Friday, April 10, 2009

Rosselkhoznadzor does not exclude the possibility of bird flu in Russia

10.04.2009 14:13

MOSCOW, April 10. / PRIME-TASS /. Rosselkhoznadzor does not exclude the possibility of bird flu in Russia. The statement was made today at a press conference, Deputy Head of Россельхознадзора Nikolai Vlasov.

He acknowledged, ITAR-TASS that "the possible drifts of avian influenza on the territory of the Russian Federation." Among the regions that may be subject to such dangers, N. Vlasov called Altai Territory, particularly the western part, Novosibirsk Region, south of Tyumen. Also, avian flu may appear at the poultry farms and households, the central part of Russia. "Beginning in November may be the problem in Dagestan, Rostov region," - added N. Vlasov.

Recognizing the danger of bird flu, Nikolai Vlasov, however, assured: "It's not expected, because people on the ground ready." Deputy Россельхознадзора sure of high qualifications and ability to act on the situation of specialists related to the control of poultry, veterinarians in the field.

The most common cases of bird flu found in South-East Asia, equatorial Africa, Indonesia. The infection is dangerous because it can become infected individuals. In this case, registered a high mortality rate - up to 50 percent. Now observed in different countries and 500 human cases of avian flu, almost half of them died.

Concern of the mutation of avian influenza in Egypt to a pandemic strain in humans


Last Updated: Friday, April 10, 2009 11:28 GMT Cairo

The Council of Ministers held an emergency meeting yesterday chaired by Dr.. Ahmed Nazif to discuss the rising incidence of disease, bird flu, amid fears it could mutate to a lethal strain passed from human to human.

Did not attend the meeting, a representative of the union of poultry producers, as the majority of casualties were among the last birds in the jam of houses and farms, which is not in a total of 17 people in the republic.

The World Health Organization warned of the increased risk of some Egyptians highly pathogenic virus without showing any symptoms of infection, which may enable the virus to mutate into a strain that can spread easily among humans. And after the growing incidence of the disease in Egypt, where the Ministry of Health recorded 12 cases including 11 cases of children under the age of 9 of them, which is the highest in the world 2009.

"John Gabor specialist emerging diseases and health organization based in Cairo: that« there is a need to conduct tests to prove the existence of such cases infected with bird flu symptoms without the emergence of the patient ». He pointed out that «the study will be the focus of the Egyptian government intends to hold the support of the organization».

Gabor said that the proliferation of such cases in Egypt, which has a total of 63 cases in which the case since 2006 «a matter of concern just now .. It is a question to be put (..) and added: The change in the pattern of avian influenza infection in humans in Egypt this year, raised concerns about the presence of the virus without showing symptoms ». According to Reuters.

He warned that «the presence of carriers of the virus show no symptoms would be a worrying development, because it may allow the virus more time to mutate into the human body .. If there were cases of this kind in Egypt, the aim is to treat immediately to stop the proliferation of the virus. Because it either through mutation or restructuring will lead to a pandemic strain. »

Of 12 Egyptians infected with bird flu this year were nine cases of children under three and I said, the incidence among adults a lot. All cases and corresponded to heal. The case differs significantly from the same period last year, as seven people were wounded, most adults and older children with HIV and three died.

Gabor said that the increase in cases among children under the emergence of similar injuries among adults raised questions about whether adults carrying the virus without showing any symptoms of the disease. He continued that «there was something strange is happening in Egypt. Why is the child now does not appear to adults? We need to know whether there are situations that do not show symptoms. »
He pointed out that «there are no known cases of this type of injury among people in other countries hit by the disease but does not yet exist».

For his part, said Dr. Abdel Rahman Shahin, spokesman of the Ministry of Health: The Ministry follows strict procedures to prevent mutation of the disease can be transmitted among humans, and that the Ministry of Health has been conducting regular research with an international high in America and Britain. He added that the death rates in cases in Egypt of the lowest world, which reflects the high degree of health care to them.

Thursday, April 9, 2009

Flying in the face of challenge

According to a World Health Organisation report, Egypt is on the front line in the battle against avian flu. Reem Leila examines the threat

Two-year-old Israa Saad Abdel-Shafi is the 60th case of the H5N1 strain of avian flu virus recorded in Egypt since the first outbreak of the disease in 2006 and the ninth victim since the start of the year. Twenty-three out of the 60 have died, the majority young girls or women from rural areas who raise fowl domestically.

In early March the World Health Organisation (WHO) called for an investigation into why Egypt is seeing increasing numbers of victims. The WHO has identified the country as being at the forefront of the spread of the disease though Abdel-Rahman Shahin, official spokesman to the Ministry of Health, points out that despite the high number of victims the percentage of fatalities from bird flu in Egypt is still less than in other countries that have seen outbreaks of the disease.

Egypt has reported nine cases since the beginning of the year, with zero fatalities. There were eight cases with four fatalities in 2008. Vietnam has reported two fatalities, and China seven victims with four fatalities. Shahin argues the figures indicate the disease is being controlled in Egypt.

"This year we do not have any fatalities whereas last year it was 50 per cent. The fatality rate in China this year is more than 50 per cent, and in Vietnam it is 100 per cent. The situation in Egypt is improving, not deteriorating."

Bird flu presents a massive challenge to the government given the uncertainty about the course of any possible pandemic. The virus has become endemic and it could take years to rid the country of the most virulent strain. The government, says Shahin, has prepared a detailed national plan to be implemented in case of a pandemic according to which half of Egypt's 150,000 hospitals beds will be reserved for avian flu patients.

Hamid Samaha, head of the General Authority for Veterinary Services, says the government is focussing on comprehensive public health efforts -- monitoring outbreaks in order to identify any change in the virus, increasing anti-viral stockpiles and building a more robust capacity for vaccine production.

Settlement patterns in Egypt, where 95 per cent of the population is concentrated on five per cent of the land, has serious implications for any pandemic outbreak. The virus has been found at nearly 300 sites and is now "rooted in the Egyptian environment" says Shahin, who now believes that following the first incidents of avian flu Egypt should have culled all poultry and taken draconian measures to stamp out the continued domestic rearing of birds.

"The whole country must resort to consuming frozen chicken instead of purchasing fresh birds. We cannot afford to implement such a scheme at the moment, but the least we must do is ensure that in cities people abide by the regulations and limit direct and indirect communication with poultry."

Shahin suggests the mortality rate resulting from bird flu infections is decreasing due to growing awareness in the wake of information campaigns conducted by the Ministry of Health.

The WHO is still concerned that human infections have escalated over a relatively short period of time, leading some experts to accuse the government of inadequate planning. Health officials, they say, are endeavouring to enforce preventive measures but are incapable of ensuring they are strictly implemented.

"Government planning is random. It is using the wrong vaccine to combat the virus," insists Talaat Khatib, professor of veterinary medicine at Assiut University. "American scientists have already confirmed the H5N1 virus has evolved into two genetically distinct strains, potentially increasing the risk to humans." Khatib believes public awareness campaigns to date have been too weak and Egypt should have begun to plan its preventative measures when the virus was first reported in the country in February 2006.

In Egypt, where poverty and illiteracy rates are high and urban rooftop and backyard rearing of poultry has long been a way of life, a more systematic approach to monitoring the disease needs to be put in place, says Samaha. "People do not respect instructions from the authorities. They consider poultry capital for which it is worth risking their health, and the health of their neighbours."

Egypt is one of very few countries affected by bird flu that does not offer compensation to farmers when poultry is destroyed. Since 2003 412 human cases of the virus have been reported in 15 countries, resulting in 256 deaths. More than 300 million birds have been culled worldwide.

For Supari

So minister Supari, If you truly believe it is a U.S. conspiracy to create bio weapons..why do you continue to take money from them? How will your country feel about you after the pandemic? They will feel you lied to them, by hiding information that could have saved their children. Even now, patients in your country are dying from your lack of cooperation in developing new vaccines that could help the entire world. How can you look them in the face and blame another country for it? How does it feel to be responsible for these deaths? Deaths you could have prevented.
Anda membuat saya sakit dengan cara berbohong anda. Suami anda sekarang meninggal. Saya berharap anda sedang meraba mirip keluarga-keluarga pasien flu burung yang sudah kehilangan yang dicintai karena anda menolak untuk melakukan seluruh itu bisa dilakukan. Ketamakan dan ketidakmampuan anda sangat mengherankan. Jika anda tidak mengubah kebijakan anda segera, mereka akan memberontak terhadap anda di cara anda tidak akan like. anda sebaiknya merasa cemas lebih banyak tentang kesehatan orang anda dan bahwa sisa dunia, lebih baik daripada mencoba menjual buku untuk perolehanmu sendiri.
You ..Supari, are of the worst kind of greedy people. Like a bad James Bond movie, you are in reality, the ultimate bad guy with the power to do good, but instead choose to harm your own people. Very soon , the Indo people and media will wake up to your deceitful ways and put you back where you belong.

Egypt must intensify efforts to combat avian flu, say experts


By Tamim Elyan
First Published: April 9, 2009
AP Photo/Nasser Nouri
Egyptian Health workers collect live ducks, confiscated from farms, for culling at the town of Qalyoub in the Qalyiubiya governorate north of Cairo, Egypt in this file picture.


AFP PHOTO/CRIS BOURONCLE
An Egyptian boy offers a live duck for sale in an street market of the populous district of Imbaba in Cairo in this file picture.

CAIRO: As the number of reported bird flu cases continues to rise in Egypt, attention is directed towards the government’s efforts in controlling and eradicating the disease.

H5N1 first hit Egypt in February 2006. So far, 63 people have contracted the virus, 23 of which died and 35 were treated. Three patients are still undergoing treatment.

On Wednesday, another case was reported of a two-year-old from a village in Giza.

This week, the Ministry of Health announced that 6,337 cases were isolated for suspicion of carrying the virus. From Cairo alone 843 cases were tested but were all found negative.

The highest infected cases were found in Menufiya with seven people carrying the disease. Six cases were reported in Fayoum and Qena each; while Menya, Qaliubiya and Gharbeya reported five cases each.

Three cases were reported in each of Cairo, Aswan, Kafr El-Sheikh and Daqahleya, two cases in each of Assiut, Sohag, Beni Suef, Damietta, and Sharqeya, while Alexandria, Suez and Beheira only reported one case each.

Young victims

The disease has spread among children between the ages of one and two over the past month.

An 18-month-old child was reported to contract the H5N1 virus on March 10.

Also early March, two two-year-old boys from Alexandria and Fayoum were reported to be infected.

Young children, old people and health workers are most likely to contract the virus, and WHO called for an investigation of this phenomenon.

“The rapid growth rate of bird flu infections in children is worrying,” John Jabbour, senior epidemiologist with WHO, told the UN news agency IRIN.

Jabbour speculated that the reason for the increased number of cases in this age group was that families were no longer as alert as they were after the last awareness campaign.

“This is a problem that will not go away in poultry; hence people who deal with birds cannot afford to relax. Those who come in contact with birds must make caution part of their daily routine,” he said.

“When children are infected then the message hasn’t arrived yet. There must be better funding, support and subsidization policies for farmers,” Diaa Salman, a virology expert who has been working on avian flu in Egypt since 2006, said.

“The Ministry of Health has implemented a comprehensive awareness plan that comprised more than 13,000 rural advisors moving from house to house, in addition to mass media campaigns,” Abdel Rahman Shahin, spokesperson of the Ministry of Health told the press.

“We also succeeded in saving the lives of children infected with the virus,” he said, adding that no fatalities were reported for children under 10 years old.

However, experts think that there is still a long way to go.

Getting the science right

Salman believes there is still room for improvement.

“Although it hasn’t reached the epidemic stage yet, Egypt is now second to Indonesia among the most affected countries by avian flu virus,” he told Daily News Egypt.

“The number of human and poultry infections show that some policies are ineffective; we need to reevaluate and assess the current capacities from laboratories and personnel operating at these laboratories, and update them as well as reviewing expenditure in this field,” he explained.

Salman also called for reassessing the types of vaccinations used, their sources and quality. He also called for cooperation between the Ministries of Health, Environmental Affairs and Agriculture in monitoring immigrant birds and the developments of the virus in Egypt.

According to Salman, monitoring the disease requires highly equipped laboratories with isolation and identification devices that can spot the microbes in live and dead infected bodies as well as high safety standards.

“They aren’t available at most places,” he said.

Nasr El-Din Al-Tantawy, a former epidemiologist at the World Health Organization (WHO), said that the Egyptian government’s efforts are not sufficient especially since the virus is now enzootic in the poultry sector.

“In Egypt, we deal with special kind of cultural and economic habits related to poultry farming especially in rural areas which demands intensifying awareness campaigns among farmers,” he previously told Al-Masry Al-Youm independent daily.

“The level of biological safety and vaccinations is excellent in major farms but it declines in small and new farms which enables the virus to become enzootic there,” he explained.

However, Hala Esmat, technical officer at the WHO, says that Egypt is on the right track concerning developing its laboratories.

“Most of the laboratories in Egypt are highly equipped; the latest was the WHO’s laboratory which has been promoted last week as the national laboratory for examinations,” Esmat told Daily News Egypt.

She added that the WHO is working closely with the Ministry of Health to follow up on various issues.

While the chances of infections remain relatively low, experts fear H5N1 could mutate into a form that can easily be passed from one person to another, leading to a pandemic which could kill millions.

“Most farmers in rural areas don’t apply safety standards like having backyards for raising poultry or separation between immigrating birds and the farm birds. The ministry doesn’t visit these places regularly for inspection nor do the local authorities help farms get rid of dead birds safely or compensate them for dead animals,” Salman said.

“Alternative policies must be implemented as well as heavy awareness campaigns especially as economic circumstances force farmers to depend on poultry rather than meat,” he added.


HAND, FOOT AND MOUTH DISEASE - CHINA (07): (HENAN, SHANDONG)

Archive Number 20090408.1357
Published Date 08-APR-2009
Subject PRO/EDR> Hand, foot & mouth disease - China (07): (HE, SD)

************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 7 Apr 2009
Source: Reuters News [edited]
<http://www.reuters.com/article/healthNews/idUSTRE5362MP20090407>


33 children in 2 crowded rural provinces of China have died in an
outbreak of hand, foot and mouth disease that could claim more
victims as it spreads in summer heat, state media reported on Tuesday
[7 Apr 2009].

The disease, a common childhood illness, is rarely fatal but can
cause fever, mouth sores and blisters. Severe forms of [the illness]
can be deadly if not properly treated.

18 children have died from the disease in central Henan province and
at least 15 in eastern Shandong province this year [2009], the
official Xinhua news agency reported.

Henan, a rural province crowded with poor farmers, is the center of
China's latest outbreak of the disease, which killed 40 children
nationwide last year [2008], spreading alarm among parents. The
deaths in Henan were among nearly 20 000 cases of the disease
confirmed in the province, including 5965 in hospital, as of Monday [6
Apr 2009], the Xinhua News Agency stated.

A provincial official warned that worse may come. "As the weather
warms, cases of hand, foot and mouth disease in Henan may rise
further," a vice governor of Henan, Song Xuantao, told Xinhua. "The
situation facing prevention and treatment is very grim."

In late March 2009, Minquan County in Henan said one child had died of
the disease. Minquan has now confirmed that 8 children have died from
the disease, the Xinhua report said. They were among the 18 dead
reported by Henan.

The report from Shandong said 11 500 children had been diagnosed with
the disease and 7100 had already recovered. Earlier this year [2009],
a 17-month-old boy died of the disease in eastern Anhui province.

[Byline: Chris Buckley]

--
Communicated by:
HealthMap Alerts via
ProMED-mail <promed@promedmail.org>

[The hand, foot & mouth disease epidemic in China continues to
escalate, from 19 deaths reported on 1 Apr 2009 to the 33 deaths
reported on 7 Apr 2009. The epidemic remains centered on the provinces
of Henan and Shandong, in contrast to the preceding year [2008], when
Anhui was the most affected province. It seems likely that the final
death toll, currently at 33, may exceed the 40 deaths recorded in
2008, since the epidemic is predicted to peak in mid-summer.

AVIAN INFLUENZA (LPAI), POULTRY - USA (02): (KENTUCKY), H7N9

Archive Number 20090408.1361
Published Date 08-APR-2009
Subject PRO/AH/EDR> Avian influenza (LPAI), poultry - USA (02): (KY), H7N9


************************************************************
A ProMED-mail post

ProMED-mail is a program of the
International Society for Infectious Diseases


Date: 9 Apr 2009
Source: OIE WAHID [edited]



Low pathogenic avian influenza (poultry), United States of America
------------------------------------------------------------------
Information received on 6 Apr 2009 from Dr John Clifford, Deputy
Administrator, Animal and Plant Health Inspection Service, United
States Department of Agriculture, Washington, United States of America

Summary
Report type Immediate notification
Start date 31 Mar 2009
Date of 1st confirmation of the event 31 Mar 2009
Report date 6 Apr 2009
Date submitted to OIE 6 Apr 2009
Reason for notification Recurrence of a listed disease
Date of previous occurrence October 2008
Manifestation of disease Sub-clinical infection
Causal agent Low pathogenic avian influenza virus Serotype H7N9
Nature of diagnosis Laboratory (advanced)
This event pertains to a defined zone within the country

New outbreaks

Outbreak 1 - Grayson County, Grayson County, Kentucky
Date of start of the outbreak 31 Mar 2009
Outbreak status Continuing (or date resolved not provided)
Epidemiological unit Farm

Affected animals: Species Birds
Susceptible 20 000
Cases -
Deaths - 0
Destroyed 20 000
Slaughtered 0

Affected population A commercial poultry broiler-breeder operation
consisting of 2 poultry broiler-breeder houses with 20 000 birds that
were 49 weeks old.

Summary of outbreaks
Total outbreaks: 1
Outbreak statistics:
Species Birds
Apparent morbidity rate **
Apparent mortality rate 0.00 percent
Apparent case fatality rate **
Proportion susceptible animals lost* 100.00 percent

* Removed from the susceptible population through death, destruction
and/or slaughter
** Not calculated because of missing information

Epidemiology
Source of the outbreak(s) or origin of infection *Unknown or inconclusive

Epidemiological comments
31 Mar 2009: a National Poultry Improvement Plan (NPIP) laboratory
reported seropositive results for avian influenza. The birds were
being tested as part of the NPIP Avian Influenza.

Clean Program (H5 and H7) for breeding facilities. No clinical signs,
other than a modest drop in egg production, were reported. There was
no increase in mortality.

1 Apr 2009: Enhanced surveillance at the broiler-breeding operation
was implemented, and additional laboratory samples were taken.

There were no clinical indications of disease at the time of
diagnostic testing.

2 Apr 2009: The National Veterinary Services Laboratory (NVSL)
confirmed H7 RRT-PCR and hemagglutinin subtype as H7 positive.

Laboratory testing is continuing, but to date, no virus has been isolated.

Kentucky State animal health officials, in coordination with USDA
APHIS Veterinary Services, implemented the LPAI response plan in
accordance with the Kentucky Initial State Response and Containment
Plan for H5 and H7 LPAI.

Implementation included:
An enhanced surveillance zone of 10 km (6.2 miles) was implemented as
outlined in the plan. There are 4 farms, all breeder facilities and
all owned by the same company, within the 10-km radius of the
positive premises. Laboratory samples were collected and submitted
from all 4 farms. Surveillance of backyard poultry flocks is being
conduced within a 3-km (2-mile) radius of the premises.

4 Apr 2009: NVSL reported that sera tested by hemagglutination
inhibition test and neuraminidase inhibition test were seropositive
for H7N9

4 Apr 2009: As a precautionary measure, all birds in the 2 houses
were depopulated.

5 Apr 2009: All laboratory samples collected from the enhanced
surveillance on the 4 breeding facilities yielded negative laboratory
results for avian influenza.

Note by the OIE Animal Health Information Department: H5 and H7 avian
influenza in its low pathogenic form in poultry is a notifiable
disease as per Chapter 10.4. on avian influenza of the Terrestrial
Animal Health Code (2008).

Control measures:

Measures applied:
* Stamping out
* Quarantine
* Zoning
* Vaccination prohibited
* No treatment of affected animals

Measures to be applied:
* Disinfection of infected premises/establishment(s)

Diagnostic test results

Laboratory name and type National Poultry Improvement Plan (NPIP)
laboratory (Local laboratory)
Tests and results:
Species - Test - Test date - Result
Birds - agar-gel immunodiffusion (AGID) - 31 Mar 2009 - Positive

Laboratory name and type National Veterinary Services Laboratory
(NVSL) (National laboratory)
Tests and results:
Species - Test - Test date - Result
Birds - agar-gel immunodiffusion (AGID) - 5 Apr 2009 - Negative
Birds - enzyme-linked immunosorbent assay (ELISA) - 5 Apr 2009 - Negative
Birds - hemagglutination inhibition test (HIT) - 4 Apr 2009 - Positive
Birds - neuraminidase inhibition assay - 4 Apr 2009 - Positive
Birds - real-time reverse transcriptase/polymerase chain reaction
(RRT-PCR) - 2 Apr 2009 - Positive
Birds - real-time reverse transcriptase/polymerase chain reaction
(RRT-PCR) - 4 Apr 2009 - Positive

Future Reporting
The event is continuing. Weekly follow-up reports will be submitted.

Calif: State reporting widespread flu outbreak

04/08/2009

California continues to report widespread cases of the flu, possibly because of a late start to an otherwise mild season, health experts said.

State health officials said that while influenza often peaks in January and February, it is not unusual to see influenza in April and May.

Health experts use the term "widespread" when flu cases are being seen in half the state.

Still, the vaccine appeared to match well with flu strains found in California, though three children died statewide this year. Residents in other states haven't been so lucky.

"It was a slower start, but we also have been very successful in vaccinating people, and the vaccine is a better match," said Gil Chavez, epidemiologist for the state's public health department.

Chavez cautioned that even a few cases can still spread if residents don't remember to wash their hands and cover their mouths when they cough.

"The most important thing with influenza is to never predict," said Alicia Fry, medical epidemiologist with the federal Centers for Disease Control and Prevention.

"It's a flu year that is still puttering along."

This season's vaccine matched three of four strains, but experts also noticed that in some cases, flu germs were resistant to the most common antiviral treatment, Tamiflu.

Last year, the CDC released new recommendations for children from 6 months to 18 years, especially those attending school, to receive the flu shot.


Advertisement

About 5 percent to 20 percent of the population gets the flu in any given year. More than 200,000 people are hospitalized from complications and about 36,000 people die, according to health experts.

Bird Flu Reoccurring

Kamis, 9 April 2009

Heard by me the news in the media indeed him had the case of bird flu in Bali. My hope to the related side so that more tightened the guarding in Balinese entrances, so as not until the smuggling of the poultry from outside the area that will endanger the Balinese condition happened.

Hundreds Birds Residents Jombang Died Suddenly

[video of residents dealing with the dead birds]
06/04/2009 06:15

Flu Burung
Hundreds of of the Resident's Jombang chickens died Mendadak Hundreds of chickens in Jombang died suddenly in two last weeks. The official still researched and did not yet confirm whether the chicken died that was attacked by the bird flu virus.

Pandemic Influenza: Challenges and Questions

Dr. Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy (CIDRAP) will be speaking in Bloomington, Minnesota on May 7, 2009 at a joint meeting of the American Filtration and Separations Society (AFS) and the Center for Filtration Research (CFR).

Minneapolis, MN (PRWEB) April 8, 2009 -- Dr. Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy (CIDRAP) will be speaking in Bloomington, Minnesota on May 7, 2009 at a joint meeting of the American Filtration and Separations Society (AFS) and the Center for Filtration Research (CFR).

"Like earthquakes, hurricanes, and tsunamis, influenza pandemics are recurring natural disasters.*"

In the March/April 2007 issue of Foreign Affairs, Dr. Osterholm sounded the alarm once again on how unprepared governments and industry are to deal with a major pandemic. A relatively mild pandemic, such as what occurred in 1968, would kill 1.4 million people and cost about $330 billion in lost economic output. If the pandemic would be as bad as 1918-19, 142 million people would die and the world's GDP would lose $4.4 trillion.

"Besides getting sick, what else could go wrong?"

Along with the obvious health issues that a pandemic creates, Dr. Osterholm will also address how a pandemic could present serious disruptions in everyday services. In a November, 2008 report published by the CIDRAP, "Pandemic Influenza, Electricity, and the Coal Supply Chain",
Dr. Osterholm demonstrates how a pandemic could disrupt coal supplied to electrical power plants and cause shortages of electricity.

"Just in time Economy"

To reduce costs, the US and world economies have developed "just in time" supply chains. In other words, many critical products like drugs, safety items and food are delivered as needed. Any disruption in the supply chain would result in shortages of critical products. Or if the pandemic produces an increased demand for certain products, they will not be quickly available.

What can be done?

Dr. Osterholm will present the questions that both the public and private sectors need to be addressing. Does your community have any type of preparedness plan? Does your company have a plan? Do you have a plan?

To register for the conference and hear Dr. Osterholm's presentation go to the web page listed below.

http://www.afssociety.org/spring2009/

To learn more about the American Filtration and Separations Society go to:

http://www.afssociety.org

To learn more about the Center for Filtration Research go to:

http://www.me.umn.edu/research/faculty/pui.shtml

To learn more about the Center for Infectious Disease Research and Policy go to:

http://www.cidrap.umn.edu/

*Foreign Affairs, Vol. 86 No. 2, March/April 2007

Contact Information:
Suzanne Sower
American Filtration and Separations Society
7608 Emerson Ave S.
Richfield, MN 55423
Phone: 612-861-1277
Fax: 612-861-7959

hat-tip Shiloh

348 * ‬ case of suspicion, and 12 * ‬ positive bird flu infection in * ‬ 3 * ‬ months

The government failed to finance the activity of the control committees

Achieve the best Emad *: ‬ failed siege of the Government's efforts in bird flu in all the governorates of Egypt after the hotbeds of the disease has spread among birds and humans in contact with the rising rate of infections and suspects at the provincial level is frightening and more than double the figures recorded in the same period a year Last *. ‬ reports of the Ministries of Health and Agriculture, which was discussed at the High Commission of avian influenza confirmed the failure of the current plan for dealing with disease and recognized that some sources of veterinary vaccination programs and the investigation and sampling and analysis suffer from a serious financial deficit,

* ‬ An official source said the current plan failed in the siege disease and is supposed to adopt a new plan to tackle the spread of the disease after the patient in spots all over Egypt *. ‬ issued Amin Abaza, Minister of Agriculture decided to travel * ‬ Dr made me director of the Institute of Animal Health Research, Dr. Mohamed Hassan Khalifa, Director General National Laboratory for the control of poultry production to United States to participate in the Seventh Conference of the bird flu virus and become acquainted with the new plans to cope with the disease, which failed efforts to curb the spread of the disease, * ‬ as Minister of Agriculture has issued a decision to travel

* ‬ Dr. Najla pilgrims and Dr. Mahmoud Znati of the National Laboratory for the task of combating the disease in other States the United States to attend training courses on new ways to diagnose and cope with bird flu *. ‬ Dr. Hamed Samaha chief of veterinary services confirmed that things are under control and that the men were cooperating with the body of the Ministry of Health in dealing with the immediate spots are detected and added that the Authority was in need of funding more cars to cope with sick spots, he said the current plan is in the way of control but there are serious and other variables are shown and we address them and promised to send all data on the disease *. ‬

For his part, admitted Dr. Amr Qandil, director of infectious diseases in the Ministry of Health that this year registered the highest incidence of The suspect said that the reports of the ministry recorded * »‬ 348 *« ‬ case of suspicion of the disease during the month of March only *. ‬ recorded positive cases of the disease since the beginning of this year and as of yesterday I * »‬ 12 *« ‬ positive cases compared with * »‬ 7 *« ‬ cases in the same period last year, "said Dr Amr said to deal with suspected cases are immediate * ‬ are also the dangers of the veterinary services to deal with the sick spots, which show the suspect cases of the disease on humans *

‬ He added that the Ministry of Health implemented a plan to train medical teams in hospitals to define the nature of the disease and symptoms that appear on the suspects, * ‬ confirmed that the ministry has allocated Line No. * »‬ 105 *« ‬ around the clock to receive complaints of citizens and foster media campaigns and visits daily to make the pioneers of rural citizens in the establishment and expansion of the factor analysis of human samples for the rapid handling *. ‬ On the other hand, Dr. Fattuh Darwish Director of the Department of Preventive Medicine Veterinary Services Corporation that the development of the disease requires the development of methods and techniques of confrontation and acknowledged that the parties concerned to confront the disease has not been able to eliminate it and said he has not yet been besieged outposts sick in Egypt and the hot new show, but not in the form of epidemiological *. ‬ Dervis stressed that the Ministry of Health and the Veterinary Services exchange In the case of communications data to tell us in the injured human or suspicion * ‬ immediately begin the work of immunization program and to explore and collect samples from birds from the nearby and caught the suspect, if confirmed, analysis of the positive cases are executed and buried the bird through the health and vice versa if we are in the form of veterinary services, we found spots * ‬ injury poultry disease * ‬ inform the Ministry of Health and the names and addresses of places to start is to take other precautions, and the withdrawal of samples from contacts of birds *

* ‬ Commenting on the travel of a group of specialists in the veterinary services to the United States to identify new ways to confront the disease, an official source Authority refused to be named, said expanding the current epidemiological situation and that it is necessary to become acquainted with the experience and expertise of developed countries in the face of disease, * ‬ The source confirmed that the bird flu disease, talk and deal with it is subject to various criteria, and therefore face the question of the need to identify new ways commensurate with the variables inherent in the development of a focused disease specialists sent to the United States to search for modern methods to curb sick spots, which began increasing significantly, *

‬ The source added that over the periods of low temperature and delayed the onset of summer has led to the continued emergence of hotbeds of disease and helped in the proliferation of cases and suspected *

Obtained ‬ * »‬ delegation *« ‬ records of suspected cases sent by the Ministry of Health to the veterinary services in the days * ‬ 2 * ‬ and 3 * ‬ and 4 * ‬ April include * ‬ 3 * ‬ lists, each containing one * ‬ 9 * ‬ injury cases of suspected bird flu from all the provinces *.

On ‬ * ‬ 2 * ‬ April recorded statements of suspicion in a noble Mohamed Ismail * »‬ 21 * ‬ years *« ‬ Almnecat the village Aqrab Hosseinieh Center Hospital East has been admitted depositing Zagazig, * ‬ and Princess Razeq Abulhasan * »‬ 20 Year * ‬ * «‬ al-Alfi, the status of the province of Qena, we inaugurated the conversion was admitted to hospital in Qena, * ‬ Hassan and Hossam Hassan *» ‬ 5 * ‬ years * «‬ Shady queens of the division of his hospital fevers were the Upper Egyptian Mohamed Medhat Abduljawad *» ‬ Year 17 * ‬ * «‬ Bazkp of the status of enemy and queens have been admitted into a hospital this morning and the enemy Mohamed Abdulaziz *» ‬ 39 * ‬ years * «‬ from the village of Kom * ‬ 2 * ‬ Rashid Center for Lake County Hospital was deposited Damanhour fevers and Samiha Mohamed Treasure * »‬ 50 * ‬ years *« ‬ Gemayzeh of the village of West County Center Alsentp entered the hospital admitted Tanta, informed Ali Shaaban * »‬ 36 * ‬ years *« ‬ Khurshid of the park and entered the hospital in Alexandria, Alexandria, fevers Rowan Ahmed Ibrahim * »‬ 7 years * ‬ * «‬ of people before me, Sir, and entered Alexandria, Alexandria, fevers and allow Mohamed Mahmoud *» ‬ 35 * ‬ years * «‬ Dronka of Assiut and entered the hospital with fevers Assiut *. ‬ registered on the lists of suspected * ‬ 3 * ‬ * ‬ isolate April 9 * ‬ diets of hospitals for suspected bird flu patients have been isolated Aida Ali Ahmed Isa * »‬ 55 * ‬ years *« ‬ Almenderp of Alexandria, Alexandria, was deposited Bhmyat Walid Mohamed Said * »‬ 6 * ‬ years *« ‬ of Sir humans and entered Alexandria Alexandria fevers and Omaima Fathi mind * »‬ 41 * ‬ years *« ‬ Kos from entering the province of Qena, was admitted hospital Qena and Ahmed Ali Yacoub * »‬ two *« ‬ of Kos and deposited QENA fevers, Zeinab Mohamed Ahawadi * »‬ 40 Year * ‬ * «‬ entered from Qena, Qena and fevers Naima Hassan Jaber *» ‬ 11 * ‬ years * «‬ Badir from a bad Albderman Moas entered Menya Menya, fevers Sana Secretary Secretary *» ‬ 39 * ‬ years * «‬ Salhia of eastern region was Hospital East deposit fevers and Mr. Muhammad grew * »‬ 13 * ‬ years *« ‬ Vaqos of the East and entered the eastern and fevers Saad Mohammed Atta * »‬ 14 * ‬ years *« ‬ Belkas of Dakahliya and deposited a Hospital Mansoura *. ‬ * testified on ‬ 4 * ‬ suspicion of wounding, April * ‬ 9 * ‬ persons were recorded fever isolation hospital lists of suspected infection of Muhammad Ali * »‬ 57 * ‬ years *« ‬ by * ‬ Izbat Osman West Shubra al-Khaimah Balqlliopip Demerdash and entered the hospital and Mr. Hiam Ahmed * »‬ 28 * ‬ years *« ‬ Srsena the status of the village met Monday Fayyoum entered fevers Fayyoum Riham Mohammed Ahmed * »‬ 10 * ‬ years *« ‬ met Monday of the deposit was admitted Fayyoum Inamul Mohammad Abu Yusuf * »‬ 27 * ‬ years * «‬ Kafr Masood Btnta West entered Tanta fevers and survival Abdulnabi Razeq *» ‬ 41 * ‬ years * «‬ Mansheya of the new West Mahala area and entered the fevers Maysp Hamid Makhluf *» ‬ 33 * ‬ years * «‬ Shabra of Umbulula Mnov Center Monoufia entered Mnov fevers and Mohammed Shehab Hawkip * »‬ 55 * ‬ years *« ‬ Itai of gunpowder and entered Lake Damanhour fevers and love the beauty Sahsah * »‬ 8 * ‬ months *« ‬ functioning status of the village of Kafr El-Sheikh and a woman Mossaad 40 year the village Allavi Balyana Center and entered the province of sohah. sohag fevers
hat-tip Sally

Wednesday, April 8, 2009

Two suspect Bird Flu Not Keep Back to RSHS


Wednesday, April 08, 2009
BANDUNG WEST (SI) - AM, 26, and Fai, 14 months, two patients suspect bird flu that escape from the treatment room Flamboyan Rumah Sakit Hasan Sadikin (RSHS) Bandung, on Monday (6 / 4), not to be returned in force RSHS .


After the coordination between health and the RSHS Cipatat, both of the Village / District Cipatat, Kabupaten Bandung Barat (KBB), only need to receive intensive supervision. Head of Puskesmas Cipatat District of Revelation says, at this time AM and Fai who previously lived in-law's house in Kampung AM Cikokosan RT 01/06, Desa / Kecamatan Cipatat, returned to her parents in the village stop RT 01/19, Desa / Kecamatan Cipatat.

Physical condition of both patients, the words of Revelation, have seen more healthy than the first time was last week RSHS. He asserts, has requested the advice to doctors who handle AM and Fai RSHS in a matter of whether they should be brought back to the home sakit.Pihak RSHS states that the health center that will oversee both. The results of laboratory tests that their negative bird flu.

"But if there are signs of the condition of the body back out, they are immediately referred back to RSHS," said the Rev. SI yesterday. Although the existing oral statement from a doctor RSHS, still must have a copy of the official states that the PM and stay negative Fai virus Avian Influenza (AI). "We need evidence that will be the guidelines of the health condition of the hospital korban.Apalagi submit to us (health center) to conduct inspections and watched as advanced disease and flu burungnya negative victims suffer only common disease," he said.

Request a copy of the written evidence of the laboratory was also Head Cipatat Eriska Hendrayana.Menurut him, if only oral statements, the evidence does not have to disclose to the public that the disease and Fai AM menular.Dengan not so, society does not exclude the victims of life in the environment. "I just heard a new orally and not 100% sure.

Therefore, I will ask the full backup or image copy of the laboratory test results of the AM and Fai negative bird flu, "said Kantor Pemkab Eriska in West Bandung, Jalan Tagog, Padalarang, KBB, yesterday. He asserted, not the decision to have one so that people remember the injured bird flu virus can spread quickly.

Because of this, he has ordered the district officials to immediately request the summary results of laboratory examination and Fai AM. Later it akan rekapan given to the village and presented to the public so that there is no fear of the neighbors of the victim at or adjacent to communicate with them. Meanwhile, in order to anticipate the spread bird flu outbreaks, especially in Cipatat, already coordinates with the Animal Husbandry and Fisheries KBB disinfectant to perform at the same time.

Moreover, in the area quite a lot of poultry, including chickens because there are some chicken farms. "We will soon perform for agendakan disinfectant so that the bird flu virus has brought the victim in the village of Kampung Andir stop and not extended to neighboring villages," said Eriska. (adi charlie at the lake)

Agriculture" is facing a U.S. avian flu plan

After the failure of the Egyptian plan:

"

اWednesday, April 8, 2009 - 10:33


After the high number of cases of avian flu, and suspected infection, which increased to 65 cases, and after the recognition of the failure of its veterinary services in the fight against the disease, according to Dr. Fattuh Darwish Director of the Department of Preventive Medicine, that the plan of the bird flu situation of a large fiscal deficit , the Minister of Agriculture and other decisions to travel a large number of veterinarians to foreign countries for training courses or to study the disease.

It was a decision to travel, Dr. Mona Mehrez research director of the Institute of Animal Health, Dr. Mohamed Hassan coach of the national control laboratory for the production of sending into exile to the United States, to participate in the Seventh Conference of the bird flu.

Abaza also issued a similar travel of pilgrims and Dr. Najla Dr. Mahmoud Znaty National Laboratory to fight the disease on a mission to the United States to attend a training course on the diagnosis of avian influenza.

detention of suspected cases of bird flu, the lake

الأربعاء، 8 أبريل 2009 - 16:45 Wednesday, April 8, 2009 - 16:45




Avian flu spread alarmingly GOVERNORATES

البحيرة - شعبان فتحى Lake - Fathy Shaaban


The fever hospital Bdinmhor 4 persons detained on suspicion of having bird flu, after the emergence of symptoms of the disease are similar to them, the high temperature and throat congestion and shortness of breath.

Received the Major General, Magdi Oboukmr, director of security of the lake, a notification from the hospital admitted the detention of each of the Damanhour Ayatollah Medhat Egyptian (3 years) Damanhour fork, and decent Abdo Hegazy (40 years housewife) in Kafr Dawar Kafr Salim, and the planet, Mr. Mohamed (42 years housewife ) Aloavadip Damanhour, and Nadia Massoud Abdel Halim (40 years housewife) Obouhms village of Zarqa.

And immediately was coordination between the Directorate of Veterinary Medicine and the Department of Health to vaccinate domestic birds infected premises and take samples for analysis by the lab to clean up the homes of suspects and the adjacent houses to them.

On the other hand, the Committee examined the existing bird house Ismail Ibrahim Taha Center Itay gunpowder, and after a hospital admitted the arrest of the child Demerdash Balqlliopip Mohamed Gomaa (6 years) suspected of having bird flu after his visit, accompanied by his mother to the house of his grandfather Baitay gunpowder.

ACS and Clinical Solutions partner to help local gov

Wednesday, 8th April 2009

07 April 2009: First-of-its-kind fully managed pandemic solution assists local government in assessing symptoms and planning for public health incidents.

Government organisations looking to better prepare for a public health outbreak will now have access to a complete pandemic management solution thanks to a new partnership between Affiliated Computer Services (NYSE: ACS) and Clinical Solutions.

In the event of a pandemic outbreak, this fully managed solution would help local healthcare professionals, governments and citizens safely and consistently assess symptoms and direct patients to the most appropriate level of care – thereby alleviating strain on local primary care providers during a public health crisis.
“As a leading provider of government healthcare solutions, ACS is pleased to add this end-to-end pandemic management solution to its wide variety of government offerings,” said Chris Deelsnyder, managing director and senior vice president of ACS’ Government Healthcare Solutions. “ACS’ mature global infrastructure and extensive customer care capabilities serve as the perfect complement for Clinical Solutions’ Web-based products. Together, we can equip local governments with the necessary tools to better prepare for and manage possible public health outbreaks.”
Under the partnership agreement, ACS will provide the infrastructure, telephony and call centre services to complement the Clinical Solutions IntefleCS™ Health Watch tools and software. With nearly 30,000 customer service representatives and 118 call centers that offer support in 20 different languages, ACS can provide an instant pool of operators that can help assess symptoms, provide further information and direct citizens to the most appropriate level of care.
Richard Craven, director at Clinical Solutions adds, “This partnership provides local governments with the combined expertise of specialists in telecoms and call centre services with Web-tools and software. The Clinical Solutions and ACS technologies offer effective tools for assessing symptoms and planning for public health incidents, pandemics and bio-threats; giving governments confidence and peace of mind that they’re fully prepared.”
IntefleCS™ Health Watch is a suite of Web-based tools used to detect, assess, contain, communicate, manage and report during a public health incident. The software was piloted in 2006 in Exercise Cumpston, Australia’s largest ever health simulation exercise, which tested the country’s preparations for a pandemic flu outbreak.
In the United Kingdom, Clinical Solutions is helping to deliver a multi-channel National Pandemic Flu Line Service ensuring the country is one of the most prepared in world. In partnership with Department of Health, NHS Direct and BT the service will provide rapid Web- and telephony-based assessment, direction of care, advice, guidance and, where appropriate, authorisation of antiviral medicine treatment to the public.
About ACS
ACS is a national leader in state healthcare program administration, offering a full spectrum of systems and complementary services through an integrated solution; from care management solutions and child health programs to pharmacy benefits management and traditional Medicaid fiscal agent services. ACS supports more than 23 million program recipients and processes nearly 550 million Medicaid healthcare claims annually, representing close to $50 billion in provider payments. As the nation's largest government program pharmacy benefits administrator, ACS serves 28 states, the District of Columbia and the Department of Labor with drug expenditures totaling more than $13 billion.
ACS, a global FORTUNE 500 company with 74,000 people supporting client operations reaching more than 100 countries, provides business process outsourcing and information technology solutions to world-class commercial and government clients. The company's Class A common stock trades on the New York Stock Exchange under the symbol "ACS."

Highly pathogenic avian influenza virus H5N1 in Africa: a comprehensive phylogenetic analysis and molecular characterization of isolates

09/Apr/09

Authors: Cattoli G, Monne I, Fusaro A, Joannis TM, Lombin LH, et al. 2009 Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Africa: A Comprehensive Phylogenetic Analysis and Molecular Characterization of Isolates. PLoS ONE 4(3): e4842. doi:10.1371/journal.pone.0004842

This work follows the appearance of A(H5N1) viruses in birds in eleven African countries (Benin, Burkina Faso, Cameroon, Djibouti, Egypt, Ghana, Ivory Coast, Nigeria, Niger, Sudan, Togo) and the implications for the poultry sector and related public health issues. These include food security in low-income countries and the potential threat to human health from circulation of A(H5N1). To date there is only limited information on the molecular evolution and epidemiology of A(H5N1) in Africa. To fill this gap the authors applied molecular analysis tools to virus sequence data and combined the results with epidemiological data related to A(H5N1) viruses isolated between 2006 and early 2008. This included 494 full gene sequences from 67 African isolates and in addition molecular analysis tools were applied to a total of 1,152 A(H5N1) sequences obtained from viruses isolated in Africa along with Europe and the Middle East for comparison. Detailed phylogenetic analyses of the 8 gene viral segments confirmed that 3 distinct sub-lineages were introduced which have persisted and spread across the African countries.

This article can be accessed by clicking here.

ECDC Comment (07-04-09): The authors note that despite phylogenetic analysis of all the gene segments of the A(H5N1) viruses in this study that did not allow them to pinpoint the origins of the different viruses. The epidemiological data here are rudimentary. It also remains unclear how, when and where the three distinct A(H5N1) sub-lineages entered the continent and spread. Resources for surveillance for avian influenza are considerably more plentiful than they were a decade ago but they still remain rudimentary compared to what is available in the European Union.
hat-tip Helblindi

Excerpts from: Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and i

From the pdf file from post below:
Excerpt:

Here we show that the HA subunit 1 (HA1) of H5N1 viruses encodes specific and highly conserved information which may determine the recognition and targeting of these HPAI viruses to their receptor. The comparison with seasonal strains suggests that a subset of H5N1 in Egypt may be evolving towards an H1N1-like receptor usage.
-snip-
Despite its low infectivity for humans, there has been evidence in Egypt of several
clusters of human-to-human transmission with very high mortality rate. ISM analysis of 95 HA sequences from Egypt 2006 and 2007 showed that these viruses can be divided into two groups. Consensus IS of a first group (Egypt-1) of 55 strains contains a dominant peak of the frequency F(0.076) which is characteristic for H5N1 HA1 and a less prominent peak of the frequency F(0.236) which is characteristic for H1N1 HA1
(Figure 2a). In contrast, consensus IS of the second group (Egypt-2) (Figure 2b), which includes 40 H5N1 HA1, contains only one significant peak of the frequency F(0.236) corresponding to the consensus IS of H1N1 HA1 in Figure 1d. Figures 2c and 2d show representative IS of individual strains of both groups. Of H5N1 viruses which were isolated in Egypt during 2006, 76% belong to the group Egypt-1, and 24% were from the group Egypt-2. In contrast, in 2007, 48% belong to the Egypt-1 and 52% to Egypt-2. Figure 4 shows the IS spectra of peptide VIN1 and of the domains identified by consensus IS of H1N1, H3N2, H5N1 and H7N7 viruses (Table 2) and the position of these domains in the molecule. As can be seen, the receptor targeting site of H5N1 virus from the group Egypt-1 (A/Egypt/0636-NAMRU3/2007) is closer to the receptor binding site than in the other viruses of Figure 4. It may be speculated that this may affect the efficacy of the virus/receptor interaction.

Finally, we compared informational properties of H1N1 pandemic strains from 1918
from GenBank and seasonal H1N1 strains. The consensus IS of these pandemic isolates (Figure 3) is characterized by a dominant peak of the frequency F(0.258) which is different from the frequency F(0.236) characteristic of other seasonal flu H1N1 isolates (Figure 1d). Table 2 shows the domain corresponding to the frequency F(0.258). In the model of A/South Carolina/1/18 (Figure 4i) the position of this domain does not overlap with the corresponding domain of other seasonal H1N1 strains, but overlaps with the corresponding domain of Egypt-2 H5N1 viruses.
-snip-
H5N1 already replicates efficiently in humans, and cause case fatality rates that are ten times higher than those seen in the 1918 pandemic. Thus, an infectivity of H5N1 similar to seasonal flu would cause a catastrophic pandemic. The main obstacle for this worst case scenario is poor human-to-human transmission of H5N1 viruses, which is attributed to the paucity of sialic acid a2,3 receptor in the epithelium of the human upper respiratory tract, and the inability of the virus to replicate efficiently at this site. Interestingly, the ISM approach identifies important differences between H5N1 viruses from Egypt. Some have the characteristics of most H5N1 strains whereas about one third of the viruses display characteristics that are also found in human H1N1 seasonal virus. Interestingly the proportion of the latter viruses has increased from 25 to about 50: between 2006 and 2007.

Similarly the results of H5N1 strains from Egypt (Figure 2) may be indicative of a
possible viral evolution towards receptor usage similar to that of H1N1 viruses, which
efficiently replicate in the upper respiratory tract. The protein domain, which seems to be involved in this subtle change, corresponds to amino acid domain 99-132 (Figure 4g).

However, the role of this domain for enhanced infectivity in humans remains elusive.
Interestingly the corresponding domain of Spanish flu viruses and Egypt-2 H5N1 viruses are much closer to the receptor binding site of HA1 than in all other H1N1 and H5N1 viruses (Figures 4e-4i and Table 2). This closer proximity may indicate more efficient virus/receptor interactions in these influenza viruses.
-snip-

Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control

Veljko Veljkovic , Nevena Veljkovic , Claude P Muller , Sybille Muller , Sanja Glisic , Vladimir Perovic and Heinz Kohler
BMC Structural Biology 2009, 9:21doi:10.1186/1472-6807-9-21

Published: 7 April 2009
Abstract (provisional)

Background

Epidemics caused by highly pathogenic avian influenza virus (HPAIV) are a continuing threat to human health and to the world's economy. The development of approaches, which help to understand the significance of structural changes resulting from the alarming mutational propensity for human-to-human transmission of HPAIV, is of particularly interest. Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction.
Results

Presented results revealed that HA proteins encode highly conserved information that differ between influenza virus subtypes H5N1, H1N1, H3N2, H7N7 and defined an HA domain which may modulate interaction with receptor. We also found that about one third of H5N1 viruses which are isolated during the 2006/07 influenza outbreak in Egypt possibly evolve towards receptor usage similar to that of seasonal H1N1.
Conclusions

The presented results may help to better understand the interaction of influenza virus with its receptor(s) and to identify new therapeutic targets for drug development.
hat-tip Niman

Indo: AG, "I felt I has been HEALTHY"


The official from the Kesehatan Service discussed with the patient was expected by bird flu, AG (left), in his house in the Halteu Village, Desa Cipatat, Kabupaten Bandung Barat, on Wednesday (8/4). According to AG, he was forced to escape from RSHS on Monday (6/4) around struck 11,00 WIB because his wish was treated in the house was not granted by the official. * Ade BAYU INDRA/PR
Admitted to be wrong, BUT did not want to return to RSHS

Kamis, 09 April 2009
NGAMPRAH - the puzzle AG (25) that escaped from space of the Poinciana Tree isolation of Rumah Sakit Hasan Sadikin Kota Bandung was solved already. Met in his parents's house in the Halteu RT Village 1 RW 19, the Cipatat Village, Kec. Cipatat, Kab. Bandung was Barat, on Wednesday early afternoon (8/4), AG that was expected terjangkit this bird flu appeared healthy and was playing in a third manner his sweetheart. "I felt I has been healthy." Whated are you doing I was treated very old. I also enggak felt in the hospital at home, [dictionary translation: "“I think already finished healthy. Why I cared for after a long time. I also/still not to bear/endure in hospital”] said AG when telling the reason he escaped from Flamboyan RSHS Space that was minded was tight enough by the nurse.

AG claimed, he escaped through the window toilet available in Flamboyan Space, on Monday (6/4) around struck 11,00 of WIB. Saat Itu gazed at rest time of the nurses so as the guarding was not too tight. By shifting the youngest child FS (14 months) that also was treated, and his wife, Rika (19), AG determined to escape. "Window glasses in toilet that has been lax, so easy was freed." Because of the location of the rather high window, I rose on the bath previously for manjat the window. From the window, I left the hospital corridor, said AG.

During in the hospital corridor, said AG, the atmosphere was not too busy. Moreover, the security units then were not available. The three of them walked and sway the arms until going out RSHS. not dared to immediately came home, AG brought his family to your house him in the Pamucatan Village, Kec. Padalarang, Kab. Bandung was West. The next day, on Tuesday (7/4), AG decided to go to his parent-in-law's house in the Cikokosan Village, Desa Kertamukti, Kec. Cipatat, Kab. Bandung was West. Overnight in his parent-in-law's house, AG decided to return to his parents's house in the Halteu Village, on Wednesday (8/4). [dictionary translation following quote]"I already finished to ask kindly to return home same doctor in RSHS, however not have been responded. I already healthy, while treated myself to bathe alone. While also when I cared for finished, who will want to give to consume food family mine. I backbone family here, father mine done elderly" said AG.

Admitted to be wrong
AG acknowledged, if his action escaped from the hospital was wrong. But, he also did not receive was made as being expected by bird flu. According to him, before eating the chicken that it was suspected was sick because of this bird flu, AG has been sick flu. "His weather still is ugly, I and children were sick with a cold." Moreover, the neighbouring child also was sick. When eating the chicken, I have been sick. Why only I and FS that was made suspect. FS breathless because he indeed had asthma and bronchitis, not bird flu, said AG.

In the meantime, the UPTD Head and the Cipatat Community Health Centre, Kab. Bandung was Barat Dr. Wahyu said, his side has tried to ask for AG so that he wants to be treated again in RSHS. Namun, all the decisions to be on the hands of AG. "We could not force AG. If he indeed did not want to be treated again, okay then," said Wahyu.

Beforehand, the Managing Director RSHS Bandung, Prof. Dr. Dr. Cissy R.s. Prawira, Sp.A. (K), M.Sc.said, was based on results of the clinic inspection and the laboratory of the patient AG and FS, did not head to bird flu. Even so results of the PCR inspection of the available poultry there the negative. (A-187)