Status of preventive measures against infection with influenza drug development progress in net domestic

2009/02/02


Medical journalists
Ebihara Yukio
Recently, CS-8958 of the net domestic treatment of influenza in the test phase III. Are also authorized to look at trends in the clinical field and face valid measures of hospital infection. The net domestic like T-705 in the current test phase II, developed in Japan and the U.S. Peramivir injection of the drug in the test phase III. Among the characteristics of the CS-8958 treatment of influenza, a type of inhaled drug in dry powder inhaler as Relenza, act directly on cells in the lung. Just one dose of treatment, has been both long and sustained prevention effect.
Article III of the test phase, the investigator was required to apply for the manufacture and sale of drugs in phase three, in the final stages of testing to confirm the safety and efficacy of treatment in close to real also known as Phase III.
The background has been focused here come the development of these new drugs, it has recently spread to humans as bird flu infection had been confirmed so far only among birds. In addition to the virus mutated, because they are危惧SA and may be a new virus of bird flu infecting humans.
In addition, another serious problem as 2001 oral influenza drug Tamiflu has been approved (generic name: oseltamivir phosphate) is the share that is increasing resistance to influenza immunity.
2009 Women in Beijing in January to 5 days (19) bird flu (H5N1 type) and died with the virus, officials announced last month, Beijing and Hong Kong insurance. The Xinhua report, this female duck in the market to buy nine of Hebei province, feathers, and that the process remove the viscera. Also, the day after January 6, now living in Vietnam's central province of Thanh-hoa 8-year-old girl, the bird flu by eating chicken of the disease (H5N1 type) that were infected with the virus, the national bird flu prevention Vietnam Guidance Committee announced that they are members of the Committee. The girl was treated, the condition of stability is good news.
According to statistics from the National Institute of Infectious Diseases, the peak of the flu epidemic in Japan in early May, the high prevalence rate is 5 years old children from the age of 10, the highest mortality rate is 75 in reverse over the age of the elderly. Children and the elderly need special care during this period.
Influenza viruses are 80-120 nanometers in diameter, the department of ORUSOMIKUSOUIRUSU much smaller than bacterial RNA virus, has a nature that it can not grow only in living cells. The antigenic differences between the A, B, C are classified into three types. Epidemic virus infection in humans in the past and all belong to type A and type Soviet (H1N1), Asian-type (H2N2), Hong Kong (H3N2) was 3. These three species, but repeated small trendy, and seasonal and pandemic flu already exist in the human world.
Virus particles on the surface of HA (= HEMAGURUCHININ hemagglutinin) and NA (neuraminidase) and called out a number of two types of projection, by the emergence of a subtype of this glycoprotein. Serotype is
H1 ─ 16, N1 ─ 9, the combination is 16 × 9 = 144 ways. Sertoli-derived virus in question is this
144 exists as a combination of all.
Influenza virus is a master of disguise, if speaking to the emergence of the virus HA and NA subtype of the new breed of discontinuous variation. This is how the mutations lead to growth and self-injection of genes in living cells.
As the first stage, the familiar occurrence of human influenza virus subtype.
The second phase will be able to grow the virus in humans.
The third phase, and gain the ability to transmit efficiently from human to human.

Thus, the avian flu virus known as influenza has never met an unknown man until now, that this cause INFURUENZAPANDEMIKKU.
Now been developed for the treatment of influenza, oseltamivir phosphate 12, 2001 allows the adaptation of health insurance (product name: Tamiflu) and Zanamivir (Product name: Relenza). But now, with full resistance to TAMI, which had the appearance of influenza virus resistance to Tamiflu in other words. CS-8958's are expected to respond to it.
Oral drugs such as Tamiflu, the stockpile is stored to the action taken in the gastrointestinal tract into the blood, then that is suitable for its medicinal properties, to maintain a certain level of concentration has been drinking blood for a certain period needs. In contrast, CS-8958 is inhalation (nebulizer or dry powder) trachea, so the advantage that show immediate results in the administration of a single cell to be incorporated directly into the lung tissue. In addition, H5N1 primary site of infection of bird flu virus is deep in the lungs, the lung tissue taken directly to the CS-8958 is thought to have been effective.
1918 pandemic (epidemic), is said to have infected nearly half of the world, is said to have been 2400 that killed more than 10,000 people. Then, this flu (H1N1) in 38 years has slowly continued to coexist in the human world as a weak flu season type of toxicity.
The influenza virus is the first place, it is not the nature of growth of living cells to be weak in the humid and hot environment. UGAI and restrooms and is quite effective prevention method is a simple one to run our own people.
If it sees that they work to survive a flu pandemic, a key point to prevent the spread by humans, perhaps in self-isolation and strong will to take action to restrain themselves from infection.