬ 33 * ‬ years * «‬ Shabra of Umbulula Mnov Center Monoufia entered Mnov fevers and Mohammed Shehab Hawkip * »‬ 55 * ‬ years *« ‬ Itai of gunpowder and entered Lake Damanhour fevers and love the beauty Sahsah * »‬ 8 * ‬ months *« ‬ functioning status of the village of Kafr El-Sheikh and a woman Mossaad 40 year the village Allavi Balyana Center and entered the province of sohah. sohag fevers
hat-tip Sally

Wednesday, April 8, 2009

Two suspect Bird Flu Not Keep Back to RSHS


Wednesday, April 08, 2009
BANDUNG WEST (SI) - AM, 26, and Fai, 14 months, two patients suspect bird flu that escape from the treatment room Flamboyan Rumah Sakit Hasan Sadikin (RSHS) Bandung, on Monday (6 / 4), not to be returned in force RSHS .


After the coordination between health and the RSHS Cipatat, both of the Village / District Cipatat, Kabupaten Bandung Barat (KBB), only need to receive intensive supervision. Head of Puskesmas Cipatat District of Revelation says, at this time AM and Fai who previously lived in-law's house in Kampung AM Cikokosan RT 01/06, Desa / Kecamatan Cipatat, returned to her parents in the village stop RT 01/19, Desa / Kecamatan Cipatat.

Physical condition of both patients, the words of Revelation, have seen more healthy than the first time was last week RSHS. He asserts, has requested the advice to doctors who handle AM and Fai RSHS in a matter of whether they should be brought back to the home sakit.Pihak RSHS states that the health center that will oversee both. The results of laboratory tests that their negative bird flu.

"But if there are signs of the condition of the body back out, they are immediately referred back to RSHS," said the Rev. SI yesterday. Although the existing oral statement from a doctor RSHS, still must have a copy of the official states that the PM and stay negative Fai virus Avian Influenza (AI). "We need evidence that will be the guidelines of the health condition of the hospital korban.Apalagi submit to us (health center) to conduct inspections and watched as advanced disease and flu burungnya negative victims suffer only common disease," he said.

Request a copy of the written evidence of the laboratory was also Head Cipatat Eriska Hendrayana.Menurut him, if only oral statements, the evidence does not have to disclose to the public that the disease and Fai AM menular.Dengan not so, society does not exclude the victims of life in the environment. "I just heard a new orally and not 100% sure.

Therefore, I will ask the full backup or image copy of the laboratory test results of the AM and Fai negative bird flu, "said Kantor Pemkab Eriska in West Bandung, Jalan Tagog, Padalarang, KBB, yesterday. He asserted, not the decision to have one so that people remember the injured bird flu virus can spread quickly.

Because of this, he has ordered the district officials to immediately request the summary results of laboratory examination and Fai AM. Later it akan rekapan given to the village and presented to the public so that there is no fear of the neighbors of the victim at or adjacent to communicate with them. Meanwhile, in order to anticipate the spread bird flu outbreaks, especially in Cipatat, already coordinates with the Animal Husbandry and Fisheries KBB disinfectant to perform at the same time.

Moreover, in the area quite a lot of poultry, including chickens because there are some chicken farms. "We will soon perform for agendakan disinfectant so that the bird flu virus has brought the victim in the village of Kampung Andir stop and not extended to neighboring villages," said Eriska. (adi charlie at the lake)

Agriculture" is facing a U.S. avian flu plan

After the failure of the Egyptian plan:

"

اWednesday, April 8, 2009 - 10:33


After the high number of cases of avian flu, and suspected infection, which increased to 65 cases, and after the recognition of the failure of its veterinary services in the fight against the disease, according to Dr. Fattuh Darwish Director of the Department of Preventive Medicine, that the plan of the bird flu situation of a large fiscal deficit , the Minister of Agriculture and other decisions to travel a large number of veterinarians to foreign countries for training courses or to study the disease.

It was a decision to travel, Dr. Mona Mehrez research director of the Institute of Animal Health, Dr. Mohamed Hassan coach of the national control laboratory for the production of sending into exile to the United States, to participate in the Seventh Conference of the bird flu.

Abaza also issued a similar travel of pilgrims and Dr. Najla Dr. Mahmoud Znaty National Laboratory to fight the disease on a mission to the United States to attend a training course on the diagnosis of avian influenza.

detention of suspected cases of bird flu, the lake

الأربعاء، 8 أبريل 2009 - 16:45 Wednesday, April 8, 2009 - 16:45




Avian flu spread alarmingly GOVERNORATES

البحيرة - شعبان فتحى Lake - Fathy Shaaban


The fever hospital Bdinmhor 4 persons detained on suspicion of having bird flu, after the emergence of symptoms of the disease are similar to them, the high temperature and throat congestion and shortness of breath.

Received the Major General, Magdi Oboukmr, director of security of the lake, a notification from the hospital admitted the detention of each of the Damanhour Ayatollah Medhat Egyptian (3 years) Damanhour fork, and decent Abdo Hegazy (40 years housewife) in Kafr Dawar Kafr Salim, and the planet, Mr. Mohamed (42 years housewife ) Aloavadip Damanhour, and Nadia Massoud Abdel Halim (40 years housewife) Obouhms village of Zarqa.

And immediately was coordination between the Directorate of Veterinary Medicine and the Department of Health to vaccinate domestic birds infected premises and take samples for analysis by the lab to clean up the homes of suspects and the adjacent houses to them.

On the other hand, the Committee examined the existing bird house Ismail Ibrahim Taha Center Itay gunpowder, and after a hospital admitted the arrest of the child Demerdash Balqlliopip Mohamed Gomaa (6 years) suspected of having bird flu after his visit, accompanied by his mother to the house of his grandfather Baitay gunpowder.

ACS and Clinical Solutions partner to help local gov

Wednesday, 8th April 2009

07 April 2009: First-of-its-kind fully managed pandemic solution assists local government in assessing symptoms and planning for public health incidents.

Government organisations looking to better prepare for a public health outbreak will now have access to a complete pandemic management solution thanks to a new partnership between Affiliated Computer Services (NYSE: ACS) and Clinical Solutions.

In the event of a pandemic outbreak, this fully managed solution would help local healthcare professionals, governments and citizens safely and consistently assess symptoms and direct patients to the most appropriate level of care – thereby alleviating strain on local primary care providers during a public health crisis.
“As a leading provider of government healthcare solutions, ACS is pleased to add this end-to-end pandemic management solution to its wide variety of government offerings,” said Chris Deelsnyder, managing director and senior vice president of ACS’ Government Healthcare Solutions. “ACS’ mature global infrastructure and extensive customer care capabilities serve as the perfect complement for Clinical Solutions’ Web-based products. Together, we can equip local governments with the necessary tools to better prepare for and manage possible public health outbreaks.”
Under the partnership agreement, ACS will provide the infrastructure, telephony and call centre services to complement the Clinical Solutions IntefleCS™ Health Watch tools and software. With nearly 30,000 customer service representatives and 118 call centers that offer support in 20 different languages, ACS can provide an instant pool of operators that can help assess symptoms, provide further information and direct citizens to the most appropriate level of care.
Richard Craven, director at Clinical Solutions adds, “This partnership provides local governments with the combined expertise of specialists in telecoms and call centre services with Web-tools and software. The Clinical Solutions and ACS technologies offer effective tools for assessing symptoms and planning for public health incidents, pandemics and bio-threats; giving governments confidence and peace of mind that they’re fully prepared.”
IntefleCS™ Health Watch is a suite of Web-based tools used to detect, assess, contain, communicate, manage and report during a public health incident. The software was piloted in 2006 in Exercise Cumpston, Australia’s largest ever health simulation exercise, which tested the country’s preparations for a pandemic flu outbreak.
In the United Kingdom, Clinical Solutions is helping to deliver a multi-channel National Pandemic Flu Line Service ensuring the country is one of the most prepared in world. In partnership with Department of Health, NHS Direct and BT the service will provide rapid Web- and telephony-based assessment, direction of care, advice, guidance and, where appropriate, authorisation of antiviral medicine treatment to the public.
About ACS
ACS is a national leader in state healthcare program administration, offering a full spectrum of systems and complementary services through an integrated solution; from care management solutions and child health programs to pharmacy benefits management and traditional Medicaid fiscal agent services. ACS supports more than 23 million program recipients and processes nearly 550 million Medicaid healthcare claims annually, representing close to $50 billion in provider payments. As the nation's largest government program pharmacy benefits administrator, ACS serves 28 states, the District of Columbia and the Department of Labor with drug expenditures totaling more than $13 billion.
ACS, a global FORTUNE 500 company with 74,000 people supporting client operations reaching more than 100 countries, provides business process outsourcing and information technology solutions to world-class commercial and government clients. The company's Class A common stock trades on the New York Stock Exchange under the symbol "ACS."

Highly pathogenic avian influenza virus H5N1 in Africa: a comprehensive phylogenetic analysis and molecular characterization of isolates

09/Apr/09

Authors: Cattoli G, Monne I, Fusaro A, Joannis TM, Lombin LH, et al. 2009 Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Africa: A Comprehensive Phylogenetic Analysis and Molecular Characterization of Isolates. PLoS ONE 4(3): e4842. doi:10.1371/journal.pone.0004842

This work follows the appearance of A(H5N1) viruses in birds in eleven African countries (Benin, Burkina Faso, Cameroon, Djibouti, Egypt, Ghana, Ivory Coast, Nigeria, Niger, Sudan, Togo) and the implications for the poultry sector and related public health issues. These include food security in low-income countries and the potential threat to human health from circulation of A(H5N1). To date there is only limited information on the molecular evolution and epidemiology of A(H5N1) in Africa. To fill this gap the authors applied molecular analysis tools to virus sequence data and combined the results with epidemiological data related to A(H5N1) viruses isolated between 2006 and early 2008. This included 494 full gene sequences from 67 African isolates and in addition molecular analysis tools were applied to a total of 1,152 A(H5N1) sequences obtained from viruses isolated in Africa along with Europe and the Middle East for comparison. Detailed phylogenetic analyses of the 8 gene viral segments confirmed that 3 distinct sub-lineages were introduced which have persisted and spread across the African countries.

This article can be accessed by clicking here.

ECDC Comment (07-04-09): The authors note that despite phylogenetic analysis of all the gene segments of the A(H5N1) viruses in this study that did not allow them to pinpoint the origins of the different viruses. The epidemiological data here are rudimentary. It also remains unclear how, when and where the three distinct A(H5N1) sub-lineages entered the continent and spread. Resources for surveillance for avian influenza are considerably more plentiful than they were a decade ago but they still remain rudimentary compared to what is available in the European Union.
hat-tip Helblindi

Excerpts from: Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and i

From the pdf file from post below:
Excerpt:

Here we show that the HA subunit 1 (HA1) of H5N1 viruses encodes specific and highly conserved information which may determine the recognition and targeting of these HPAI viruses to their receptor. The comparison with seasonal strains suggests that a subset of H5N1 in Egypt may be evolving towards an H1N1-like receptor usage.
-snip-
Despite its low infectivity for humans, there has been evidence in Egypt of several
clusters of human-to-human transmission with very high mortality rate. ISM analysis of 95 HA sequences from Egypt 2006 and 2007 showed that these viruses can be divided into two groups. Consensus IS of a first group (Egypt-1) of 55 strains contains a dominant peak of the frequency F(0.076) which is characteristic for H5N1 HA1 and a less prominent peak of the frequency F(0.236) which is characteristic for H1N1 HA1
(Figure 2a). In contrast, consensus IS of the second group (Egypt-2) (Figure 2b), which includes 40 H5N1 HA1, contains only one significant peak of the frequency F(0.236) corresponding to the consensus IS of H1N1 HA1 in Figure 1d. Figures 2c and 2d show representative IS of individual strains of both groups. Of H5N1 viruses which were isolated in Egypt during 2006, 76% belong to the group Egypt-1, and 24% were from the group Egypt-2. In contrast, in 2007, 48% belong to the Egypt-1 and 52% to Egypt-2. Figure 4 shows the IS spectra of peptide VIN1 and of the domains identified by consensus IS of H1N1, H3N2, H5N1 and H7N7 viruses (Table 2) and the position of these domains in the molecule. As can be seen, the receptor targeting site of H5N1 virus from the group Egypt-1 (A/Egypt/0636-NAMRU3/2007) is closer to the receptor binding site than in the other viruses of Figure 4. It may be speculated that this may affect the efficacy of the virus/receptor interaction.

Finally, we compared informational properties of H1N1 pandemic strains from 1918
from GenBank and seasonal H1N1 strains. The consensus IS of these pandemic isolates (Figure 3) is characterized by a dominant peak of the frequency F(0.258) which is different from the frequency F(0.236) characteristic of other seasonal flu H1N1 isolates (Figure 1d). Table 2 shows the domain corresponding to the frequency F(0.258). In the model of A/South Carolina/1/18 (Figure 4i) the position of this domain does not overlap with the corresponding domain of other seasonal H1N1 strains, but overlaps with the corresponding domain of Egypt-2 H5N1 viruses.
-snip-
H5N1 already replicates efficiently in humans, and cause case fatality rates that are ten times higher than those seen in the 1918 pandemic. Thus, an infectivity of H5N1 similar to seasonal flu would cause a catastrophic pandemic. The main obstacle for this worst case scenario is poor human-to-human transmission of H5N1 viruses, which is attributed to the paucity of sialic acid a2,3 receptor in the epithelium of the human upper respiratory tract, and the inability of the virus to replicate efficiently at this site. Interestingly, the ISM approach identifies important differences between H5N1 viruses from Egypt. Some have the characteristics of most H5N1 strains whereas about one third of the viruses display characteristics that are also found in human H1N1 seasonal virus. Interestingly the proportion of the latter viruses has increased from 25 to about 50: between 2006 and 2007.

Similarly the results of H5N1 strains from Egypt (Figure 2) may be indicative of a
possible viral evolution towards receptor usage similar to that of H1N1 viruses, which
efficiently replicate in the upper respiratory tract. The protein domain, which seems to be involved in this subtle change, corresponds to amino acid domain 99-132 (Figure 4g).

However, the role of this domain for enhanced infectivity in humans remains elusive.
Interestingly the corresponding domain of Spanish flu viruses and Egypt-2 H5N1 viruses are much closer to the receptor binding site of HA1 than in all other H1N1 and H5N1 viruses (Figures 4e-4i and Table 2). This closer proximity may indicate more efficient virus/receptor interactions in these influenza viruses.
-snip-

Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control

Veljko Veljkovic , Nevena Veljkovic , Claude P Muller , Sybille Muller , Sanja Glisic , Vladimir Perovic and Heinz Kohler
BMC Structural Biology 2009, 9:21doi:10.1186/1472-6807-9-21

Published: 7 April 2009
Abstract (provisional)

Background

Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the world's economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction.
Results

Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1.
Conclusions

The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
hat-tip Niman

Indo: AG, "I felt I has been HEALTHY"


The official from the Kesehatan Service discussed with the patient was expected by bird flu, AG (left), in his house in the Halteu Village, Desa Cipatat, Kabupaten Bandung Barat, on Wednesday (8/4). According to AG, he was forced to escape from RSHS on Monday (6/4) around struck 11,00 WIB because his wish was treated in the house was not granted by the official. * Ade BAYU INDRA/PR
Admitted to be wrong, BUT did not want to return to RSHS

Kamis, 09 April 2009
NGAMPRAH - the puzzle AG (25) that escaped from space of the Poinciana Tree isolation of Rumah Sakit Hasan Sadikin Kota Bandung was solved already. Met in his parents's house in the Halteu RT Village 1 RW 19, the Cipatat Village, Kec. Cipatat, Kab. Bandung was Barat, on Wednesday early afternoon (8/4), AG that was expected terjangkit this bird flu appeared healthy and was playing in a third manner his sweetheart. "I felt I has been healthy." Whated are you doing I was treated very old. I also enggak felt in the hospital at home, [dictionary translation: "“I think already finished healthy. Why I cared for after a long time. I also/still not to bear/endure in hospital”] said AG when telling the reason he escaped from Flamboyan RSHS Space that was minded was tight enough by the nurse.

AG claimed, he escaped through the window toilet available in Flamboyan Space, on Monday (6/4) around struck 11,00 of WIB. Saat Itu gazed at rest time of the nurses so as the guarding was not too tight. By shifting the youngest child FS (14 months) that also was treated, and his wife, Rika (19), AG determined to escape. "Window glasses in toilet that has been lax, so easy was freed." Because of the location of the rather high window, I rose on the bath previously for manjat the window. From the window, I left the hospital corridor, said AG.

During in the hospital corridor, said AG, the atmosphere was not too busy. Moreover, the security units then were not available. The three of them walked and sway the arms until going out RSHS. not dared to immediately came home, AG brought his family to your house him in the Pamucatan Village, Kec. Padalarang, Kab. Bandung was West. The next day, on Tuesday (7/4), AG decided to go to his parent-in-law's house in the Cikokosan Village, Desa Kertamukti, Kec. Cipatat, Kab. Bandung was West. Overnight in his parent-in-law's house, AG decided to return to his parents's house in the Halteu Village, on Wednesday (8/4). [dictionary translation following quote]"I already finished to ask kindly to return home same doctor in RSHS, however not have been responded. I already healthy, while treated myself to bathe alone. While also when I cared for finished, who will want to give to consume food family mine. I backbone family here, father mine done elderly" said AG.

Admitted to be wrong
AG acknowledged, if his action escaped from the hospital was wrong. But, he also did not receive was made as being expected by bird flu. According to him, before eating the chicken that it was suspected was sick because of this bird flu, AG has been sick flu. "His weather still is ugly, I and children were sick with a cold." Moreover, the neighbouring child also was sick. When eating the chicken, I have been sick. Why only I and FS that was made suspect. FS breathless because he indeed had asthma and bronchitis, not bird flu, said AG.

In the meantime, the UPTD Head and the Cipatat Community Health Centre, Kab. Bandung was Barat Dr. Wahyu said, his side has tried to ask for AG so that he wants to be treated again in RSHS. Namun, all the decisions to be on the hands of AG. "We could not force AG. If he indeed did not want to be treated again, okay then," said Wahyu.

Beforehand, the Managing Director RSHS Bandung, Prof. Dr. Dr. Cissy R.s. Prawira, Sp.A. (K), M.Sc.said, was based on results of the clinic inspection and the laboratory of the patient AG and FS, did not head to bird flu. Even so results of the PCR inspection of the available poultry there the negative. (A-187)

WHO: Avian influenza – situation in Viet Nam - update 5

8 April 2009 -- The Ministry of Health in Viet Nam has reported a new confirmed case of human infection with the H5N1 avian influenza virus. The case has been confirmed at the National Institute of Hygiene and Epidemiology (NIHE).

The case is a 3 year old boy from Chau Thanh District, Dong Thap Province. He developed symptoms on 12 March, was hospitalized on 13 March, and died on 19 March.

Investigations into the source of infection indicated a history of close contact with sick and dead poultry prior to the onset of symptoms.

Of the 110 cases confirmed to date in Viet Nam, 55 have been fatal.

Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO

Click on image

Recombinomics: WHO H5N1 Transmission Omissions in Beheira Egypt

Commentary


Recombinomics Commentary 17:44
April 8, 2009

Both boys had contact with sick/dead poultry prior to the illness onset.

Close contacts of both boys have been identified and none has shown symptoms of the infection .

The above comments from the latest WHO update represent glaring commission by omission. The update claims “contact with sick/dead poultry”, but fails to give results of testing of such poultry. The SAIDR site, which has poultry results through April 3 does not include any confirmed poultry cases in the proximity (see updated map) of the Beheira cluster.

Moreover, the above comments imply that neither confirmed case has transmitted H5N1 to any contact, yet the update fails to mention that the two confirmed cases live "in adjacent houses", and are cousins.

The four day gap in disease onset dates leaves little doubt that the index case infected his cousin, who lives text door. This toddler to toddler transmission is cause for concern, because both cases had mild H5N1, including the index case, who began oseltamivir treatment after the recommended 48 hours after disease onset.

These mild bird flu cases in Egypt are not new, and were cause for concern in 2007, when children between the ages of 3-10 rapidly recovered and were infected with H5N1 sequences that were virtually identical and signaled extensive human to human transmission because the cases with identical H5N1 sequences were not epidemiologically linked.

Although WHO has recently acknowledged concern for silent transmission of H5N1, the above commissions by omission of an obvious case of human to human transmission raises serious pandemic concerns about WHO’s ability to analyze scientific data and transparently present results of such analysis.

Media Links

Recombinomics: Confirmation of Toddler H5N1 Transmission in Beheira Egypt

Commentary

Confirmation of Toddler H5N1 Transmission in Beheira Egypt
Recombinomics Commentary 16:24
April 8, 2009

But Jabbour said there was still no evidence of the disease being passed from person to person in Egypt. He added that two toddlers from the northern province of Beheira infected within days of one another in March were cousins.

The above comments on the Beheira cluster leave little doubt that the infections involved toddler to toddler transmission, based on the four day gap in disease onset dates. Local media reports indicated the two cases were next door neighbors, and the above comments state that they were cousins, yet neither the SAIDR updates, nor the WHO update by its Mediterranean branch mention that these two cases were cousins and almost certainly had contact, supporting human to human transmission.

The failure of these government agencies to include this most relevant information, and the delay in posting situation updates for the three most recent confirmations in Egypt by WHO in Geneva, creates significant cause for concern.

Media Links

Arbor Vita Receives FDA Clearance of Its AVantage(TM) A/H5N1 Flu Diagnostic First Rapid Test for Avian Influenza in Humans

SUNNYVALE, CA -- (Marketwire) -- 04/07/09 -- Arbor Vita Corporation (AVC), a biopharmaceutical company developing both diagnostics and therapeutics, announced that it has received 510(k) clearance from the U.S. Food and Drug Administration for its AVantage(TM) A/H5N1 Flu Test. This is a non-invasive rapid diagnostic device for the specific detection of the avian influenza A/H5N1 virus in humans. AVC's AVantage A/H5N1 Flu Test detects the influenza virus nonstructural protein 1 (NS1) in specimens from throat swabs or nose swabs collected from patients with flu symptoms.

"We applaud the FDA's efforts to foster fast, early identification of the avian influenza A/H5N1 virus in humans. Rapid, early detection of avian influenza is paramount to early treatment and containment of a deadly disease with pandemic potential," said Peter S. Lu, M.D., Founder and Chief Executive Officer of Arbor Vita Corporation. "We are excited to receive FDA clearance for the first rapid test to diagnose patients with this serious respiratory infection."

While the AVantage flu test is highly sophisticated, it is easy-to-use. It is a rapid test that can detect the presence of the avian influenza A/H5N1 virus in less than 40 minutes, without complicated sample preparation.

The U.S. Navy was an integral partner in evaluating this flu test for FDA clearance, with the Naval Health Research Center (NHRC) in San Diego, CA providing testing on both archival and prospective clinical specimens to ensure the specificity of the test, while Navy Medical Research Unit-3 (NAMRU-3) provided invaluable access to avian influenza isolates for development and testing.

"This new rapid test will provide an extra level of protection for not only the general U.S. population, but for our forward-deployed troops in areas with avian influenza activity," commented Dennis Faix, M.D., Commander, NHRC.

Christopher A. Myers, Ph.D., Laboratory Director, Department of Respiratory Diseases Research, NHRC continued, "This test can help detect an isolated case or outbreak in an austere environment, allowing for the rapid, targeted interventions necessary if we hope to contain or slow an avian influenza outbreak."

About AVantage A/H5N1 Flu Test

The AVantage A/H5N1 Flu Test is the first rapid diagnostic device that will be used to detect the H5N1 virus strain from throat swabs or nose swabs collected from patients with flu symptoms. In studies conducted in collaboration with NHRC and NAMRU-3, the AVC flu test demonstrated exceptional sensitivity and specificity for the H5N1 subtype of influenza A. The AVC flu test utilizes the company's proprietary PDZ protein technology to uniquely detect the virulence factor NS1 protein from A/H5N1 viruses, which accounts for the excellent sensitivity and specificity of this diagnostic device.

About Influenza Viruses

As of March 30, 2009, the World Health Organization (WHO) had reported 413 confirmed human cases of avian influenza A/H5N1 virus in 15 countries, with 256 deaths. Influenza is one of the most common acute, highly contagious respiratory infections in humans, caused by immunologically diverse single-stranded-RNA viruses. Among the three types of influenza viruses: A, B, and C, type A viruses are the most prevalent and are associated with most serious epidemics. There are many subtypes of type A influenza viruses, distinguished on the basis of different surface proteins (hemagglutinin [HA] and neuraminidase [NA] proteins). The H5N1 subtype of influenza A is known to cause life-threatening illness and to date has a high death rate in excess of 60%.

Symptoms of avian influenza virus in humans have included typical influenza-like symptoms (e.g., fever, sore throat, cough, and muscle aches) which progress to more severe respiratory conditions such as pneumonia and acute respiratory distress and other complications.

About NHRC

Naval Health Research Center (NHRC) serves as a leading research and development laboratory for the Department of Defense. NHRC manages and executes expeditionary operational medical research, development and test and evaluation programs for the Naval Medical Research Command, Silver Spring, MD, Navy Medicine Support Command, Jacksonville, FL and the Navy Bureau of Medicine and Surgery (BUMED).

About NAMRU-3

The Naval Medical Research Unit No. 3 (NAMRU-3), based in Cairo, Egypt, conducts infectious disease research, including the evaluation of vaccines, therapeutic agents, diagnostic assays and vector control measures, and performs public health activities, principally aimed toward improved disease surveillance and outbreak response assistance. NAMRU-3 works closely with the Egyptian Ministry of Health, the U.S. National Institutes of Health (NIH), the World Health Organization (WHO), the U.S. Agency for International Development (USAID) and the U.S. Centers for Disease Control and Prevention (CDC).


About Arbor Vita Corporation

Arbor Vita (www.arborvita.com) is a biopharmaceutical company pioneering the discovery, development and commercialization of novel drugs and diagnostics through a new family of targets -- PDZ proteins. PDZ proteins are key cellular organizers in human signaling pathways. Recruited by viral pathogens, PDZ proteins are highly conserved and provide an ideal platform for identification of diagnostic markers for cancers, infectious diseases and other complex diseases. The company capitalizes on its unique mix of expertise, intellectual property, and novel PDZ drug discovery platform to accelerate discovery and development programs for both therapeutics and diagnostics. Arbor Vita's current programs address major health areas including complex diseases such as cervical cancer and stroke, as well as infectious diseases such as influenza.
hat-tip AlaskaDenise

The government is ignoring the bird flu crisis !

8/4/2009



Warning of the collapse of the poultry farms * .. ‬ The data from the Health and Agriculture

Nasser Fayad wrote *: ‬ government ignored the report of the World Health Organization in the occupation of Egypt, the first number in the world, * ‬ human cases of bird flu *. Calendar ‬ ago the Council of Ministers of the reference to the seriousness of the spread of * ‬ * ‬ injuries and losses * ‬ of the infected poultry farms in Lower Egypt *. ‬ ignore the last two meetings of the Council of Ministers the high incidence of bird flu *. ‬ ago as the meeting of the Council's agenda tomorrow * ‬ * »‬ Thursday *« ‬ reference to the subject * ‬ *. ‬ the owners of poultry farms sharply criticized Association * ‬ * ‬ poultry producers because of its failure to take action to combat the disease, * ‬ and raise a memo to senior producers * ‬ Amin Abaza, Minister of Agriculture * ‬ demanding compensation for the loss of educators, * ‬ and * ‬ * reached ‬ 100% * ‬ * ‬ spots in injury * ‬ Qaliubiya provinces and the lake, Dakahliya, western and other provinces *. ‬

The Ministry of Health has just the announcement of human cases, * ‬ developments and the spread of the disease on the way * ‬ * ‬ Socialist Union without the announcement of a joint plan * ‬ with the Ministry of Health to combat *. The ‬ * ‬ Spokesman of the Ministry of the injury, No. * ‬ 63 * ‬ Qaliubiya province, injuring a baby and was preceded by less than two years old in the province, the lake * ‬ *. ‬ warned the collapse of agricultural sources of the poultry industry and the closure of a large proportion of the poultry farms because of fears of disease, * ‬ and the high cost of production, * ‬ and the escalation of prices of chickens, * ‬ and doubling the price of * »‬ vaccine immunization *« ‬ against the disease, * ‬ and * ‬ useless because of several types of mutation of the virus that causes the disease *. ‬ noteworthy that the number of poultry farms Official * ‬ a * ‬ 17 * ‬ alpha, * ‬ * ‬ to the rural homes by raising chickens on the roofs of houses, * ‬ As a result, high rates of home injuries, * ‬ * ‬ and the spread of infections and its transition to * ‬ many farms
hat-tip Florida1

China's Capacity to Manage Infectious Diseases: Global Implications

Apr 8, 2009

During the Seventeenth Party Congress in October 2007, it was made clear that improving health care in China had become a political priority for the country’s leadership. Three decades of double-digit economic growth had not been matched by progress in China’s ability to prevent and treat diseases. The rudimentary Maoist-era health care infrastructure had largely collapsed in the reformist years of Deng Xiaoping and Jiang Zemin, and by the time Hu Jintao took office in 2002, it was in tatters, particularly in rural China.

At the same time, the socioeconomic changes wrought by China’s economic explosion and openness to the outside world created enormous new health care challenges and strains on the country’s capacity to manage them. As part of his government’s efforts to reduce social inequities resulting from 30 years of breakneck economic growth, Hu made improving China’s health care system a priority. The SARS crisis of 2003 was a catalyzing period for China, and since then Beijing’s blueprint for national health care has been drawn and redrawn several times. The problems are deep and multifaceted; identifying solutions is not easy, no matter how high a priority the task is considered.

If China cannot meet its health care challenges, it will further tax an already strained international infrastructure. On the other hand, if China is successful, it can not only short-circuit an international spread of disease but also become a net donor to the global health community. To that end, the Freeman Chair in China Studies at the Washington D.C.-based Center for Strategic and International Studies (CSIS) assembled a group of international experts to address the current health care situation in China, China’s efforts to tackle the problems of infectious disease and health care reform, and the regional and global dimensions of these reform efforts. This report is intended as a tool to help international policymakers and practitioners--as well as Chinese officials and academics--meet the challenges of health care in China head on.

Free PDF download:
http://www.csis.org/media/csis/pubs/090325_freeman_chinacapacity_web.pdf

From the CSIS website:
http://www.csis.org/component/option,com_csis_pubs/task,view/id,5378/type,1/

INTERVIEW-Concerns arise over symptomless Egypt bird flu cases

By Cynthia Johnston
Wed Apr 8, 2009 11:13am GMT


CAIRO, April 8 (Reuters) - The World Health Organisation is concerned some Egyptians may carry the highly pathogenic bird flu virus without showing symptoms, which could give it more of a chance to mutate to a strain that spreads easily among humans.

Whether such cases exist still has to be put to the test and will be the focus of a planned Egyptian government study backed by the global health body, said John Jabbour, a Cairo-based emerging diseases specialist at WHO.

"This is a concern only, now. It is a question to be asked," Jabbour told Reuters. He said a change in the pattern of human bird flu infections this year in Egypt had raised concerns about the existence of so-called sub clinical cases.

The most populous Arab country, which has been hit harder by bird flu than any other country outside of Asia, has seen a surge in infections this year.

While the H5N1 virus only rarely infects people, experts fear it could mutate into a form that humans could easily pass to one another, sparking a pandemic that could kill millions.

The emergence of symptomless human carriers of the virus would be a worrisome development because it could allow the virus, undetected and untreated, more time to mutate inside the human body, Jabbour said.

"If there is any sub clinical case in Egypt, the aim is to treat immediately to stop the reproduction of the virus. Because whether (through) mutation or reassortment, this will lead to the pandemic strain," he said.

Of the 11 Egyptians infected with bird flu this year, all but two have been children under age three while adult cases have all but dried up. All have survived.

That is starkly different from the same period a year ago, when seven people -- mostly adults and older children -- contracted the virus and three died.

'SOMETHING STRANGE HAPPENING'

Jabbour said the rise in infections in children without similar cases among adults had triggered questions as to whether adults were being infected with the virus but not falling ill.

"There is something strange happening in Egypt. Why in children now and not in adults?" he said. "We need to see if there are sub clinical cases in the community."

Jabbour said there had been no known instances of sub clinical bird flu cases in humans in other countries where the disease was present. Some birds, like ducks, are known to carry and spread the virus without showing symptoms, he said.

The Egyptian study, which Jabbour said should begin in the coming months, would test the blood of people who may have been in contact with infected birds but had not become sick.

Since 2003 the avian influenza virus has infected more than 400 people in 15 countries and killed 256 of them. It has killed or forced the culling of more than 300 million birds across Asia, the Middle East, Africa and Europe.

Some 23 Egyptians have died after contracting the virus, most after contact with infected domestic birds in the country where roughly 5 million households depend on domestically raised poultry as a major source of food and income.

But Jabbour said there was still no evidence of the disease being passed from person to person in Egypt.

He added that two toddlers from the northern province of Beheira infected within days of one another in March were cousins. But he said the boys were believed to have contracted the virus from the same sick birds, not from each other.

"There is no change in the virus at all in the virus strain in Egypt. It is the same since the beginning of the outbreak. There is no mutation, nothing," he said.

(Writing by Cynthia Johnston)
hat-tip Pixie

Stock Gone of AI Vaccine

At this time, the Magelang Regency, Central Java, in no way had vaccine supplies avian influenza (AI).

Apart from not yet getting help from the government of the centre and the Central Javan Provincial Government, the Magelang Regional Government could not also prepare the procurement of the AI vaccine because of the limitations of the APBD fund 2009. ”Dengan the stock emptiness of the vaccine at this time, the only method that could be carried out to prevent the spread of the bird flu virus being with biosecurity,” said Section Head Peternakan and fisheries Tri Agung Sucahyono, on Monday (6/4) in the Magelang Regency.

In 2008, the regency got help of the AI vaccine from the government of the centre totalling 400,000 doses. (EGI)

Pointed out as RS Rujukan Flu Burung

Rabu, 08 April 2009

The Bojonegoro Regional Government might be proud. Because, RSUD Dr R Sosodoro Djatikoesoemo Bojonegoro was indicated by the Health Minister (menkes) as the hospital (RS) bird flu reconciliation. That is, to serve the bird flu patient from the Bojonegoro territory, Lamongan and Tuban.

Public relations of RSUD drg Thomas Djaja said, beforehand the patient who was stated positive infected the bird flu illness must be sent to RS reconciliation. That is, beforehand only was in RSU Dr Soetomo Surabaya.

"From this year, the handling" of the "bird flu patient was enough to be carried out in Bojonegoro," explained he to this newspaper reporter yesterday (7/4).

According to Thomas, post penunjukkan that menkes also sent a set of medical equipment to handle the bird flu patient. In part, concentrate oxygen, the ventilator, X raay mobile, the monitor patient and APD (the protective equipment himself). Especially for APD, said he, only could be used to very much with.
-snip-

Tuesday, April 7, 2009

24 chickens in Cipatat was destroyed

OFFICIALLY Livestock Breeding and Bandung Regency fisheries West (KBB) yesterday destroyed (depopulation) around 24 chickens belonging to Isom Sopandi, 70, the resident of the Village of Andir RT 02/14, the Village of Cipataharja,Kecamatan Cipatat, KBB, that was infected by the bird flu virus.

The official was forced to dig up the cemetery 14 chickens that have been buried and killed the hen as well as his child that was numbering 10 tails that still to be alive. Official also destroyed two chicken coops belonging to Isom. The official of the Health of the Animal and the Health of the Veteriner Community of the Section (Kesmavet) the Livestock Breeding Service and fisheries KBB the smoke of Setiawan mengatakan,depopulasi selective or limited by being burnt this was carried out so that the virus that has descended on chickens and his pen did not spread. Since, worried this bird flu virus infected the community around especially that was directly neighbours with the Isom family. ”Depopulasi this was carried out to kill the virus that already penetrate to the animal including his pen. The total chicken that has been destroyed by us around 24 of ekor,”kata Asep in process gaps of depopulation yesterday. In the same opportunity, the Village Head Ciptaharja M. Iyas said, in his territory was gotten by the chicken population or the poultry in large quantities.

Therefore, his side worried if being not carried out by depopulation and disinfectant, this bird flu virus will spread and about the other poultry. He estimated the chicken belonging to the resident reached 25,000 tails. The number not yet including the chicken that was gotten in livestock breeding of PT Poskar that reached approximately 60,000 tails. Iyas admitted to contacting the poultry farm manager and ask for to carry out anticipation so that the bird flu virus does not spread to their animal of the property livestock. He also asked for the livestock breeding side mengarantina chickens including the normal official cleaned the chicken coop. Because, if they already infected, will be easy to spread him to the other animal or humankind. ”Karena the poultry population in this territory many, then must be carried out by the prevention immediately. This depopulation was the matter that must be done and sterilised the place of the incident because worried still had the livestock or the pen that already terkontaminasi,” said Iyas.

Isom personally admitted to not objecting the chicken togethered with his pen dimusnahkan. Hal that to prevent so that the illness that fell on his chicken does not spread to humankind. He claimed worried because of seeing the case that struck the resident in the neighbouring village that infected bird flu from his kept chicken. (superior haryanto)

Two Suspect Flu Burung Kabur from RSHS Bandung

[Toggletext and dictionary]
Tuesday, 07 April 2009
Two patients suspect bird flu that was treated in the Hasan Sadikin Hospital (RSHS) Bandung escaped. AM, 26, and Fai, 14 months, the patient from the Village/the Subdistrict of Cipatat,Kabupaten Bandung West (KBB), was known left special maintenance space of bird flu (the Poinciana Tree) last Monday (6/4) around struck 12,00 WIB. The escape of the two patients was acknowledged by the Managing Director RSHS Bandung Dr Cissy RS Prawira Kartasasmita. He said, both of them made use of the official's carelessness of the security unit and the nurse of Poinciana Tree space. ”Mereka not bolted, but went out without permission. He (AM) has come home had. At that time, the official and the nurse were having lunch, possibly he made use of torque tersebut,” said Cissy to the reporter in RSHS Bandung yesterday.

When bolting, AM patient brought his child, Fai. Although the two patients suspect this bird flu bolted, the RSHS side will not carry out the search. ”Because, the laboratory side has stated the negative to the two patients those,” he said. Now, when both of them positive bird flu, his side will at once drop the team off to look for them because of being worried infected the other resident. ”If the positive patient, we will bring returned to the hospital. Although in this manner, we coordinated Officially Health Department local to monitor them,” firm Cissy. According to him, if the patient wanted to come home had to have to to continue to say goodbye to the official. However, the security unit's member who was on duty at this room also did not know that the two patients escaped. Uptil now Poinciana Tree space was minded by one of the security unit's members, whereas the gate headed there was not locked.

The incident just the first time was experienced by RSHS. Karena, his side will tighten the security, including increasing the guard's personnel. ”We will increase the guarding but also important parts like the window or the door would restricted,”ujar him.

Nginap in the Parent-in-law's House

In the meantime, after bolting from RSHS Bandung, AM and Fai learned by now to be at house parent-in-law [a parent of a person’s spouse] in the Village of Cikokosan RT 01/06, the Village/the Cipatat Subdistrict, KBB, that be at a distance around 8 km to the north from casualties's house in the Halte Village of RT 1/19 the Village/the Subdistrict Cipatat. On arrival they were at once reported by the resident to the government side of the local village. Village apparatus then at once headed the location by bringing one ambulance. The village head Cipatat Darya Sugangga said, at this time his side was persuading AM in order to want to return to the hospital. Darya worried if being not treated in the hospital, the condition for the health of the two patients will be increasingly bad, especially his youngest child, Fai, that still was 14 months old. Nevertheless for the sake of pleasantness process “abducting” to return suspect bird flu above-mentioned will carried out day this around hour 10:00 WB.

Escaped whether second positive or negative contracted bird flu, both of them continued to have to undergo the maintenance in the hospital. He admitted to accepting escape information of his two residents from the doctor who treated them. ”We still tried to persuade casualties so that wanted to return. To him, we stressed, they were not yet it was said positive bird flu because at this time results of the inspection of the doctor's laboratory did not yet go out. For the sake of the security and the health service that good, he was asked to return to the hospital and that will be carried out tomorrow (today) ,” said Darya when being contacted SI through his cellular phone. Contacted was separated, the Sub-district Head Cipatat Eriska regretted the weakness of the security in RSHS that caused two patients to be able to slip away from observation and bolted easily. That was very dangerous moreover if being proven both of them positive infected the bird flu virus because of could spread quickly to the other resident.

“Hopefully guarding carelessness of the patient in RSHS this was not repeated in afterwards hari,” said Ersika. He suspected, the AM escape and F from RSHS because worried with the size of the maintenance cost during in the hospital that must be borne by his family. In fact, all the maintenance fees have been borne by the government. His side then issued the certificate of the poor family the area (gaki you) for casualties so as to be able to be freest from the medical treatment cost. As being reported, AM was reconciled the Cipatat Community Health Centre to RSHS Bandung last Friday (3/4) around struck 23,00 of WIB. Sementara his child, Fai, entered on Saturday (4/4) around struck 12,30 of WIB. Keduanya immediately was treated intensive in Poinciana Tree space. When arriving in RSHS, his condition in the hot situation was high enough to be accompanied by the cough. The RSHS side at once examined the two patients because of being worried by them indeed infected the virus H5N1 because beforehand they had contact with the poultry and had the poultry belonging to their neighbour who died suddenly.

Apart from AM and his child, four other residents who were the family and the AM neighbour also infected suspect bird flu. The four of them suffered was sick with the sign like hot, breathless, pilek, and the cough. The four people namely At, 65, that was the AM father; Wir, 2, and Wel, 2, both of them the AM twin; also the AM neighbour, Dik, 2. Beforehand, as many as 70 chickens died suddenly in the Halte RT Village 1 RW 19, the Cipatat Village, Kecamatan Cipatat, KBB, since Wednesday (1/4) to the end of last week. The chickens were based on results rapid test positive infected bird flu and infected six residents. At intervals of two days, around 11 chickens belonging to Isom Sopandi, 70, the resident of the Village of Andir RT 02/14 the Ciptaharja Village, the Cipatat Subdistrict, also died suddenly. Now, his eight property chickens that still were living, after being carried out rapid test, positive contracted bird flu. (yugi prasetyo/superior haryanto)

Serang bird flu the Child the Egyptian Resident

[This is from The Infection hospital Prof. Dr. Sulianti Saroso site, infeksi.com, out of Indonesia, regarding Egypt]

06/04/2009
A Egyptian male child who was six years old was attacked by the deadly bird flu virus, the sixth case in this month in the Arabian country have a population solidest, said the MENA News Agency. MENA identified the child as Ali Mahmoud Ali Somaa, that came from the province Nile Delta Qalyubia. Penjangkitannya increased the number of cases was confirmed the virus avian influenza H5N1 became 63 in Egypt, that was attacked more serious compared with the other country outside Asia. The spokesperson the Ministry of the Health Egyptian Abdel Rahman Shahine said, Somaa began to show signs of the illness of two last week and was treated in the hospital a week afterwards, where he was given medicine antivirus tamiflu, said MENA. Somaa was in the critical condition and breathed with help of the respirator, added the news agency.

On Friday, Egypt reported that a baby was 21 months old teserang bird flu. Since 2003, the virus H5N1 infected at least 410 people in 15 countries and killed 254 people from them. The virus killed or forced elimination more than 300 million poultries in 61 countries in Asia, the Middle East, Africa and Europe.

Approximately 23 Egyptian residents were killed resulting from terjangkit this virus, most after carrying out contact with the poultry piaraan that was attacked in the country, where around five million families begantung to the livestock animal as the important source of food and the income. Although H5N1 rarely infected the person, the experts revealed the concern that the virus would bermutasi became a form that was easy to be contagious from humankind to humankind, that possibly lighted the plague that could kill millions orang./kompas

Officials quarantine western Kentucky poultry farm after bird flu discovered

April 7, 2009
By Roger Alford

FRANKFORT, Ky. (AP) - State and federal authorities are investigating an outbreak of bird flu on a poultry farm in western Kentucky.

State Veterinarian Robert C. Stout said the strain discovered is "nonpathogenic or low-pathogenic" and poses a minimal risk to human health. Stout said it is not the "high pathogenic strain" associated with human and poultry deaths in other countries.

Stout quarantined the farm, which produces hatching eggs for Perdue Farms Inc. He said some 20,000 chickens have been euthanized.

"It does occur naturally in wild birds and it can spread to domestic birds, which is why we have the occurrence in Kentucky," said Cindy Ragin, a spokeswoman for the U.S. Department of Agriculture. "This is something that is not uncommon."

Stout declined to identify the farm, but he said it is near Brownsville in Edmondson County.

"The state and federal government and Perdue are acting aggressively to contain and eliminate the disease," Stout said. "There is no evidence that any infected poultry are in the human food supply as a result of this infection. We will do what is necessary to minimize the disruption to overseas trade."

Already, Stout said, Japan and Russia have banned imports of poultry from Kentucky.

The Kentucky Department of Agriculture is conducting surveillance on backyard flocks within a two-mile radius of the farm.

"The people of Kentucky and our trading partners should rest assured that we are doing everything possible to address the situation," Agriculture Commissioner Richie Farmer said.

Stout said a minimal drop in egg production at the farm was noticed in mid-March. Perdue's veterinary services laboratory took samples from chickens at the farm and found antibodies for avian influenza.

Testing by the National Veterinary Services Laboratory in Ames, Iowa, resulted in a presumptive positive finding for the H7 strain. Subsequent testing by NVSL and the Breathitt Veterinary Center in Hopkinsville confirmed the finding.

Stout said it was the first confirmed case of bird flu in Kentucky.

In 2007, two outbreaks occurred in turkey farms in Virginia and West Virginia. Some 25,000 turkeys had to be euthanized on each farm after the pathogenicity avian influenza was discovered.

Bird flu is a virus that affects domestic poultry and some wild birds. It is spread by direct contact with infected birds.

Needed RS [Hospital] Fast Preceptive during the Disaster

7/4/09

Rumah Sakit (RS) or health facilities and the health power in the middle of an emergency became the theme of the Health Se- Dunia Day warning on April 7 this year.

The organisation of the Health of the World (WHO) focussed on RS, to be precise RS that was safe in the middle of the disaster, as well as the preceptive health power the disaster.

According to Director General WHO Dr Margaret Chan, when RS or other health facilities collapse when the disaster happening, the life that depended on the maintenance in emergency could be lost. In the condition for the emergency, like the flood, the earthquake, several countries lost the RS capacity as far as 50 percent exact at the time of the service critically urgent really was needed. The RS security included construction endurance, planning, and the preceptive training of the emergency.

Moreover, said Margaret, RS readiness must be in the disaster situation begun from the simple early-warning system, protected equipment and equipment to prepare the staff helped casualties in the mass number and did not lose important was the control of the infection.
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Foundation/Base/Rational

Beside the natural disaster, the plague of infectious diseases also became the cause of the death. In 12 months till May 31 2008, 162 plagues of the infection happened, a third him happened in South Africa. Especially in overcoming the plague of the illness that the level of his spread was high, like bird flu (Avian influenza), was needed by RS that had facilities that were good for treated the patients, including protecting the health power from the spread.

An emergency did not only have an impact on humankind, also had a big impact on RS, the clinic, and other health facilities. Even, when destruction of the infrastructure of health facilities, precisely happening health facilities were most needed. For example when the tsunami in Aceh, happening 61 percent broken of health facilities. In Singapore, for example, there was RS that especially for infectious diseases, namely RS Tan Tock Seng, Di Jakarta, there was RSPI Sulianti Saroso. In Hong Kong, the local government built RS with modern technological facilities to anticipate infectious diseases, learned from the plague of the acute respiratory syndrome serious (severe acute respiratory syndrome/SARS).

Damage could also happen in the middle of the conflict. Why must health facilities stay safe in the situation kedaruratan? According to WHO, there were three reasons. Firstly, health facilities and the health power helped rescued the life and protected the health. Secondly, protected investment, because constructive repeated RS that was broken made the burden of economics bigger. Thirdly, maintained the social stability. RS was the protected place for the community while the conflict, and RS were neutral.