Vietnam: A Number of Cases Showing Reduced Sensitivity to Tamiflu for SF

To propose the Ministry of Health completed the exposed control influenza A (H1N1)
14-07-2009


Handling environmental prevention
after the hospital patients.
NDDT - By now, after 45 days from the cases the first country has nearly 300 cases influenza A (H1N1), all the way under treatment in health facilities. Although no cases of drug resistance but have a number of cases reduced the sensitivity of Tamiflu, a prolonged time of treatment. Concerned states drug resistance, 14 - 7, Ministry of Health organized the workshop to share experiences in treatment of influenza A (H1N1).


Dr. Nguyen Thi Xuyen, Deputy Minister of Health confirmed: from the World Health announced pandemic, the Ministry of Health establish expert urgently building and issuing Guide diagnosis, the of infection and influenza A (H1N1) / improve plans to prevent pandemic, strengthening supervision and control and health ... The fact of treatment for patients in recent years also shows instructions efficiency , all of which are cured from the disease, without complication and death.


However, it appears some people after 10 to 13 days of treatment with Tamiflu drug is still a flu virus (H1N1) in people. They usually only need three to five days as people were viruses. Institute at the infectious disease and tropical countries, there are two cases of influenza A (H1N1) 10 days after treatment, test results are positive.

PTN England, 38 years old, from Australia to go, starting after a sick day, and spread to the house he is PTM. Even if the hospital and during treatment, he said PTN does not have anything special, but it must be after 12 days, the new waste-virus, while PTM he also spent six days after virus treatment.
Case as the second child TMC, 22 months old, traveling with her mother and grandmother in Australia on. Mother, grandmother infection, declaring in Vietnam were infected, the virus after 4 - 6 days of treatment. While you must take up to 11 days.


Hospital in Tropical Ho Chi Minh City also has two cases. LQT which is 21 years old, weighs 81 kg from Vietnam on, fever 40oC, was located on treatment from 29 - 6 to 14 - 7 and the first 14 days with negative results for influenza. Patients remaining NCB is female, 15 years old, 45 kg, as a student Vietnamese American, and only waste the virus after being used twice the dose of Tamiflu in the days 13, 14.


According to Dr. Tran Tinh Hien, Director of Institute of Tropical Diseases in Ho Chi Minh City, can the delayed response to treatment occurred in this case is due to concentration of drug is absorbed in the body not enough, or the local of each person. By analyzing the results showed that the influenza virus vaccine that patients infected with this are not found with gen R294 and H274Y variables related to resistance or reduced levels of sensitive influenza virus A (H1N1) and Tamiflu. Treatment for people infected with influenza A (H1N1) at the Institute of infectious diseases and tropical countries.


Meanwhile, the PGS, Dr. Nguyen Tran Hien, results analysis the nucleotide sequence of the HA genes of the vaccine virus is showing up: We H1N1 virus in Vietnam now have a similar level with all chủng are circulating in the world from 99 - 100%, in New York, Moscow and Shanghai. Results raising trees and the NA genes to sudden changes related to resistance to drugs Tamilflu not detect sudden changes in positions 274 and 294 relating to the resistance or lower levels of sensitive Tamilflu with influenza A/H1N1 virus new


PGS, Dr. Nguyen Tran Hien also adds, the world has four country reports recorded in Tamiflu drug resistance. However, WHO and countries will evaluate the Tamiflu anti-virus performance.



To cope with the situation slowly respond to medications, experts suggest the Ministry of Health staff exposed to the control of HPAI, the official guide to the legal basis for implementation in the treatment for patients. MA Nguyen Hong Ha, Vice Director of the infectious diseases and tropical countries for that: the treatment of virus diseases slow today, Director of the hospital decision the next treatment and must charge responsible for the safety of patients. There are two directions, or to continue long-time treatment with Tamiflu and zanamivir to use, because this medication does not have the resistance.


The old cầm 45 days is a major cause of flu A (H1N1) has not spread to the community. Of cases are most people from those countries are about or have close contact with patients. The focus of disease in the entry, or in healthy virus can bring light. 50% of patients detected through the border gate, the rest through the work shows the role of the flu, to the hospital itself.