Experimental Ebola Vaccine
- Tracy Hampton, PhD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
A research team led by scientists at Arizona State University in Tempe has engineered a candidate vaccine that protects mice against Ebola hemorrhagic fever (Phoolcharoen W et al. Proc Natl Acad Sci U S A. 2011;108[51]:20695-20700). This vaccine, which includes the Ebola viral surface glycoprotein fused to a monoclonal antibody that recognizes the glycoprotein, was injected into mice along with polyinosinic:polycytidylic acid (PIC), a chemical that activates a biochemical cascade involved in innate immunity.
Scientists have engineered an experimental vaccine that helped protect mice against the effects of infection with Ebola virus.
(Photo credit: Fredrick A. Murphy/CDC)
More than 80% of mice pretreated with the therapy survived after receiving a high dose of Ebola virus, while all mice given the immune complex without PIC died. Surviving animals showed a mixed T helper 1 and T helper 2 immune response, suggesting that this type of response may be important for protection.
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