NAMRU-3 gene discovered among humans with the H5N1 virus in Egypt
Saturday, May 8th, 2010 - 17:43
Discovered the laboratories of the Research Unit, U.S. NAMRU-3, of the U.S. Navy in Egypt, the existence of viral sequences in cases of bird flu (H5N1) virus similar to the characteristics of seasonal flu transmitted between humans, raising fears the spread of the virus.
Where they found NAMRU-3 on the sequences Sub-HA and NA in the cases examined in Egypt (11 cases in 2009, and 12 cases in 2010), and found that the 23 cases included A seldom explored characteristic of existing seasonal influenza virus and transmitted between humans, which indicates that these character began to become fixed in the virus in Egypt.
The study had been conducted earlier had shown the existence of similarities between the H5N1 and seasonal influenza H1N1, which has led to growing concerns about the transmission of the virus among humans, especially those cases, which included one of the genetic traits which were found in cases that have been examined.
She had raised fears of HIV transmission among humans, after the discovery of a number of cases among children in 2007, which mostly contains the same genetic character, and appeared at the time the symptoms of moderate disease, were infected with pneumonia.
It is worth mentioning that the NAMRU-3, working with the Egyptian Ministry of Health in the analysis of samples suspected of being infected with influenza viruses present.
[Note: The following story was taken from this site: http://www.recombinomics.com/News/05061003/H5N1_125del_Fix.html ]
Fixing of 125del In Human H5N1 In Egypt
Fri May 7 13:52
Recombinomics has the story.
NAMRU-3 has recently released HA and NA sequences from recent H5N1 cases in Egypt (11 from 2009 and 12 from 2010). All 23 HA sequences had 125del (3 BP deletion), indicating the deletion is becoming fixed in human H5N1 in Egypt. An earlier paper, “Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control” had noted similarities between H5N1and seasonal H1N1, raising concerns of increased human transmission (H2H) of H5N1 with 125del. This concern was increased by the recent paper describing the detection of H5N1 in donkeys and serological evidence of widespread H5N1 antibodies in donkeys.
Concerns of human to human H5N1 transmission in Egypt were raised when mild cases in children were reported in the spring of 2007. Several had the 3 BP deletion and sequences were closely related. There children had a mild course, which did not include pneumonia.
In early 2009, mild cases were reported in toddlers. The large number of cases reduced the case fatality rate for H5N1 in 2009 to approximately 10%. The sequences from these toddlers also had 125del, which was followed by the most recent 23 sequences which were from the summer of 2009 to March 31, 2010.
Poultry H5N1 sequences collected in the past year were more diverse and included vaccine resistant H5N1. However, all human sequences contained 125del and many of the 2010 sequences were closely related to each other raising additional concerns that H5N1 is transmitting H2H.
Since Egypt does not H5N1 test patients who do not have a poultry contact, the full extent of H5N1 remains largely unknown. Serological testing has been discussed for over a year. During that time a serological survey on donkeys was conducted, which showed widespread antibodies in donkey serum.
Results for a comparable test in humans, using a 125del H5N1 target is long overdue.
http://beforeitsnews.com/news/41/063/Fixing_of_125del_In_Human_H5N1_In_Egypt.html
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