Friday, February 6, 2009

Russia: To prevent a pandemic flu can not be. Mitigate its effects can be, said Gennady Onishchenko

"Rossiyskaya Gazeta" - Week number 4843 dated February 5th, 2009

In January, the world situation is complicated by the incidence of people, caused by a virus A/N5N1.

This is the virus (the result of mutations of the virus bird flu N5N1) - the most likely candidate that can cause a pandemic. According to the World Health Organization, at the end of January, the incidence was high in Austria, Denmark, Ireland, Luxembourg and Switzerland.

In Russia there is no epidemic. In many ways, because 26.5 million people were vaccinated against this infection. But in some cities, the incidence has gone up, mostly among children.

Can we prevent a flu pandemic, or at least mitigate it? This is our conversation with the Chief Medical Officer of the Russian Federation, Academician of RAMS Gennady Onishchenko.

Rossiyskaya gazeta: Gennady Grigorievich! The situation is more than alarming. However, bird flu epidemic, at least not yet, there was no ...

Gennady Onishchenko: This is a result of timely prevention. I mean in the quarantine arrangements, disposal of infected birds, vaccination of high-risk groups. And has been able to isolate pockets of influenza in birds. And thereby prevent them from developing into epidemic phase.

WP: A rare year without cost to the South-East Asia razrodilas epidemic, more precisely, epizootic, avian influenza among birds ...

Onyshchenko: This is dangerous. Because of these circumstances, the risk of moving the virus to human immeasurably increased. By the way, pigs, as close to humans in their physiological characteristics (they are - an excellent biological model of man), it is able to catch up and that and another kind of virus. If such occur simultaneously and en masse, it can happen in trouble.

RG: How are human infection with bird flu virus?

Onyshchenko: In close contact with infected domestic and wild birds. Possible contamination with eating meat and eggs of birds of patients without sufficient heat treatment. Potentially dangerous selection of infected birds, which, coming into contact with plants, air, water, and can infect people through drinking water and bathing with, airborne dust and air through, through dirty hands. At temperatures of minus bird flu virus remains. But when heated to plus 70 degrees, it dies within a few minutes.

RG: Avian influenza declares itself immediately? ..

Onyshchenko: Or ... From infection until the first signs of the disease may take from several hours to 5 days. There are chills, temperature of 38 degrees or higher, muscle and headaches, pain in the throat. Chance of watery, liquid stool, vomiting infinite. The condition is deteriorating rapidly. After two or three days begin to torment moist cough, sometimes with blood, shortness of breath. Then perhaps shortness of breath, kidney failure, liver and brain.

WP: All the so fatally? Salvation is possible?

Onyshchenko: In the strictest observance of preventive measures. In regions where the disease N5N1 bird virus, it should be, as far as possible, avoid contact with chickens, ducks, other domestic and wild birds. Children and those over 60 years, such contact is prohibited. Unauthorized persons and those suffering from cardiovascular and pulmonary diseases.

WP: What if the home fell Compound chicken or duck? ..

Onyshchenko: If this happens, do not have to spend time searching for the causes of loss. You should immediately report the incident to the local veterinary service. After contact with potentially infected birds must be within seven days to measure the temperature. If you are having fever if the temperature is above 37.5, if there were signs of acute respiratory illness or infection eyes, immediately contact the facility.

WP: In Russia, before the flu season vaccinated 26.5 million people. But avian flu is not saved? A vaccine against the bird as it was not, or not ...

Onyshchenko: Not sure saves, but reduces the risk of infection. Around the world, is the active development of vaccines against avian influenza. Their production and storage is very important to prepare for a pandemic. In our country, have created several versions of the pilot series of such vaccines, which have already passed clinical trials. According to experts, prevention, and the massive use of these vaccines and antiviral drugs to prevent serious consequences of a pandemic. But we must understand that the most effective vaccine appears only when it can be manufactured on the basis of a pandemic strain. Such a framework has anywhere in the world, because, fortunately, there is no pandemic. If any, then we, and foreign laboratories are prepared to proceed immediately to the creation of such a vaccine. How quickly it will be made, used, is its efficiency, effectiveness of the fight against dangerous infections.

Rospotrebnadzor

1 comments:

Dipl.-Ing. Wilfried Soddemann said...

CUT THE CHAIN OF INFECTIONS ! Spread of avian flu by drinking water:

Proved awareness to ecology and transmission is necessary to understand the spread of avian flu. For this it is insufficient exclusive to test samples from wild birds, poultry and humans for avian flu viruses. Samples from the known abiotic vehicles as water also have to be analysed. Proving viruses in water is difficult because of dilution. If you find no viruses you can not be sure that there are not any. On the other hand in water viruses remain viable for a long time. Water has to be tested for influenza viruses by cell culture and in particular by the more sensitive molecular biology method PCR.

Transmission of avian flu by direct contact to infected poultry is an unproved assumption from the WHO. There is no evidence that influenza primarily is transmitted by saliva droplets: “Transmission of influenza A in human beings” http://www.thelancet.com/journals/laninf/article/PIIS1473309907700294/abstract?iseop=true.

There are clear links between the cold, rainy seasons as well as floods and the spread of influenza. There are clear links between avian flu and water, e.g. in Egypt to the Nile delta or in Indonesia to residential districts of less prosperous humans with backyard flocks of birds and without a central water supply as in Vietnam: http://www.cdc.gov/ncidod/EID/vol12no12/06-0829.htm. See also the WHO web side: http://www.who.int/water_sanitation_health/emerging/h5n1background.pdf. That is just why abiotic vehicles as water have to be analysed. The direct biotic transmission from birds, poultry or humans to humans can not depend on the cold, rainy seasons or floods. Water is a very efficient abiotic vehicle for the spread of viruses - in particular of fecal as well as by mouth, nose and eyes excreted viruses. Infected humans, mammals, birds and poultry can contaminate drinking water everywhere. All humans have very intensive contact to drinking water. Spread of avian flu by drinking water can explain small clusters in households too.

Avian flu infections may increase in consequence to increase of virus circulation. Human to human and contact transmission of influenza occur - but are overvalued immense. In the course of influenza epidemics in Germany, recognized clusters are rare, accounting for just 9 percent of cases e.g. in the 2005 season. In temperate climates the lethal H5N1 virus will be transferred to humans via cold drinking water, as with the birds in February and March 2006, strong seasonal at the time when (drinking) water has its temperature minimum.

The performance to eliminate viruses from the drinking water processing plants regularly does not meet the requirements of the WHO and the USA/USEPA. Conventional disinfection procedures are poor, because microorganisms in the water are not in suspension, but embedded in particles. Even ground water used for drinking water is not free from viruses.

In temperate regions influenza epidemics recur with marked seasonality around the end of winter, in the northern as well as in the southern hemisphere. Although seasonality is one of the most familiar features of influenza, it is also one of the least understood. Indoor crowding during cold weather, seasonal fluctuations in host immune responses, and environmental factors, including relative humidity, temperature, and UV radiation have all been suggested to account for this phenomenon, but none of these hypotheses has been tested directly. Influenza causes significant morbidity in tropical regions; however, in contrast to the situation in temperate zones, influenza in the tropics is not strongly associated with a certain season.

In the tropics, flood-related influenza is typical after extreme weather. The virulence of influenza viruses depends on temperature and time. Especially in cases of local water supplies with “young” and fresh influenza-contaminated water from low local wells, cisterns, tanks, rain barrels, ponds, rivers or rice paddies, this pathway can explain H5N1 infections. At 24°C, for example, in the tropics the virulence of influenza viruses in water exists for 2 days. In temperate climates with “older” water from central water supplies, the temperature of the water is decisive for the virulence of viruses. At 7°C the virulence of influenza viruses in water extends to 14 days.

Ducks and rice (paddies = flooded by water) are major factors in outbreaks of avian flu, claims a UN agency: Ducks and rice fields may be a critical factor in spreading H5N1. Ducks, rice (fields, paddies = flooded by water; farmers at work drink the water from rice paddies) and people – not chickens – have emerged as the most significant factors in the spread of avian influenza in Thailand and Vietnam, according to a study carried out by a group of experts from the United Nations Food and Agriculture Organization (FAO) and associated research centres. See http://www.un.org/apps/news/story.asp?NewsID=26096&Cr=&Cr1

The study “Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia: ducks, rice and people” also concludes that these factors are probably behind persistent outbreaks in other countries such as Cambodia and Laos. This study examined a series of waves of H5N1, a highly pathogenic avian influenza, in Thailand and Vietnam between early 2004 and late 2005. Through the use of satellite mapping, researchers looked at several different factors, including the numbers of ducks, geese and chickens, human population size, rice cultivation and geography, and found a strong link between duck grazing patterns and rice cropping intensity.

In Thailand, for example, the proportion of young ducks in flocks was found to peak in September-October; these rapidly growing young ducks can therefore benefit from the peak of the rice harvest in November-December, at the beginning of the cold: Thailand, Vietnam, Cambodia, Laos – as opposed to Indonesia – are located in the northern hemisphere.

These peaks in the congregation of ducks indicate periods in which there is an increase in the chances for virus release and exposure, and rice paddies often become a temporary habitat for wild bird species. In addition, with virus persistence becoming increasingly confined to areas with intensive rice-duck agriculture in eastern and south-eastern Asia, the evolution of the H5N1 virus may become easier to predict.

Dipl.-Ing. Wilfried Soddemann - Epidemiologist - Free Science Journalist soddemann-aachen@t-online.de http://www.dugi-ev.de/information.html