Wednesday, February 8, 2012

Nature International Journal of Science: Facing up to flu

Facing up to flu

Nature 482, 131
(09 February 2012)
doi:10.1038/482131a
Published online

The potential for mutant-flu research to improve public health any time soon has been exaggerated. Timely production of sufficient vaccine remains the biggest challenge.

Amid the scientific controversy over lab-created strains of the H5N1 avian influenza virus that can skip between mammals, it is easy to lose sight of an important public-health question: what will help the wider world to prepare for a flu pandemic? The question is crucial, because when it comes to setting priorities, the fuss over how to regulate the controversial research must not be allowed to distract from a much bigger concern. The world is ill-prepared for a severe flu pandemic of any type. In particular, it cannot yet produce enough vaccine to protect more than just a small proportion of people.

[Click on Title for full article]

WHO: Vietnam 26 yo Confirmed #Birdflu #H5N1 #avian influenza

The Ministry of Health (MoH) has announced a confirmed case of human infection with avian influenza A (H5N1) virus.

The case was a 26 year-old pregnant female from Soc Trang province. She developed symptoms on 23 January 2012, and was admitted to hospital on 25 January. She was treated with Oseltamivir on 27 January, she died on 28 January. Confirmatory test results for influenza A (H5N1) were obtained on 30 January by Pasteur Institute, the WHO National Influenza Centre in Ho Chi Minh City, Viet Nam. Samples from the newborn infant of the fatal case tested negative for H5N1.

The case had slaughtered and eaten sick chickens. MoH, the local health sector and Pasteur Institute in Ho Chi Minh City are conducting epidemiological investigation and strengthening surveillance and response activities. Close contacts of the fatal case have received prophylaxis and are being monitored; to date all remain well. The Department of Animal Health is collaborating with the human health sector.

The case is the 121st person in Viet Nam to become infected with the H5N1 virus. To date, 61 of these cases have died from complications of the disease.

Indonesia: Suspect Bird Flu Patient Dies

Excerpt:

He says, patients had no history of direct contact with dead poultry.
However, behind the house there are patients who keep ducks neighbors. "SA does not have a history of contact with poultry mati.Tapi, SA with his family had experienced the flu, but had recovered. Therefore, patients designated as suspect bird flu, "he said.

Certainty of patients tested positive for bird flu or Avian Influenza H5N1 is still waiting for a new laboratory test results are sent Monday (6/2) and the Research and Development in Jakarta.

SA will be buried to a TPU Ciburuy, day ini.Keluarga absolutely not allowed to see or approach the corpse SA. While the patient is bathed by a special officer.

The man who works as a newspaper deliveryman had a wife and two children.
Primal added, the team of doctors headed by Emmy Herniyati Flamboyan Pranggono have coordinated with the Health Office (DHO) and the West Java city of Bandung (West Java) to check the location of the patient's home.

Head of Development and Environmental Health Office of Disease Prevention Dr. Fita Rosemary Jabar said the suspect cases of SA became the first in 2012. "This year was the first (for cases of suspected bird flu)," said Fita.

While in the past year, positive cases of avian influenza in humans occur as many as four cases, three of whom died suspect.

According Fita, preparedness against bird flu has been carried out since two weeks ago. It was, further Fita, since similar cases have occurred in Tangerang. "There are already two weeks ago, we've made ​​have made ​​a circular letter to the district health office / town for bird flu preparedness. In addition, dengue fever, cikungunya, and others, "he added.  huyogo Simbolon

Indo/Central Java: Bird Flu Alert Java-High Potential Transmission to Humans #H5N1 #Birdflu

Wednesday, 08 February 2012
Semarang - Central Java Community asked to remain vigilant against the spread of bird flu virus.Therefore, the virus avian influenza (AI) that can be transmitted from birds to humans.

Head of Disease Prevention and Environmental Health (P2PL) Central Java Provincial Health Office Dr. Djoko Mardijanto added, as long as there are cases of bird flu in poultry, the potential transmission to humans remains high. "We have to communicate with the health department in each region, including the regional hospital , "he said yesterday. To prevent bird flu can be done by implementing good governance poultry.

Namely, the cage should be much the settlement, the cage should be clean, well ventilated, enough sunlight to keep it dry. "From his own people should behave in healthy living, including washing hands with sabun.Bisa reduce direct contact, so as not infected with H5N1 virus," said Djoko Mardijanto.Deaths from bird flu is suspected, further Djoko, biasanyalebihdisebabkanolehdeteksi late.

Because the case is similar to ordinary flu, which is crowded napasdanbiasanya tidakmenyerang differentiate directly to farmers. Instead of ordinary people who die are usually experienced as a seamstress from Manila in 2005. In 2011 and no deaths, despite the findings of bird flu. Was in 2010 one person died in Sukoharjo.

"Cases of bird flu in Central Java is similar to the Capital Jakarta.Rata average every year that passed 1-2 people," he explained. Head of Central Java Provincial Health Office Dr. Anung Sugihantono asked the residents to not underestimate the flu symptoms, especially if the surrounding area there is the death of poultry in large quantities suddenly.

"If you had the flu not long ago after the sudden death of poultry, is expected to immediately check into the nearest health center or health care," he explained connection with it, it has been socialized to all districts and cities, especially the area of ​​bird flu, such as Wonosobo, Sragen , Jepara, Cilacap, Brebes and Tegal.

DHO also been reminded to each referral hospital to be ready to accept the case flu burung. "In the department of Dr. RS Moewardi Kariadi and drug ada.Mudah I hope there are no cases of influenza (bird flu)," he explained.  wise purniawan / hendrati Hapsari

Indonesia's Classification of Human Bird Flu is Unprincipled

"In 2011 there were eight people with bird flu supsek, but after the treatment was positive for the H5N1 virus, was until early 2012 there was no suspect AI,"
http://tinyurl.com/86lcgb2

Indonesia classifies their confirmed cases after they have been on Tamiflu and have returned a negative result. Only when they arrive too late and die, are they confirmed "positive" of H5N1 Bird Flu.

They go into the hospital sick, having all the correct signs, being around infected poultry, or, another person who is "suspected". They get put on Tamiflu, after 3 more days, they get tested again, and usually it returns a Negative result. And that is what the Authorities record.

Then you read articles like this...and shake your head....

Based on data from Central Java health office, during 2005-2011 recorded 120 persons declared suspected bird flu, but who tested positive for avian influenza (AI) as many as 14 people. Of the 14 men, 13 died. With details of 2006 as many as three persons, 2007 as many as five people, three people in 2008, 2009 and 2010 of each one.

Vietnam: 2 Confirmed Cases Died 5-6 Days From Onset of Sym's

Dr Nguyen Van Kinh, director of the Tropical Disease Hospital Central (Hanoi) said: From the onset of illness until hospitalization, 2 patients did not receive immediate treatment with Tamiflu is only when severe new drug, it is then too late. Meanwhile, in the first 3 days of early diagnosis, if the dose is doubled risk of death much reduced.

He therefore recommended Glass: "If you suspect the flu, Tamiflu should be used immediately. We have no shortage of drugs, the problem is not detected early, avoid the risk of death ".



Mr. Nguyen Trong Khoa, Deputy Director of medical management agrees with this view and said the two deaths,
from the onset of disease until treatment regimen H5N1 flu take up to 4 days, 5-6 days after the victim died. Not to mention the disease rapidly changes, and another is pregnant.



Also this excerpt:
Specifically, the first patients confirmed with H5N1 have died after signs of disease and 6 days.
Case 2 also visits two times at the hospital and was prescribed Tamiful, A/H5N1 flu cure at day 5 of illness.
http://tinyurl.com/759fhqt


From my list:
I see I have a discrepancy between an article, and the WHO. But the WHO date would coincide with the statement in the article above. Both cases died within 5-6 days of onset.


Hau Giang Province

Date: 1/19

Name: N 18 yo male

From: Kien Giang Province. Employed in Hau Giang. Duck Farmer

Adm: 1/10 Kien Giang Hospital, sent specimen out. (WHO: 1/14)

Onset: 1/10

DOD: 1/19 (WHO: 1/16)

Notes: (test results received 1/17)

WHO Update 1/20/12.

Confirmed: Positive


Soc Trang Province

2/1/12 Confirmed Human Case
Name: Female (26)
From: ti p B1,Tan Thanh Commune, District: Thanh Tri
Onset: 1/23 fever, cough
Adm: 1/25 Bac Lieu Province
Recon: 1/23 Thanh Tri district hospital
DOD: 1/28

Notes: Patient was slaughtering and eating infected meat, in areas of sick dead poultry.
Confirmed: Positive


Vietnam: Bac Lieu Province Poultry suspected #H5N1 #Birdflu

Bac Lieu is located at the extreme Southern tip of Vietnam, indicated on the map by the blue postmark tabbed "A". You can see how close it is to our other confirmed and suspected human cases.
Click on map to enlarge.

http://maps.google.com/maps/ms?msid=203813299286646113648.0004b615b3bee87f2d7ad&msa=0&ll=9.841686,106.083984&spn=1.90234,2.688904

Excerpt:
(TNO) the Veterinary Department of Bac Lieu Province said recently detected in clusters of Economics, P.Nha Mat, 200 TP.Bac Lieu of a household ducks died of unknown causes. Bac Lieu province is allocated 1 million doses of flu vaccine for poultry districts in the province prevention.

Excerpt:

According to MARD, from early 2012 to date on avian influenza H5N1 has reappeared in Quang Tri, Thanh Hoa and Soc Trang. In addition, Thai Nguyen, Bac Lieu, Ha Noi, Nghe An, Kien Giang has suspected bird deaths due to H5N1 avian influenza. Ministry of Agriculture and Rural Development will receive a new outbreak of H5N1 influenza outbreak on a large scale.
http://tinyurl.com/84dm87e

Vietnam: Poultry #H5N1 #Birdflu in Bac Kan Province

Red Postmark with "A". Extreme northern Vietnam. Click on map to enlarge.

Excerpt:
Love In An commune, Na Ri district (Bac) had 2109 birds, waterfowl infected with H5N1 flu, concentrated in four villages: Coc Phja, Leng Na, Na Mu looks and General, Social pulsar.The province has decided to publish H5N1 bird flu in this community and organizations on the number of birds destroyed.


Original:
Tại xã Ân Tình, huyện Na Rì (Bắc Cạn) đã có 2.109 con gia cầm, thủy cầm bị nhiễm cúm H5N1, tập trung ở bốn thôn, bản: Cốc Phja, Nà Lẹng, Nà DườngThẳm Mu, xã Ân Tình. Tỉnh đã có quyết định công bố dịch cúm gia cầm H5N1 tại xã này và tổ chức tiêu hủy số gia cầm trên.

Tuesday, February 7, 2012

No way of stopping leak of deadly new flu, says terror chief #H5N1 #BIRDFLU

US biosecurity board expert warns against details of H5N1 bird flu getting into wrong hands


Suspect Bird Flu Patient Dies #H5N1 #BIRDFLU

Wednesday, 08 February 2012
Suspect Bird Flu Patient Dies
BLK. FACTORY, (GM) -
Patient suspect bird flu (H5N1), SA (37), a resident of Kampung Mengger Girang, Village Pasirluyu, Regol District, City of London passed away in the Bubble Flamboyan, Hasan Sadikin Hospital (RSHS) at 16:35 GMT, Tuesday (7/2) . For the incident, the Public Health in collaboration with the Department of Agriculture directly conduct direct investigations in the region where the suspect lived.
According to spokesman Tim RSHS war on bird flu, dr. Primal Sudjana, SA patients undergoing treatment at the entry and RSHS Flamboyan Space Monday (6/2). Previous patient care at hospitals run Sartika Mercy."When you get to RSHS, the patient was in critical condition with severe respiratory symptoms experienced. Even pneumonia is declining rapidly and the patient suffered respiratory failure. Therefore, was fitted with a ventilator," he said.
Primal is added, the patients were referred from other hospitals ruamh. SA comes to RSHS, Monday (6/2) at 11.00. When it comes the condition of fever, shortness of breath, flu, and pneumonia or critical (worse, red).

"In addition, the victim had respiratory failure and liver failure. Based on the information, SA previously had contact with dead birds. SA does not have poultry at home, but neighbors in the back of the house there is a free poultry or chicken," he said.
Described, when entered Flamboyan Space, SA directly fitted ventilator. But because she was critical, SA is not beyond help and died Tuesday at around 16:30 pm.

Regarding the examination, Primal said already took samples for examination in the laboratory smear. However, based on information from the patient's family, mentioned no history of contact with poultry. Any family member who had flu symptoms but recovered and healthy.Investigation

Head of Health Office Bandung, dr. Achyani Raksanagara said, according to a report of RSHS, rapid test performed in patients with SA turned out negative. But for the rapid examination of the second test is still awaiting the results.
"However, according to our procedure has kept the patient's status as a suspect SA, which is using the crate when it will be buried," he said by telephone.
While awaiting the results of a second rapid test, he continued, rapid steps carried out by direct coordination with the Department of Agriculture. Health Office has lowered the officers to conduct investigations in humans / citizens to know for sure if there is contact with poultry. Even to be given counseling to improve alertness and healthy and clean life behavior (PHBs).
"As for poultry or livestock, which will conduct the examination of Department of Agriculture. DHO priority to residents," he explained.
About the radius of the examination, not restricted. "The information from the patient's family had no contact with poultry. But we need to gather as much information as possible so appropriate," he said.
Suspect cases of bird flu was the first time in the city of Bandung in 2012. Previously, the bird flu case was not heard again. But the health office has actually been increasing kewaspaan when it appeared a few months cases of bird flu in Bali and Jakarta  http://www.klik-galamedia.com/index.php?id=201202080931273

Vietnam: Children infected flock crowded hospital

After Tet, more than 4,000 children every day to visit and more than 1,000 hospitalized cases 1 and 2 Children in Ho Chi Minh City, most gastrointestinal illness, respiratory and infectious diseases.


Patients hospitalized at Children's Hospital 1 is transferred to a ward. Photo: Thien Chapter
Patients hospitalized at Children's Hospital 1 is transferred to a ward. Photo: Thien Chapter

Recognition of pv at Children's Hospital on 3 1/2, the faculty at Children's Hospital were filled with patients first. Is the largest gastroenterology, respiratory and infection - Neurology.

Gastroenterology doctors said many patients hospitalized after Tet. Mainly due to diarrhea, dysentery, gastrointestinal disorders and food poisoning. Every day this department has more than 100 cases of hospital treatment.

Of Respiratory and no less crowded with more than 150 children in the department store, in which many children with bronchiolitis and pneumonia. Infection Doctors - Neuro also said that patients gradually east from the 4th Year.

Cause of hospitalization of patients examined and east, according to doctors is due on New Year babies are not brought to medical attention because of intolerance to a hospital, or not see serious illness parents should not give in to the hospital.

"From the 6th Year to date, patients presenting a progressive increase. Not much in the rainy season, but every day from 4000 to 4500 also to check the case and more than 1,000 children were hospitalized," Dr. Nguyen Thanh Hung, Deputy Director of Children's Hospital 1 said.

2 Children's Hospital, Dr. Truong Quang Dinh, average per day after New Year are over 4,000 children turn their parents to visit. The number of children hospitalized every day about 1,000 children.

"Pediatric patients are scattered in the department, but the digestive disease, respiratory more still. Of which still have many problems and complications because her hand, foot and mouth disease," Dr. Dinh said.

Morning 4/2, even on weekends, the clinic's Hospital nghit 2 still frozen. Nearly half of patients from Binh Thuan, Tay Ninh, Dong Nai, Ba Ria - Vung Tau. The rest are children in HCMC.

Recorded at the clinic showed that fever, cough, diarrhea, viral infection, bronchitis is the most common. Of which not less than 5 days sick children new parents sent to hospital just to check that has been designated hospital.

Affirming children susceptible to respiratory diseases, gastrointestinal and infectious diseases of the day after New Year, Dr. Nguyen Thanh Hung in a Children's Hospital advised parents should keep children warm, attention in food hygiene and should full vaccination for children.

"When children with prolonged fever, taking over 2 days still no relief should be taken to the nearest medical facility for examination," Dr. Hung said.

Vietnam: Emergency bird flu prevention

MARD Minister Cao Duc Phat has sent urgent work in the country of urgent work to prevent bird flu is back and dangerous events.


Currently, all provinces from south to north there are many poultry disease and death, mainly in ducks and chickens. Figures from the Ministry of Health, there are two cases of patients in Kien Giang and Soc Trang died of A/H5N1 flu.

Avian influenza evolution of increasingly complex. Many places in the North do not have appropriate vaccine, the virus that causes avian influenza could be turned. Mr. Hoang Van Nam, Director of Veterinary Department said the flu vaccine to poultry imported from China are no longer effective in the northern region. While in the south, many localities to "EM" bird flu information to keep achievements in emulation.

MARD requested the specialized agencies urgently need to find appropriate vaccines to prevent avian influenza virus denaturation

Vietnam: Set up seven working groups to check bird flu prevention

Associated Press - 2 hours 43 minutes ago

TT - At the meeting the Steering Committee for prevention of avian influenza and foot and mouth 7-2 pm, Pham Van Dong - Deputy Director of Veterinary Department (Ministry of Agriculture and Rural Development) - has made up of seven missions to test the prevention of avian influenza caused by H5N1 virus are at risk of widespread outbreaks.
According to East, in the past four weeks have been three outbreaks at Soc Trang, Quang Tri and Thanh Hoa.

Mr. Nguyen Thanh Son - Deputy Director of Animal Husbandry (Ministry of Agriculture and Rural Development) - for that bird flu happened not too serious but notably over the same time, in 2011 did not happen any outbreak.

Besides the number of people infected with H5N1 virus but only two people have died and the Ministry of Health assessment stronger virulent virus. So worried wider outbreak occurs with viral transformation are unfounded.

Victim died of bird flu in a newspaper deliveryman RSHS #H5N1 #BIRDFLU


 
antara between
  BANDUNG (business-jabar.com): SA unexpectedly died of bird flu in the Flamboyant Room, Hasan Sadikin Hospital (RSHS) Bandung, Tuesday at 16:35 works as a newspaper deliveryman.
 According to Juju Komarudin, elder brother were both SA profession come into contact with poultry.  "He was inter-builders between the newspapers," he met in London on Tuesday RSHS.  Although no contact with poultry, in the back of the house there apparently SA entog neighbor's home.
  "I do not accuse, because there is no lab test results," says Juju.  Primal doctors also make sure the same thing.About contact with poultry, the family is unclear. To be sure in the back of the victim's home that nurtures entog there, "says Primal.

 According to Viking, the first SA complained of shortness of breath heavy day last week.  He then brought his family went to Sartika Mercy Hospital, Bandung. KaBecause the condition is more critical, he referred to the RSHS Monday at 11 noon. The condition (health) it was ugly," said Dr. Primal Sudjana, spokesman for Infectious Diseases Special Handling Team RSHS Bandung.
  SA is included in the critical state was unable to rescue the team doctor.  "The hospital has a maximum, is so determined to maintain (life) my brother," said 51-year-old man.
  Kampung residents Mengger Girang, Regol, Bandung is survived by his wife and two small children.  His first son was attending the third grade.  http://translate.googleusercontent.com/translate_c?hl=en&ie=UTF8&prev=_t&rurl=translate.google.com&sl=id&tl=en&u=http://bisnis-jabar.com/index.php/2012/02/korban-meninggal-flu-burung-di-rshs-seorang-loper-koran/&usg=ALkJrhhmERJCquJrF1uAyNTHX85qlj4Q-A

Vietnam Warns bird flu outbreak #H5N1 #Birdflu

08/02/2012

(HNM) - As the weather changes with the carriage trade in livestock and poultry during the Lunar New Year to rise, many localities have not been suitable for vaccine inoculation has made ​​avian influenza (CGC ) flare up again


In January, there were 2 patients in the province of Kien Giang and Soc Trang influenza virus infection and death. In this situation, 7-2 pm, MARD conference discussed measures urgent anti-epidemic.

Avian Influenza Vaccination in Long Bien District (Ha Noi).
Photo: Khanh Nguyen
Department of Animal Health (MARD), said from the beginning of the year, translate CGC broke out in four communes in 3 provinces of Thanh Hoa, Quang Tri and Soc Trang with a total of 1683 children infected poultry must be destroyed 4032 children, of which 3610 ducks and 422 chickens. There are four provinces, including Hanoi, Nghe An, Kien Giang, Thai Nguyen and Bac Lieu started the phenomenon of infected poultry, dead. However, DAH no formal epidemiological tests in these localities.

Mr. Nguyen Thanh Son, Deputy Director of Livestock identification, although the current number of bird deaths due to disease not much but there have been 2 deaths from bird flu epidemic in the provinces appear to signal output a new pandemic virus strain highly motivated.

According to Mr Son, there are many causes leading to the outbreak but is mainly due before and after Tet, the trade, movement of poultry on the nationwide surge has created many loopholes in the work quarantine.
Weather cold weather lasting damage in the North also facilitate virus CGC development. In particular, after a long time quiet CGC service, many local to neglect, subjective with the ratio of vaccinating poultry vaccination is very low (only about 50%).

Meanwhile, animal health agencies have not yet found an effective vaccine for epidemic virus strain H5N1, clade 2.3.2 so vaccination vaccines used primarily imported from China were no longer effective.
The localities are in shortage of vaccines, Soc Trang, Ca Mau, Bac Lieu to 6 million doses of vaccine but only 1 million doses.

Previous situation CGC risk spreading, the Ministry of Agriculture and Rural Development has the urgent sending of local requirements to consolidate the steering committee of prevention and CGC, maintains briefings periodically; assigned specific responsibilities for the members in implementing the measures uniform prevention services. The provinces are at risk should be established immediately translate the inspection team urging prevention and supervising the transportation and trade of poultry, enhance safety at the point of epidemic risk such as the duck herding, slaughter poultry areas, markets ...

Pham Van Dong, Deputy Director, Department of Animal Health said, to prevent the spread of the disease, the Department has coordinated with other units of the Ministry of Agriculture and Rural Development set up seven groups interdisciplinary inspection to check and the main some local authorities to monitor the outbreak, and to direct the unit members timely sample to find out which vaccines offer appropriate and effective, not to a large scale epidemic . However, immediate measures is, the animal health agencies to coordinate with the local authorities immediately conduct vaccination 1st 2012 CGC for 13 southern provinces.

Currently, there is still a new virus strain CGC no effective vaccine. Therefore, MARD will direct the research of professional agencies to find alternative vaccines to prevent virus and denatured by CGC prevention and effective. However, in the opinion of many participants in the conference, if in case of outbreak back to the new strain, Veterinary Department should expedite the trial production to serve the local prevention services.In addition, Vietnam can order the new vaccines on the injection of foreign countries instead of waiting for test current study.

Ebola Virus 3D Model: Staring Death in the Face #H5N1 #BIRDLFU


February 6th, 2012
by: Range
Made famous by its deadliness, the Ebola virus was first described in 1976. It was made famous by The Hot Zone by Richard Preston and some small epidemics that thankfully didn’t kill off most of the planet. While it never reached the epidemic levels feared, it’s still interesting to check out the intricacies of this 3D model of the deadly virus.
ebola virus poster 01
This intricate 3D model was done by Visual Science and it’s based on X-ray analysis and data that was published in the last twenty years. Some of the protein structures were predicted using computer modeling techniques.
ebola virus poster 02
This new model is 10 times more complex than the last one they did of HIV, which is kind of astounding. Where can I print mine?
ebola virus poster 03
[via designyoutrusthttp://technabob.com/blog/2012/02/06/ebola-virus-3d-model/