Wednesday, June 26, 2013

WHO - Middle East respiratory syndrome coronavirus (MERS-CoV) - update 6/26/13

The Ministry of Health (MoH) in Saudi Arabia has announced seven additional laboratory-confirmed cases and a death in a previously confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV). 

Four cases have been detected among contacts of confirmed cases in Riyadh and the Eastern Region. They range in age from seven to 15 years, and all were asymptomatic. Two further asymptomatic cases have been record among female healthcare workers in the Eastern Region and Al-Ahsa. A seventh case has been detected in a 50 year-old female in the Eastern Region. She is currently hospitalized with pulmonary disease and her condition is considered stable.

In addition, the MoH has announced the death of a previously reported confirmed case from the Eastern Region (the 32 year-old male first reported on 23 June).
Globally, from September 2012 to date, WHO has been informed of a total of 77 laboratory-confirmed cases of infection with MERS-CoV, including 40 deaths. 

WHO has received reports of laboratory-confirmed cases originating in the following countries in the Middle East to date: Jordan, Qatar, Saudi Arabia, and the United Arab Emirates (UAE). France, Germany, Italy, Tunisia and the United Kingdom also reported laboratory-confirmed cases; they were either transferred there for care of the disease or returned from the Middle East and subsequently became ill. In France, Italy, Tunisia and the United Kingdom, there has been limited local transmission among patients who had not been to the Middle East but had been in close contact with the laboratory-confirmed or probable cases.
Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns.
Health care providers are advised to maintain vigilance. Recent travellers returning from the Middle East who develop SARI should be tested for MERS-CoV as advised in the current surveillance recommendations. Specimens from patients’ lower respiratory tracts should be obtained for diagnosis where possible. Clinicians are reminded that MERS-CoV infection should be considered even with atypical signs and symptoms, such as diarrhoea, in patients who are immunocompromised.
Health care facilities are reminded of the importance of systematic implementation of infection prevention and control (IPC). Health care facilities that provide care for patients suspected or confirmed with MERS-CoV infection should take appropriate measures to decrease the risk of transmission of the virus to other patients, health care workers and visitors.
All Member States are reminded to promptly assess and notify WHO of any new case of infection with MERS-CoV, along with information about potential exposures that may have resulted in infection and a description of the clinical course. Investigation into the source of exposure should promptly be initiated to identify the mode of exposure, so that further transmission of the virus can be prevented.
WHO does not advise special screening at points of entry with regard to this event nor does it currently recommend the application of any travel or trade restrictions.
WHO continues to closely monitor the situation. 
http://www.who.int/csr/don/2013_06_26/en/index.html 

Oman - No Cases of #MERS #Coronavirus

Junee 26, 2013
Excerpt:

In Oman, the Department of Communicable Disease Surveillance and Control at the Ministry of Health, Oman, has identified the south of Oman (Dhofar) as a high-risk area where nCoV infections could occur because of the climate, overpopulation, and the different types of animals in the region.

To date, however, there have been no cases of nCoV infections in Oman. "We have tested more than 90 people and have not found any positive cases," a senior official said.

Between June 10 to 16, officials identified 12 suspected cases of coronavirus in different parts of the country, but there were no positive cases.

"From Muscat, there were five cases, two from Dhofar, Sharqiyah, and Dhahirah, and one from North Batinah, but there are no positive cases," a senior official at the Ministry of Health (MoH) said.

Further, from June 3 to 9, 12 people with suspected cases were admitted to different hospitals across the country. But these did not develop into the coronavirus.



An international team of doctors who investigated a large number of cases in eastern Saudi Arabia found nCoV has some striking similarities to SARS.

Currently, Saudi Arabia has reported 55 cases, of which 33 were fatal. Unlike SARS, though, scientists remain baffled as to the source of nCoV.

'A distant relative'
A report in the New England Journal of Medicine said the Middle East respiratory syndrome coronavirus not only spreads easily between people, but within hospitals. That was also the case with SARS, a distant relative of the new virus.

"However, we could not nail down how it was spread in every case — through droplets from sneezing or coughing, or a more indirect route.

Some of the hospital patients were not close to the infected person, but somehow picked up the virus. In the right circumstances, the spread could be explosive," the report said.

Cases have continued to trickle in, and there appears to be a continuing outbreak in Saudi Arabia, where 33 people have been killed. Also, nCoV virus cases have been reported in the UAE, Jordan, Qatar, Britain, France, Germany, Italy and Tunisia. Most of the victims have had a direct connection to the Middle East region.

But coronavirus nCoV appears more lethal than SARS. Compared to SARS, with an 8 per cent death rate, the fatality rate for nCoV in the Saudi outbreak was about 65 per cent, though experts could be missing mild cases that might skew these figures,
noted authorities.

The incubation period for nCoV is approximately two to seven days, although in some cases it may take as long as 10 days.

Also in some cases, incubation period of up to 14 days have been reported, especially in immune-compromised patients.

Some of the signs and symptoms are high fever, headache and chills, a general feeling of discomfort and body ache.

"In some cases, patients may develop a dry, non-productive cough that might progress to a condition in which the oxygen levels in the blood become low (hypoxia) and the patient could develop pneumonia," said an official.


http://www.timesofoman.com/News/Article-18740.aspx 

MERS: Greffex Does It Again

Press Release
MERS-CoV: In one month Greffex builds an advanced vaccine against the Middle East Respiratory Syndrome coronavirus
AURORA, Colo.--(BUSINESS WIRE)--June 26, 2013-- 
A scant two months after creating the first comprehensive vaccine for H7N9 avian influenza, Greffex developed a vaccine to protect against the Middle East Respiratory Syndrome coronavirus (MERS-CoV.) The vaccine was readied in just four weeks after MERS-CoV had moved to the WHO's "alert phase" that also includes the human bird flu viruses H5N1 and H7N9. "We have big competitors who claim they can initiate vaccine production faster than we can," says Dr. Uwe D. Staerz, Chief Scientific Officer at Greffex. "That they can go from algorithm to gene synthesis in matter of days invoking synthetic biology. But after they've constructed the necessary genes, they still need several months to deliver an actual vaccine. Once we get the genetic information for a new virus, we can give you a testable vaccine in a month. Our platform is therefore ideally suited to combat fast emerging infections."

Continued:  http://online.wsj.com/article/PR-CO-20130626-903503.html?mod=googlenews_wsj

Tuesday, June 25, 2013

#H7N9 may reappear later, and spread


The researchers, from the Chinese Centre for Disease Control and Prevention (CDC) in Beijing and the University of Hong Kong, said the potential lull in H7N9 could offer health officials the chance to properly discuss and plan ahead for the possibility of the flu's return and wider spread. 

This should include plans to build healthcare capacity in the region “in view of the possibility that H7N9 could spread beyond China's borders,” they said.

“Continued vigilance and sustained intensive control efforts against the virus are need to minimise risk of human infection, which is greater than previously recognised,” they said.

http://www.iol.co.za/scitech/science/news/h7n9-may-reappear-later-and-spread-1.1536995

Death rate of #H7N9 believed to be 36%

6/25/13
Excerpt:
After making some adjustments for missing data, the Chinese scientists estimated the overall death rate to be 36 percent. The outbreak was stopped after China closed many of its live animal markets — scientists had assumed the virus was infecting people through exposure to live birds.

That makes the new strain less deadly than H5N1, which kills about 70 percent of the people it infects. Still, H7N9 is more lethal than the swine flu that caused a 2009 global epidemic. That had a death rate of less than 1 percent.

http://www.japantimes.co.jp/news/2013/06/25/asia-pacific/death-rate-of-h7n9-believed-to-be-36/?utm_source=rss&utm_medium=rss&utm_campaign=death-rate-of-h7n9-believed-to-be-36#.UcmSMOvlX_s

#MERS #Coronavirus WHO Experts Meeting Cairo Outcome: Strengthen Global Awareness...

 [this is the outcome of the meeting that took place in Cairo]
June 24, 2013
 Excerpt:
The WHO meeting on the virus, which took place in Cairo, called for continued surveillance and strengthened global awareness campaign against the virus.
The meeting acknowledged that despite no current evidence of sustained human-to-human transmission, MERS-CoV might evolve to spread quickly among humans and affect wider geographical areas.
While major knowledge gaps remain in understanding the emergence of this virus, clinical manifestations as well as the transmission risk, recent scientific research is enhancing the global knowledge on the disease.
This new knowledge now needs to be translated into a set of concrete public health actions in order to improve global and regional public health preparedness, said the WHO official.

#MERS WHO Meeting in Cairo Outcome: MERS-CoV might evolve to spread quickly among humans and affect wider geographical areas

June 24, 2013
Excerpt:

The WHO meeting on the virus, which took place in Cairo, called for continued surveillance and strengthened global awareness campaign against the virus.
The meeting acknowledged that despite no current evidence of sustained human-to-human transmission, MERS-CoV might evolve to spread quickly among humans and affect wider geographical areas.
While major knowledge gaps remain in understanding the emergence of this virus, clinical manifestations as well as the transmission risk, recent scientific research is enhancing the global knowledge on the disease.
This new knowledge now needs to be translated into a set of concrete public health actions in order to improve global and regional public health preparedness, said the WHO official.

http://arabnews.com/news/456126 

IBC Life Sciences Influenza & Coronavirus Pandemic Preparedness Conference Asia 2013

About The Conference

IBC Asia’s Influenza & Coronavirus Pandemic Preparedness Asia 2013 Conference brings together international and regional experts in one platform to review strategies and best practices to deal with a potential pandemic.
In addition, issues with establishing sustainable public-private partnerships to effectively address the looming threats of novel viruses will be critically examined.

Event Overview

The mortality rate from the MER-CoV virus has now hit 60%, with 30 deaths to date across the Middle East and now spreading to France, Britain and Germany (as at 1 June 2013).
Not only has this virus been in the news, but also the recent occurrence of H7N9, which has had 130 confirmed cases to date (as at 1 June 2013).
Most countries are armed with more experience to deal with such outbreaks than 10 years ago when there was the SARs outbreak. However, issues of rapid development and deployment of vaccines/drugs and efficient disease surveillance and control remain significant.
Hampered by insufficient understanding of the new viruses, efficient and effective contingency planning is in particular important to containing the spread of a new disease.

IBC Asia’s Pandemic Preparedness Asia 2013 Conference brings together international and regional experts in one platform to review strategies and best practices to deal with a potential pandemic.
In addition, issues with establishing sustainable public-private partnerships to effectively address the looming threats of novel viruses will be critically examined.








Monday, June 24, 2013

Researchers Say #H7N9 Incubation Period is about 3 Days

ProMED:  Avian influenza, human (88): China, H7N9, relative severity
Published Date: 2013-06-24 19:18:24
Archive Number: 20130624.1789634

A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Mon 24 Jun 2013
Source: South China Morning Post, Agence France-Presse report [edited]
http://m.scmp.com/news/china/article/1267754/h7n9-bird-flu-kills-about-third-hospitalised-patients-study-finds


The H7N9 bird flu that hit China this year [2013] killed over a third of hospitalised patients, putting the severity of the infection between that of swine A(H1N1) flu and the A(H5N1) avian virus, said researchers on Monday [24 Jun 2013]. In a study published on Monday [24 Jun 2013], University of Hong Kong researchers analysed data from most of the 132 H7N9 avian influenza patients since its emergence 3 months ago. With reference to the H1N1 swine influenza outbreak in 2009, they estimated the overall death rate of H7N9 to be between 0.16 per cent to 2.8 per cent. The rate of fatality in hospitalised H7N9 patients was 36 per cent, compared to 5 per cent to 20 per cent in the case of swine flu patients and 65 per cent in H5N1 patients in China.

"One-third hospital fatality is not a small figure. Killing of chickens and market closures may still be needed when the epidemic reappears. I believe these measures should not be relaxed," said Professor Gabriel Leung, director of the university's Public Health Research Centre who announced the findings on Monday [24 Jun 2013]. They warned watchdogs not to take comfort from a lull in new infections, as the virus may reappear in the autumn.
-snip-
"The warm season has now begun in China, and only one new laboratory-confirmed case of H7N9 in human beings has been identified since 8 May 2013. If H7N9 follows a similar pattern to H5N1, the epidemic could reappear in the autumn," they wrote. "This potential lull should be an opportunity for discussion of definitive preventive public health measures, optimisation of clinical management, and capacity building in the region in view of the possibility that H7N9 could spread beyond China's borders."

The team also estimated the virus's incubation period -- the time between infection and the onset of symptoms -- at about 3 days, shorter than previous estimates.

Continued:  http://www.promedmail.org/direct.php?id=20130624.1789634

Saudi Arabia: Private hospitals and clinics are reluctant to diagnose'' Corona''

6/24/13
Translation

Resulting panic raging recently in the province of Hasa, in particular in the Kingdom in general from the specter of HIV Corona and backlash toward the observer disease Ahsa as is the case with Discovered Kingdom who met the ministry to end services, led to the reluctance of many private hospitals for diagnosis with the virus fearing referred to as the source of the virus, especially after the bitter experience faced by a prestigious hospitals to maintain after the fact faced responsibly and discovered the first case of surprise by making such a source of the epidemic rather than gratitude.
The number of citizens appealed to the concerned authorities, led by the Ministry of Health calls upon everyone to assume their responsibility towards the fight against the virus and get away from the concealment of information on this disease infection Ochkhis as the World Health Organization announced recently.

"Al-Ahsa News" met two people lived bitter experience of suspicion "reserves the newspaper their names," he said, "Fahd" I went to a private hospital struggling death of high temperature and shortness of breath and pain in the throat and noted confusion of proceeded as I address in the private hospital and immediately told me what was not sway and the maximum what he did the doctor made ​​sure Kamamth and went out of them heading to King Fahd Hospital, which Sarhani suspicion and did the job required and thankfully I am now completed anyway. 
either "Muhammad" he says, came Carry many indications of HIV infection and once checking vital signs at a hospital antidepressants has been disbursed, antipyretic and advised me Emadat but my brother, who was accompanying me was not convinced he took me to one of the other private hospitals which treated me as a suspicion of taking the case with me all the procedures so that case proven drawbacks samples and thankfully.

On the other hand met  , "Al-Ahsa News"  some citizens respondents their opinions about those actions that are beyond humanity and honor of the medical profession, where he spoke, Mr. Maher Cjager saying that such hospitals shameful and regrets her hearts do not deserve to be on this earth generous What is the benefit of hospitals, including where doctors and medical devices unless they cooperate in the fight against this serious disease and limit the spread of the inverse, whatever the results Omah on the reputation of this hospital because very nominal medicine and the greatest attention Bhetwavh the things Fgaath is attention to the health and safety of everyone living on this earth generous.

As Mr. Khalid trainers, he said thankfully the situation is reassuring now thanks to God and the efforts of the Ministry of Health to control and reduce it after what we live in fear and panic because of the large number of speakers through the means of social communication knowledge and without knowledge. 
There gesture taken by the Ministry of Health is published preventive steps about the disease through its front page on the internet, and I hope that the ministry hold negligent health centers or private hospitals that prevented the reception of this sickness or evaded diagnosed.

For his part, has said Hani caused that such action is a far cry from Humanity and the meaning that afford hospitals and I think now the people have full awareness about the disease I guess they will accept the news would not affect the reputation of the hospital. 
spoke Umm Ahmed housewife, saying that unfortunately some of private hospitals only concern material and collect money impartial of all human values ​​and so for their own interests and the nearest such as what happened with the virus Corona In some of those hospitals refused to disclose the existence of some patients and evasion of diagnosing HIV-infected media and with great regret that this frequently dramatically in Mschvina private and that in the absence of health control by the Ministry of Health esteemed company. 

As Abdullatif Duwaisan has stressed the need to demonstrate that private hospitals transparent and professional medical and in collaboration with the concerned authorities in uncovering the facts direction of the disease stressing at the same time the need to demonstrate that health facilities professionalism in their work and the fear of God Almighty. 

As Hamoud bin Fauzan Al-Shammari has called for the Ministry of Health to intensify campaigns oversight on those private hospitals and emphasized the need for the cooperation of the hospitals in the fight against the virus to perform their work with all Onsaúah with pasture conditions humanitarian cases poor physically stressing that the honor of the profession Medicine is totally incompatible with evasion for the diagnosis or treatment of any patient no matter what the illness. 

And it said Mohammed Saad to evade diagnosis for fear of the reaction of people are negative towards the disease but it is a look deficient and conduct incompatible with the honor of the medical profession, especially as citizens become more aware and Adarka towards this act stressing that the evasion of diagnostic displays established for the negative outlook and a lack of trust of citizens when he discovers the disease other hospitals in a sign of poor diagnostic capacity of the hospital refusing to declare the diagnosis and on the contrary find quite a lot of confidence in hospitals that succeed in the diagnosis, especially with the presence models Chavt of this virus recovered God and you.

Vietnam: 2 More Confirmed with #H1N1 in Vinh Long

The two other cases of H1N1 in Vinh Long are below.  It looks like the two today are from  they are from the same place.

 
Name:  Woman
From:  Mang Thit District, Long Tan Commune, Vinh Long Prov.
Onset:  6/11
Adm:  6/15
Note:  Bought chicken at market in commune on 6/8.
DOD:  6/17.

Name:  55yo
From:  16B Dinh Tien Hoang St., Ward 8, Vinh Long
Adm:  Gia Dinh Hospital, Vinh Long
 Note:  Was in Cancer Treatment 12.6 days (12 ½).  Showed signs of illness and went to Gia Dinh Hospital.
DOD:  6/14



Translation
June 24, 2013

(TNO) Two cases of influenza A/H1N1 infection iếu Thuận, H.Vũng Liêm và xã Hòa Hiệp, H.Tam Bình Vĩnh Long province are, both test results are positive for the flu.

Test results by the Pasteur Institute in Ho Chi Minh City today announced 24.6.
According to authorities in Vinh Long province, Hieu Thuan commune patients in isolation and being treated in hospital in Vinh Long province.
According to medical records, 21.6 days hospitalized patients with symptoms of high fever, sore throat and nasal pharynx is taken for testing.
Patients being treated with medication Taminflu, good health recovery, fever, ease sore throat, lung X.Quang normal shooting. Patients will continue to be monitored treatment.
Particularly in patients receiving treatment Hoa Hiep Commune in HCMC Tropical Hospital.
Thus, just over one week, the province of Vinh Long has 4 positive cases of A/H1N1 flu, of which 2 cases were fatal.

http://www.thanhnien.com.vn/pages/20130624/them-2-truong-hop-duong-tinh-cum-a-h1n1-o-vinh-long.aspx 

#Coronavirus deja un muerto y unos siete nuevos infectados en Arabia Saudí

24 junio - 9:46 am
Arabia Saudí.- El Ministerio saudí de Sanidad, informó que una persona que estaba infectada con el coronavirus falleció en el este de Arabia Saudí.

Asimismo, el Ministerio explicó que el fallecido era un enfermo de cáncer, al tiempo que destacó que se detectaron siete personas más infectadas.

Vale destacar, que los siete nuevos casos se registraron en el este y el centro del país, elevándose de esa manera a 62 la cifra de infectados en Arabia Saudí con el denominado Síndrome Respiratorio Coronavirus.

http://www.fmcenteresnoticia.com.ve/?p=14561

Un muerto y siete nuevos casos de infectados por #coronavirus en Arabia Saudi

June 24, 2013

24-06-2013 / 16:30 h EFE
Una persona que estaba infectada con el coronavirus ha muerto en el este de Arabia Saudí, mientras que se han detectado siete nuevos casos, anunció hoy el Ministerio saudí de Sanidad en su página web.

El ministerio explicó que el fallecido era un enfermo de cáncer que tenía 32 años y estaba ingresado en la sección de Cuidados Intensivos desde que se descubrió que era portador del virus.

En cuanto a los nuevos infectados, cuatro de ellos tienen siete y quince años, y el resto son mujeres.
Dos de ellas trabajan en centros médicos y no muestran síntomas del virus, mientras que la otra infectada es una mujer de cincuenta años que está ingresada porque sufre de neumonía, pero se encuentra estable.
Los siete nuevos casos se registraron en el este y el centro del país y elevan a 62 la cifra de infectados en Arabia Saudí con el denominado Síndrome Respiratorio Coronavirus de Oriente Medio (MERS-CoV), de los que 34 ya han muerto.

Según el Ministerio, hay otros veinte casos que no han mostrado síntomas del coronavirus y que sólo eran sospechosos de portar el virus.

Los primeros síntomas de este virus son fiebre y tos, que se agravan hasta causar una neumonía. El Gobierno saudí ha apuntado que la mayoría de los infectados sufren enfermedades crónicas que debilitan su sistema inmunitario y los hacen más vulnerables.

Los coronavirus constituyen una familia viral que pueden causar enfermedades en los seres humanos que van desde el resfriado común hasta el Síndrome Respiratorio Agudo Severo conocido como SARS.

http://www.abc.es/agencias/noticia.asp?noticia=1444615
 

Lancet Studay Links #MERS Case to UAE and Qatar #Coronavirus

There is much news today, regarding a case back in March 2013.  A 73yo from UAE.  The news today, is in relation to a Lancet study, in regards to the sequencing, that ties the man to Qatar, the Lancet publication is below.

Prof Christian Drosten MD a Corresponding AuthorEmail Address, Michael Seilmaier MD b, Victor M Corman MD a, Wulf Hartmann MD b, Gregor Scheible MD b, Prof Stefan Sack MD b, Wolfgang Guggemos MD b, Rene Kallies PhD a, Doreen Muth PhD a, Sandra Junglen PhD a, Marcel A Müller PhD a, Walter Haas MD c, Hana Guberina MD d, Tim Röhnisch MD f, Prof Monika Schmid-Wendtner MD f, Souhaib Aldabbagh DVM a, Prof Ulf Dittmer PhD e, Hermann Gold MD g, Petra Graf MD g, Frank Bonin MD h, Andrew Rambaut DPhil i j, Prof Clemens-Martin Wendtner MD b Corresponding AuthorEmail Address

Summary

Background

The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. We provide a full description of a fatal case of MERS-CoV infection and associated phylogenetic analyses.

Methods

We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. We did diagnostic RT-PCR and indirect immunofluorescence. From time of diagnosis, respiratory, faecal, and urine samples were obtained for virus quantification. We constructed a maximum likelihood tree of the five available complete MERS-CoV genomes.

Findings

A 73-year-old man from Abu Dhabi, United Arab Emirates, was transferred to Klinikum Schwabing on March 19, 2013, on day 11 of illness. He had been diagnosed with multiple myeloma in 2008, and had received several lines of treatment. The patient died on day 18, due to septic shock. MERS-CoV was detected in two samples of bronchoalveolar fluid. Viral loads were highest in samples from the lower respiratory tract (up to 1·2 × 106 copies per mL). Maximum virus concentration in urine samples was 2691 RNA copies per mL on day 13; the virus was not present in the urine after renal failure on day 14. Stool samples obtained on days 12 and 16 contained the virus, with up to 1031 RNA copies per g (close to the lowest detection limit of the assay). One of two oronasal swabs obtained on day 16 were positive, but yielded little viral RNA (5370 copies per mL). No virus was detected in blood. The full virus genome was combined with four other available full genome sequences in a maximum likelihood phylogeny, correlating branch lengths with dates of isolation. The time of the common ancestor was halfway through 2011. Addition of novel genome data from an unlinked case treated 6 months previously in Essen, Germany, showed a clustering of viruses derived from Qatar and the United Arab Emirates.

Interpretation

We have provided the first complete viral load profile in a case of MERS-CoV infection. MERS-CoV might have shedding patterns that are different from those of severe acute respiratory syndrome and so might need alternative diagnostic approaches.

Funding

European Union; German Centre for Infection Research; German Research Council; and German Ministry for Education and Research.
 

Saudi restricts Makkah visits during Haj: Fear of Spread of Virus - Unprecedented Move #Coronavirus #MERS

Manama, 7 hours, 44 minutes ago

Saudi Arabia has reduced the number of applications to visit Makkah during the Haj season amid major expansion work taking place at Makkah and fears of the spread of the deadly coronavirus, said a report.

The unprecedented move aims to prevent stampedes and ensure the safety of people, Bahraini Haj delegation head Shaikh Abdulnasser Abdulrahman was quoted as saying in the Gulf Daily News, our sister publication.

"The move follows a decision of the Haj Council in Saudi Arabia to reduce the number of pilgrims temporarily due to the ongoing massive expansions," he said.

"The Bahrain quota for Haj will be reduced from 4,675 to 3,700.

"The number of expatriates planning to perform the annual pilgrimage will also decrease from 1300 to 1000."

Shaikh Abdulrahman revealed that the number of administrative and support staff travelling with each Bahraini caravan will also be reduced by 50 per cent.


Shaikh Abdulrahman urged Bahrainis, who earlier performed Haj, to give others the chance to travel this year.

"This is because typically, between 30 per cent to 40 per cent of Bahraini pilgrims perform the Haj every year," he added.

He also said Bahraini authorities have been taking precautionary measures and coordinating with their counterparts in Saudi to protect pilgrims.

A special taskforce has already been formed by the Health Ministry to screen thousands of pilgrims travelling to and from Saudi Arabia for the Middle East respiratory syndrome coronavirus (MERS-CoV).

Bahraini travellers will be provided with three types of vaccinations before crossing the border, where they will be closely monitored. They will also undergo thorough medical tests after returning.

The Severe Acute Respiratory Syndrome (SARS)-like virus has already killed 39 people worldwide, including 33 people in Saudi Arabia, and infected 70 globally.

"However, Bahraini authorities have not received any instructions from their Saudi counterparts to undertake any exceptional measures in this regard," said Shaikh Abdulrahman. – TradeArabia News Service

http://www.tradearabia.com/news/HEAL_238360.html

Thailand: Minister of Public Health on High Alert for Sym's of #Coronavirus #MERS

BANGKOK, 24 June 2013 (NNT) - The Ministry of Public Health is on high alert for possible symptoms of the deadly Middle East respiratory syndrome coronavirus (MERS) which has killed 38 people worldwide.

Health Minister Dr Pradit Sinthawanarong said 68 people in 9 countries have been confirmed as having contracted the virus since September. The number of the infected is expected to rise as the World Health Organization reported that the virus could be trasmitted from humans, though they are still searching for the source of the outbreak.

No case of MERS infection has been reported in Thailand so far but health professionals are continuing to closely monitor the situation.

Major provinces which are frequented by tourists such as Bangkok, Chiang Mai, Phuket and Khon Kaen have been advised to be on the lookout for patients with flu-like symptoms.


The Middle East Respiratory Syndrome Coronavirus first emerged in the Arabian peninsula last September and belongs to the same family of viruses as the one responsible for Sars.

http://thainews.prd.go.th/centerweb/newsen/NewsDetail?NT01_NewsID=WNEVN5606240010005

Taiwan CDC Press Release: Domestic appear isolated from respiratory diseases H6N1 flu virus cases, the patient has been cured, the CDC urged people to make personal health management

(2013-06-21)

    Disease Control, Department of Health on May 20 received a notification of a hospital, a 20-year-old woman living in central Patients with mild pneumonia isolated from respiratory specimens of not subtyped influenza A viruses, further examination by the Board and DNA sequencing was carried H6N1 influenza virus. After investigation of close contacts 36 cases, of which four people have flu-like symptoms, the test found no H6N1 influenza virus infection, the council will continue to strengthen monitoring.     CDC pointed out that the woman tied to a breakfast shop work, never to go abroad, but also no history of exposure to related birds, May 5 with fever, cough, headache and muscle pain and other symptoms, May 8 morning because persistent fever and shortness of hospitalization and medical treatment, the X-ray examination showed a slight pneumonia, influenza antivirals in the administration of the symptoms improved, was discharged on May 11, has been recovered. May 7 were collected from patients' respiratory specimens isolated H6N1 virus, May 24 patient serum specimens H6N1 antibody HI titer of 1:20,6 August serum was collected from 1:40. In addition to the acquisition of the council respiratory specimens tested for influenza viruses, but also against the viruses such as respiratory infections common adenovirus, respiratory syncytial virus, coronavirus, enterovirus and rhinovirus and other 23 kinds of testing, with negative results. Agricultural authorities also grouped cases within 1 km around the house poultry farm poultry collected two specimens tested, the results were not detected H6N1 avian influenza virus.     The council since 1999, in addition to the statutory infectious diseases (influenza complications) patient monitoring tests, but also to the community regularly hospitalized influenza patients and patients with unexplained pneumonia collected specimens for influenza virus testing, systematic monitor the activities of domestic influenza virus and the clinical situation the actual situation. The number of samples tested annually about 1 to 20,000, has accumulated more than 250,000, identification and separation of about 86,000 strains of influenza virus, in addition to this (102) inspection of an imported H7N9 avian influenza viruses, never detected from the human body, including H6N1 physical examination, including other non-H1, H3 subtype influenza A viruses.     Case by invited agricultural agencies and related medical and veterinary experts meeting to discuss, according to the existing epidemiological findings judged the case based on the performance of minor sporadic cases of pneumonia, no evidence of human to human transmission phenomenon, health and agricultural authorities will also continue to strengthen humans, birds and environment monitoring.     H6N1 is widespread among poultry low pathogenic avian influenza virus has not been found in human cases of infection worldwide. The patients are separated by a viral gene sequences are shown in the case of avian origin, and the local poultry H6N1 strain of the virus most closely on Tamiflu and other antiviral drugs Relenza sensitive.     CDC appealed against avian influenza virus infection, livestock related practitioners should be prepared to personal protective measures, the public should avoid unnecessary contact with livestock animals, and should wash their hands, eat well cooked poultry meat and eggs class, in order to reduce the risk of infection. In addition, flu-like symptoms or conjunctivitis, etc., should wear masks for medical treatment as soon as possible, and take the initiative to inform physicians livestock work history and history of exposure to birds. Relevant international bird flu epidemic and the related control measures can be found in the council WWW ( http://www.cdc.gov.tw ), or call the national toll-free reporting and caring people dedicated 1922 epidemic, such as the phone can not make simple code phone numbers, please dial 0800-001922 prevention hotline.

Lancet: Human infection with avian influenza A H7N9 virus: an assessment of clinical severity

The Lancet, Early Online Publication, 24 June 2013
doi:10.1016/S0140-6736(13)61207-6

Hongjie Yu MD a †, Benjamin J Cowling PhD e †, Luzhao Feng MD a †, Eric HY Lau PhD e †, Qiaohong Liao MD a, Tim K Tsang MPhil e, Zhibin Peng MD a, Peng Wu PhD e, Fengfeng Liu MD a, Vicky J Fang MPhil e, Honglong Zhang MD a, Ming Li ME a, Lingjia Zeng MSc a, Zhen Xu MD a, Zhongjie Li MD a, Huiming Luo MD b, Qun Li MD c, Zijian Feng MD c, Bin Cao PhD f, Weizhong Yang MD d, Dr Joseph T Wu PhD e Corresponding AuthorEmail Address, Dr Yu Wang PhD d Corresponding AuthorEmail Address, Prof Gabriel M Leung MD e
 

Summary

Background

Characterisation of the severity profile of human infections with influenza viruses of animal origin is a part of pandemic risk assessment, and an important part of the assessment of disease epidemiology. Our objective was to assess the clinical severity of human infections with avian influenza A H7N9 virus, which emerged in China in early 2013.

Methods

We obtained information about laboratory-confirmed cases of avian influenza A H7N9 virus infection reported as of May 28, 2013, from an integrated database built by the Chinese Center for Disease Control and Prevention. We estimated the risk of fatality, mechanical ventilation, and admission to the intensive care unit for patients who required hospital admission for medical reasons. We also used information about laboratory-confirmed cases detected through sentinel influenza-like illness surveillance to estimate the symptomatic case fatality risk.

Findings

Of 123 patients with laboratory-confirmed avian influenza A H7N9 virus infection who were admitted to hospital, 37 (30%) had died and 69 (56%) had recovered by May 28, 2013. After we accounted for incomplete data for 17 patients who were still in hospital, we estimated the fatality risk for all ages to be 36% (95% CI 26—45) on admission to hospital. Risks of mechanical ventilation or fatality (69%, 95% CI 60—77) and of admission to an intensive care unit, mechanical ventilation, or fatality (83%, 76—90) were high. With assumptions about coverage of the sentinel surveillance network and health-care-seeking behaviour for patients with influenza-like illness associated with influenza A H7N9 virus infection, and pro-rata extrapolation, we estimated that the symptomatic case fatality risk could be between 160 (63—460) and 2800 (1000—9400) per 100 000 symptomatic cases.

Interpretation

Human infections with avian influenza A H7N9 virus seem to be less serious than has been previously reported. Many mild cases might already have occurred. Continued vigilance and sustained intensive control efforts are needed to minimise the risk of human infection.

Funding

Chinese Ministry of Science and Technology; Research Fund for the Control of Infectious Disease; Hong Kong University Grants Committee; China—US Collaborative Program on Emerging and Re-emerging Infectious Diseases; Harvard Center for Communicable Disease Dynamics; US National Institute of Allergy and Infectious Disease; and the US National Institutes of Health.