The mayor made the remarks during a press conference this afternoon and says the city is closely monitoring the outbreak.
St. Francis Prep in Fresh Meadows will remain closed tomorrow.
Officials say all of the students reported mild symptoms and none were taken to the hospital.
Despite the illnesses, St. Francis went ahead with its 25-year and 50-year reunions last night. Those in attendance say there was some concern about whether to show up.
"It was definitely a controversy on whether or not we were going to attend. Half of us have decided to come and half of us decided not to come so in a way that's sort of sad," said St. Francis Alumnus Diana Brobmann.
The city's health department was also investigating a possible outbreak at a Bronx day care facility, where 30 children got sick. Five of the six samples sent out for testing, however, came back negative.
Department officials say they haven't seen any recent city-wide increases in flu-like symptoms, but that they are monitoring the situation every 12 hours to make sure more people aren't getting sick.
Health Commissioner Thomas Frieden is urging anyone who feels sick to stay home, but says the city is ready for any emergency.
"The city is very well prepared. We have been preparing for years at every level. We've been preparing with detection, so we can track whether a pandemic or other serious problem comes, and if so where it is, what the characteristics are," said Frieden.
Governor David Paterson has directed the state Department of Health to monitor and respond to possible cases of swine flu. He says 1,500 treatment courses of the antiviral Tamiflu have been sent to New York City.
Tamiflu is believed to be effective in treating serious cases of swine flu.
The state Department of Health has set up a 24-hour hotline to answer questions about swine flu and can be reached at 1-800-808-1987.
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