A gene mutation known to help
influenza resist Tamiflu was found in the first of three H7N9
bird-flu patient specimens in China, sequence data show.
The flu virus from the patient in Shanghai has a mutation
known as R292K that causes high-level resistance to the Roche
Holding AG (ROG) pill and reduced sensitivity to a related drug from
GlaxoSmithKline Plc (GSK) called Relenza, genetic sequence information
posted on the website of the Global Initiative on Sharing Avian
Influenza Data show. Subsequent H7N9 specimens from a patient in
Shanghai and one in Anhui province don’t show the mutation.
The Chinese Center for Disease Control and Prevention in
Beijing has studied H7N9 specimens and confirmed that the virus
is sensitive to neuraminidase inhibitors, Tashiro said.
Full article: http://www.bloomberg.com/news/2013-04-11/tamiflu-resistance-gene-in-h7n9-bird-flu-spurs-drug-tests.html