Wednesday, November 6, 2013

CDC: Full Genome of Influenza A (H7N9) Virus Derived by Direct Sequencing without Culture

Emerging Infectious Diseases

Volume 19, Number 11—November 2013 

Xianwen Ren1, Fan Yang1, Yongfeng Hu1, Ting Zhang1, Liguo Liu1, Jie Dong, Lilian Sun, Yafang Zhu, Yan Xiao, Li Li, Jian Yang, Jianwei Wang, and Qi JinComments to Author 
Author affiliations: MOH Key Laboratory of Systems Biology of Pathogens, Beijing, China


An epidemic caused by influenza A (H7N9) virus was recently reported in China. Deep sequencing revealed the full genome of the virus obtained directly from a patient’s sputum without virus culture. The full genome showed substantial sequence heterogeneity and large differences compared with that from embryonated chicken eggs.

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