United National Library of Medicine
National Institute of Health
J Infect.
2014 Jan 6. pii: S0163-4453(14)00002-4. doi: 10.1016/j.jinf.2013.12.014. [Epub ahead of print]
To KK1, Tsang AK2, Chan JF1, Cheng VC2, Chen H1, Yuen KY3
Abstract
In December 2013,
China reported the first human case of avian influenza A(H10N8). A
73-year-old female with chronic diseases who had visited a live poultry
market succumbed with community-acquired pneumonia. While human
infections with avian influenza viruses are usually associated with
subtypes prevalent in poultries, A(H10N8) isolates were mostly found in
migratory birds and only recently in poultries. Although not possible to
predict whether this single intrusion by A(H10N8) is an accident or the
start of another epidemic like the preceding A(H7N9) and A(H5N1),
several features suggest that A(H10N8) is a potential threat to humans.
Recombinant H10 could attach to human respiratory epithelium, and
A(H10N4) virus could cause severe infections in minks and chickens.
A(H10N8) viruses contain genetic markers for mammalian adaptation and
virulence in the haemagglutinin (A135T, S138A[H3 numbering]), M1(N30D,
T215A), NS1(P42S) and PB2(E627K) protein. Studies on this human A(H10N8)
isolate will reveal its adaptability to humans. Clinicians should alert
the laboratory to test for A(H5,6,7,9,10) viruses in patients with
epidemiological exposure in endemic geographical areas especially when
human influenza A(H1,3) and B are negative. Vigilant virological and
serological surveillance for A(H10N8) in human, poultry and wild bird is
important for following the trajectory of this emerging influenza
virus.
Copyright © 2014. Published by Elsevier Ltd.
http://www.ncbi.nlm.nih.gov/pubmed/24406432
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