"The evolution of influenza vaccine breakthrough" to the News

2009/1/29

The flu vaccine that is inoculated with a lot of people every year, or get out of the year the epidemic strain blockhead, and until the beginning of the epidemic, I think I have had off years. Such a "bet" was developed a new generation of flu vaccine that does not need to go.

Article is as follows.

Flu vaccine study group ministry universal ...
Jan. 29 - 3:03 minutes Distributor: Yomiuri Shimbun

Labor and Welfare Ministry research team has developed a vaccine effective against different types of influenza viruses.

Unlike conventional vaccines, the characteristics of the continuing effects of the virus to mutate to check on animal experiments. To practical use is expected to take several years, is also expected to help prevent avian flu.

Research Group, National Institute of Infectious Diseases, Hokkaido University, Saitama Medical University, oil, chemical manufacturers.

The vaccine is usually made based on the protein covering the surface like a splinter virus. After inoculation, the virus entering the body, to prevent the proliferation and the antibody recognizes a thorn. However, the flu, the pandemic virus is often different in form of thorns, for the mutant form of the spine, frequently had to re-create the flu vaccine every year. And prediction of type to be out of fashion, diminished the effect of vaccination.

Study group, the protein synthesized in the mutant virus compared to the surface difficult. Stuck with a vaccine made with a special membrane and lipids. If you received the vaccine, the immune cells that attack virus-infected cells.

In the experiment, the highly pathogenic bird flu virus could mutate into a new flu virus H5N1, A Soviet-type, A-Hong Kong police internal proteins common species, prepared a vaccine. After inoculation of mice incorporating human genes involved in immunity, the virus 3表REZU symptoms in mice infected with the seeds, and low growth.

The type of vaccine so unprecedented, with no significant side effects in humans, have to look carefully. University of Oxford in England to research the exact vaccine.

Senior Researcher of the representative call Utita Tetsuya infection study "examined the amount of effective and safe in humans, TSUNAGETAI practical as soon as possible" (article here)

Influenza vaccine in the past, A shares from a Soviet-type, A-Hong Kong to share, B share and choose from one type, mix and produce the vaccine, and vaccination. 100 Number of shares to choose from and what is in the thousands, WHO is determined by the ease of viral culture and recommendations are published in the selection process, including the website of National Institute of Infectious Diseases .

Influenza virus, but its shape (genetic composition) change frequently. Vaccine in the past, it was like to attack and capture the structure of the surface of the virus, often gets worse and worse little effect in changing the shape of the virus, the vaccine "off" and causes . (However, the prevalence of selected shares, so should have been reduced, because一概NI the shares of another epidemic, "off" and I think also the cut)

This vaccine was developed, the flu virus changes easily "surfaces" as well, the vaccine targets the most difficult to change. 動物実験では効果が確かめられているようなので、ヒトに有効かどうか、有害ではないかどうか、どれくらいの量を打てばいいかが検証されて使えるということになれば、ワクチンの使い方や効果が全面的may vary.

At the moment, whether the overall change is not anything that came out of this research will lead to brighter prospects for the future. "NAKUSHITARA flu virus does not function as a" vaccine would be the part that captures the attack might be so怖GARANAKU the flu itself. Whether you need it to.