Leiden, The Netherlands (July 7, 2011) - Dutch biopharmaceutical company Crucell N.V. and The Scripps Research Institute today published an article in the world's leading journal of original scientific research Science describing Crucell's novel anti-influenza antibody CR8020 and how it neutralizes group 2 influenza A viruses. Attempts to isolate broadly neutralizing antibodies against group 2 viruses have not been previously described. The broad neutralizing ability of the CR8020 makes it a potentially groundbreaking therapy against seasonal and pandemic flu.
"Influenza is an elusive enemy" said Jaap Goudsmit, Chief Scientific Officer at Crucell. "The need for innovative approaches to the control of seasonal influenza is highlighted by its death toll - estimated at 500,000 annually. Having successfully discovered these antibodies, Crucell is determined to develop an antibody therapy for flu."
In February 2009, Crucell and The Scripps Research Institute published a paper in Science, reporting the discovery of a panel of human monoclonal antibodies showing neutralizing activity against almost all influenza A group 1 viruses. The most potent of these antibodies, called CR6261, prevents or cures influenza, in animal tests, to deadly levels of the H5N1 and H1N1 viruses.
In this new study, Crucell reports that, by recognizing a novel conserved epitope in the hemagglutinin stem, the antibody CR8020 shows broad neutralizing activity against most influenza A group 2 viruses, including the H3N2 and H7N7 viruses, which cause severe human infection.
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