Wednesday, September 15, 2010
New superbug gene, NDM-1, confirmed in Japan
Excerpt:
According to the WHO, NDM-1 needs more monitoring and further study.
Additionally, the UN agency recommends that governments focus their efforts to four areas: surveillance, rational antibiotic use, legislation to stop sales of antibiotics without prescription and rigorous infection prevention measures.
Meanwhile, on Thursday (September 9), Taiwan declared that NDM-1 had been classified as a category-four communicable disease, Tamil News Network (TNN) said. A category four means that hospitals and clinics will have to immediately report any suspected cases.
TNN also reported on Friday that the World Health Organization had recently designated antimicrobial resistance to be the official global theme for World Health Day 2011 scheduled on April 7.
UPDATE: New Drug-Resistant Superbugs Found in 3 States
| Associated Press
The U.S. cases occurred this year in people from California, Massachusetts and Illinois, said Brandi Limbago, a lab chief at the Centers for Disease Control and Prevention. Three types of bacteria were involved, and three different mechanisms let the gene become part of them.
"We want physicians to look for it," especially in patients who have traveled recently to India or Pakistan, she said.
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The CDC advises any hospitals that find such cases to put the patient in medical isolation, check the patient's close contacts for possible infection, and look for more infections in the hospital.
Any case "should raise an alarm," Limbago said.
New Drug-Resistant 'Superbug' Reaches U.S. Shores
Excerpts:
In the United States, carbapenem-resistant bacteria -- designated carbapenem-resistant carbapenemase (KPC) -- are usually transmitted in health-care facilities such as hospitals and nursing homes, and are typically spread from patient to patient from contaminated surfaces and hands, he said.
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In the United States, three cases have been reported. They were in Massachusetts, Illinois and California, Kallen said. None of the U.S. patients died from their infections, he said.
While NDM-1 is new, carbapenem resistance has been increasing, Kallen said.
How dangerous NDM-1 will become isn't known, Kallen said. But some studies have found the death rate from KPC [the North American bacterium] to be as high as 40 percent, he said.
Most of the transmission of the NDM-1 (Indian) and the KPC (North American) bacteria happen as infected people travel around the world, Kallen added. "These people carry with them all their antibiotic-resistant bacteria and that mechanism [travel] has been recognized lots of times, including with NDM-1 and KPC," he said.
Docs: drug-resistant superbug is "time bomb" requiring global response
Published 15 September 2010
Researchers warn that the spread of a drug-resistant bacterial gene could herald the end of antibiotics; the bleak prediction follows his research into a drug-resistant bacterial gene called NDM-1, or New Delhi metallo-beta-lactamase 1, which was first identified in India; the bug was found attached to E.coli bacteria, but the enzyme can easily jump from one bacterium to another and experts fear it will start attaching itself to more dangerous diseases causing them to become resistant to antibiotics.
[click on title for full story]
FAO says H5N1 outbreaks are up this year
Sep 13, 2010 (CIDRAP News) – Reversing a trend that began in 2007, the number of countries affected by H5N1 avian influenza and the number of reported H5N1 outbreaks in birds have increased this year, the United Nations Food and Agriculture Organization (FAO) says.
Sixteen countries (plus Hong Kong) had H5N1 outbreaks this year through August, compared with about 11 in all of 2009, according to charts in the Sep 2 issue of FAO AIDE News, a bulletin that reports periodically on avian flu.
In the first 6 months of this year, 390 H5N1 outbreaks were reported, versus 297 for all of 2009, the FAO said. However, those numbers do not include Indonesia, which reports the majority of H5N1 poultry outbreaks worldwide, because Indonesia, unlike other countries, counts outbreaks at the village level rather than the household level, the report says.
The FAO cautioned that the number of outbreaks is more subjective than the number of affected countries, because it is strongly influenced by such variables as the case definition, awareness level, and effectiveness of surveillance.
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The FAO also reports that H5N1 outbreaks have occurred this year in several countries where the disease was thought to have been eliminated: Cambodia, Israel, Laos, Myanmar, Nepal, and Romania. The only country newly affected by the virus so far this year is Bhutan.
CytoGenix, Inc. Announces Positive Results from DNA Vaccine Study for Avian Flu
(BUSINESS WIRE) -- CytoGenix, Inc. (Pink sheets: CYGX-News) today announced publication of positive results of a study using CytoGenix's novel liner DNA technology.
CytoGenix reports positive results of an animal study where mice were immunized with CYDBA507, CytoGenix avian influenza vaccine candidate, protected against lethal challenge with avian influenza virus. CYDBA507 is CytoGenix's avian influenza vaccine candidate which built on CytoGenix's synDNA platform and expresses influenza virus type A/H5N1 HA and NA proteins. The ability of CYDBA507 to express HA and NA proteins in human cells was confirmed in laboratory studies.
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Reassortant between Human-Like H3N2 and Avian H5 Subtype Influenza A Viruses in Pigs: A Potential Public Health Risk
Abstract
Background
Human-like H3N2 influenza viruses have repeatedly been transmitted to domestic pigs in different regions of the world, but it is still uncertain whether any of these variants could become established in pig populations. The fact that different subtypes of influenza viruses have been detected in pigs makes them an ideal candidate for the genesis of a possible reassortant virus with both human and avian origins. However, the determination of whether pigs can act as a “mixing vessel” for a possible future pandemic virus is still pending an answer. This prompted us to gather the epidemiological information and investigate the genetic evolution of swine influenza viruses in Jilin, China.
Methods
Nasopharyngeal swabs were collected from pigs with respiratory illness in Jilin province, China from July 2007 to October 2008. All samples were screened for influenza A viruses. Three H3N2 swine influenza virus isolates were analyzed genetically and phylogenetically.
Results
Influenza surveillance of pigs in Jilin province, China revealed that H3N2 influenza viruses were regularly detected from domestic pigs during 2007 to 2008. Phylogenetic analysis revealed that two distinguishable groups of H3N2 influenza viruses were present in pigs: the wholly contemporary human-like H3N2 viruses (represented by the Moscow/10/99-like sublineage) and double-reassortant viruses containing genes from contemporary human H3N2 viruses and avian H5 viruses, both co-circulating in pig populations.
Conclusions
The present study reports for the first time the coexistence of wholly human-like H3N2 viruses and double-reassortant viruses that have emerged in pigs in Jilin, China. It provides updated information on the role of pigs in interspecies transmission and genetic reassortment of influenza viruses.
Tuesday, September 14, 2010
VLA: H1N1 Virus Predisposed to Streptococcus Suis
Monday, September 13, 2010
UK - Pandemic H1N1 (2009) influenza virus has been predisposed to porcine Streptococcus suis septicaemia, according to the Veterinary Laboratories Agency (VLA) in its report for June 2010.
Pandemic H1N1 2009 influenza virus infection was detected in one of three post weaned pigs submitted to Bury to investigate and outbreak of disease presenting with lameness, recumbency, nervous signs and some deaths. A fibrinopurulent polyarthritis was identified together with meningitis. Streptococcus suis type 2 was isolated from all three pigs. As there was patchy cranioventral consolidation in two of the pigs, testing for swine influenza was undertaken and one pig was found to be infected by PCR. This is similar to several recent outbreaks of swine influenza virus infection where streptococcal infections have been diagnosed concurrent with swine influenza virus infection.
Thirsk also diagnosed swine influenza having carried out an investigation into a transient cough noticed among gilts after their arrival from a breeding company. Gilts were vaccinated for enzootic pneumonia and PRRSv on arrival. Some gilts were also bled for paired serology. On PCR testing of the swabs for swine influenza, three of the six swabs proved positive for influenza A RNA. Virus isolation was attempted on two of the three positive swabs and an H1 influenza virus was isolated which was similar to A/SW/Eng/438207/94 (H1N2).
Monday, September 13, 2010
New drug-resistant superbugs found in 3 states
By MARILYNN MARCHIONE
AP Medical Writer
BOSTON (AP) - An infectious-disease nightmare is unfolding: A new gene that can turn many types of bacteria into superbugs resistant to nearly all antibiotics has sickened people in three states and is popping up all over the world, health officials reported Monday.
The U.S. cases and two others in Canada all involve people who had recently received medical care in India, where the problem is widespread. A British medical journal revealed the risk last month in an article describing dozens of cases in Britain in people who had gone to India for medical procedures.
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Thailand: WHO warns dengue fever is on the rise
Thailand needs to strengthen its measures to limit the outbreak of dengue fever, the World Health Organisation says.
The disease is continuing to spread across the country.
"High-end treatment can save patients' lives from dengue but cannot tackle the outbreak itself as long as the public health intervention essential for controlling the vector is still weak," WHO Southeast Asia regional director Samlee Pianbangchang said.
Epidemiologists are on high alert for a dengue outbreak this year as there have been 70,902 cases nationwide with 87 reported deaths, a 117.23% increase over the same period last year.
Dengue cases have been reported across the country. The hardest-hit provinces include Pattani, Songkhla, Krabi, Narathiwat, Phatthalung, Satun, Chanthaburi, Phitsanulok and Tak.
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Sunday, September 12, 2010
27 provinces have died of rabid dog bite
"September 11, Rabies office, said recently the number of people infected with rabies virus by being bitten by dogs and died on the increase, complicated and tends to spread to the provinces without rabies. "
The source said that rabies continues to be the top leader has the highest mortality rates of infectious disease outbreaks in Vietnam, with 27/63 provinces and cities have had patients die from this disease.
Bee.net given the statistics show that the province has the highest number of deaths due to rabies in recent times include: Phu Tho (92 cases), Tuyen Quang (78 cases), Yen Bai (44 cases) , Hanoi, Vietnam (33 cases), Gia Lai (36 cases).
Philippines - Cholera in pigs
13 Sep 2010
Authorities confirmed this week that cholera and Reproductive and Respiratory Syndrome (PRRS) caused infection among the pigs.
Lab tests carried out at the Philippine Animal Health Centre in Manila, revealed that cholera and PRRS was indeed present among the hogs.Godofredo Laed from the Provincial Veterinary Office (PVO) has said that there were reports from hog raisers of widespread cases of severe diarrhoea and still births among hogs since July this year.
To prevent an even further spread of viruses, the PVO sprayed disinfectants among infected pig pens and asked swine owners to increase body resistance of their pigs through vitamins and proper feedings.
No outbreak
Laed further added that the PVO cannot yet declare the situation an outbreak, “since we lack further ualifying requirements for such a declaration,” despite the pig deaths considered to be a high number, said a report by Manila Bulletin.
It is possible that the virus could have come from infected pig meats and live hogs brought into the town, Laed said.
Hog cholera causes excessive diarrhea, while PRRS leads to abortion, still births, mummified fetus and very weak piglets.
Dozens Dead Chicken, Bird Flu worries residents
12/09/2010 - 15:45
(Inilah.com) INILAH.COM, Pacitan - Suspected bird flu, dozens of chickens owned by residents Pacitan sudden death. Residents were alarmed.
"In five days the hens out of cages," said Mistam, one of the village residents Sukoharjo, Sunday (09/12/2010).
According Mistam, signs of the attack was in fact already seen before Lebaran yesterday. But it was not so careful. Consequently then, in a short time peliharaanya dead chickens.
"At first one. But in a row and then followed the others," he said.
The same is also expressed other residents, Sulastri. He said the attack was sudden and the disease is difficult to predict. Usually, during the afternoon and evening chicken still look healthy. But the next morning was found dead.
"As the night can be 3 to 5 birds that died," he said.
In the dead chickens were found similar signs of bird flu attack. Among wattles which change color to black. Similar signs are also found in the chest and the anus.
Actually, in addition to pets, especially big cock, already prepared for Lebaran. Because, according to tradition, when the great day of celebration, the citizens held a friendship that accompanied the culinary activity. Serves dishes like chicken soup or curry.
"Yes, how else. In fact it (chicken, red) for the preparation of Eid," said Sulastri.
Science Researchers For First Time Able To Design & Produce Cells That Don't Exist in Pre-Existing Biological matter
Friday, Sept. 10, 2010
By Rachel Oswald
Global Security Newswire
WASHINGTON --The newfound ability of scientists to produce disease materials from scratch has led to concerns that extremists might seek the same capabilities to carry out acts of bioterrorism (see GSN, Aug. 11).
Synthetic pathogens are man-made infectious agents that are produced either from the manufacture or adaptation of DNA, cells and other biological structures.
While scientists have been engineering genetic sequences for decades and commercial gene sequencing has been around for years, the field continues to move into uncharted territory. This year, researchers for the first time were able to design and produce cells that do not exist in nature without using pre-existing biological matter -- marking the latest evolution in the rapidly advancing field of synthetic biology.
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Saturday, September 11, 2010
Hundreds of Poultry in South Lampung Sudden Death
Kalianda, South Lampung (ANTARA News) - Hundreds of poultry owned by some residents in South Lampung regency, Lampung Province, died suddenly due to suspected bird flu virus attacks.
According to villagers Kertosari, District Tanjungsari, Tarmin, Saturday, the bird flu virus attacks occurred since the last few days.
The number of poultry that died suddenly reach hundreds of property several residents in the village, he said.
He said the hundreds of avian species infected chicken is starting in just a matter of days.
He explained that the characteristics of these dead birds infected with avian bird flu that is colored bluish comb, issued a clear liquid until thick of the oral cavity and bleeding feet flat on the avian form of red spots.
"Most sick birds would die overnight, without any exception," he said.
The residents themselves, he said, not knowing whether the attack was an attack of bird flu or not, because until now there has been no local Animal Husbandry Department who examined or do a quick test or a "rapid test" to the birds that belong to citizens.
Similar has been said by people in the same location of the attack, Handoyo.
He said the attack had already occurred penyakt poultry in recent days with poultry deaths in the tens of tails in one night.
She said the number of chicken carcasses are dumped in the river without mengatahui and considering the danger of transmission to humans.
Until today, he said, the local Animal Husbandry Department has not come down to do a quick test or a "rapid test" because it coincided with the Idul Fitri.
"We hope the Animal Husbandry Department menindakanjutinya immediately before transmitted to humans," he said.
Meanwhile, Chief of Animal Husbandry Department and Head of Animal Health of South Lampung district could not be contacted despite active cell phone in a condition to be confirmed avian attack this problem.
Congo fever kills two in Iran
TEHRAN, Sept. 11 (MAN) -- The Majlis Agricultural Committee says that two people have died in Iran as a result of sporadic cases of Crimean-Congo hemorrhagic fever (CCHF).
The importation of livestock to Iran to supplement the domestic production of meat has been the cause of the spread of the disease, MP Kazem Farahmand, the deputy chairman of the parliamentary committee, told the Mehr News Agency on Saturday.
CCHF is a viral disease and it has reached Yazd, Fars, and Sistan-Baluchestan provinces so far, he said.
The importation of livestock to the country is unavoidable, and thus it is imperative that the Veterinary Organization of Iran conduct a quarantine period on imported livestock on the borders in order to prevent the spread of various diseases, he stated.
However, Farahmand said that the pervasiveness of livestock smuggling into the country has made the control and quarantine process more difficult.
He said that a total of six people have been infected by the disease so far, and two of them have died.
This disease is transmitted through blood, and people who are in direct contact with infected meat are most susceptible to the virus, Farahmand added.
But the virus is killed if the infected meat is frozen or cooked, he noted.
CCHF is a widespread tick-borne viral disease that affects domestic and wild animals and may also be transmitted to humans.
Influenza updates
10 September 2010 -- On August 10 the WHO Director-General Dr Margaret Chan announced that the H1N1 influenza event has moved into the post-pandemic period. The influenza situation update will no longer be posted on the Disease Outbreak News website. The global influenza programme will continue to monitor the influenza activity worldwide on a weekly basis and every two weeks a WHO influenza update will be published on the link below.
10 September 2010 - Influenza activity is currently most intense in the temperate areas of the Southern Hemisphere and southern Asia.
India is still experiencing a country-wide outbreak of H1N1 (2009) with active transmission and a substantial number of fatal cases in several states across the country.
Chile reported on a sharp increase in respiratory disease activity in the last two weeks. All age groups are affected but the age groups below 65 years appear to be more affected that the older population. The level of activity in Chile in September is very unusual for this time of the year, as the country usually experiences a peak of respiratory disease in June and July. H1N1 (2009) virus has been the most commonly detected influenza virus so far this season but in the recent weeks there has been a shift towards influenza virus type B and influenza A (H3N2), with a decreasing proportion of H1N1 (2009) viruses. Respiratory Syncitial Virus transmission has also been widespread and intense, primarily affecting young children.
Australia has reported increasing influenza activity throughout August and September, though recently, the numbers of patients seen in emergency departments for influenza-like illness seem to have levelled off in parts of the country. Overall, influenza activity is well below the activity observed in the winter of 2009. The most commonly identified influenza virus in Australia is H1N1 (2009), though influenza type B is also being detected.
In New Zealand, influenza activity has decreased in the last week of August, although activity is still well above baseline levels and with significant regional differences. The majority of influenza detections have been characterized as H1N1 (2009). Levels of influenza transmission in 2010 are below 2009 levels nationally but have exceeded 2009 in some localized areas of the country.
In Africa, the Central African Republic reported on their first ever detection of H1N1 (2009). South Africa observed a decrease in detection rate of influenza viruses in outpatients seen for respiratory disease for the second week in a row. Influenza type B has been the most commonly detected influenza virus throughout this winter season in South Africa though in recent weeks the proportion of H1N1 (2009) viruses has increased and a small, decreasing number of influenza A (H3N2) continues to be detected. 0 September 2010
China authorities baffled by tick-borne disease
BEIJING (AFP) – Health authorities in China are scrambling to allay public fears about a tick-borne disease that has killed more than 30 people since 2007, but admitted they do not know how many have been infected.
The illness known as human granulocytic anaplasmosis (HGA) has spread to 12 provinces including Henan in central China and Shandong in the east, where the deaths have been reported, the China Daily reported Saturday.
HGA is treatable if detected early. Symptoms include fever, headache and muscle aches, but the infection can reduce a patient's white blood cell and platelet count, leading to organ failure and death.
So far we have no details on the general epidemic situation across the country,"..
A total of 182 cases have been identified in Shandong since May 2008..
It is still difficult to pinpoint the pathogen of the disease since it may be caused by a new virus," Wang Shiwen, an expert at the Chinese Centre for Disease Control and Prevention, was quoted as saying by Xinhua news agency.
Strengthening prevention blue ear pig disease
Phu Yen province has just written request DARD, districts, towns and cities enhance direct and implement coordinated measures against blue ear pig disease, not subjective, d. wary of complicated diseases.
Accordingly, DARD Veterinary direct agencies strengthen animal quarantine, and coordinate with related agencies to ensure your purchase pork products in the market, management, control closely at slaughter. The district, town and city to direct the communes in implementing monitoring the situation of blue ear pig disease each famer. Organization focus preventive vaccination blood infections, cholera, typhoid deal; spray pesticides, disinfect barns, cattle at slaughter, where trade in pork products. Provincial Police directing traffic police maintain forces on duty at stations, checkpoints animals temporarily.
Strengthening prevention and ear diseases nationwide
* Lao Cai publication all blue ear epidemic
* Dac Lac appear Foot and Mouth Disease
ND-On 11-9, Ministry of Agriculture and Rural Development has submitted written 2947/BNN-TY Chairman of the provinces and cities directly under the Central Government on "Enhancing prevention and ear nationwide green. "
Accordingly, the Chairman suggested the provinces and direct the implementation of some urgent follows: The province has announced service to service. Assignment of members of the Steering Committee, responsible for epidemic control in each locality, to actively monitor individual farmers to detect epidemics early to avoid the outbreak only know when people have reported. Guidance and publicity support definitely regime (719/QD-TTg Decision of the Prime Minister and Circular of the Ministry of Finance or 80/2008/TT-BTC support policies of each province) to the livestock. According to the Department of Animal Health, the country is still 29 provinces and cities have blue ear epidemic is not over 21 days.
In Binh Phuoc, the day 10-9, PRRS continues to arise more in 54 762 households in the pig herd infected children 1510, in which 219 children died and destroyed. So, from now on 28-7, PRRS had occurred in 70 communes of 10 districts: Mango Dong, Dong Phu, Chon Thanh, Hon Administration, Binh Long, Loc Ninh, Bu Dop, Bu Gia Map , and Bu Dang Phuoc Long. Total pigs infected herd is 14,344 children in 29,601 children, death and destruction of the 5209 children. In Tay Ninh, from 9-9, PRRS continues to arise more in 85 households in 42 communes in nine districts: Tan Bien, Chau Thanh, Go Dau Hoa Thanh, Tan Chau and Ben Cau, Duong Minh Chau, Trang Bang and Tay Ninh. Total number of pigs infected herd is 55,943 children in 73,192 children. In Khanh Hoa, from 23-8 to 8-9, PRRS continued to be detected in five communes of the new town of Cam Ranh, Dien Khanh district. At the same time, the Veterinary Department of Khanh Hoa province to continue the destruction of pig disease in 994 communes of 29 districts are seven services. Long An from 7 to 9-9, students continue to add blue ear pig disease in 134 households in 11 districts. Infected pigs was 1123 children, in which 406 children died and destroyed.
10-9 pm, Lao Cai province has officially announced the end of blue ear epidemic in the province. The blue ear checkpoints in the province will be lifted. However, before the blue ear epidemic risk recurrence or other diseases arising in cattle and poultry is very high, Lao Cai Province People's Committee asked departments, local authorities in the province continues to increase effective prevention of epidemics, to control sources of infection, and to promptly detect and deal with outbreaks, not to spread.
According to the Department of Animal Health, Foot and Mouth Disease (LMLM) occurred on buffalo, cow's households Ea pil commune, district and commune M'Drak Dar Ea, Ea Kar district (Dac). The total number of infected cattle is 68 children, including 55 cows and 13 buffaloes. Currently, the Animal Health Department along with the local authorities are conducting measures to prevention services as prescribed. Thus, the country has LMLM province of Dac Lac has not translated over 21 days.
Superbugs top focus of leading microbiology meet
| Superbugs top focus of leading microbiology meet |
| Updated on: 11 Sep 10 08:22 AM |
Serious public health risks due to a lack of new antibiotics at a time of rising antibiotic-resistant "superbugs" will be the main focus of a top microbiology conference in Boston that starts Sunday. "We are increasingly concerned about the decline in antibiotic discovery," warned Lindsay Grayson of Austin Hospital in Melbourne, Australia, who is program chair at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) at its 50th annual conference, running from September 12-14. For Grayson, the key reason for the marked decline in discoveries "is a changing of focus of drugs companies away from antibiotics," he told AFP, saying the lack of new drugs means people are seeing more "infections that are untreatable with antibiotics because we don't have new drugs to treat them." Drug resistance in bacteria, blamed on excessive and improper use of antibiotics, is not new, and health experts warn of an increasingly dangerous environment where the problem can flourish. |
The World Health Organization (WHO) last month issued a fresh warning over the metallo-lactamase-1 (NDM-1) gene that enables some micro-organisms to be highly resistant to almost all antibiotics.
The Lancet medical journal said bacteria containing the NDM-1 gene had been found in 37 Britons who had received medical treatment in South Asia in recent months...
Japan Approves Inavir (laninamivir) for Flu
Robert Roos * News Editor
Sep 10, 2010 (CIDRAP News) – Japan today approved a new long-acting influenza antiviral drug, Inavir (laninamivir), made by Daiichi Sankyo Co. Ltd., marking the second new flu drug licensed there this year.
In announcing the approval, Daiichi said one dose of laninamvir, which is inhaled, has been shown to be as effective as 5 days of treatment with oral oseltamivir (Tamiflu), the most widely used flu drug. Laninamivir is a neuraminidase inhibitor, like oseltamivir and zanamivir (Relenza), which have been in use for about 10 years.
Laninamivir is administered with an inhaling device, like zanamivir. Daiichi said it is effective against influenza A and B viruses.
In January Japan approved another new neuraminidase inhibitor, peramivir, which is given intravenously, a route that permits its use in critically ill patients who might not be able to take oseltamivir or zanamivir. Peramivir, known in Japan as Rapiacta, is sold there by Shionogi & Co. Ltd. under an agreement with BioCryst Pharmaceuticals of Birmingham, Ala.
Neither peramivir nor laninamivir has been approved in the United States. Peramivir, however, is being tested in two US phase 3 clinical studies, and it was given to a limited number of patients during the H1N1 pandemic after the Food and Drug Administration issued an emergency use authorization (EUA) in October 2009.
Laninamivir, formerly known as CS-8958, was developed by Daiichi Sankyo but is co-owned by Biota Holdings, based in Melbourne, Australia, according to company reports. A Dow Jones news report published today said the Japanese firm has not completed its overseas development plan for the drug.
The results of a laninamivir trial in children under the age of 10 were published in Antimicrobial Agents and Chemotherapy in April. About 180 children who had flu symptoms for 36 hours or less were randomly assigned to receive either oseltamivir or one 20-mg or 40-mg dose of laninamivir.
For patients who had influenza A/H3N2 or influenza B, there were no significant differences in recovery time between the laninamivir and oseltamivir groups, according to the report. But laninamivir shortened the recovery time by more than 2 days for patients who had oseltamivir-resistant H1N1 infections (seasonal H1N1 viruses were widely resistant to oseltamivir in the 2008-09 flu season).
In August 2009, Biota reported that laninamivir compared well with oseltamivir in a phase 3 trial in adults. The trial, conduced by Daiichi in Japan, Korea, Taiwan, and Hong Kong, showed that a single dose of the new antiviral was as effective as oseltamivir given twice a day for 5 days, the company said.
The use of antivirals, especially oseltamivir, to treat seasonal flu patients has been described as much more common in Japan than in the United States and most other countries. In recent years there have been some reports, mainly from Japan, about confusion and self-injury in adolescents being treated with neuraminidase inhibitors.
The reports led the FDA's Pediatric Advisory Committee in 2007 to recommend stronger label warnings for oseltamivir and zanamivir, though the panel said it was unclear if the two drugs played any role in the reported adverse events.
Friday, September 10, 2010
Anthrax
A total of 447 people in eight districts across the country have been infected with anthrax in the last three weeks, confirmed Institute of Epidemiology, Disease Control and Research (IEDCR) yesterday.
"Since the disease symptoms are prominent, we are not continuing lab tests. However, we will run tests if a new area is affected," said IEDCR virologist ASM Alamgir.
He said treatment has been made available in all the affected districts and more than half the infected people have already been cured.
This year, Sirajganj district has witnessed the most number of infected, 207, which is likely to be overtaken as the medical team at Lalmonirhat claimed to have found 320 suspected patients at Kisamot Harati village.
Our Lalmonirhat correspondent reports: nine more people have been confirmed to be contracted anthrax at Kisamot Harati yesterday. The total number of infected in the district now stands at 85.
Anthrax infected Motiar Rahman said, "Four sick cows were slaughtered in the village a few days ago and at least 400 villagers consumed the meat as it sold at a lower price, Tk 100 a kg."
Meanwhile, Veterinary Field Assistant Saidur Rahman said four anthrax-infected cows died at Char Kulaghat and Baro Basuriya in Lalmonirhat sadar yesterday.
District livestock officer Abu Hossain Sarkar said officials are vaccinating the infected and suspected-to-be-infected cows in the district. But the office is suffering acute vaccine crisis.
He said there are at least 3.5 lakh cows in the district but the government has sent only 2,700 vaccines.
Meanwhile, two cows yesterday died of anthrax at Tampat village under Rangpur sadar upazila creating panic among the cattle farmers of the area.
Our Thakurgaon correspondent adds: one suspected anthrax infected patient had been admitted to Thakurgaon Sadar hospital yesterday.
Unchecked red meat slips through
Jurisdictional mess, inspector shortage jeopardise govt's anti-anthrax fight
Thursday, September 9, 2010
Front Page
Although the government directed livestock department officials to remain on highest alert to prevent spread of anthrax, the efforts seem to be dogged down by a lack of proper coordination among different relevant agencies, and an acute shortage of veterinary inspectors.
According to doctors, anthrax is caused by a spore forming bacterium called Bacillus anthracis. It commonly infects plant-eating mammals which ingest or inhale the spores while grazing. Humans can become infected with gastrointestinal anthrax by eating undercooked meat from infected animals.
Inspection of cattle prior to slaughter is an important way of preventing spread of the disease among humans. But most of the red meat available on the country's markets come from cattle slaughtered at kitchen markets without inspection.
The entire process of authorising slaughter of animals for consumption lies with either city corporations or municipalities --- not with the livestock department, said officials of the Department of Livestock Services (DLS).
"We are not authorised to inspect cattle for slaughter," said an official of the department on condition of anonymity.
"Officially every municipality or city corporation must assign a veterinary inspector and a sanitary inspector for certifying each cattle before slaughter," he added.
"We are solely responsible for treatment of animals brought to veterinary hospitals, and to create mass awareness about animal diseases including the ones that can be transmitted to humans," said Dr Saiful Islam, district livestock officer in Sirajganj. "We don't monitor slaughterhouses," he added.
And officials of city corporations and municipalities are saying they are not adequately staffed and equipped to inspect all cattle before slaughter.
Veterinary Officer of Dhaka City Corporation (DCC) Dr Azmat Ali told The Daily Star on Monday,
"We have only two veterinary inspectors for five DCC-run slaughterhouses." Moreover, the equipment there are antiquated, he added.
He said more than 700 cows, 250 buffaloes, and 5,000 goats are slaughtered everyday in the city for consumption. Thirty percent of those are slaughtered in DCC-run slaughterhouses while the remaining 70 percent are slaughtered mostly at butcher shops of kitchen markets.
Most of the cattle in DCC slaughterhouses cannot be checked, Azmat said. And what happens in other places is anyone's guess.
Secretary of Pabna Municipality Saidur Rahman said it is not possible for them to check all cattle to be slaughtered across the district, due to inadequate manpower, and a lack of cooperation from cattle traders and butchers.
Although the district administration -- after a meeting with officials of the district health department, district livestock department and the municipality on Monday -- asked all butchers not to slaughter cattle without approval from government appointed veterinarians, the authorities actually do not have enough inspectors to appoint, he said.
Moreover, the government appointed inspectors can only check for visible symptoms of diseases, no diagnostic test is possible due to lack of proper equipment and inadequate manpower, he added.
Sirajganj District Livestock Officer Dr Shafiqul Islam said they in collaboration with the district administration selected a slaughterhouse in the district headquarters where cattle are examined before slaughter. But in other places cattle are slaughtered without inspection.
Kushtia Municipality Mayor Anwar Ali said he appointed a veterinarian to inspect cattle before slaughter. But the veterinarian cannot check all such cattle in the district. He can only check the ones that are to be slaughtered at a certain place and time.
"Although we have been requesting the authorities over a long period to increase manpower, to make the slaughterhouses bigger, and to procure modern equipment, they do not pay heed to us," said Azmat of DCC.
The government however is hoping to start construction of six modern slaughterhouses in the six city corporations by the end of this year with financial assistance from the Asian Development Bank, said Shawpan Kumar Shil, a research assistant at the bank.
DCC will also get a modern slaughterhouse at Gabtoli with the capacity of slaughtering 5,000 cattle a day, he added.
A joint secretary of the Ministry of Fisheries and Livestock said on condition of anonymity, "We have drafted a new act for cattle slaughtering, to end the confusion about jurisdiction. The drafted act is waiting in the cabinet for final approval. If it is passed, the whole responsibility of certifying cattle for slaughter will be on livestock officials."
To address the current crisis, all livestock officers were directed to work in collaboration with city corporations and municipalities, the joint secretary added.
When asked how the collaboration will work, he said, "If municipality or city corporation slaughterhouse authorities request for veterinarians from the livestock department, they will send them there."
He also said so far there has been no report of anthrax transmission to humans from any slaughterhouse, humans have so far been infected mostly through direct contact with infected animals in rural areas.
Meanwhile, every day cattle are imported through 24 points of the border, and DLS has no jurisdiction to inspect those animals. But within the next six months, however, cattle and fodder inspection centres of DLS will be set up at 22 of those points, said Director General of DLS Ashraf Ali.
"Bangladesh Rifles now inspect the cattle that are imported through the border," he added.
When asked if any DLS official is assigned to help the border guards in the task, he answered, "No," adding that BDR checks the animals but cannot perform any pathological test, since no veterinarian is posted with the guards.
Around 7,000 cattle including cows, buffaloes, and goats arrive in the capital's largest cattle market at Gabtoli every day, but so far only one veterinary inspector have been assigned to inspect the animals.
Asked whether the number of inspectors at the cattle market is inadequate, the DLS DG said, "The inspector only checks the temperature of the animals, he does not perform any pathological test."
When asked whether even for that the number is inadequate, he said, "He has two assistants as well."
Dr Azmat of DCC said, "If all the cattle arriving at Gabtoli from different parts of the country and India are not checked, the chance of anthrax spreading in the city will remain high."
But the livestock and fisheries joint secretary said the chance of anthrax being transported to Dhaka with imported animals is very little, since infected cattle die within a day or two of the infection, so if an infected cattle is imported from India it will most probably die before reaching Dhaka.
ANTHRAX INFECTION
Twenty-two more cases of anthrax infection were detected in Lalmonirhat, Tangail and Rangpur on Wednesday, taking to 435 the total number of such cases in seven districts after it was first detected in Siraganj on August 19.
Nine cases were detected in Lalmonirhat, 10 in Tangail and 3 in Rangpur on Wednesday.
Other districts from where the infection has been reported are Pabna, Tangail, Kushita and Meherpur.
The New Age correspondent in Lalmonirhat said nine more anthrax cases were detected at Kisamat Harati in the district
headquarters on Wednesday.
A medical team gave treatment to the anthrax-infected people in the village for the second day on Wednesday. The total number of anthrax infection cases in the district reached 85 till Wednesday afternoon.
A member on the medical team Ahsan Ali Babu, Lalmonirhat upazila health and family planning officer, said the team had enlisted the names of 320 people suspected of having been infected with anthrax at the place.
‘All the 320 men and women dressed and ate the meat of four anthrax-infected cows slaughtered in the village on August 20 and 28,’ he said.
Motiyar Rahman, infected with anthrax, said the villagers of Kisamot Harati village slaughtered four cows, which fell ill a few days ago after they had bought them for lower prices from neighbours.
‘There are at least four hundred people of a hundred families in this village and all ate the beef,’ said Majedul Islam, another villager who has been infected with anthrax.
‘Our medical team has been treating the anthrax-infected people since Tuesday. The team is still working in the area,’ the Lalmonirhat civil surgeon, Jahangir Alam, said.
The Lalmonirhat district livestock officer, Abu Hossain Sarker, said livestock officials were treating the cattle infected or suspected to have been infected with anthrax but the livestock office was facing a shortage of vaccines.
There are at least 3,58,650 cows in the district but the government has sent only 2,700 vaccines, he said.
The correspondent in Tangail said 10 cases of anthrax were detected at Dakkhin Bildanga of Gopalpur in the district on Wednesday.
The upazila livestock officer, Monoranjan Dhar, said people who came in contact with the blood and meat of an infected cow brought from Gobindasi on September 1 had been infected.
The civil surgeon, Abdul Basit, said cases had so far been detected.
The correspondent in Rangpur said three more cases of anthrax infection had been detected in the district.
The district livestock department said two of the three cows suspected to have been infected with anthrax at Hawai Kattari died on Tuesday.
Livestock officials visited the village on Wednesday and ensured treatment of the cows which fell ill.
The district livestock officer, Nasir Khan, said they were not certain whether the cows died of anthrax as they were buried a day before.
‘We have made all the preparations for anthrax infection treatment. We have a huge quantity of vaccines at our disposal,’ he said.
Deaths have increased Streptococcus
Number of deaths and patients infected with swine Streptococcus recent increase "dizziness." The reason for slaughter or eat sick pigs, not hygiene.
Enter Doctor Vu Minh, Faculty of active treatment, Tropical Central Hospital, said early this year there were nearly 20 concerned patients hospitalized for an emergency situation, in danger of meningitis , severe sepsis, blood pressure dropped, the money shock, coma, limb gangrene smells ...
Many deaths
According to statistics from the Hue Central Hospital, in August alone in 12 cases broke swine streptococcus infections admitted to hospital (both in 2009 while only less than 10 recorded cases). Especially, there were 10 deaths out of 34 cases hospitalized since early April to present.
Tropical Disease Hospital in Central, is also infected five patients being treated swine streptococcus. All patients were male and hospitalization in a critical condition.
Patients T. still comatose a week after treatment. Photo Wall Spirit.
Van T. Dinh patients, 28 (Duy Tien, Tam Duong, Vinh Phuc) hospitalization was 7 days is still in deep coma, limb swelling, necrosis. The patient who said, patients do not eat blood pudding is eating pork but by the self-slaughter. After eating, he T. abdominal pain, diarrhea, high fever, imported tropical disease hospital in central deep coma, rapid pulse, blood pressure of 0, breathing squeeze ball, hepatomegaly, skin much the bleeding, gangrene. Dialysis patients were constantly in danger but still plays.
Dinh Van K. Patients (Ly Nhan, Ha Nam) by eating infected swine streptococcus swine hearts on buying from the market. There have been over a month despite treatment with three dialysis filter results, but still breathing machine, vaguely spiritual, full body peeling by deep black necrotic spots ...
Dr. Fill, most patients are required mechanical ventilation and continuous hemodialysis with filtration results (can not be filtered as usual) by septicemia, severe shock, multiple organs failure ... Medical expenses for treatment up to a hundred million, but many patients still do not pull through. In particular, patients infected with Streptococcus meningitis may, after leaving the hospital still heavy sequelae.
Detection and early treatment
Intermediate Nguyen MSc, Faculty of active treatment, Hospital for Tropical Diseases Central Committee, said the streptococcus bacteria that normally reside year-round situation in some pigs throat without causing disease. But when the blue ear pig virus, the immune health decline that streptococcus bacteria thrive, causing pneumonia, blood infections for pigs. When the pigs slaughtered this disease, or to destroy incorrectly, or when the meat before cooking, because not many people even know swine should still eat more fresh produce such as farming, pig heart , nem paste ..., then the body will absorb a large amount of streptococcus bacteria that live pigs. Especially on the background of patients such as diabetes, liver failure, alcoholism ... then the more likely situation Streptococcus disease.
MSc level warning, danger from exposure, disease eating pork, time-onset disease is very fast. Moreover, even had pigs infected with streptococcus bacteria, patients can still get completely back later. Because the disease is the same as normal streptococcus infections, leaving no lasting immunity to the body.
Thus, the MSc level, after eating pork, if symptoms appear such as abdominal pain, nausea, go liquid, high fever ... must be taken to emergency patients. By this stage of disease risk, greatly affecting their lives without intervention.
It is worth saying, the expression of disease susceptible Streptococcus mistakenly diagnosed with other diseases such as septicemia, hemorrhagic fever, meningitis latex ....
Health experts warned people not to be feared that a boycott pork disease which affects the economic and health. Because pork is very good food. Things to do is not purchase, slaughter pig disease. Pathogenic viruses are easily destroyed at high temperatures, use of processed meat
Vietnam: The girl nearly died from diabetes have no symptoms
Coma when admitted to hospital but no symptoms to physicians diagnose, so on The weaker baby in a coma. Until the implementation of intensive testing, new patients were identified with diabetes.
The family said, two days before admission, she Method (4 years) with signs of fever, cough, runny nose, wheezing, vomiting several times and then suddenly Bruce weaker.
Science City in general a Children's Hospital, she was a monitoring and treatment based on symptoms described by family. But her health condition is getting more critical.
Before patients comatose state, rapid breathing, pale, with signs of dehydration, sunken eyes dry lips, dry skin, doctors conducted tests emergency. Results showed that her blood sugar 3 times higher than normal (expression of diabetes). This is also the cause of coma.
Immediately after the conclusion illness, she was treated by passing through intravenous insulin adjustment effects blood sugar, rehydration and respiratory assistance. Results after more than a week of treatment, the baby was awake method.
Doctor Nguyen Minh Tien, vice-Emergency Department Children's Hospital, said diabetes in children eat expression through multiple, small lot, weight loss, are far less common. Instead, children have respiratory symptoms, digestive easily confused with other pathologies.
"Diabetes in children but rare complications such as coma, acidosis ceton cases can progress on serious, even fatal if not detected early and treated promptly," Mr Tien said.
The children had signs of diabetic acidosis ceton ambiguous with gastrointestinal diseases were nausea, stop eating, abdominal pain, shortness of breath, enough lu, struggle. When you see these symptoms, parents need to quickly bring the child to hospital emergency promptly.
Wednesday, September 8, 2010
Beijing to keep eye on superbug
The country's capital will strengthen its ongoing surveillance of antibiotic resistant bacteria by establishing a network to monitor all local major medical institutions by the end of the year.
The announcement by the Beijing Municipal Health Bureau came in response to a new superbug, which first surfaced in South Asia. It is resistant to almost all antibiotics and is spreading globally.
"The new bacterium carrying the New Delhi metallo-lactamase-1 (NDM-1) gene has not been detected on the mainland so far, but it has a high probability of surfacing here due to increased international exchange," said Lu Yuan, deputy director of the institute of clinical pharmacology at Peking University.
After initially emerging in India and Pakistan, the drug-resistant bacteria has been reported in countries like Britain, Australia, Canada, the Netherlands, the United States, Sweden, and Japan, according to the World Health Organization (WHO).
International trips were largely responsible for the new bug spreading, since most patients in these countries had traveled to India or Pakistan, experts said.
"Given its geographic proximity to the two countries, China is also at risk of the new superbug," Lu said.
The overuse of existing antibiotics and poor sanitation in most hospitals where the superbug has been reported put China at great risk of a potential outbreak, she warned.
Approximately 5 million people on the mainland annually contract a variety of infections during hospitalization, accounting for 10 percent of the country's inpatients each year, official statistics show.
The Ministry of Health has acted quickly to draw up measures to prevent the new bug from appearing and spreading in China, including increased monitoring of antibiotic use and the promotion of good hygiene practices, such as hand washing and environmental sanitation, Lu noted.
While drug-resistant bacteria, which has been blamed on the excessive and improper use of antibiotics, is not a new phenomenon, the WHO has called on health authorities across the globe to be vigilant because bacteria containing the NDM-1 gene are much more drug resistant.
The overuse and abuse of antibiotics is prevalent in China, said Zhao Minggang, deputy director of the medical administration department of the health ministry.
"That leads to extra medical expenditure of 80 billion yuan ($11.7 billion) nationwide and many patients take antibiotics as a panacea," he said.
Last month, the Ministry of Health ordered surveillance posts to be established at key hospitals in each province to keep watch over the situation.
Panic as anthrax spreads
Egypt: Approval for Production of Vaccine for Avian Influenza
September 7, 2010
Approved by Engineer Amin Abaza, Minister of Agriculture and Land Reclamation to launch an international tender by the Ministry so as to produce a vaccine to fight bird flu strains local isolated and selected according to the latest changes in the virus, according to the conditions and specifications, laboratory and field established by the concerned ministry and a guarantee to increase the efficiency of vaccines in disease control and eradication it.
وصرح الدكتور سعد نصار مستشار الوزير بأن ذلك جاء بناء علي توصية اللجنة الفنية لمكافحة انفلونزا الطيور بوزارة الزراعة واستصلاح الأراضي بجلستها مؤخرا برئاسة الدكتور فتحي سعد أستاذ أمراض الدواجن ومحافظ 6 أكتوبر.
Dr. Saad Nassar, Advisor to the Minister that this was based on the recommendation of the Technical Committee to combat bird flu, the Ministry of Agriculture and Land Reclamation Listing recently, headed by Dr. Fathi Saad, professor of poultry diseases and the Governor October 6.
وأضاف الدكتور نصار أن اللجنة قد أوصت أيضا بسرعة اتخاذ الاجراءات اللازمة من الجهات المعنية لإنشاء خط لانتاج اللقاح محلياً .
Dr. Al-Nassar, the Committee had also recommended quickly take the necessary action from the concerned authorities to create a line to produce vaccine locally. وكان الدكتور أحمد نظيف رئيس الوزراء قد سبق أن أشار إلي توفير 40 مليون جنيه من وزارة المالية لوزارة الزراعية واستصلاح الأراضي للبدء في انشاء خط لانتاج لقاح لمكافحة انفلونزا الطيور محليا من العترات المحلية المعزولة والمختارة وذلك ضمانا لزيادة كفاءة اللقاحات في مكافحة المرض والقضاء عليه.
Dr. Ahmed Nazif, the Prime Minister had already pointed out the provision of 40 million pounds from the Ministry of Finance to the Ministry of Agriculture and Land Reclamation to start construction of a pipeline to produce a vaccine to fight bird flu locally strains the local isolated and selected in order to ensure more efficient vaccines for disease control and eradication.
Search EGYPTIAN of the Avian Flu locked drawers 7 months ago
Hit by the crisis and the epidemic of avian influenza poultry industry, the Egyptian killed, after the disease is endemic in the nests, could not the Government's efforts to control him, Egypt is becoming to one of the most dangerous spots in the disease around the world, reached the price of chicks to 7 pounds a kilo of poultry to 20 pounds, after the death of a large number of mothers and the small number of the supply of broiler chicks.
A team of Egyptian researchers at the National Research Centre and the Centre for serum and vaccine, and College of Pharmacy, to draw the vaccine to increase the immune chicks against Newcastle disease and avian flu, despite the departure of research to light since 7 months and published in scientific journals and the World, not accompanied by conditions of the Egyptian crisis in the face of rising prices for Government to take a look at research as those responsible for it confirms to their fate recent intra-stairs.
Explains Dr. Ahmed Hamed J'areh - one of the members of the team - and the researcher, Department of chemistry of natural compounds at the National Center for Research - the new vaccine, saying: "find the research project to extract pollen from the plant jatropha because it contains materials Alflavonidip which helps to activate the compounds the immune chicks, applied research at 360 chicks a house fortified in Fayoum through the nursery to make sure they are free from diseases, and managed search results in raising the immune chicks against Newcastle disease more dangerous than bird flu poultry, because it leads to death of large numbers in a short time, the more ferocity in the large farms, with the increasing immunity of chicks can resist various other diseases such as avian influenza ".
He says "growing jatropha plant in the tropics, and can cope with the sandy areas, but costly economically, is growing at any type of salt water or sanitation."
-snip-
Tuesday, September 7, 2010
Mongolia-Two Provinces Quarantined Over Foot-and-Mouth Disease Outbreak
Tuesday, September 07, 2010.
Authorities of Sukhbaatar and Dornod provinces have quarantined cattle movement and restricted the sale of meat and milk in their territories following an outbreak of foot and mouth disease.
According to the emergency commission, over 968 heads of cattle had been infected but death had not been reported yet. The number of infection is likely to grow further.
The problem was detected on August 29 in a farm in Chuluunkhoroot Soum, Dornod Province when a local veterinarian examined three cows showing symptoms of the foot and mouth disease. The central vegetarian laboratory has confirmed that the three cows are infected with the disease.
There are 15251 heads of cattle from 23 herding families in four epicenters in the two provinces, 968 heads of them are infected so far since the outbreak.
In connection with the high probability of spread, the State Emergency Commission held an emergency meeting and ordered relevant bodies and officials to take prompt actions against the spread. In particular, it is ordered to carry immediate disinfection and liquidations in epicenters and in major autoroad posts, co-work with force agencies to enforce the quarantine regime efficiently, limit some traffic in and out and appoint a field emergency staff in epicenters. Besides, the SEC has decided to immediately conduct preliminary tests and vaccination for all cattle’s in Dornogobi, Dundgobi, Umnugobi, Gobisumber and Tuv provinces as well in Ulaanbaatar City.
It is also decided to submit a draft resolution on the allocation of MNT50 million for fight against the disease in Sukhbaatar and Dornod provinces respectively and another MNT10 million for preventive measures, to Cabinet meeting.