Friday, April 5, 2013

#H7N9: 2 New Cases in Jiangsu Province - Total Cases 16

The Jiangsu Province Department of Health Statement
Translated out of China
4/5/13
Jiangsu Province 2 new cases of human infection of H7N9 avian influenza confirmed cases

Health Department of Jiangsu Province, April 5 Bulletin, Jiangsu Province, the new confirmed cases of human infection of H7N9 avian influenza.
  Patients Yin, female, 61 years old, Qinhuai District in Nanjing, retirement home. March 20 onset.April 2 to go to a hospital in Nanjing sicker treatment. Currently, patients in critical condition, is to rescue.April 3, Jiangsu Province CDC laboratory test results for the H7N9 avian influenza virus nucleic acid weakly positive. The morning of April 5, the provincial CDC deep collection of patients with lung aspirate specimens detected again, the results were positive for the H7N9 avian influenza virus nucleic acid. Noon on April 5, issued by the Province, according to the state Health and Family Planning Commission, the Group "treatment program, 1 (2013), the diagnosis of the cases of human infection of H7N9 avian influenza confirmed cases of human infection with the H7N9 avian influenza. After investigation, the close contacts of the cases of a total of 12 people, until now, were not found to have a fever or respiratory symptoms.
  Patients 陆某, male, 79 years old, Qinhuai District in Nanjing, retirement home. March 21 onset.March 31 due to exacerbations to treatment in a hospital in Nanjing. Currently, patients with severe illness, is to rescue. In the evening of April 2, the preliminary test results of the Jiangsu Provincial Center for Disease Laboratory weakly positive for the H7N9 avian influenza virus nucleic acid. April 4, again test results still show a weak positive for the H7N9 avian influenza virus nucleic acid. The morning of April 5, the provincial CDC deep collection of patients with lung aspirate detected again, the results for the H7N9 avian influenza virus nucleic acid positive. April 5 at noon, the the Provincial Expert Group issued according to the state Health and Family Planning "human infection H7N9 avian influenza treatment program, 1 (2013), the diagnosis of the cases of human infection H7N9 confirmed cases of avian flu. After investigation, the close contacts of the cases of a total of 53 people, until now, were not found to have a fever or respiratory symptoms.
  At noon on April 5, the provincial expert group at the same time two cases of unexplained pneumonia cases (Wuxi city Zhang and Suzhou Wujiang Zhao) consultation analysis, due to lack of sufficient evidence of pathogen detection, according to the National Health issued and Family Planning Commission of the treatment program, 1 (2013), the diagnosis of suspected cases of human infection with the H7N9 avian influenza.
  Provincial Health Department is organizing experts to make every effort to rescue cases, to implement various epidemic prevention and control measures.

#H7N9: Contact of Confirmed Case with Symptoms Tests Negative

 This update on the contact mentions a cough in addition to runny nose and fever reported earlier.  The contact however, has tested negative.
 Also, over 20,000 chickens, ducks, geese & pigeons were slaughtered at the first market closed due to the virus.  The Wholesale Market is located in Songjiang District.  A hotline has been established and they have designated two "hospitals" to receive H7N9 patients in Shanghai, the Public Health Clinic Center and the Children's Hospital of Fudan University.

Excerpts:
4/5/13

Of the 119 people who have had close contact with H7N9 patients in Shanghai, only one of them has developed symptoms of a cough, runny nose and itchy throat, but the person's test result of H7N9 was negative, Xu Jianguang, director of the Health and Family Planning Commission of Shanghai, said on the same occasion.

Shanghai Public Health Clinical Center and the Children's Hospital of Fudan University have been designated hospitals for receiving or treating H7N9 patients in Shanghai.

An around-the-clock hotline, 12320, has been launched for people wanting a consultation.


A total of 20,536 chickens, ducks, geese and pigeons from Huhuai Agricultural Products Wholesale Market were slaughtered after the H7N9 bird flu virus was detected from samples of pigeons in the market, Shanghai health authorities said Friday.
The market, located at Dongjing Township of Songjiang District, was the first to be closed earlier this morning.

http://news.xinhuanet.com/english/health/2013-04/05/c_132286567.htm 
 

#H7N9: Hong Kong Girl, 7, becomes first suspected patient

April 5, 2013

A seven-year-old girl, who had visited Shanghai and had contact with live poultry, is

suspected to be infected with the killer H7N9 virus, Health Minister Ko Wing-man said today.
She is in quarantine and tests will be conducted.
This comes as Hong Kong marked the 10th anniversary of epidemic of Severe Acute Respiratory Syndrome (SARS), whcih began in China.
Ko also said the government will follow standard guidelines in responding to detections of the H7 or H5 avian flu viruses in local poultry.
As for border protection, he said more staff will be deployed to monitor the body temperature of arrivals.

-snip-
http://www.thestandard.com.hk/breaking_news_detail.asp?id=34405&icid=1&d_str=

Thursday, April 4, 2013

Jiangsu Taicang informed #H7N9 avian flu deaths Details

This article speaks of the Case from Zhejiang. I have 3 cases from Zhejiang. I believe they speak here of Hong (38).  Translated out of China.
Zhejiang Province
Date of Report:  4/3/13
Name:  Hong (38) – Cook, worked in Taicang City, Jiangsu Province
From:  Hangzhou Jiande, Zhejiang Province
Onset:  3/7
Adm:  3/18
DOD:  3/27
Confirmed:  4/1 Zhejiang Province CDC
Confirmed:  4/3 China CDC
Notes:  125 contacts monitored.

  Yangtze Evening News (reporter Zhang Bi Wing) yesterday afternoon, Taicang City released the latest situation of the H7N9 avian flu prevention and control: As of April 4, Zhejiang illness the chef Mr. Hong worked Zhejiang earth Steel Structure Co., Ltd. Taicang Branch employees and related to close contact with staff of 131 people, the time of the last contact with the patients have more than 7 days, fever, colds and other related symptoms were obtained by medical observation.
  It is understood that the Zhejiang Provincial Health Department released on April 3 in the province occurred two cases of human infection with the H7N9 avian influenza deaths case work in Taicang City, Mr. Hong. In this regard, the the Taicang Municipal Center for Disease Control immediately organize epidemiological investigation related to the prevention and control measures. Survey: patients, Mr. Hong, male, born May 1, 1974, Zhejiang earth Steel Co., Ltd. Taicang Branch chef, February 17 to March 8 without going out from Zhejiang to Taicang history, husband and children 3 people together resident Taicang. March 8 to 10, Mr. Hong Xiaoshan Corporation training, the 10th back Taicang. Felt unwell 17 18 Back Jiande a hospital; 20, 2009 transferred to Xiaoshan a hospital for treatment, 24 patients sicker after she died on the morning of the 27th.
  As of April 4, the company staff and 131 close contact with the patient last contact time have been more than 7 days, fever, colds and other related symptoms were obtained after medical observation. CDC in Suzhou, Taicang City staff to guide the investigation and handling, disinfection of patients living and workplace. The Taicang government has held a meeting and made a special deployment of Taicang City, the prevention and control of human infection of H7N9 avian influenza.
http://news.sohu.com/20130405/n371745886.shtml

Sequences from #H7N9 Reveal Already Acquired Some Genetic Changes Needed to Transmit Person To Person

Excerpt:
4/5/13
"The gene sequences confirm that this is an avian virus, and that it is a low pathogenic form [meaning it is likely to cause mild disease in birds]," said Wendy Barclay, a flu virologist at Britain's Imperial College London. "But what the sequences also reveal is that there are some mammalian adapting mutations in some of the genes."

This, she said, meant the H7N9 virus has already acquired some of the genetic changes it would need to mutate into a form that could be transmitted from person to person.

While the official Xinhua news agency said it was unfair to compare SARS with H7N9, as the new bird flu virus had yet to show signs of human-to-human transmission, it did warn that the government's credibility was on the line.

"If there is anything that SARS has taught China and its government, it's that one cannot be too careful or too honest when it comes to deadly pandemics.

http://www.voafanti.com/gate/big5/www.voanews.com/content/reuters-china-mobilizes-to-fight-new-bird-flu-japan-hk-on-guard/1634556.html

Flu experts across the world are studying samples isolated from the patients to assess the human pandemic potential of the strain

April 4, 2013

China Mobilizes to Fight New Bird Flu; Japan, HK on Guard


Excerpts:

In Japan, airports have put up posters at entry points warning all airline passengers from China to seek medical attention if they suspect they have bird flu.
-snip-

In Hong Kong, authorities activated the preliminary "Alert Response Level" under a preparedness plan for an influenza pandemic, which calls for close monitoring of chicken farms, vaccination, culling drills, and a suspension of imports of live birds from the mainland.

All passengers on flights in and out of Hong Kong were being asked to notify flight attendants or airport staff if they were feeling unwell.

Vietnam said it had banned poultry imports from China,  citing the risk from H7N9.
  
http://www.voafanti.com/gate/big5/www.voanews.com/content/reuters-china-mobilizes-to-fight-new-bird-flu-japan-hk-on-guard/1634556.html 

World Experts Debate Case for New Bird Flu Vaccine

Reuters

The next contagion







analysis of the genes of these viruses suggested that although they have evolved from avian viruses...

No vaccine currently available for human infection with H7N9: WHO
Excerpt:
4/5/13
 To date, China has confirmed 14 H7N9 cases and five have died.

More than 400 close contacts of the confirmed cases are being closely monitored. Thus far, none of them have developed any symptoms of illness, according to the WHO. "At this time there is no evidence of ongoing human-to-human transmission," it said.

The WHO said it was yet to know the reason for the virus to infect humans. However, analysis of the genes of these viruses suggested that although they have evolved from avian viruses, they showed signs of adaption to growth in mammalian species.

These adaptations included an ability to bind to mammalian cells, and to grow at temperatures close to the normal body temperature of mammals, which is lower than that of birds, it said.


http://www.shanghaidaily.com/article/article_xinhua.asp?id=134895

Commentary on #H7N9 Avian Influenza Outbreak

A few points:

  • Poultry Culls order in Wholesale Market [Huhuai wholesale market in Songjiang District]
  • Shanghai Two Markets Suspend Poultry Sales:  Minhang District - Jingchuan and Fengzhuang
  • A Contact of Deceased Confirmed Case is symptomatic (fever, runny nose) - The case is the 52(F) from Shanghai, adm. to Huashan Hospital, Date of Death: 4/3/13.  The contact is in quarantine.  
  • No vaccine currently available for humans
  • Total of 14 cases (confirmed)
  • Total of  6 Deaths
  • Total of 7 Critical Condition
  • 1 is recovering, satisfactory condition
  • The WHO said it was yet to know the reason for the virus to infect humans. However, analysis of the genes of these viruses suggested that although they have evolved from avian viruses, they showed signs of adaption to growth in mammalian species.

    These adaptations included an ability to bind to mammalian cells, and to grow at temperatures close to the normal body temperature of mammals, which is lower than that of birds, it said.

Poultry cull ordered at Shanghai market #H7N9

4/5/13
SHANGHAI'S agriculture commission yesterday ordered the immediate shutdown of the poultry trading area at the Huhuai wholesale market in Songjiang District and the slaughter of all poultry there.

Earlier, the H7N9 bird flu virus had been detected in pigeon samples taken from the market, the Ministry of Agriculture said.

They tested positive at the national avian flu reference laboratory.

The agriculture commission also ordered thorough disinfection and suspension of poultry sales at two markets in the city's Minhang District - Jingchuan and Fengzhuang - where a similar H7 flu virus had been detected, and stricter monitoring of poultry trading areas.

One contact of dead Shanghai #H7N9 patient shows flu symptoms

2013-4-5
SHANGHAI, April 5 (Xinhua) -- A person who had close contact with a dead H7N9 bird flu patient in Shanghai has been under treatment in quarantine after developing symptoms of fever, running nose and throat itching, local authorities said late Thursday.

So far, China has confirmed 14 H7N9 cases -- six in Shanghai, four in Jiangsu, three in Zhejiang and one in Anhui, in the first known human infections of the lesser-known strain. Of all, four died in Shanghai and one died in Zhejiang.

#H7N9: CHP Announcement: Notification of three more human cases of H7N9 in Shanghai

Hong Kong (HKSAR) - The Centre for Health Protection (CHP) of the Department of Health received notification from the National Health and Family Planning Commission (the Commission) tonight (April 4) concerning three more confirmed human cases of influenza A (H7N9).

A CHP spokesman said the three cases involved a 67-year-old woman, who is in critical condition; a 4-year-old boy, who is in satisfactory condition; and a 52-year-old female patient who passed away yesterday (April 3).

Laboratory tests on the three patients' specimens by the Mainland health authorities yielded a positive result for H7N9.

According to the Commission, no epidemiological link between the three cases was identified. So far, except a close contact of the 52-year-old female patient developed fever and runny nose, no abnormality was detected among the other 51 close contacts of three cases.

The spokesman said that influenza A (H7) is a statutorily notifiable infectious disease in Hong Kong. The CHP is maintaining close liaison with the Mainland health authorities to obtain more information on the cases.

"We will heighten our vigilance and continue to maintain stringent port health measures in connection with this development," the spokesman said.

The spokesman also advised travellers especially those returning from Shanghai, Anhui, Jiangsu and Zhejiang with respiratory symptoms to wear facial masks and seek medical attention and reveal their travel histories to doctors.

Source: HKSAR Government

#H7N9: CHP Announcement: 64(M) Zhejiang Died; 48(M) Shanghai Died

Hong Kong (HKSAR) - The Centre for Health Protection (CHP) of the Department of Health received notification from the National Health and Family Planning Commission (the Commission) today (April 4) concerning two confirmed human cases of influenza A (H7N9).

A CHP spokesman said the case in Zhejiang was a 64-year-old man, who passed away today. As regards the case in Shanghai, the 48-year-old male patient died yesterday (April 3).



Laboratory tests on the two patients' specimens by the Mainland health authorities yielded a positive result for H7N9.

According to the Commission, the 48-year-old man was a poultry worker. No epidemiological link between the two cases was identified.

So far, no abnormality was detected among the 63 close contacts of two cases.

The spokesman said that influenza A (H7) is a statutorily notifiable infectious disease in Hong Kong. The CHP is maintaining close liaison with the Mainland health authorities to obtain more information on the cases.



"We will heighten our vigilance and continue to maintain stringent port health measures in connection with this development," the spokesman said.

The spokesman also advised travellers especially those returning from Shanghai, Anhui, Jiangsu and Zhejiang with respiratory symptoms to wear facial masks and seek medical attention and reveal their travel histories to doctors. Health-care professionals should also pay special attention to those travellers who might have contact with birds or poultry in the four places.

Source: HKSAR Government

Additional three cases of human infection with the #H7N9 avian flu cases in Shanghai

Translation out of China:
4/4/13

Additional three cases of human infection with the H7N9 avian flu cases in Shanghai] As at 21:00 on the 4th, diagnosed three cases of human infection with the H7N9 avian influenza. The city of 6 patients 4 deaths, a 4-year-old children in the other two patients, condition minor recovering. 3, 2 patients were Tongji Hospital, Huashan Hospital, died a death, and the 4th has confirmed human cases of infection with the H7N9 avian flu.

http://news.ahwang.cn/china/20130404/1263681.shtml

14 Cases #H7N9; Virus Found in Pigeons Around Marketplace in Songjiang District Shanghai

Excerpt:


So far, China has confirmed 14 H7N9 cases -- six in Shanghai, four in Jiangsu, three in Zhejiang and one in Anhui, in the first known human infections of the lesser-known strain. Of all, four died in Shanghai and one died in Zhejiang.

China's Ministry of Agriculture said Thursday the H7N9 avian flu virus has been detected from pigeon samples collected at a marketplace in Songjiang District of Shanghai.

After gene sequence analysis, the national avian flu reference laboratory concluded that the strain of the H7N9 virus found on pigeons was highly congenetic with those found on persons infected with H7N9 virus.
 http://news.xinhuanet.com/english/china/2013-04/04/c_132285178.htm

China Reports 5th Death from #H7N9

Excerpt:
4/4/13
SHANGHAI, April 4 (Xinhua) -- Authorities in Shanghai said Thursday night that another person has died from H7N9 bird flu, bringing the death toll from the new deadly strain to five around the country.

The city has reported six infections to date, and four have died, said the Shanghai Municipal Health and Family Planning Commission.

Of the rest two, there was a four-year-old, the agency said. The baby was recovering from mild illness, it added.

The person died at Huashan Hospital on Wednesday and was confirmed infected with the H7N9 strain on Thursday. The commission gave no further information on the latest case.

Continued:  http://www.shanghaidaily.com/article/latest.asp

Cambodia Case List H5N1

This list is located on the right side-bar for future reference.

Cambodia

Report Date/Province/District/ Con. Date /Name/DOD
Jan 27/Kampong Speu/Kong Pisei/1-23/35(M)/DOD 1-21
Jan 27/Takeo/Prey Kabass/1-22/15(F)/DOD 1/21
Jan 27/Phnom Penh/Porsenchey/1-22/8(mos)/Recovered
Jan 28/Kampong Speu/Kong Pisei/1-26/17(mos)/DOD 1-28
Jan 29/Kampot/Teouk Chhou/1-28/9(F)/DOD 1-28
Feb 8/Takeo/Prey Kabass/1-22/5(F)/DOD 2-7
Feb 13/Kampot/Angkor Chey/2-11/3 (F)/DOD 2-13
Feb 21/Kampot/Angkor Chey/2-19/2 (M)/DOD 2-19
Feb 26/Kampong Cham/Trung Trang/2-23/35(M)/DOD 2-25
Apr 3/Kampot/Phnom Penh/4-2/6(M)/


Kampong Speu​
Date 1/27/13
Name:  35(M)
From: 
Trapeang Sla village, Preah Nipean commune,  Kong Pisey district, Kampong Speu
Onset:  1/13
Adm:  Treated by private practioner
Adm:  1/21
Hospital:  Khmer-Soviet Friendship Hosp. Phnom Penh, sym's fever, dyspnea
DOD:  
1/21
Notes:  Prepared sick chicken for food prior to being sick.
Confirmation:  1/23/13 - Positive
Takeo
Date:  1/27/13
Name:  15(F)
From: 
Snao village, Prey Kabass district, Takeo Province
Onset:  1/11/13
Adm:  Treated by private practioner.
Hospital:  Kantha Bopha
Adm:  1/17/13 sym's fever & shortness of breath.
DOD:  1/21/13
Notes:  Previous dead poultry in village.  Prepared sick chicken for food prior to being sick.
Confirmed:  1/22/13 - Positive

Phnom Penh
Date:  1/27/13
Name:  8 month male
From: 
Chrey Korng Village, Sangkat Chorm Chao, Khan Porsenchey district, Phnom Penh
Onset:  1/8/13
Hospital:  National Pediatric Hosp.
Adm:  1/9 sym's fever, cough, runny nose, vomiting.
Notes:  Samples sent on 1/11.  History of contact with poultry.
DOD:  survived and recovered
Confirmed:  1/22/13 - positive
Kampong Speu
Date 1/28/13
Name:  17 month girl
From:  Kong Pisei district,
Prey Nhat commune, Kampong Speu
Onset:  1/13, fever, runny nose, vomiting
Adm:  private practitioner
Adm: 
1/17 fever, cough, somnolence & dyspnoea 
Hospital: Kantha Bopha Phnom Penh
Notes:  Recent poultry death in village.  Contact with poultry.
DOD:  1/28
Confirmed:  Positive 1/26
Kampot Province
Date 1/29/13
Name:  9 yo girl
From:  Thmei village, Thmei commune, Toeuk Chhou district, Kampot Province
Onset:  1/19, fever, cough
Adm:  Initially treated by a private practitioner
Adm:  1/27
Hospital:  Kantha Bopha with fever, cough, somnolence and dyspnoea
DOD:  1/28
Notes:   Poultry dead around village.
Confirmed:  Positive - 1/28

Takeo Province
Date  2/8/13
Name:  5 yo female
From:  Angk Krasang Village, Prey Lvea commune, Prey Kabass district, Takeo Province.
Onset:  1/25
Adm:  local private practitioner
Adm:  1/31 with fever, cough & dyspnoea
Hospital:  Kantha Bopha Hospital
Confirmed:  Positive, diagnosed on 2/7
DOD:  2/7
Notes:  recent deaths of poultry in village.  Touched & ate dead chicken. 

Kampot Province
Date:  2/13/13
Name:  3 yo female
From:  Trapeang Kamphleanh village, Ang Phnom Toch commune, Angkor Chey District, Kampot Province
Adm:  2/6
Hospital:  Kantha Bopha Hospital, fever, abdominal pain, drowsiness
Onset:  2/3 red rash, initially treated by private practioner
Notes:  Recent death of poultry in village, history of contact.  Critical Condition w/severe breathing problems.
Confirmation:  2/11/13
DOD:  2/13/13

Kampot Province
Date:  2/21/13
Name:  20 month old male
From:  Ang Romduol Village, Angkor Chey commune, Angkor Chey district, Kampot Province
Onset:  2/6, runny nose & fever.  Treated by local private practioner.
Adm:  2/18 Kantha Bopha Hospital, Phnom Penh with fever, cough, dyspnea
Confirmation:  2/19/13
DOD:  2/19/13 (18 hours after admission)
Note:  Poultry death in Village.  Eighth death this year.  29th person to become infected.  26th to die.  Of the 29 confirmed Cases, 20 were children under 14.  19 of the 29 were Female.



Kampong Cham Province
Date:  February 26, 2013
Name:  Thoeun Doeun (35) (Male)
From:  Kbl Ou Village, Me Sar Chrey commune, Stueng Trang, Kampong Cham Province
Onset:  2/8  fever; worsened on 2/10 w/frequent cough, dypsnea
Adm:  Local practitioner
Adm:  2/13 Kampong Cham Hosp.  Treated with Tamiflu
Adm:  2/19, Hospital Benh Calmete, Phnom Penh  (MOH Statement says 2/21)  Developed pneumonia
Notes:  Contact with dead Ducks and eating. 
Confirmation:  Positive on 2/23/19
Phnom Penh site:  Onset:  2/6; Health Clinic 2/13; & adm to Provincial Hosp. immediately, adm Calmette Hosp 2/22.
DOD:  2/25

Kampot Province
Date:  4/3/13
Name:  6 (M)
From:  Phnom Penh, Kampot Province
Onset:  Fever, convulstions, shortness of breath
Adm:  3/31 Kantha Bopha Hospital, Phnom Penh
Note:  Critical condition.  Not known if contact with poultry.

#H5N1: Cambodia Latest Victim Update

Excerpt:

The boy developed fever, convulsions and dyspnea (shortness of breath) on March 27, and his mother had bought some medicines from a local pharmacy for him until his condition worsened. The boy was sent to the Kantha Bopha Hospital in Phnom Penh on March 31.

"Currently, the boy is in a critical condition," the statement said Thursday, adding that it is not known whether the boy had direct contact with poultry.

Full article:  http://www.shanghaidaily.com/article/article_xinhua.asp?id=134818

Shanghai: City zoo, parks on alert for bird flu

Excerpt:
By Hu Min  |   2013-4-4

THE Shanghai Zoo is stepping up monitoring and sterilization of areas where birds live following a number of human infections of a lesser-known strain of bird flu in the country, the zoo operator said yesterday.
-snip-
The zoo's birds are given vaccines for other strains of bird flu on a regular basis, officials said. There are no vaccines for the H7N9 strains.
-snip-
The management office at People's Square said no symptoms of bird flu had been found among pigeons at the square.

An official surnamed Fu said over 600 pigeons are given a vaccine for other bird flu strains at birth and once a year.

Century Park officials said about 950 pigeons just received vaccines in March, and daily cleaning and disinfection are being conducted.

http://www.shanghaidaily.com/nsp/Metro/2013/04/04/City%2Bzoo%2Bparks%2Bon%2Balert%2Bfor%2Bbird%2Bflu/