Russia: Influenza vaccine

[In trying to find more information on the Soviet A Strain mentioned here:
"Meanwhile, A-Hong Kong, A Soviet-type, B type of the virus in three types, the resistance to Tamiflu A trend of this year the virus has spread throughout Japan-Soviet resistance". (http://pandemicinformationnews.blogspot.com/2009/01/japan-fury-in-full-working-tami-flu.html)...I came upon this. It's more or less advertising their adjuvant called "Grippol".]

A few excerpts. Click on the title of the story for the full article.

Stage 1 - Create tselnovirionnyh vaccines. This is a live vaccine containing attenuated influenza virus, and tselnovirionnaya inactivated vaccine containing the whole of irusy flu since inactivation and clearance. Vaccines are the first generation to be the most reactogenicity, which severely limits their use, especially among children. Moreover, sometimes even dangerous to use a live vaccine. Take predpandemichnuyu situation in the world today. WHO experts now recommend immunization only inactivated influenza vaccines. The problem is that influenza virus is very Kowary: easily transmitted through airborne droplets, rapidly mutates to form new strains against which the human immune system for another set. At the same time finding different influenza viruses in one organism (eg, avian influenza virus and human) is likely to exchange genetic material of these two strains and the emergence of new strains with new properties. So imagine, if vaccination of live vaccines a person becomes a carrier for 2-3 weeks and distributor of the virus, albeit weakened, but it is viable.
Worth it for the patient to sneeze pigeon, chicken, or, for example, a pig - further events will be unpredictable.
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Stage 2 - the creation of split vaccines containing particles «destroyed» virus surface and internal proteins attached to the sites of lipid membranes. Vaccines 2 generations contain 15 micrograms of antigen each type of influenza (A, B) relevant strains.
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Stage 3 - Create subedinichnyh vaccines consisting only of high-surface antigens. These vaccines also contain 15 micrograms of antigen per strain, but they are no longer additional impurity proteins. Subedinichnye vaccines are highly immunogenic and better, compared with the split vaccine, portability.
As you can see, the evolution of influenza vaccine was on the path to greater security - improved cleaning technology viral material from ballast compounds. However, WHO still has the developers of vaccines to enhance the effectiveness of drugs and, most importantly, their security for all populations. Therefore, the last 5-7 years, the efforts of scientists around the world aimed at finding a safe «immunopotentsiatora», adjuvant that can enhance the immune response, increase the speed of its development and duration.
In Russia, this adjuvant has long been there - Polioksidony. Inclusion Polioksidoniya in prot ivogrippoznyh subedinichnyh vaccines Grippol and Grippol Plus allowed us to create a new - the fourth generation of vaccines that are better immunogenicity and the high profile security, as well as in 3 times reduces the antigen load on the body. One immunizing dose (0.5 ml) plus Grippol vaccine contains 5 mg gemagglyutinina relevant strains of influenza virus type A (H1N1), A (H3N2), B, and 500 mcg Polioksidoniya. With such a seemingly small dose of antigen after vaccination Grippolom and Grippolom plus defined pronounced immune response necessary to produce a full protection against influenza. A rapid rate of development of the immune response without the excess immune system and make Grippol Grippol plus the only vaccines, immunization, which can be up to the beginning of the rise of epidemic disease.
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